Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration

References

• RajabzadehN, FathiE, FarahzadiR. Stem cell-based regenerative medicine. Stem Cell Investig. 2019;6:19. doi:10.21037/sci
   PubMedGoogle Scholar
• CoreyS, BonsackB, BorlonganCV. Stem cell-based regenerative medicine for neurological disorders: a special tribute to Dr. Teng Ma. Brain Circ. 2019;5(3):97–100. doi:10.4103/bc.bc_39_1931620654
   PubMedGoogle Scholar
• LeeWS, KimHJ, KimKI, KimGB, JinW. Intra-articular injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of knee osteoarthritis: a phase IIb, randomized, placebo-controlled clinical trial. Stem Cells Transl Med. 2019;8(6):504–511. doi:10.1002/sctm.18-012230835956
   PubMed Web of Science ®Google Scholar
• KhanS, MafiP, MafiR, KhanW. A systematic review of mesenchymal stem cells in spinal cord injury, intervertebral disc repair and spinal fusion. Curr Stem Cell Res Ther. 2018;13(4):316–323. doi:10.2174/1574888X1166617090712003028891440
   PubMed Web of Science ®Google Scholar
• JayaramP, IkpeamaU, RothenbergJB, MalangaGA. Bone marrow-derived and adipose-derived mesenchymal stem cell therapy in primary knee osteoarthritis: a narrative review. PM R. 2019;11(2):177–191. doi:10.1016/j.pmrj.2018.06.01930010050
   PubMedGoogle Scholar
• QaziTH, DudaGN, OrtMJ, PerkaC, GeisslerS, WinklerT. Cell therapy to improve regeneration of skeletal muscle injuries. J Cachexia Sarcopenia Muscle. 2019;10(3):501–516. doi:10.1002/jcsm.1241630843380
   PubMed Web of Science ®Google Scholar
• LemckeH, VoroninaN, SteinhoffG, DavidR. Recent progress in stem cell modification for cardiac regeneration. Stem Cells Int. 2018;2018:1909346.29535769
   PubMed Web of Science ®Google Scholar
• GrimmD, EgliM, KrugerM, et al. Tissue engineering under microgravity conditions-use of stem cells and specialized cells. Stem Cells Dev. 2018;27(12):787–804.29596037
   PubMed Web of Science ®Google Scholar
• MadrigalM, RaoKS, RiordanNH. A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med. 2014;12:260.25304688
   PubMed Web of Science ®Google Scholar
• Mendez-FerrerS, MichurinaTV, FerraroF, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829–834. doi:10.1038/nature0926220703299
   PubMed Web of Science ®Google Scholar
• RodriguesM, GriffithLG, WellsA. Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Res Ther. 2010;1(4):32. doi:10.1186/scrt3220977782
   PubMed Web of Science ®Google Scholar
• HuMS, BorrelliMR, LorenzHP, LongakerMT, WanDC. Mesenchymal stromal cells and cutaneous wound healing: a comprehensive review of the background, role, and therapeutic potential. Stem Cells Int. 2018;2018:6901983. doi:10.1155/2018/690198329887893
   PubMed Web of Science ®Google Scholar
• ShafeiAE, AliMA, GhanemHG, et al. Mesenchymal stem cell therapy: a promising cell-based therapy for treatment of myocardial infarction. J Gene Med. 2017;19:12. doi:10.1002/jgm.2995
   Web of Science ®Google Scholar
• LiuF, QiuH, XueM, et al. MSC-secreted TGF-beta regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway. Stem Cell Res Ther. 2019;10(1):345. doi:10.1186/s13287-019-1447-y31771622
   PubMed Web of Science ®Google Scholar
• WuR, LiuC, DengX, ChenL, HaoS, MaL. Enhanced alleviation of aGVHD by TGF-beta1-modified mesenchymal stem cells in mice through shifting MPhi into M2 phenotype and promoting the differentiation of Treg cells. J Cell Mol Med. 2019.
