295
Views
30
CrossRef citations to date
0
Altmetric
Original Research

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

ORCID Icon, , , , , , , , & show all
Pages 3015-3027 | Published online: 28 Jul 2020

References

  • VinaER, KwohCK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol. 2018;30(2):160–167. doi:doi:10.1097/BOR.000000000000047929227353
  • HunterDJ, Bierma-ZeinstraS. Osteoarthritis. Lancet. 2019;393(10182):1745–1759. doi:doi:10.1016/S0140-6736(19)30417-931034380
  • IshidouY, MatsuyamaK, SakumaD, et al. Osteoarthritis of the hip joint in elderly patients is most commonly atrophic, with low parameters of acetabular dysplasia and possible involvement of osteoporosis. Arch Osteoporos. 2017;12(1):30. doi:doi:10.1007/s11657-017-0325-428332125
  • WallaceG, CroS, DoreC, et al. Associations between clinical evidence of inflammation and synovitis in symptomatic knee osteoarthritis: a cross-sectional substudy. Arthritis Care Res. 2017;69(9):1340–1348. doi:doi:10.1002/acr.23162
  • AtukoralaI, KwohCK, GuermaziA, et al. Synovitis in knee osteoarthritis: a precursor of disease? Ann Rheum Dis. 2016;75(2):390–395. doi:doi:10.1136/annrheumdis-2014-20589425488799
  • OstojicM, OstojicM, PrlicJ, SoljicV. Correlation of anxiety and chronic pain to grade of synovitis in patients with knee osteoarthritis. Psychiatr Danub. 2019;31(Suppl 1):126–130.30946731
  • AshrafS, MappPI, ShahtaheriSM, WalshDA. Effects of carrageenan induced synovitis on joint damage and pain in a rat model of knee osteoarthritis. Osteoarthritis Cartilage. 2018;26(10):1369–1378. doi:doi:10.1016/j.joca.2018.07.00130031926
  • McAllisterMJ, ChemalyM, EakinAJ, GibsonDS, McGilliganVE. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis Cartilage. 2018;26(5):612–619. doi:doi:10.1016/j.joca.2018.02.90129499288
  • ZhaoLR, XingRL, WangPM, et al. NLRP1 and NLRP3 inflammasomes mediate LPS/ATP-induced pyroptosis in knee osteoarthritis. Mol Med Rep. 2018;17(4):5463–5469. doi:doi:10.3892/mmr.2018.852029393464
  • JiangD, ChenS, SunR, ZhangX, WangD. The NLRP3 inflammasome: role in metabolic disorders and regulation by metabolic pathways. Cancer Lett. 2018;419:8–19. doi:doi:10.1016/j.canlet.2018.01.03429339210
  • KelleyN, JeltemaD, DuanY, HeY. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20:13. doi:doi:10.3390/ijms20133328
  • HeY, HaraH, NunezG. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41(12):1012–1021. doi:doi:10.1016/j.tibs.2016.09.00227669650
  • WilliamsCA, HarborneJB, NewmanM, GreenhamJ, EaglesJ. Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry. 1997;46(8):1349–1353. doi:doi:10.1016/s0031-9422(97)00514-19419900
  • MohosV, Fliszar-NyulE, SchilliG, et al. Interaction of chrysin and its main conjugated metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with serum albumin. Int J Mol Sci. 2018;19:12. doi:doi:10.3390/ijms19124073
  • ZhaoQ, ZhangY, WangG, et al. A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. Sci Adv. 2016;2(4):e1501780. doi:doi:10.1126/sciadv.150178027152350
  • MengX, FangS, ZhangZ, et al. Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1–20 in mice. Cell Mol Immunol. 2017;14(8):702–711. doi:doi:10.1038/cmi.2015.10726996065
  • ZhengW, TaoZ, CaiL, et al. Chrysin attenuates IL-1beta-Induced expression of inflammatory mediators by suppressing NF-kappaB in human osteoarthritis chondrocytes. Inflammation. 2017;40(4):1143–1154. doi:doi:10.1007/s10753-017-0558-928364187
  • DarwishHA, ArabHH, AbdelsalamRM. Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. Toxicol Appl Pharmacol. 2014;279(2):129–140. doi:doi:10.1016/j.taap.2014.05.01824932515
