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Original Research

Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine

, , , , & ORCID Icon
Pages 5623-5632 | Published online: 22 Dec 2020

References

  • TalleyNJ, LockeGR 3rd, LahrBD, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut. 2006;55(7):933–939. doi:10.1136/gut.2005.07863416322108
  • CurranMP, RobinsonDM. Mosapride in gastrointestinal disorders. Drugs. 2008;68(7):981–991. doi:10.2165/00003495-200868070-0000718457463
  • El-SeragHB, TalleyNJ. Systemic review: the prevalence and clinical course of functional dyspepsia. Aliment Pharmacol Ther. 2004;19(6):643–654. doi:10.1111/j.1365-2036.2004.01897.x15023166
  • LacyBE, WeiserKT, KennedyAT, CrowellMD, TalleyNJ. Functional dyspepsia: the economic impact to patients. Aliment Pharmacol Ther. 2013;38(2):170–177. doi:10.1111/apt.1235523725230
  • EnckP, AzpirozF, BoeckxstaensG, et al. Functional dyspepsia. Nat Rev Dis Primers. 2017;3:17081.29099093
  • AsanoH, TomitaT, NakamuraK, et al. Prevalence of gastric motility disorders in patients with functional dyspepsia. J Neurogastroenterol Motil. 2017;23(3):392–399. doi:10.5056/jnm1617328423481
  • ToniniM, CipollinaL, PoluzziE, CremaF, CorazzaGR, De PontiF. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004;19(4):379–390. doi:10.1111/j.1365-2036.2004.01867.x14871277
  • O’MahonyS, DinanTG, KeelingPW, ChuaAS. Central serotonergic and noradrenergic receptors in functional dyspepsia. World J Gastroenterol. 2006;12(17):2681–2687. doi:10.3748/wjg.v12.i17.268116718753
  • HoltmannG, GapasinJ. Failed therapy and directions for the future in dyspepsia. Dig Dis. 2008;26(3):218–224. doi:10.1159/00012135018463439
  • RaoAS, CamilleriM. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010;31(1):11–19. doi:10.1111/j.1365-2036.2009.04189.x19886950
  • DoggrellSA, HancoxJC. Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactagogue medicine. Expert Opin Drug Saf. 2014;13(1):131–138. doi:10.1517/14740338.2014.85119324147629
  • TackJ, TalleyNJ, CamilleriM, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5):1466–1479. doi:10.1053/j.gastro.2005.11.05916678560
  • MonkemullerK, MalfertheinerP. Drug treatment of functional dyspepsia. World J Gastroenterol. 2006;12(17):2694–2700. doi:10.3748/wjg.v12.i17.269416718755
  • ChenLC, LeeMH, ChouMH, LinMF, YangLL. Pharmacokinetic study of paeoniflorin in mice after oral administration of Paeoniae radix extract. J Chromatogr B Biomed Sci Appl. 1999;735(1):33–40. doi:10.1016/S0378-4347(99)00408-910630888
  • ZhongSZ, GeQH, LiQ, QuR, MaSP. Peoniflorin attentuates Abeta ((1-42))-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats. J Neurol Sci. 2009;280(1–2):71–78. doi:10.1016/j.jns.2009.01.02719268972
  • LiuHQ, ZhangWY, LuoXT, YeY, ZhuXZ. Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease by activation of adenosine A1 receptor. Br J Pharmacol. 2006;148(3):314–325. doi:10.1038/sj.bjp.070673216582933
  • MaoQQ, ZhongXM, QiuFM, LiZY, HuangZ. Protective effects of paeoniflorin against corticosterone-induced neurotoxicity in PC12 cells. Phytother Res. 2012;26(7):969–973. doi:10.1002/ptr.367322131171
  • LanZ, ChenL, FuQ, et al. Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. Brain Res. 2013;1498:9–19. doi:10.1016/j.brainres.2012.12.04023295189
  • QiuZK, HeJL, LiuX, et al. Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder. Metab Brain Dis. 2018;33(4):1175–1185. doi:10.1007/s11011-018-0216-429633071
  • LiuLS, WinstonJH, ShenoyMM, SongGQ, ChenJD, PasrichaPJ. A rat model of chronic gastric sensorimotor dysfunction resulting from transient neonatal gastric irritation. Gastroenterology. 2008;134(7):2070–2079. doi:10.1053/j.gastro.2008.02.09318448102
  • AsanoT, AidaS, SuemasuS, TaharaK, TanakaK, MizushimaT. Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia. Sci Rep. 2015;5:17519. doi:10.1038/srep1751926620883
  • HagiwaraSI, KaushalE, ParuthiyilS, PasrichaPJ, HasdemirB, BhargavaA. Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia. PLoS One. 2018;13(9):e0203704. doi:10.1371/journal.pone.020370430192883
  • KawachiM, MatsunagaY, TanakaT, et al. Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats. Eur J Pharmacol. 2011;666(1–3):218–225. doi:10.1016/j.ejphar.2011.05.04921651906
  • UchidaM, KobayashiO, IwamotoC. Effects of L-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats. J Pharmacol Sci. 2015;127(2):229–231. doi:10.1016/j.jphs.2014.12.00825727962
  • LiuJ, LiF, TangXD, et al. XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain-gut axis and production of neuropeptides. BMC Complement Altern Med. 2015;15:387. doi:10.1186/s12906-015-0913-z26508134