   Web of Science ®Google Scholar
• ZhangB, WangM, GongA, et al. HucMSC-exosome med-Wnt4 signaling is required for cutaneous wound healing. Stem Cells. 2015;33(7):2158–2168. doi:10.1002/stem.177124964196
   PubMed Web of Science ®Google Scholar
• FurutaT, MiyakiS, IshitobiH, et al. Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model. Stem Cells Transl Med. 2016;5(12):1620–1630. doi:10.5966/sctm.2015-028527460850
   PubMed Web of Science ®Google Scholar
• WangLS, WangH, ZhangQL, YangZJ, KongFX, WuCT. Hepatocyte growth factor gene therapy for ischemic diseases. Hum Gene Ther. 2018;29(4):413–423. doi:10.1089/hum.2017.21729409352
   PubMed Web of Science ®Google Scholar
• SongH, SongBW, ChaMJ, ChoiIG, HwangKC. Modification of mesenchymal stem cells for cardiac regeneration. Expert Opin Biol Ther. 2010;10(3):309–319. doi:10.1517/1471259090345599720132054
   PubMed Web of Science ®Google Scholar
• LiX, WangQ, DingL, et al. Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens. Stem Cell Res Ther. 2019;10(1):267. doi:10.1186/s13287-019-1384-931443680
   PubMed Web of Science ®Google Scholar
• LiL, ZhangD, LiP, DamaserM, ZhangY. Virus integration and genome influence in approaches to stem cell based therapy for andro-urology. Adv Drug Deliv Rev. 2015;82-83:12–21. doi:10.1016/j.addr.2014.10.01225453258
   PubMed Web of Science ®Google Scholar
• SzeSK, de KleijnDP, LaiRC, et al. Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol Cell Proteomics. 2007;6(10):1680–1689. doi:10.1074/mcp.M600393-MCP20017565974
   PubMed Web of Science ®Google Scholar
• TsujiK, KitamuraS, WadaJ. Secretomes from mesenchymal stem cells against acute kidney injury: possible heterogeneity. Stem Cells Int. 2018;2018:8693137. doi:10.1155/2018/869313730651737
   PubMed Web of Science ®Google Scholar
• LiuCH, HwangSM. Cytokine interactions in mesenchymal stem cells from cord blood. Cytokine. 2005;32(6):270–279. doi:10.1016/j.cyto.2005.11.00316377203
   PubMed Web of Science ®Google Scholar
• HochAI, BinderBY, GenetosDC, LeachJK. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012;7(4):e35579. doi:10.1371/journal.pone.003557922536411
   PubMed Web of Science ®Google Scholar
• OskowitzA, McFerrinH, GutschowM, CarterML, PochampallyR. Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic. Stem Cell Res. 2011;6(3):215–225. doi:10.1016/j.scr.2011.01.00421421339
   PubMed Web of Science ®Google Scholar
• CaplanAI, DennisJE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98(5):1076–1084. doi:10.1002/(ISSN)1097-464416619257
   PubMed Web of Science ®Google Scholar
• AggarwalS, PittengerMF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105(4):1815–1822. doi:10.1182/blood-2004-04-155915494428
   PubMed Web of Science ®Google Scholar
• ZhangH, YangR, WangZ, LinG, LueTF, LinCS. Adipose tissue-derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration. J Sex Med. 2011;8(2):437–446. doi:10.1111/j.1743-6109.2010.02128.x21114767
   PubMed Web of Science ®Google Scholar
• ArthurA, CakourosD, CooperL, et al. Twist-1 enhances bone marrow mesenchymal stromal cell support of hematopoiesis by modulating CXCL12 expression. Stem Cells. 2016;34(2):504–509. doi:10.1002/stem.226526718114
   PubMed Web of Science ®Google Scholar
• ChenX, NomaniA, PatelN, NouriFS, HatefiA. Bioengineering a non-genotoxic vector for genetic modification of mesenchymal stem cells. Biomaterials. 2018;152:1–14. doi:10.1016/j.biomaterials.2017.10.02829078136
   PubMed Web of Science ®Google Scholar
