The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages

References

• NathanC, DingA. Nonresolving inflammation. Cell. 2010;140(6):871–882. doi:10.1016/j.cell.2010.02.02920303877
   PubMed Web of Science ®Google Scholar
• ReuterS, GuptaSC, ChaturvediMM, AggarwalBB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010;49(11):1603–1616. doi:10.1016/j.freeradbiomed.2010.09.00620840865
   PubMed Web of Science ®Google Scholar
• LeeHT, KimSK, KimSH, et al. Transcription-related element gene expression pattern differs between microglia and macrophages during inflammation. Inflamm Res. 2014;63(5):389–397. doi:10.1007/s00011-014-0711-y24468891
   PubMed Web of Science ®Google Scholar
• MosserDM, EdwardsJP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8(12):958–969. doi:10.1038/nri244819029990
   PubMed Web of Science ®Google Scholar
• ShinJS, HongY, LeeHH, et al. Fulgidic Acid isolated from the rhizomes of cyperus rotundus suppresses LPS-Induced iNOS, COX-2, TNF-α, and IL-6 expression by AP-1 inactivation in RAW264.7 macrophages. Biol Pharm Bull. 2015;38(7):1081–1086. doi:10.1248/bpb.b15-0018626133719
   PubMed Web of Science ®Google Scholar
• JeongYH, OhYC, ChoWK, YimNH, MaJY. Anti-Inflammatory effect of rhapontici radix ethanol extract via inhibition of NF-κB and MAPK and induction of HO-1 in macrophages. Mediators Inflamm. 2016;2016:7216912. doi:10.1155/2016/721691227524868
   PubMed Web of Science ®Google Scholar
• SchankJR, HeiligM. Substance P and the neurokinin-1 receptor: the New CRF. Int Rev Neurobiol. 2017;136:151–175.29056150
   PubMed Web of Science ®Google Scholar
• KookYA, LeeSK, SonDH, et al. Effects of substance P on osteoblastic differentiation and heme oxygenase-1 in human periodontal ligament cells. Cell Biol Int. 2009;33(3):424–428. doi:10.1016/j.cellbi.2008.12.00719356703
   PubMed Web of Science ®Google Scholar
• KoonHW, ShihD, KaragiannidesI, et al. Substance P modulates colitis-associated fibrosis. Am J Pathol. 2010;177(5):2300–2309. doi:10.2353/ajpath.2010.10031420889569
   PubMed Web of Science ®Google Scholar
• EbnerK, MuiggP, SingewaldG, SingewaldN. Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry. Ann N Y Acad Sci. 2008;1144(1):61–73. doi:10.1196/annals.1418.01819076365
   PubMed Web of Science ®Google Scholar
• MouL, KangY, ZhouY, ZengQ, SongH, WangR. Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP). J Biol Chem. 2013;288(1):306–318. doi:10.1074/jbc.M112.38978323166329
   PubMed Web of Science ®Google Scholar
• FriessH, ZhuZ, LiardV, et al. Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer. Lab Invest. 2003;83(5):731–742. doi:10.1097/01.LAB.0000067499.57309.F612746482
   PubMed Web of Science ®Google Scholar
• PatelL, LindleyC. Aprepitant-a novel NK1-receptor antagonist. Expert Opin Pharmacother. 2003;4(12):2279–2296. doi:10.1517/14656566.4.12.227914640927
   PubMed Web of Science ®Google Scholar
• QuartaraL, AltamuraM. Tachykinin receptors antagonists: from research to clinic. Curr Drug Targets. 2006;7(8):975–992. doi:10.2174/13894500677801938116918326
   PubMed Web of Science ®Google Scholar
• LiuX, ZhuY, ZhengW, QianT, WangH, HouX. Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. Artif Cells Nanomed Biotechnol. 2019;47(1):1628–1634. doi:10.1080/21691401.2019.157317731010320
   PubMed Web of Science ®Google Scholar
• WangC, ShaoL, PanC, et al. Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition. Stem Cell Res Ther. 2019;10(1):175–186. doi:10.1186/s13287-019-1265-231196164
   PubMed Web of Science ®Google Scholar
