Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS

References

• KhandelwalP, YavagalDR, RalphL. Sacco. Acute ischemic stroke intervention. J Am Coll Cardiol. 2016;67:2631–2644. doi:10.1016/j.jacc.2016.03.55527256835
   PubMed Web of Science ®Google Scholar
• LozanoR, NaghaviM, ForemanK. 6-Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the 6-global burden of disease study 2010. Lancet. 2012;380:2095–2128. doi:10.1016/S0140-6736(12)61728-023245604
   PubMed Web of Science ®Google Scholar
• LiH, GuoJ, WangA, et al. Assessment of risk factors for cerebrovascular disease among the elderly in Beijing: A 23-year community-based prospective study in China. Arch Gerontol Geriatr. 2018;79:39–44. doi:10.1016/j.archger.2018.07.01730096587
   PubMed Web of Science ®Google Scholar
• JiangW, ZhangFJ, ZaoBH. Effect of Huangqi Guizhi Wuwu Decoction on patients with convalescent cerebral infarction. World J Traditional Chinese Med. 2017;12:1555–1559.
   Google Scholar
• YinYX, RenHQ. Treatment of 46 cases of sequelae of cerebral infarction with Huangqi Guizhi Wuwu Decoction. Inner Mongolia Traditional Chinese Med. 2017;36:11–14.
   Google Scholar
• MaY, WangHW, YangPP, WangBL. Treatment of 80 cases of shoulder-hand syndrome after stroke with Huangqi Guizhi Wuwu Decoction combined with rehabilitation training. Chinese. Med Mod Distance Educ. 2016;14:76–80.
   Google Scholar
• ZhangLJ, LiuHK, HsiaoPC. New isoflavonoid glycosides and related constituents from astragali radix (Astragalus membranaceus) and their inhibitory activity on nitric oxide production. J Agric Food Chem. 2011;59:1131–1137. doi:10.1021/jf103610j21280630
   PubMed Web of Science ®Google Scholar
• FuS, GuY, JiangJQ, et al. Calycosin-7-O-β-D6-Glucoside regulates nitric oxide/caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury. J Ethnopharmacol. 2014;155:692–701. doi:10.1016/j.jep.2014.06.01524930357
   PubMed Web of Science ®Google Scholar
• GuoC, TongL, XiM, YangH, DongH, WenA. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012;144:768–774. doi:10.1016/j.jep.2012.09.05623123262
   PubMed Web of Science ®Google Scholar
• RenM, WangX, DuG, TianJ, LiuY. Calycosin-7-O-β-D-6-Glucoside attenuates ischemia-reperfusion injury in vivo via activation of the PI3K/Akt pathway. Mol Med Rep. 2016;13:633–640. doi:10.3892/mmr.2015.461126648122
   PubMed Web of Science ®Google Scholar
• LiS, WangY, FengC, WuG, YeY, TianJ. Calycosin inhibits the migration and invasion of human breast cancer cells by downregulation of Foxp3 expression. Cell Physiol Biochem. 2017;44:1775–1784. doi:10.1159/00048578429241196
   PubMedGoogle Scholar
• QuanGH, WangH, CaoJ, et al. Calycosin suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB. Int J Mol Sci. 2015;16:29496–29507. doi:10.3390/ijms16122617926690415
   PubMed Web of Science ®Google Scholar
• YuDH, BaoYM, WeiCL, AnLJ. Studies of chemical constituents and their antioxidant activities from Astragalus mongholicus Bunge. Biomed Environ Sci. 2005;18:297–301.16370311
   PubMed Web of Science ®Google Scholar
• FanY, WuDZ, GongYQ, ZhouJY, HuZB. Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol. 2003;481:33–40. doi:10.1016/j.ejphar.2003.09.00714637172
   PubMed Web of Science ®Google Scholar
• WuXL, WangYY, ChengJ, ZhaoYY. Calcium channel blocking activity of calycosin, a major active component of Astragali Radix, on rat aorta. Acta Pharmacol Sin. 2006;27:1007–1012. doi:10.1111/j.1745-7254.2006.00349.x16867251
   PubMed Web of Science ®Google Scholar
• WangY, DongX, LiZ, WangW, TianJ, ChenJ. Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats. J Neurol Sci. 2014;339:144–148. doi:10.1016/j.jns.2014.02.00224548484