• ChanJ, O’DonoghueK, DeL, et al. Human fetal mesenchymal stem cells as vehicles for gene delivery. Stem Cells. 2010;23(1):93–102. doi:10.1634/stemcells.2004-0138
   Web of Science ®Google Scholar
• ParkJS, SuryaprakashS, LaoYH, LeongKW. Engineering mesenchymal stem cells for regenerative medicine and drug delivery. Methods. 2015;84:3–16. doi:10.1016/j.ymeth.2015.03.00225770356
   PubMed Web of Science ®Google Scholar
• AslanH, ZilbermanY, ArbeliV, et al. Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration. Tissue Eng. 2006;12(4):877–889. doi:10.1089/ten.2006.12.87716674300
   PubMedGoogle Scholar
• Santiago-TorresJE, LovaszR, BertoneAL. Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction. World J Stem Cells. 2015;7(1):223–234. doi:10.4252/wjsc.v7.i1.22325621122
   PubMed Web of Science ®Google Scholar
• StenderS, MurphyM, O’BrienT, et al. Adeno-associated viral vector transduction of human mesenchymal stem cells. Eur Cell Mater. 2007;13:93–99; discussion 99. doi:10.22203/eCM.v013a10
   PubMed Web of Science ®Google Scholar
• HamannA, NguyenA, PannierAK. Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications. J Biol Eng. 2019;13(1):7. doi:10.1186/s13036-019-0140-030675180
   PubMed Web of Science ®Google Scholar
• SantosJL, PanditaD, RodriguesJ, PegoAP, GranjaPL, TomasH. Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration. Curr Gene Ther. 2011;11(1):46–57. doi:10.2174/15665231179452010221182464
   PubMed Web of Science ®Google Scholar
• GheisariY, SoleimaniM, AzadmaneshK, ZeinaliS. Multipotent mesenchymal stromal cells: optimization and comparison of five cationic polymer-based gene delivery methods. Cytotherapy. 2008;10(8):815–823. doi:10.1080/1465324080247430719058061
   PubMed Web of Science ®Google Scholar
• LuCH, LinKJ, ChiuHY, et al. Improved chondrogenesis and engineered cartilage formation from TGF-beta3-expressing adipose-derived stem cells cultured in the rotating-shaft bioreactor. Tissue Eng Part A. 2012;18(19–20):2114–2124. doi:10.1089/ten.tea.2012.001022712565
   PubMed Web of Science ®Google Scholar
• LoWH, HwangSM, ChuangCK, ChenCY, HuYC. Development of a hybrid baculoviral vector for sustained transgene expression. Mol Ther. 2009;17(4):658–666. doi:10.1038/mt.2009.1319240695
   PubMed Web of Science ®Google Scholar
• HeCX, ZhangTY, MiaoPH, et al. TGF-beta1 gene-engineered mesenchymal stem cells induce rat cartilage regeneration using nonviral gene vector. Biotechnol Appl Biochem. 2012;59(3):163–169. doi:10.1002/bab.100123586825
   PubMed Web of Science ®Google Scholar
• SeoKW, SohnSY, BhangDH, NamMJ, LeeHW, YounHY. Therapeutic effects of hepatocyte growth factor-overexpressing human umbilical cord blood-derived mesenchymal stem cells on liver fibrosis in rats. Cell Biol Int. 2014;38(1):106–116. doi:10.1002/cbin.1018624115681
   PubMed Web of Science ®Google Scholar
• TanZ, ZhaoQ, GongP, et al. Research on promoting periodontal regeneration with human basic fibroblast growth factor-modified bone marrow mesenchymal stromal cell gene therapy. Cytotherapy. 2009;11(3):317–325. doi:10.1080/1465324090282475719308772
   PubMed Web of Science ®Google Scholar
• GandraN, WangDD, ZhuY, MaoC. Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells. Angew Chem Int Ed Engl. 2013;52(43):11278–11281. doi:10.1002/anie.20130111324038718
   PubMed Web of Science ®Google Scholar
