Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes

References

• AkkirajuH, NoheA. Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J Dev Biol. 2015;3(4):177–192. doi:10.3390/jdb304017727347486
   PubMed Web of Science ®Google Scholar
• ZuscikMJ, HiltonMJ, ZhangX, ChenD, O’KeefeRJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest. 2008;118(2):429–438. doi:10.1172/JCI3417418246193
   PubMed Web of Science ®Google Scholar
• ByunK, YooY, SonM, et al. Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. Pharmacol Ther. 2017;177:44–55. doi:10.1016/j.pharmthera.2017.02.03028223234
   PubMed Web of Science ®Google Scholar
• SaudekDM, KayJ. Advanced glycation endproducts and osteoarthritis. Curr Rheumatol Rep. 2003;5(1):33–40. doi:10.1007/s11926-003-0081-x12590883
   PubMedGoogle Scholar
• SonS, HwangI, HanSH, ShinJS, ShinOS, YuJW. Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages. J Biol Chem. 2017;292(50):20437–20448. doi:10.1074/jbc.M117.80630729051224
   PubMed Web of Science ®Google Scholar
• AhmedSM, LuoL, NamaniA, WangXJ, TangX. Nrf2 signaling pathway: pivotal roles in inflammation. Biochim Biophys Acta Mol Basis Dis. 2017;1863(2):585–597. doi:10.1016/j.bbadis.2016.11.00527825853
   PubMed Web of Science ®Google Scholar
• JhangJJ, YenGC. The role of Nrf2 in NLRP3 inflammasome activation. Cell Mol Immunol. 2017;14(12):1011–1012. doi:10.1038/cmi.2017.11429129911
   PubMed Web of Science ®Google Scholar
• WhiteMV. The role of histamine in allergic diseases. J Allergy Clin Immunol. 1990;86(4 Pt 2):599–605. doi:10.1016/S0091-6749(05)80223-41699987
   PubMed Web of Science ®Google Scholar
• TaylorDJ, WoolleyDE. Evidence for both histamine H1 and H2 receptors on human articular chondrocytes. Ann Rheum Dis. 1987;46(6):431–435. doi:10.1136/ard.46.6.4312820319
   PubMed Web of Science ®Google Scholar
• TetlowLC, WoolleyDE. Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage. Ann Rheum Dis. 2003;62(10):991–994. doi:10.1136/ard.62.10.99112972479
   PubMed Web of Science ®Google Scholar
• TetlowLC, WoolleyDE. Histamine stimulates matrix metalloproteinase-3 and −13 production by human articular chondrocytes in vitro. Ann Rheum Dis. 2002;61:737–740. doi:10.1136/ard.61.8.73712117684
   PubMed Web of Science ®Google Scholar
• SohenS, OoeH, HashimaM, NonakaT, FukudaK, HamanishiC. Activation of histamine H1 receptor results in enhanced proteoglycan synthesis by human articular chondrocyte: involvement of protein kinase C and intracellular Ca(2+). Pathophysiology. 2001;8(2):93–98. doi:10.1016/S0928-4680(01)00066-911720804
   PubMedGoogle Scholar
• MayJR, DolenWK. Management of allergic rhinitis: a review for the community pharmacist. Clin Ther. 2017;39(12):2410–2419. doi:10.1016/j.clinthera.2017.10.00629079387
   PubMed Web of Science ®Google Scholar
• BelsitoDV. Second-generation antihistamines for the treatment of chronic idiopathic urticaria. J Drugs Dermatol. 2010;9(5):503–512.20480793
   PubMed Web of Science ®Google Scholar
• BachertC, MasperoJ. Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma. J Asthma. 2011;48(9):965–973. doi:10.3109/02770903.2011.61661621970671
   PubMed Web of Science ®Google Scholar
• RaithelM, NägelA, ZopfY, et al. Plasma histamine levels (H) during adjunctive H1-receptor antagonist treatment with loratadine in patients with active inflammatory bowel disease (IBD). Inflamm Res. 2010;59(Suppl 2):S257–8. doi:10.1007/s00011-009-0120-920087628
   PubMed Web of Science ®Google Scholar
• MondilloC, VarelaML, AbiusoAMB, VázquezR. Potential negative effects of anti-histamines on male reproductive function. Reproduction. 2018;155(5):R221–R227. doi:10.1530/REP-17-068529523718
   PubMed Web of Science ®Google Scholar