• LeeSI, KangKS, KangKS. Omega-3 fatty acids modulate cyclophosphamide induced markers of immunosuppression and oxidative stress in pigs. Sci Rep. 2019;9(1):2684–2691. doi:10.1038/s41598-019-39458-x30804435
   PubMed Web of Science ®Google Scholar
• AshleyJW, HancockWD, NelsonAJ, et al. Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2). J Biol Chem. 2016;291(44):23268–23281. doi:10.1074/jbc.M116.75494527650501
   PubMed Web of Science ®Google Scholar
• ZhengW, PanH, WeiL, GaoF, LinX. Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes. Int Immunopharmacol. 2019;74:105649. doi:10.1016/j.intimp.2019.05.03431185450
   PubMed Web of Science ®Google Scholar
• WeitzmanSA, GordonLI. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood. 1990;76(4):655–663. doi:10.1182/blood.V76.4.655.6552200535
   PubMed Web of Science ®Google Scholar
• RossoM, MuñozM, BergerM. The role of neurokinin-1 receptor in the microenvironment of inflammation and cancer. ScientificWorldJournal. 2012;2012:381434.22545017
   PubMedGoogle Scholar
• O’ConnorTM, O’ConnellJ, O’BrienDI, GoodeT, BredinCP, ShanahanF. The role of substance P in inflammatory disease. J Cell Physiol. 2004;201(2):167–180. doi:10.1002/jcp.2006115334652
   PubMed Web of Science ®Google Scholar
• ZhouX, ZhangHL, GuGF, et al. Investigation of the relationship between chromobox homolog 8 and nucleus pulposus cells degeneration in rat intervertebral disc. In Vitro Cell Dev Biol Anim. 2013;49(4):279–286. doi:10.1007/s11626-013-9596-223572236
   PubMed Web of Science ®Google Scholar
• GuhaM, MackmanN. LPS induction of gene expression in human monocytes. Cell Signal. 2001;13(2):85–94. doi:10.1016/S0898-6568(00)00149-211257452
   PubMed Web of Science ®Google Scholar
• GuX, GuB, LvX, et al. 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. Cell Death Dis. 2016;7(10):e2423. doi:10.1038/cddis.2016.30027763638
   PubMed Web of Science ®Google Scholar
• PhullAR, NasirB, HaqIU, KimSJ. Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis. Chem Biol Interact. 2018;281:121–136. doi:10.1016/j.cbi.2017.12.02429258867
   PubMed Web of Science ®Google Scholar
• KiemerAK, HartungT, HuberC, VollmarAM. Phyllanthusamarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway. J Hepatol. 2003;38(3):289–297. doi:10.1016/S0168-8278(02)00417-812586294
   PubMed Web of Science ®Google Scholar
• PanMH, LaiCS, WangYJ, HoCT. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol. 2006;72(10):1293–1303. doi:10.1016/j.bcp.2006.07.03916949556
   PubMed Web of Science ®Google Scholar
• JohnsonGL, LapadatR. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298(5600):1911–1912. doi:10.1126/science.107268212471242
   PubMed Web of Science ®Google Scholar
• TakPP, FiresteinGS. NF-κB: a key role in inflammatory diseases. J Clin Invest. 2001;107(1):7–11. doi:10.1172/JCI1183011134171
   PubMed Web of Science ®Google Scholar
• ChernovaI, LaiJP, LiH, et al. (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J Leukoc Biol. 2009;85(1):154–164. doi:10.1189/jlb.040826018835883
   PubMed Web of Science ®Google Scholar
• PakaiE, TekusV, ZsiborasC, et al. The neurokinin-1 receptor contributes to the early phase of lipopolysaccharide-induced fever via stimulation of peripheral cyclooxygenase-2 protein expression in mice. Front Immunol. 2018;5(9):166. doi:10.3389/fimmu.2018.00166
   Web of Science ®Google Scholar
• FulenwiderHD, SmithBM, NichenkoAS, et al. Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation. J Neuroinflammation. 2018;15(1):60. doi:10.1186/s12974-018-1098-429486768
   PubMed Web of Science ®Google Scholar