• MunJY, ShinKK, KwonO, LimYT, OhDB. Minicircle microporation-based non-viral gene delivery improved the targeting of mesenchymal stem cells to an injury site. Biomaterials. 2016;101:310–320. doi:10.1016/j.biomaterials.2016.05.05727315214
   PubMed Web of Science ®Google Scholar
• HubbsAF, MercerRR, BenkovicSA, et al. Nanotoxicology - a pathologist’s perspective. Toxicol Pathol. 2011;39(2):301–324. doi:10.1177/019262331039070521422259
   PubMed Web of Science ®Google Scholar
• NorppaH, CatalánJ, FalckG, HannukainenK, SiivolaK, SavolainenK. Nano-specific genotoxic effects. J Biomed Nanotechnol. 2011;7(1):19. doi:10.1166/jbn.2011.117921485781
   PubMed Web of Science ®Google Scholar
• FierroFA, KalomoirisS, SondergaardCS, NoltaJA. Effects on proliferation and differentiation of multipotent bone marrow stromal cells engineered to express growth factors for combined cell and gene therapy. Stem Cells. 2011;29(11):1727–1737. doi:10.1002/stem.72021898687
   PubMed Web of Science ®Google Scholar
• ChenYA, QianH, ZhuW, et al. Hepatocyte growth factor modification promotes the amelioration effects of human umbilical cord mesenchymal stem cells on rat acute kidney injury. Stem Cells Dev. 2011;20(1):103–113. doi:10.1089/scd.2009.049520446811
   PubMed Web of Science ®Google Scholar
• GonzálezMN, de MelloW, Butler-BrowneGS, et al. HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway. Skelet Muscle. 2017;7(1):20. doi:10.1186/s13395-017-0138-629017538
   PubMed Web of Science ®Google Scholar
• WangSX, QinX, SunDD, et al. Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts. Cell Biochem Funct. 2012;30(7):574–581. doi:10.1002/cbf.v30.722592978
   PubMed Web of Science ®Google Scholar
• ZhaoMZ, NonoguchiN, IkedaN, et al. Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. J Cereb Blood Flow Metab. 2006;26(9):1176–1188. doi:10.1038/sj.jcbfm.960027316421510
   PubMed Web of Science ®Google Scholar
• MoonHH, JooMK, MokH, et al. MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine. Biomaterials. 2014;35(5):1744–1754. doi:10.1016/j.biomaterials.2013.11.01924280192
   PubMed Web of Science ®Google Scholar
• YanfuH, RanT, YanqingH, et al. Microencapsulated VEGF gene-modified umbilical cord mesenchymal stromal cells promote the vascularization of tissue-engineered dermis: an experimental study. Cytotherapy. 2014;16(2):160–169. doi:10.1016/j.jcyt.2013.10.01424438897
   PubMed Web of Science ®Google Scholar
• TeeJK, SetyawatiMI, PengF, LeongDT, HoHK. Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness. Nanotoxicology. 2019;13(5):682–700. doi:10.1080/17435390.2019.157164630776942
   PubMed Web of Science ®Google Scholar
• SunL, CuiM, WangZ, et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction. Biochem Biophys Res Commun. 2007;357(3):779–784. doi:10.1016/j.bbrc.2007.04.01017445769
   PubMed Web of Science ®Google Scholar
• MeiSH, McCarterSD, DengY, ParkerCH, LilesWC, StewartDJ. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007;4(9):e269. doi:10.1371/journal.pmed.004026917803352
   PubMed Web of Science ®Google Scholar
• XuJ, QuJ, CaoL, et al. Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J Pathol. 2008;214(4):472–481. doi:10.1002/path.230218213733
   PubMed Web of Science ®Google Scholar
• LiY, ZhengL, XuX, et al. Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing. Stem Cell Res Ther. 2013;4(5):113. doi:10.1186/scrt32424477049
   PubMed Web of Science ®Google Scholar
• SchabitzWR, SommerC, ZoderW, KiesslingM, SchwaningerM, SchwabS. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke. 2000;31(9):2212–2217. doi:10.1161/01.STR.31.9.221210978054
