Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats

References

• LuitseMJ, BiesselsGJ, RuttenGE, KappelleLJ. Diabetes, hyperglycaemia, and acute ischaemic stroke. Lancet Neurol. 2012;11(3):261–271. doi:10.1016/S1474-4422(12)70005-422341034
   PubMed Web of Science ®Google Scholar
• PasseroS, CiacciG, UlivelliM. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology. 2003;61(10):1351–1356. doi:10.1212/01.WNL.0000094326.30791.2D14638954
   PubMed Web of Science ®Google Scholar
• ZhengJW, ShiLG, LiangF, et al. Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats. Front Neurosci. 2018;12:414–428. doi:10.3389/fnins.2018.0041429970985
   PubMed Web of Science ®Google Scholar
• Acuna-CastroviejoD, EscamesG, VenegasC, et al. Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci. 2014;71(16):2997–3025. doi:10.1007/s00018-014-1579-224554058
   PubMed Web of Science ®Google Scholar
• WangZ, ZhouF, DouY, et al. Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and mitochondria injury. Transl Stroke Res. 2018;9(1):74–91. doi:10.1007/s12975-017-0559-x28766251
   PubMed Web of Science ®Google Scholar
• LiT, NiL, ZhaoZ, et al. Melatonin attenuates smoking-induced hyperglycemia via preserving insulin secretion and hepatic glycogen synthesis in rats. J Pineal Res. 2018;64(4):e12475. doi:10.1111/jpi.1247529437243
   PubMed Web of Science ®Google Scholar
• YessoufouA, WahliW. Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med Wkly. 2010;140:w13071. doi:10.4414/smw.2010.1307120842602
   PubMed Web of Science ®Google Scholar
• KliewerSA, FormanBM, BlumbergB, et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 1994;91(15):7355–7359. doi:10.1073/pnas.91.15.73558041794
   PubMed Web of Science ®Google Scholar
• SchulerM, AliF, ChambonC, et al. PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab. 2006;4(5):407–414. doi:10.1016/j.cmet.2006.10.00317084713
   PubMed Web of Science ®Google Scholar
• GirroirEE, HollingsheadHE, HeP, et al. Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice. Biochem Biophys Res Commun. 2008;371(3):456–461. doi:10.1016/j.bbrc.2008.04.08618442472
   PubMed Web of Science ®Google Scholar
• ShiQ, GibsonGE. Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer Dis Assoc Disord. 2007;21(4):276–291. doi:10.1097/WAD.0b013e31815721c318090434
   PubMed Web of Science ®Google Scholar
• DickeyAS, PinedaVV, TsunemiT, et al. PPAR-delta is repressed in Huntington’s disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016;22(1):37–45. doi:10.1038/nm.400326642438
   PubMed Web of Science ®Google Scholar
• GuvenC, TaskinE, AkcakayaH. Melatonin prevents mitochondrial damage induced by doxorubicin in mouse fibroblasts through Ampk-Ppar Gamma-dependent mechanisms. Med Sci Monit. 2016;22:438–446. doi:10.12659/MSM.89711426861593
   PubMed Web of Science ®Google Scholar
• LiuJ, GaoBB, ClermontAC, et al. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med. 2011;17(2):206–210. doi:10.1038/nm.229521258336
   PubMed Web of Science ®Google Scholar
• KitaokaT, HuaY, XiG, HoffJT, KeepRF. Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage. Stroke. 2002;33(12):3012–3018. doi:10.1161/01.STR.0000037673.17260.1B12468805
   PubMed Web of Science ®Google Scholar
• ZeitzerJM, DuffyJF, LockleySW, DijkDJ, CzeislerCA. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep. 2007;30(11):1437–1443. doi:10.1093/sleep/30.11.143718041478
   PubMed Web of Science ®Google Scholar
• FreretT, BouetV, LeconteC, et al. Behavioral deficits after distal focal cerebral ischemia in mice: usefulness of adhesive removal test. Behav Neurosci. 2009;123(1):224–230. doi:10.1037/a001415719170448
   PubMed Web of Science ®Google Scholar
• WangJ, ShiY, ZhangL, et al. Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke. Neurobiol Dis. 2014;68:91–103. doi:10.1016/j.nbd.2014.04.01424794156
   PubMed Web of Science ®Google Scholar
• DangG, YangY, WuG, et al. Early erythrolysis in the hematoma after experimental intracerebral hemorrhage. Transl Stroke Res. 2017;8(2):174–182. doi:10.1007/s12975-016-0505-327783383
   PubMed Web of Science ®Google Scholar
• ParienteR, ParienteJA, RodriguezAB, EspinoJ. Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation. J Pineal Res. 2016;60(1):55–64. doi:10.1111/jpi.1228826462739
   PubMed Web of Science ®Google Scholar
• Di LibertoG, PantelyushinS, KreutzfeldtM, et al. Neurons under T cell attack coordinate phagocyte-mediated synaptic stripping. Cell. 2018;175(2):458–471.e419. doi:10.1016/j.cell.2018.07.04930173917
   PubMed Web of Science ®Google Scholar
