Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

References

• FrijsteinMM, LokCAR, ShortD, et al. The results of treatment with high-dose chemotherapy and peripheral blood stem cell support for gestational trophoblastic neoplasia. Eur J Cancer. 2019;109:162–171. doi:10.1016/j.ejca.2018.12.03330731277
   PubMed Web of Science ®Google Scholar
• LeeJB, AdrowerC, QinC, FischerPM, de MoorCH, GershkovichP. Development of cordycepin formulations for preclinical and clinical studies. AAPS PharmSciTech. 2017;8(8):3219–3226. doi:10.1208/s12249-017-0795-0
   Web of Science ®Google Scholar
• AhnYJ, ParkSJ, LeeSG, ShinSC, ChoiDH. Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J Agric Food Chem. 2000;48(7):2744–2748. doi:10.1021/jf990862n10898616
   PubMed Web of Science ®Google Scholar
• LiY, LiK, MaoL, et al. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ. 2016;4:e1992. doi:10.7717/peerj.199227190710
   PubMed Web of Science ®Google Scholar
• ChenYC, ChenYH, PanBS, ChangMM, HuangBM. Functional study of cordyceps sinensis and cordycepin in male reproduction: a review. J Food Drug Anal. 2017;25(1):197–205. doi:10.1016/j.jfda.2016.10.02028911537
   PubMed Web of Science ®Google Scholar
• LeuSF, ChienCH, TsengCY, KuoYM, HuangBM. The in vivo effect of cordyceps sinensis mycelium on plasma corticosterone level in male mouse. Biol Pharm Bull. 2005;28(9):1722–1725. doi:10.1248/bpb.28.172216141547
   PubMed Web of Science ®Google Scholar
• PanBS, WangYK, LaiMS, MuYF, HuangBM. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015;5:13372. doi:10.1038/srep1337226303320
   PubMed Web of Science ®Google Scholar
• ZengY, LianS, LiD, et al. Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-kappaB pathway in mice. Biomed Pharmacother. 2017;95:1868–1875. doi:10.1016/j.biopha.2017.09.06928968944
   PubMed Web of Science ®Google Scholar
• HwangJH, JooJC, KimDJ, et al. Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells. Am J Cancer Res. 2016;6(8):1758–1771.27648363
   PubMed Web of Science ®Google Scholar
• WangXA, XiangSS, LiHF, et al. Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells. Molecules. 2014;19(8):11350–11365. doi:10.3390/molecules19081135025090123
   PubMed Web of Science ®Google Scholar
• LiaoY, LingJ, ZhangG, et al. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in leukemia cells. Cell Cycle. 2015;14(5):761–771. doi:10.1080/15384101.2014.100009725590866
   PubMed Web of Science ®Google Scholar
• TsaiYJ, LinLC, TsaiTH. Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of cordyceps sinensis in rat. J Agric Food Chem. 2010;58(8):4638–4643. doi:10.1021/jf100269g20302371
   PubMed Web of Science ®Google Scholar
• KristensenAR, SchandorffS, Hoyer-HansenM, et al. Ordered organelle degradation during starvation-induced autophagy. Mol Cell Proteomics. 2008;7(12):2419–2428. doi:10.1074/mcp.M800184-MCP20018687634
   PubMed Web of Science ®Google Scholar
• BaeH, GuanJL. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Mol Cancer Res. 2011;9(9):1232–1241. doi:10.1158/1541-7786.MCR-11-009821807966
   PubMed Web of Science ®Google Scholar
• LeeSW, KimH-K, LeeN-H, et al. The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells. Cancer Lett. 2015;360(2):195–204. doi:10.1016/j.canlet.2015.02.01225681668
   PubMed Web of Science ®Google Scholar
• SehgalAR, KonigH, JohnsonDE, et al. You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia. Leukemia. 2015;29(3):517–525. doi:10.1038/leu.2014.34925541151
   PubMed Web of Science ®Google Scholar
• XieBS, ZhaoHC, YaoSK, et al. Autophagy inhibition enhances etoposide-induced cell death in human hepatoma G2 cells. Int J Mol Med. 2011;27(4):599–606. doi:10.3892/ijmm.2011.60721274505
   PubMed Web of Science ®Google Scholar
• ParkJM, JungCH, SeoM, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12(3):547–564. doi:10.1080/15548627.2016.114029327046250
   PubMed Web of Science ®Google Scholar
• TanidaI, UenoT, KominamiE. LC3 and autophagy. Methods Mol Biol. 2008;445:77–88. doi:10.1007/978-1-59745-157-4_418425443
   PubMedGoogle Scholar
• LiY, LiR, ZhuS, et al. Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells. Oncol Lett. 2015;9(6):2541–2547. doi:10.3892/ol.2015.306626137103
   PubMed Web of Science ®Google Scholar