   PubMed Web of Science ®Google Scholar
• WangZ, YaoW, DengQ, ZhangX, ZhangJ. Protective effects of BDNF overexpression bone marrow stromal cell transplantation in rat models of traumatic brain injury. J Mol Neurosci. 2013;49(2):409–416. doi:10.1007/s12031-012-9908-023143881
   PubMed Web of Science ®Google Scholar
• KurozumiK, NakamuraK, TamiyaT, et al. BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther. 2004;9(2):189–197.14759803
   PubMed Web of Science ®Google Scholar
• LiWJ, TuliR, OkaforC, et al. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. 2005;26(6):599–609.15282138
   PubMed Web of Science ®Google Scholar
• HerrmannJL, WangY, AbarbanellAM, WeilBR, TanJ, MeldrumDR. Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. Shock. 2010;33(1):24–30.19996917
   PubMed Web of Science ®Google Scholar
• HuangAH, MotlekarNA, SteinA, DiamondSL, ShoreEM, MauckRL. High-throughput screening for modulators of mesenchymal stem cell chondrogenesis. Ann Biomed Eng. 2008;36(11):1909–1921.18791827
   PubMed Web of Science ®Google Scholar
• ScioliMG, CervelliV, ArcuriG, et al. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. J Cell Physiol. 2014;229(12):2077–2087.24818995
   PubMed Web of Science ®Google Scholar
• SaviM, BocchiL, FiumanaE, et al. Enhanced engraftment and repairing ability of human adipose-derived stem cells, conveyed by pharmacologically active microcarriers continuously releasing HGF and IGF-1, in healing myocardial infarction in rats. J Biomed Mater Res A. 2015;103(9):3012–3025.25727843
   PubMed Web of Science ®Google Scholar
• Gomez-MauricioG, MoscosoI, Martin-CanchoMF, et al. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model. Stem Cell Res Ther. 2016;7(1):94.27423905
   PubMed Web of Science ®Google Scholar
• ChenB, LiQ, ZhaoB, WangY. Stem cell-derived extracellular vesicles as a novel potential therapeutic tool for tissue repair. Stem Cells Transl Med. 2017;6(9):1753‐1758.
   Web of Science ®Google Scholar
• ChoiJS, YoonHI, LeeKS, et al. Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. J Control Release. 2016;222:107–115.26699421
   PubMed Web of Science ®Google Scholar
• TsujiK, KitamuraS, WadaJ. Immunomodulatory and regenerative effects of mesenchymal stem cell-derived extracellular vesicles in renal diseases. Int J Mol Sci. 2020;21:3.
   Web of Science ®Google Scholar
• TanCY, LaiRC, WongW, DanYY, LimS-K, HoHK. Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models. Stem Cell Res Ther. 2014;5(3):76.24915963
   PubMed Web of Science ®Google Scholar
• ChoiJS, YoonHI, LeeKS, et al. Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. J Control Release. 2016;222:107–115.26699421
   PubMed Web of Science ®Google Scholar
• ShafeiAE, AliMA, GhanemHG, et al. Mesenchymal stem cells therapy: a promising cell based therapy for treatment of myocardial infraction. J Gene Med. 2017;19:12. doi:10.1002/jgm.2995
   Web of Science ®Google Scholar
• IkedaN, NonoguchiN, ZhaoMZ, et al. Bone marrow stromal cells that enhanced fibroblast growth factor-2 secretion by herpes simplex virus vector improve neurological outcome after transient focal cerebral ischemia in rats. Stroke. 2005;36(12):2725–2730.16282547
   PubMed Web of Science ®Google Scholar
• PollockK, DahlenburgH, NelsonH, et al. Human mesenchymal stem cells genetically engineered to overexpress brain-derived neurotrophic factor improve outcomes in Huntington’s disease mouse models. Mol Ther. 2016;24(5):965–977.26765769