  • VanheelH, VicarioM, VanuytselT, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut. 2014;63(2):262–271. doi:10.1136/gutjnl-2012-30385723474421
  • LiuS, HagiwaraSI, BhargavaA. Early-life adversity, epigenetics, and visceral hypersensitivity. Neurogastroenterol Motil. 2017;29:9. doi:10.1111/nmo.13170
  • UekiS, MatsunagaY, YonetaT, TamakiH, ItohZ. Gastroprokinetic activity of nizatidine during the digestive state in the dog and rat. Arzneimittelforschung. 1999;49(7):618–625.10442211
  • SninskyCA, DavisRH, ClenchMH, ThomasKD, MathiasJR. Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A double-blind study. Gastroenterology. 1986;90(1):68–73. doi:10.1016/0016-5085(86)90076-43940258
  • FulopK, ZadoriZ, RonaiAZ, GyiresK. Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence. Eur J Pharmacol. 2005;528(1–3):150–157. doi:10.1016/j.ejphar.2005.10.02516313902
  • KawachiM, HoriN, TakeiM, KurimotoT, AkaikeN, ItoY. Gastric relaxation induced by electrical and chemical stimulation of the area postrema in the rat. Gen Physiol Biophys. 2008;27(4):243–252.19202197
  • IwanagaY, MiyashitaN, MorikawaK, MizumotoA, KondoY, ItohZ. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990;99(2):401–408. doi:10.1016/0016-5085(90)91022-X2365190
  • MineY, YoshikawaT, OkuS, NagaiR, YoshidaN, HosokiK. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther. 1997;283(3):1000–1008.9399969
  • ChenJY, WuHX, ChenY, et al. Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled receptor kinase 2. Planta Med. 2012;78(7):665–671. doi:10.1055/s-0031-129832722411721
  • HatatB, YahiaouiS, LecouteyC, et al. A novel in vivo anti-amnesic agent, specially designed to express both acetylcholinesterase (AChE) inhibitory, serotonergic subtype 4 receptor (5-HT4R) agonist and serotonergic subtype 6 receptor (5-HT6R) inverse agonist activities, with a potential interest against alzheimer’s disease. Front Aging Neurosci. 2019;11:148.31316368
  • TomitaR. Regulation of vasoactive intestinal peptide and substance P in the human pyloric sphincter. Hepatogastroenterology. 2009;56(94–95):1403–1406.19950799
  • MurphyKG, DhilloWS, BloomSR. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev. 2006;27(7):719–727. doi:10.1210/er.2006-002817077190
  • YagiT, AsakawaA, UedaH, MiyawakiS, InuiA. The role of ghrelin in patients with functional dyspepsia and its potential clinical relevance (Review). Int J Mol Med. 2013;32(3):523–531. doi:10.3892/ijmm.2013.141823778458
  • GankoM, CalkaJ. Prolonged acetylsalicylic-acid-supplementation-induced gastritis affects the chemical coding of the stomach innervating vagal efferent neurons in the porcine dorsal motor vagal nucleus (DMX). J Mol Neurosci. 2014;54(2):188–198. doi:10.1007/s12031-014-0274-y24643520
  • DuL, ChenB, KimJJ, ChenX, DaiN. Micro-inflammation in functional dyspepsia: A systematic review and meta-analysis. Neurogastroenterol Motil. 2018;30(4):e13304. doi:10.1111/nmo.1330429392796
  • ZhangS, BianH, LiX, et al. Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis. Oncol Rep. 2016;35(5):2825–2832. doi:10.3892/or.2016.469126987083
  • HeY, YangC, WangP, et al. Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats. J Ethnopharmacol. 2019;240:111953. doi:10.1016/j.jep.2019.11195331082513
  • JarupongprapaS, UssavasodhiP, KatchamartW. Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors: a systematic review and meta-analysis. J Gastroenterol. 2013;48(7):830–838. doi:10.1007/s00535-012-0717-623208017
  • JiaZ, HeJ. Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2. Exp Ther Med. 2016;11(2):655–659. doi:10.3892/etm.2015.290826893662
  • TanakaF, TominagaK, FujikawaY, et al. Concentration of glial cell line-derived neurotrophic factor positively correlates with symptoms in functional dyspepsia. Dig Dis Sci. 2016;61(12):3478–3485. doi:10.1007/s10620-016-4329-527718082
  • Van ItallieCM, AndersonJM. Architecture of tight junctions and principles of molecular composition. Semin Cell Dev Biol. 2014;36:157–165. doi:10.1016/j.semcdb.2014.08.01125171873
  • XiaoY, LiuYY, YuKQ, OuyangMZ, LuoR, ZhaoXS. Chinese herbal medicine liu jun zi tang and xiang sha liu jun zi tang for functional dyspepsia: meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2012;2012:936459. doi:10.1155/2012/93645923304226
  • ChangX, ZhaoL, WangJ, LuX, ZhangS. Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia. BMC Complement Altern Med. 2017;17(1):432. doi:10.1186/s12906-017-1938-228854971