125
Views
20
CrossRef citations to date
0
Altmetric
Original Research

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway

, , , &
Pages 2021-2031 | Published online: 25 May 2020

References

  • KhoshnamSE, WinlowW, FarzanehM, FarboodY, MoghaddamHF. Pathogenic mechanisms following ischemic stroke. Neurol Sci. 2017;38(7):1167–1186.28417216
  • GalloA, GalliazzoS, GrazioliS, GuastiL, AgenoW, SquizzatoA. Epidemiology and secondary prevention of ischemic stroke in patients on antiplatelet drug: a retrospective cohort study. J Thromb Thrombolysis. 2019;48(2):336–344. doi:10.1007/s11239-019-01893-y31177486
  • NavisA, Garcia-SantibanezR, SkliutM. Epidemiology and outcomes of ischemic stroke and transient ischemic attack in the adult and geriatric population. J Stroke Cerebrovasc Dis. 2019;28(1):84–89. doi:10.1016/j.jstrokecerebrovasdis.2018.09.01330297169
  • VenoSK, BorkCS, JakobsenMU, et al. Marine n-3 polyunsaturated fatty acids and the risk of ischemic stroke. Stroke. 2019;50(2):274–282. doi:10.1161/STROKEAHA.118.02338430602356
  • SunL, ClarkeR, BennettD, et al. Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults. Nat Med. 2019;25(4):569–574. doi:10.1038/s41591-019-0366-x30858617
  • NaveAH, von EckardsteinA. Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism? Clin Res Cardiol Suppl. 2019;14(Suppl 1):28–32. doi:10.1007/s11789-019-00101-830838553
  • VarboA, NordestgaardBG. Remnant cholesterol and risk of ischemic stroke in 112,512 individuals from the general population. Ann Neurol. 2019;85(4):550–559. doi:10.1002/ana.2543230723955
  • ShakibN, Khadem AnsariMH, KarimiP, RasmiY. Neuroprotective mechanism of low-dose sodium nitrite in oxygen-glucose deprivation model of cerebral ischemic stroke in PC12 cells. EXCLI J. 2019;18:229–242. doi:10.17179/excli2018-194731217786
  • UrabeT, WatadaH, OkumaY, et al. Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients. Stroke. 2009;40(4):1289–1295. doi:10.1161/STROKEAHA.108.52255719164796
  • BjerkreimAT, KhanevskiAN, ThomassenL, et al. Five-year readmission and mortality differ by ischemic stroke subtype. J Neurol Sci. 2019;403:31–37. doi:10.1016/j.jns.2019.06.00731185434
  • LiX, YanX, WangF, et al. Down-regulated lncRNA SLC25A5-AS1 facilitates cell growth and inhibits apoptosis via miR-19a-3p/PTEN/PI3K/AKT signalling pathway in gastric cancer. J Cell Mol Med. 2019;23(4):2920–2932. doi:10.1111/jcmm.1420030793479
  • BaiR, CuiZ, MaY, et al. The NF-kappaB-modulated miR-19a-3p enhances malignancy of human ovarian cancer cells through inhibition of IGFBP-3 expression. Mol Carcinog. 2019;58(12):2254–2265. doi:10.1002/mc.2311331513316
  • LeeS, LeeH, BaeH, ChoiEH, KimSJ. Epigenetic silencing of miR-19a-3p by cold atmospheric plasma contributes to proliferation inhibition of the MCF-7 breast cancer cell. Sci Rep. 2016;6:30005. doi:10.1038/srep3000527445062
  • ZhangB, LiuY, ZhangJ. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019;17(1):414–421. doi:10.3892/ol.2018.959230655782
  • JiangXM, YuXN, LiuTT, et al. microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. Biomed Pharmacother. 2018;105:1147–1154. doi:10.1016/j.biopha.2018.06.09730021351
  • Gollmann-TepekoyluC, PolzlL, GraberM, et al. miR-19a-3p containing exosomes improve function of ischemic myocardium upon shock wave therapy. Cardiovasc Res. 2019.
  • GeXL, WangJL, LiuX, ZhangJ, LiuC, GuoL. Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis. Cell Mol Biol Lett. 2019;24:37. doi:10.1186/s11658-019-0160-231168302
  • CarlingD. AMPK signalling in health and disease. Curr Opin Cell Biol. 2017;45:31–37. doi:10.1016/j.ceb.2017.01.00528232179
  • GuptaAP, SinghP, GargR, et al. Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice. Biomed Pharmacother. 2019;116:108959. doi:10.1016/j.biopha.2019.10895931108350
  • SunP, YinJB, LiuLH, et al. Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway. Biosci Rep. 2019;39:1. doi:10.1042/BSR20180902
  • LuQ, LiX, LiuJ, et al. AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases. Biosci Rep. 2019;39:2. doi:10.1042/BSR20181995
  • DayEA, FordRJ, SteinbergGR. AMPK as a therapeutic target for treating metabolic diseases. Trends Endocrinol Metab. 2017;28(8):545–560. doi:10.1016/j.tem.2017.05.00428647324
  • BaylissJA, LemusMB, StarkR, et al. Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinson’s disease. J Neurosci. 2016;36(10):3049–3063. doi:10.1523/JNEUROSCI.4373-15.201626961958
  • DuanJ, CuiJ, YangZ, et al. Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3beta/Nrf2 signaling. J Neuroinflammation. 2019;16(1):24. doi:10.1186/s12974-019-1406-730709405
  • DagonY, AvrahamY, MagenI, GertlerA, Ben-HurT, BerryEM. Nutritional status, cognition, and survival: a new role for leptin and AMP kinase. J Biol Chem. 2005;280(51):42142–42148. doi:10.1074/jbc.M50760720016203737
  • LiuR, LiaoXY, PanMX, et al. Glycine exhibits neuroprotective effects in ischemic stroke in rats through the inhibition of M1 microglial polarization via the NF-kappaB p65/Hif-1alpha signaling pathway. J Immunol. 2019;202(6):1704–1714. doi:10.4049/jimmunol.180116630710045
  • CaiCC, ZhuJH, YeLX, et al. Glycine protects against hypoxic-ischemic brain injury by regulating mitochondria-mediated autophagy via the AMPK pathway. Oxid Med Cell Longev. 2019;2019:4248529. doi:10.1155/2019/424852930881590
  • LinSC, HardieDG. AMPK: sensing glucose as well as cellular energy status. Cell Metab. 2018;27(2):299–313. doi:10.1016/j.cmet.2017.10.00929153408