   PubMed Web of Science ®Google Scholar
• ZhaoGY, CuiL, GaoJ, DaiRT, ZhangP. Study on the levels of DA and metabolite in striatum in rats with Parkinson’s disease treated by BDNF gene modified bone mesenchymal stem cells. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013;29(1):82–85.23662416
   PubMedGoogle Scholar
• ChenH, XiaR, LiZ, et al. Mesenchymal stem cells combined with hepatocyte growth factor therapy for attenuating ischaemic myocardial fibrosis: assessment using multimodal molecular imaging. Sci Rep. 2016;6:33700.27804974
   PubMed Web of Science ®Google Scholar
• GaoF, HeT, WangH, et al. A promising strategy for the treatment of ischemic heart disease: mesenchymal stem cell-mediated vascular endothelial growth factor gene transfer in rats. Can J Cardiol. 2007;23(11):891–898.17876381
   PubMed Web of Science ®Google Scholar
• LiZ, MeiJ, ZhangB. Cell transplantation of 5-aza cytidine induced bone marrow stromal cells transfected by angiogenin gene ex vivo into infarcted myocardium, an experimental study. Zhonghua Yi Xue Za Zhi. 2002;82(19):1319–1323.12509935
   PubMedGoogle Scholar
• FanL, LinC, ZhuoS, et al. Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction. Eur J Heart Fail. 2009;11(11):1023–1030.19875403
   PubMed Web of Science ®Google Scholar
• WangH, SunRT, LiY, et al. HGF Gene Modification in mesenchymal stem cells reduces radiation-induced intestinal injury by modulating immunity. PLoS One. 2015;10(5):e0124420.25933295
   PubMed Web of Science ®Google Scholar
• HaoL, WangJ, ZouZ, et al. Transplantation of BMSCs expressing hPDGF-A/hBD2 promotes wound healing in rats with combined radiation-wound injury. Gene Ther. 2009;16(1):34–42.18701914
   PubMed Web of Science ®Google Scholar
• XueJ, LiX, LuY, et al. Gene-modified mesenchymal stem cells protect against radiation-induced lung injury. Mol Ther. 2013;21(2):456–465.23299797
   PubMed Web of Science ®Google Scholar
• HuangJH, SurgeryBDO, HospitalD, et al. Intravenous injection of nerve growth factor gene-modified bone marrow stromal stem cells on the apoptosis of the mouse hepatic cells induced by radiation. J Clin Rehab Tissue Eng Res. 2008;12(38):7503–7506.
   Google Scholar
• KumarS, NagyTR, PonnazhaganS. Therapeutic potential of genetically modified adult stem cells for osteopenia. Gene Ther. 2010;17(1):105–116.19741731
   PubMed Web of Science ®Google Scholar
• DulameaAO. The potential use of mesenchymal stem cells in stroke therapy–From bench to bedside. J Neurol Sci. 2015;352(1–2):1–11.25818674
   PubMed Web of Science ®Google Scholar
• SuYR, WangJ, WuJJ, ChenY, JiangYP. Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin. Neurosci Bull. 2007;23(2):67–74.17592528
   PubMedGoogle Scholar
• LundbergJ, JussingE, LiuZ, et al. Safety of intra-arterial injection with tumor-activated T cells to the rabbit brain evaluated by MRI and SPECT/CT. Cell Transplant. 2017;26(2):283–292.27725029
   PubMed Web of Science ®Google Scholar
• BhatiaV, GuptaV, KhuranaD, SharmaRR, KhandelwalN. Randomized assessment of the safety and efficacy of intra-arterial infusion of autologous stem cells in subacute ischemic stroke. AJNR. 2018;39(5):899–904.29545253
   PubMed Web of Science ®Google Scholar
• FengCJ, PerngCK, LinCH, TsaiCH, HuangPH, MaH. Intra-arterial injection of human adipose-derived stem cells improves viability of the random component of axial skin flaps in nude mice. J Plast Reconstr Aesthet Surg. 2020;73(3):598–607.