• LeeHH, KimSO, KimGY, et al. Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells. Environ Toxicol Pharmacol. 2014;38(1):239–250. doi:10.1016/j.etap.2014.06.00324973666
   PubMed Web of Science ®Google Scholar
• Bettencourt-DiasM, GloverDM. Centrosome biogenesis and function: centrosomics brings new understanding. Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol. 2007;8(6):451–463. doi:10.1038/nrm218017505520
   PubMed Web of Science ®Google Scholar
• SchliwaM, EuteneuerU, GrafR, UedaM. Centrosomes, microtubules and cell migration. Biochem Soc Symp. 1999;65:223–231.10320941
   PubMedGoogle Scholar
• HinchcliffeEH, SluderG. “It takes two to tango”: understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev. 2001;15(10):1167–1181. doi:10.1101/gad.89400111358861
   PubMed Web of Science ®Google Scholar
• WangCY, HuangEY, HuangSC, ChungBC. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. Oncogene. 2015;34(10):1263–1269. doi:10.1038/onc.2014.7424662822
   PubMed Web of Science ®Google Scholar
• LienWC, ChenTY, SheuSY, et al. 7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells. J Cell Biochem. 2018;119(6):4729–4741. doi:10.1002/jcb.2665229280173
   PubMed Web of Science ®Google Scholar
• LaiPY, WangCY, ChenWY, et al. Steroidogenic factor 1 (NR5A1) resides in centrosomes and maintains genomic stability by controlling centrosome homeostasis. Cell Death Differ. 2011;18(12):1836–1844. doi:10.1038/cdd.2011.5421566663
   PubMed Web of Science ®Google Scholar
• ChenTY, SyuJS, LinTC, ChengHL, LuFL, WangCY. Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells. Oncogenesis. 2015;4:e180. doi:10.1038/oncsis.2015.3726690546
   PubMed Web of Science ®Google Scholar
• D’AngiolellaV, DonatoV, VijayakumarS, et al. SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466(7302):138–142. doi:10.1038/nature0914020596027
   PubMed Web of Science ®Google Scholar
• WangCY, HongYH, SyuJS, et al. LRWD1 regulates microtubule nucleation and proper cell cycle progression in the human testicular embryonic carcinoma cells. J Cell Biochem. 2018;119(1):314–326. doi:10.1002/jcb.2618028569402
   PubMed Web of Science ®Google Scholar
• ChenTY, LienWC, ChengHL, KuanTS, SheuSY, WangCY. Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150(glued). J Cell Physiol. 2019;234(7):10445–10457. doi:10.1002/jcp.2771230417365
   PubMed Web of Science ®Google Scholar
• SchallerMD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci. 2010;123(Pt 7):1007–1013. doi:10.1242/jcs.04511220332118
   PubMed Web of Science ®Google Scholar
• DodsonH, BourkeE, JeffersLJ, et al. Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J. 2004;23(19):3864–3873. doi:10.1038/sj.emboj.760039315359281
   PubMed Web of Science ®Google Scholar
• DurocherD, JacksonSP. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol. 2001;13(2):225–231. doi:10.1016/s0955-0674(00)00201-511248557
   PubMed Web of Science ®Google Scholar
• ShintaniT, KlionskyDJ. Autophagy in health and disease: a double-edged sword. Science. 2004;306(5698):990–995. doi:10.1126/science.109999315528435
   PubMed Web of Science ®Google Scholar
• IshikawaF, UshidaK, MoriK, ShibanumaM. Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling. Cell Death Dis. 2015;6:e1619. doi:10.1038/cddis.2014.58325611393
   PubMed Web of Science ®Google Scholar
• LiSZ, RenJW, FeiJ, ZhangXD, DuRL. Cordycepin induces baxdependent apoptosis in colorectal cancer cells. Mol Med Rep. 2019;19(2):):901–908. doi:10.3892/mmr.2018.971730535479
   PubMed Web of Science ®Google Scholar
• XuJC, ZhouXP, WangXA, et al. Cordycepin induces apoptosis and G2/M phase arrest through the ERK pathways in esophageal cancer cells. J Cancer. 2019;10(11):2415–2424. doi:10.7150/jca.3207131258746
   PubMed Web of Science ®Google Scholar
• BourkeE, DodsonH, MerdesA, et al. DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep. 2007;8(6):603–609. doi:10.1038/sj.embor.740096217468739
   PubMed Web of Science ®Google Scholar
• LinYF, ShihHY, ShangZ, MatsunagaS, ChenBP. DNA-PKcs is required to maintain stability of Chk1 and claspin for optimal replication stress response. Nucleic Acids Res. 2014;42(7):4463–4473. doi:10.1093/nar/gku11624500207
   PubMed Web of Science ®Google Scholar
• PantaGR, KaurS, CavinLG, et al. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol. 2004;24(5):1823–1835. doi:10.1128/mcb.24.5.1823-1835.200414966265
   PubMed Web of Science ®Google Scholar