• YingGY, JingCH, LiJR, et al. Neuroprotective effects of valproic acid on blood-brain barrier disruption and apoptosis-related early brain injury in rats subjected to subarachnoid hemorrhage are modulated by heat shock protein 70/matrix metalloproteinases and heat shock protein 70/AKT pathways. Neurosurgery. 2016;79(2):286–295. doi:10.1227/NEU.000000000000126427244466
   PubMed Web of Science ®Google Scholar
• KinarivalaN, PatelR, BoustanyRM, Al-AhmadA, TrippierPC. Discovery of aromatic carbamates that confer neuroprotective activity by enhancing autophagy and inducing the anti-apoptotic protein B-Cell lymphoma 2 (Bcl-2). J Med Chem. 2017;60(23):9739–9756. doi:10.1021/acs.jmedchem.7b0119929110485
   PubMed Web of Science ®Google Scholar
• MakoukjiJ, SaadehF, MansourKA, et al. Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses. Ann Clin Transl Neurol. 2018;5(9):1089–1103. doi:10.1002/acn3.62530250865
   PubMed Web of Science ®Google Scholar
• BesagFMC, VaseyMJ, LaoKSJ, WongICK. Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs. 2019;33(12):1167–1186. doi:10.1007/s40263-019-00680-w31722088
   PubMed Web of Science ®Google Scholar
• MillerCM, VespaPM, McArthurDL, HirtD, EtchepareM. Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios. Neurocrit Care. 2007;6(1):22–29. doi:10.1385/NCC:6:1:2217356187
   PubMed Web of Science ®Google Scholar
• VespaPM. Metabolic penumbra in intracerebral hemorrhage. Stroke. 2009;40(5):1547–1548. doi:10.1161/strokeaha.108.54280319286575
   PubMed Web of Science ®Google Scholar
• ZazuliaAR, VideenTO, PowersWJ. Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage. Stroke. 2009;40(5):1638–1643. doi:10.1161/strokeaha.108.53603719286594
   PubMed Web of Science ®Google Scholar
• PengY, LiuJ, ShiL, et al. Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons. J Neurochem. 2016;137(5):701–713. doi:10.1111/jnc.1356326926143
   PubMed Web of Science ®Google Scholar
• ChiuCD, ChenCC, ShenCC, et al. Hyperglycemia exacerbates intracerebral hemorrhage via the downregulation of aquaporin-4: temporal assessment with magnetic resonance imaging. Stroke. 2013;44(6):1682–1689. doi:10.1161/STROKEAHA.113.67598323592763
   PubMed Web of Science ®Google Scholar
• GanieSA, DarTA, BhatAH, et al. Melatonin: a potential anti-oxidant therapeutic agent for mitochondrial dysfunctions and related disorders. Rejuvenation Res. 2016;19(1):21–40. doi:10.1089/rej.2015.170426087000
   PubMed Web of Science ®Google Scholar
• LekicT, HartmanR, RojasH, et al. Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. J Neurotrauma. 2010;27(3):627–637. doi:10.1089/neu.2009.116320350200
   PubMed Web of Science ®Google Scholar
• LuJ, SunZ, FangY, et al. Melatonin suppresses microglial necroptosis by regulating deubiquitinating enzyme A20 after intracerebral hemorrhage. Front Immunol. 2019;10:1360. doi:10.3389/fimmu.2019.0136031258534
   PubMed Web of Science ®Google Scholar
• XuW, LuX, ZhengJ, et al. Melatonin protects against neuronal apoptosis via suppression of the ATF6/CHOP pathway in a rat model of intracerebral hemorrhage. Front Neurosci. 2018;12:638. doi:10.3389/fnins.2018.0063830283292
   PubMed Web of Science ®Google Scholar
• VuralEM, van MunsterBC, de RooijSE. Optimal dosages for melatonin supplementation therapy in older adults: a systematic review of current literature. Drugs Aging. 2014;31(6):441–451. doi:10.1007/s40266-014-0178-024802882
   PubMed Web of Science ®Google Scholar
• GittoE, ReiterRJ, CordaroSP, et al. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol. 2004;21(4):209–216. doi:10.1055/s-2004-82861015168319
   PubMed Web of Science ®Google Scholar
• Acuna CastroviejoD, LopezLC, EscamesG, et al. Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem. 2011;11(2):221–240. doi:10.2174/15680261179486351721244359
   PubMed Web of Science ®Google Scholar
• KinarivalaN, SuhJH, BotrosM, WebbP, TrippierPC. Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor beta/delta agonists with neuroprotective activity. Bioorg Med Chem Lett. 2016;26(8):1889–1893. doi:10.1016/j.bmcl.2016.03.02826988304
   PubMed Web of Science ®Google Scholar
• CuiL, JeongH, BoroveckiF, et al. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 2006;127(1):59–69. doi:10.1016/j.cell.2006.09.01517018277
   PubMed Web of Science ®Google Scholar
• HondaresE, Pineda-TorraI, IglesiasR, et al. PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle. Biochem Biophys Res Commun. 2007;354(4):1021–1027. doi:10.1016/j.bbrc.2007.01.09217275789
   PubMed Web of Science ®Google Scholar
• HockMB, KralliA. Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol. 2009;71:177–203. doi:10.1146/annurev.physiol.010908.16311919575678
   PubMed Web of Science ®Google Scholar