   Web of Science ®Google Scholar
• Di SpignaG, IannoneM, LadoganaP, et al. Human cardiac multipotent adult stem cells in 3D matrix: new approach of tissue engineering in cardiac regeneration post-infarction. J Biol Regul Homeost Agents. 2017;31(4):911–921.29254293
   PubMed Web of Science ®Google Scholar
• TangYL, TangY, ZhangYC, QianK, ShenL, PhillipsMI. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol. 2005;46(7):1339–1350.16198853
   PubMed Web of Science ®Google Scholar
• LiuN, ZhangY, FanL, et al. Effects of transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin on experimental stroke in rats. J Transl Med. 2011;9:105.21733181
   PubMed Web of Science ®Google Scholar
• LiW, MaN, OngLL, et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells. 2007;25(8):2118–2127.17478584
   PubMed Web of Science ®Google Scholar
• MangiAA, NoiseuxN, KongDL, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003;9(9):1195–1201.12910262
   PubMed Web of Science ®Google Scholar
• GnecchiM, HeH, NoiseuxN, et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 2006;20(6):661–669.16581974
   PubMed Web of Science ®Google Scholar
• GalloS, SalaV, GattiS, CrepaldiT. Cellular and molecular mechanisms of HGF/Met in the cardiovascular system. Clin Sci (Lond). 2015;129(12):1173–1193.26561593
   PubMed Web of Science ®Google Scholar
• ForteG, MinieriM, CossaP, et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells. 2006;24(1):23–33. doi:10.1634/stemcells.2004-017616100005
   PubMed Web of Science ®Google Scholar
• LuF, ZhaoX, WuJ, et al. MSCs transfected with hepatocyte growth factor or vascular endothelial growth factor improve cardiac function in the infarcted porcine heart by increasing angiogenesis and reducing fibrosis. Int J Cardiol. 2013;167(6):2524–2532. doi:10.1016/j.ijcard.2012.06.05222981278
   PubMed Web of Science ®Google Scholar
• Gomez-MauricioG, MoscosoI, Martin-CanchoMF, et al. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model. Stem Cell Res Ther. 2016;7(1):94. doi:10.1186/s13287-016-0350-z27423905
   PubMed Web of Science ®Google Scholar
• YangZJ, MaDC, WangW, et al. Experimental study of bone marrow-derived mesenchymal stem cells combined with hepatocyte growth factor transplantation via noninfarct-relative artery in acute myocardial infarction. Gene Ther. 2006;13(22):1564–1568. doi:10.1038/sj.gt.330282016810195
   PubMed Web of Science ®Google Scholar
• ZhangJ, WangLL, DuW, et al. Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells. PLoS One. 2014;9(10):e111246. doi:10.1371/journal.pone.011124625360679
   PubMed Web of Science ®Google Scholar
• LaddhaAP, KulkarniYA. VEGF and FGF-2: promising targets for the treatment of respiratory disorders. Respir Med. 2019;156:33–46. doi:10.1016/j.rmed.2019.08.00331421589
   PubMed Web of Science ®Google Scholar
• GiriTK, AlexanderA, AgrawalM, SarafS, SarafS. Ajazuddin. Current status of stem cell therapies in tissue repair and regeneration. Curr Stem Cell Res Ther. 2019;14(2):117–126. doi:10.2174/1574888X1366618050210383129732992
   PubMed Web of Science ®Google Scholar
• KongF, ShiX, XiaoF, et al. Transplantation of HGF modified dental pulp stem cells prevents bone loss in the early phase of ovariectomy-induced osteoporosis. Hum Gene Ther. 2018;29(2):271–282. doi:10.1089/hum.2017.09128950723
   PubMed Web of Science ®Google Scholar
• ZhangJ, ChenJ. Bone tissue regeneration - application of mesenchymal stem cells and cellular and molecular mechanisms. Curr Stem Cell Res Ther. 2017;12(5):357–364. doi:10.2174/1574888X1166616092112155527658728
   PubMed Web of Science ®Google Scholar
• PacelliS, BasuS, WhitlowJ, et al. Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration. Adv Drug Deliv Rev. 2017;120:50–70. doi:10.1016/j.addr.2017.07.01128734899
   PubMed Web of Science ®Google Scholar
• BrungerJM, HuynhNP, GuentherCM, et al. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proc Natl Acad Sci U S A. 2014;111(9):E798–E806. doi:10.1073/pnas.132174411124550481
   PubMed Web of Science ®Google Scholar
