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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Clinical Trial Report

Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial

Dongyue Wang1 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8935-7732
ORCID Icon,
Min Wang1 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-7712-6360
ORCID Icon,
Hui Zhang1 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China
,
He Zhu1 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China
,
Na Zhang1 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China
&
Jindong Liu2 Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence[email protected]
Pages 3263-3270 | Published online: 11 Aug 2020

References

  • JammerI, WickboldtN, SanderM, et al. Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol. 2015;32(2):88–105. doi:10.1097/EJA.000000000000011825058504
  • CanetJ, GallartL, GomarC, et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology. 2010;113(6):1338–1350. doi:10.1097/ALN.0b013e3181fc6e0a21045639
  • MathisMR, DuggalNM, LikoskyDS, et al. Intraoperative mechanical ventilation and postoperative pulmonary complications after cardiac surgery. Anesthesiology. 2019;131(5):1046–1062. doi:10.1097/ALN.000000000000290931403976
  • KoikeK, IshigamiA, SatoY, et al. Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration. Am J Respir Cell Mol Biol. 2014;50:347–357. doi:10.1165/rcmb.2013-0121OC24032444
  • ShaghaghiH, KadlecekS, SiddiquiS, et al. Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using 31P and hyperpolarized 13C nuclear magnetic resonance. Free Radic Biol Med. 2015;89:62–71. doi:10.1016/j.freeradbiomed.2015.06.04226165188
  • Costa LemeA, HajjarLA, VolpeMS, et al. Effect of intensive vs moderate alveolar recruitment strategies added to lung-protective ventilation on postoperative pulmonary complications: a randomized clinical trial. JAMA. 2017;317(14):1422–1432. doi:10.1001/jama.2017.229728322416
  • FutierE, ConstantinJM, Paugam-BurtzC, et al. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med. 2013;369(5):428–437. doi:10.1056/NEJMoa130108223902482
  • HulzebosEH, HeldersPJ, FaviéNJ, et al. Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery: a randomized clinical trial. JAMA. 2006;296:1851–1857. doi:10.1001/jama.296.15.185117047215
  • KroenkeK, LawrenceVA, TherouxJF. Operative risk in patients with severe obstructive pulmonary disease. Arch Intern Med. 1992;152(5):967–971. doi:10.1001/archinte.1992.004001700570111580723
  • HillA, WendtS, BenstoemC, et al. Vitamin C to improve organ dysfunction in cardiac surgery patients-review and pragmatic approach. Nutrients. 2018;10(8):974. doi:10.3390/nu10080974
  • LevineM, RumseySC, DaruwalaR, et al. Criteria and recommendations for vitamin C intake. JAMA. 1999;281:1415–1423. doi:10.1001/jama.281.15.141510217058
  • Desai M, Gurusamy KS, Ghanbari H, et al. Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular surgical procedures. Cochrane Database Syst Rev. 2011;12:CD008472.
  • Han M, Pendem S, Teh SL, et al. Ascorbate protects endothelial barrier function during septic insult: role of protein phosphatase type 2A. Free Radic Biol Med. 2010;48:128–135. doi:10.1016/j.freeradbiomed.2009.10.034
  • TymlK. Vitamin C and microvascular dysfunction in systemic inflammation. Antioxidants (Basel). 2017;6(3):49.
  • Oudemans-van StraatenHM, Spoelstra-de ManAM. Vitamin C revisited. Crit Care. 2014;18(4):460. doi:10.1186/s13054-014-0460-x25185110
  • FukushimaR. Vitamin C requirement in surgical patients. Curr Opin Clin Nutr Metab Care. 2010;13(6):669–676. doi:10.1097/MCO.0b013e32833e05bc20689415
  • Spoelstra-de ManAME, ElbersPWG. Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Crit Care. 2018;22:70. doi:10.1186/s13054-018-1996-y29558975
  • PutzuA, DaemsAM, Lopez-DelgadoJC, et al. The effect of Vitamin C on clinical outcome in critically Ill patients: a systematic review with meta-analysis of randomized controlled trials. Crit Care Med. 2019;47:774–783. doi:10.1097/CCM.000000000000370030839358
  • BjordahlPM, HelmerSD, GosnellDJ, et al. Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients. Am J Surg. 2012;204(6):862–7; discussion 867. doi:10.1016/j.amjsurg.2012.03.012
  • AntonicM, LipovecR, GregorcicF, et al. Perioperative ascorbic acid supplementation does not reduce the incidence of postoperative atrial fibrillation in on-pump coronary artery bypass graft patients. J Cardiol. 2017;69:98–102. doi:10.1016/j.jjcc.2016.01.01026917198
  • DehghaniMR, MadjidiN, RahmaniA, et al. Effect of oral vitamin C on atrial fibrillation development after isolated coronary artery bypass grafting surgery: a prospective randomized clinical trial. Cardiol J. 2014;21:492–499. doi:10.5603/CJ.a2013.015424293167

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