• TiligadaE, ZampeliE, SanderK, StarkH. Histamine H3 and H4 receptors as novel drug targets. Expert Opin Investig Drugs. 2009;18:1519–1531. doi:10.1517/14728220903188438
   PubMed Web of Science ®Google Scholar
• de Lange-brokaarBJ, KloppenburgM, AndersenSN, et al. Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters. Osteoarthritis Cartilage. 2016;24(4):664–671. doi:10.1016/j.joca.2015.11.01126671522
   PubMed Web of Science ®Google Scholar
• ShirinskyI, ShirinskyVH. (1)-antihistamines are associated with lower prevalence of radiographic knee osteoarthritis: a cross-sectional analysis of the osteoarthritis initiative data. Arthritis Res Ther. 2018;20(1):116. doi:10.1186/s13075-018-1619-729880063
   PubMed Web of Science ®Google Scholar
• GoldringMB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol. 2006;20(5):1003–1025. doi:10.1016/j.berh.2006.06.00316980220
   PubMed Web of Science ®Google Scholar
• TetlowLC, WoolleyDE. Histamine, histamine receptors (H1 and H2), and histidine decarboxylase expression by chondrocytes of osteoarthritic cartilage: an immunohistochemical study. Rheumatol Int. 2005;26(2):173–178. doi:10.1007/s00296-005-0622-x15986084
   PubMed Web of Science ®Google Scholar
• SteenvoordenMM, HuizingaTW, VerzijlN, et al. Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis Rheum. 2006;54(1):253–263. doi:10.1002/art.2152316385542
   PubMed Web of Science ®Google Scholar
• LaneT, FlamB, LockeyR, KolliputiN. TXNIP shuttling: missing link between oxidative stress and inflammasome activation. Front Physiol. 2013;4:50. doi:10.3389/fphys.2013.0005023520439
   PubMed Web of Science ®Google Scholar
• SutterwalaFS, HaaskenS, CasselSL. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci. 2014;1319:82–95. doi:10.1111/nyas.1245824840700
   PubMed Web of Science ®Google Scholar
• KhanNM, AhmadI, HaqqiTM. Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis. Free Radic Biol Med. 2018;116:159–171. doi:10.1016/j.freeradbiomed.2018.01.01329339024
   PubMed Web of Science ®Google Scholar
• MarchevAS, DimitrovaPA, BurnsAJ, KostovRV, Dinkova-KostovaAT, GeorgievMI. Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime? Ann N Y Acad Sci. 2017;1401(1):114–135. doi:10.1111/nyas.1340728662306
   PubMed Web of Science ®Google Scholar
• ZhangQY, ChuXY, JiangLH, LiuMY, MeiZL, ZhangHY. Identification of non-electrophilic Nrf2 activators from approved drugs. Molecules. 2017;22:6.
   Web of Science ®Google Scholar
• TheodoreM, KawaiY, YangJ, et al. Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2. J Biol Chem. 2008;283(14):8984–8994. doi:10.1074/jbc.M70904020018238777
   PubMed Web of Science ®Google Scholar
• ZhouY, GaoC, WangH, LiuL, HuangZ, FaX. Histamine H1 type receptor antagonist loratadine ameliorates oxidized LDL induced endothelial dysfunction. Biomed Pharmacother. 2018;106:1448–1453. doi:10.1016/j.biopha.2018.07.02530119218
   PubMed Web of Science ®Google Scholar
• WangM, HanJ, DomenicoJ, ShinYS, JiaY, GelfandEW. Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function. Allergy. 2016;71(11):1561–1574. doi:10.1111/all.1290427059534
   PubMed Web of Science ®Google Scholar
• EdaR, SugiyamaH, HoppRJ, BewtraAK, TownleyRG. Effect of loratadine on human eosinophil function in vitro. Ann Allergy. 1993;71(4):373–378.8214802
   PubMedGoogle Scholar
• GebauerM, SaasJ, SohlerF, et al. Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta. Osteoarthritis Cartilage. 2005;13(8):697–708. doi:10.1016/j.joca.2005.04.00415950496
   PubMed Web of Science ®Google Scholar
• von der MarkK, GaussV, von der MarkM, MullerP. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. 1977;267(5611):531–532. doi:10.1038/267531a0559947
   PubMed Web of Science ®Google Scholar