• WangT, LiaoT, WangH, DengW, YuD. Transplantation of bone marrow stromal cells overexpressing human vascular endothelial growth factor 165 enhances tissue repair in a rat model of radiation-induced injury. Chin Med J (Engl). 2014;127(6):1093–1099.24622441
   PubMed Web of Science ®Google Scholar
• HuS, ChenY, LiL, et al. Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease. Int J Radiat Oncol Biol Phys. 2009;75(5):1537–1544. doi:10.1016/j.ijrobp.2009.07.169719931736
   PubMed Web of Science ®Google Scholar
• LiQ, SunH, XiaoF, et al. Protection against radiation-induced hematopoietic damage in bone marrow by hepatocyte growth factor gene transfer. Int J Radiat Biol. 2014;90(1):36–44. doi:10.3109/09553002.2014.84729424059647
   PubMed Web of Science ®Google Scholar
• ZhangJ, ZhouS, ZhouY, et al. Hepatocyte growth factor gene-modified adipose-derived mesenchymal stem cells ameliorate radiation induced liver damage in a rat model. PLoS One. 2014;9(12):e114670. doi:10.1371/journal.pone.011467025501583
   PubMed Web of Science ®Google Scholar
• ChenS, ChenX, WuX, et al. Hepatocyte growth factor-modified mesenchymal stem cells improve ischemia/reperfusion-induced acute lung injury in rats. Gene Ther. 2017;24(1):3–11. doi:10.1038/gt.2016.6427556817
   PubMed Web of Science ®Google Scholar
• ShaoY, ShenJ, ZhouF, HeD. Mesenchymal stem cells overexpressing Ang1 attenuates phosgene-induced acute lung injury in rats. Inhal Toxicol. 2018;30(7–8):313–320. doi:10.1080/08958378.2018.152148330395743
   PubMed Web of Science ®Google Scholar
• SageEK, ThakrarRM, JanesSM. Genetically modified mesenchymal stromal cells in cancer therapy. Cytotherapy. 2016;18(11):1435–1445. doi:10.1016/j.jcyt.2016.09.00327745603
   PubMed Web of Science ®Google Scholar
• WeissDJ, CasaburiR, FlanneryR, LeRoux-WilliamsM, TashkinDP. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest. 2013;143(6):1590–1598. doi:10.1378/chest.12-209423172272
   PubMed Web of Science ®Google Scholar
• WilsonJG, LiuKD, ZhuoH, et al. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015;3(1):24–32. doi:10.1016/S2213-2600(14)70291-725529339
   PubMed Web of Science ®Google Scholar
• RipaRS, WangY, JørgensenE, JohnsenHE, HesseB, KastrupJ. Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease. European Heart Journal. 2006;27(15):1785–1792.16825290
   PubMed Web of Science ®Google Scholar
• WheelockV, TempkinT, DuffyA, et al. PRE-CELL: clinical and novel biomarker measures of disease progression in a lead-in-observational study for a planned phase 1 trial of genetically modified mesenchymal stem cells over-expressing BDNF in patients with Huntington’s disease (S25.004) Neurology. 2016;86(16 Supplement):S25.004.
   Google Scholar
• DengP, TorrestA, PollockK, et al. Clinical trial perspective for adult and juvenile Huntington’s disease using genetically-engineered mesenchymal stem cells. Neural Regen Res. 2016;11(05):702–705. doi:10.4103/1673-5374.18268227335539
   PubMed Web of Science ®Google Scholar
• DaleyGQ, HyunI, ApperleyJF, et al. Setting global standards for stem cell research and clinical translation: the 2016 ISSCR guidelines. Stem Cell Reports. 2016;6(6):787–797. doi:10.1016/j.stemcr.2016.05.00127185282
   PubMed Web of Science ®Google Scholar
• Munoz RuizM, RegueiroJR. New tools in regenerative medicine: gene therapy. Adv Exp Med Biol. 2012;741:254–275.22457115
   PubMed Web of Science ®Google Scholar
• PoulosJ. The limited application of stem cells in medicine: a review. Stem Cell Res Ther. 2018;9(1):1. doi:10.1186/s13287-017-0735-729291747
   PubMed Web of Science ®Google Scholar
• ImamuraA, KajiyaH, FujisakiS, et al. Three-dimensional spheroids of mesenchymal stem/stromal cells promote osteogenesis by activating stemness and Wnt/beta-catenin. Biochem Biophys Res Commun. 2020;523(2):458–464. doi:10.1016/j.bbrc.2019.12.06631882121
   PubMed Web of Science ®Google Scholar
• KingNM, PerrinJ. Ethical issues in stem cell research and therapy. Stem Cell Res Ther. 2014;5(4):85. doi:10.1186/scrt47425157428
   PubMed Web of Science ®Google Scholar