   PubMed Web of Science ®Google Scholar
• ChenYF, WuKJ, WoodWG. Paeonia lactiflora extract attenuating cerebral ischemia and arterial intimal hyperplasia is mediated by paeoniflorin via modulation of VSMC migration and Ras/MEK/ERK signaling pathway. Evid Based Complement Alternat Med. 2013;482428.23818926
   PubMed Web of Science ®Google Scholar
• WuYM, JinR, YangL, et al. Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H2O2-induced neural progenitor cell injury. Neuroscience. 2013;240:54–62. doi:10.1016/j.neuroscience.2013.02.03723485815
   PubMed Web of Science ®Google Scholar
• CaoBY, YangYP, LuoWF, et al. Paeoniflorin, a potent natural compound protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol. 2010;131:122–129. doi:10.1016/j.jep.2010.06.00920558269
   PubMed Web of Science ®Google Scholar
• MaoQQ, ZhongXM, FengCR, PanAJ, LiZY, HuangZ. Protective effects of paeoniflorin against 6-glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca2+ antagonism. Cell Mol Neurobiol. 2010;30:1059–1066. doi:10.1007/s10571-010-9537-520577899
   PubMed Web of Science ®Google Scholar
• WangK, ZhuL, ZhuX, et al. Protective effect of paeoniflorin on Ab25–35-induced SH-SY5Y cell injury by preventing mitochondrial dysfunction. Cell Mol Neurobiol. 2014;34:227–234. doi:10.1007/s10571-013-0006-924263411
   PubMed Web of Science ®Google Scholar
• NamKN, YaeCG, HongJW, ChoDH, LeeJH, LeeEH. Paeoniflorin, monoterpene 6-Glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain micro 6-Gial inflammatory response. Biotechnol Lett. 2013;35:1183–1189. doi:10.1007/s10529-013-1192-823559368
   PubMed Web of Science ®Google Scholar
• ZhangY, QiaoL, XuW, et al. Paeoniflorin attenuates cerebral ischemia-induced injury by regulating Ca/CaMKII/CREB signaling pathway. Molecules. 2017;22.
   PubMed Web of Science ®Google Scholar
• WattanathornJ, JittiwatJ, TongunT, MuchimapuraS, IngkaninanK. Zingiber officinale mitigates brain damage and improves memory impairment in focal cerebral ischemic rat. Evid Based Complement Alternat Med. 2011;2011429505.
   Web of Science ®Google Scholar
• NaJY, SongK, LeeJW, KimS, KwonJ. Pretreatment of 6-shogaol attenuates oxidative stress and inflammation in middle cerebral artery occlusion-induced mice. Eur J Pharmacol. 2016;788:241–247. doi:10.1016/j.ejphar.2016.06.04427346834
   PubMed Web of Science ®Google Scholar
• LongaEZ, WeinsteinPR, CarlsonS, CumminsR. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91. doi:10.1161/01.STR.20.1.842643202
   PubMed Web of Science ®Google Scholar
• LiaoF, MengY, ZhengH, et al. Biospecific isolation and characterization of angiogenesis-promoting ingredients in Buyang Huanwu decoction using affinity chromatography on rat brain microvascular endothelial cells combined with solid-phase extraction, and HPLC-MS/MS. Talanta. 2018;179:490–500. doi:10.1016/j.talanta.2017.11.01829310265
   PubMed Web of Science ®Google Scholar
• ZhangY, HuoM, ZhouJ, XieS, SolverPK. An add-in program for pharmacokinetic and pharmacodynamic data analysis in microsoft excel. Comput Methods Programs Biomed. 2010;99:306–314. doi:10.1016/j.cmpb.2010.01.00720176408
   PubMed Web of Science ®Google Scholar
• TianX, ChenS, ZhangY, et al. Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-ß-d-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS. J Pharm Biomed Anal. 2018;148:350–354. doi:10.1016/j.jpba.2017.10.02729111489
   PubMed Web of Science ®Google Scholar
• JiangSZ, WangNS, MiSQ. Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm Drug Dispos. 2008;29(9):529–537. doi:10.1002/bdd.63819051331
   PubMed Web of Science ®Google Scholar