  • ElKI, AbdelsalamRM, ElbrairyAI, AttiaAS. Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2019;112:108619. doi:doi:10.1016/j.biopha.2019.10861930797156
  • GeorgeMY, EsmatA, TadrosMG, El-DemerdashE. In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis. Eur J Pharmacol. 2018;818:486–498. doi:doi:10.1016/j.ejphar.2017.11.00829126792
  • GoesA, JesseCR, AntunesMS, et al. Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson’s disease: involvement of neuroinflammation and neurotrophins. Chem Biol Interact. 2018;279:111–120. doi:doi:10.1016/j.cbi.2017.10.01929054324
  • ZhangL, ZhangL, HuangZ, et al. Increased HIF-1alpha in knee osteoarthritis aggravate synovial fibrosis via Fibroblast-Like synoviocyte pyroptosis. Oxid Med Cell Longev. 2019;2019:6326517. doi:doi:10.1155/2019/632651730755787
  • LiTF, MaJ, HanXW, et al. Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway. Neurochem Int. 2019;129:104496. doi:doi:10.1016/j.neuint.2019.10449631247243
  • WuP, HuangZ, ShanJ, et al. Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS. Chin Med. 2020;15:9. doi:doi:10.1186/s13020-020-0290-531998403
  • JasminL, KohanL, FranssenM, JanniG, GoffJR. The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. Pain. 1998;75(23):367–382. doi:doi:10.1016/s0304-3959(98)00017-79583773
  • YinS, WangP, XingR, et al. Transient receptor potential ankyrin 1 (TRPA1) mediates lipopolysaccharide (LPS)-Induced inflammatory responses in primary human osteoarthritic Fibroblast-Like synoviocytes. Inflammation. 2018;41(2):700–709. doi:doi:10.1007/s10753-017-0724-029318481
  • MintenM, BlomA, SnijdersGF, et al. Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results of three prospective cohort studies. Osteoarthritis Cartilage. 2019;27(1):71–79. doi:doi:10.1016/j.joca.2018.10.01430448532
  • MathiessenA, ConaghanPG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19(1):18. doi:doi:10.1186/s13075-017-1229-928148295
  • YaoJ, JiangM, ZhangY, LiuX, DuQ, FengG. Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma. Int Immunopharmacol. 2016;32:24–31. doi:doi:10.1016/j.intimp.2016.01.00526780233
  • ChoiJK, JangYH, LeeS, et al. Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes. Food Chem Toxicol. 2017;110:142–150. doi:doi:10.1016/j.fct.2017.10.02529050978
  • DouW, ZhangJ, ZhangE, et al. Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-kappaB signaling pathway. J Pharmacol Exp Ther. 2013;345(3):473–482. doi:doi:10.1124/jpet.112.20186323536316
  • HaSK, MoonE, KimSY. Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-kappaB and JNK activations in microglia cells. Neurosci Lett. 2010;485(3):143–147. doi:doi:10.1016/j.neulet.2010.08.06420813161
  • QiSM, LiQ, JiangQ, QiZL, ZhangY. [Chrysin inhibits lipopolysaccharide-induced inflammatory responses of macrophages via JAK-STATs signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38(3):243–250. Chinese.29643028
  • XuM, ShiH, LiuD. Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Exp Ther Med. 2019;17(3):2256–2262. doi:doi:10.3892/etm.2019.718930867710
  • RaniN, BhartiS, BhatiaJ, NagTC, RayR, AryaDS. Chrysin, a PPAR-gamma agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation. Chem Biol Interact. 2016;250:59–67. doi:doi:10.1016/j.cbi.2016.03.01526972669
  • SarkakiA, FarboodY, MansouriS, et al. Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury. Life Sci. 2019;226:202–209. doi:doi:10.1016/j.lfs.2019.04.02730991061
  • SuM, WangW, LiuF, LiH. Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential. Curr Med Chem. 2020;27. doi:10.2174/0929867327666200123093544.
  • WangX, FanJ, DingX, SunY, CuiZ, LiuW. Tanshinone i inhibits IL-1beta-Induced apoptosis, inflammation and extracellular matrix degradation in chondrocytes CHON-001 cells and attenuates murine osteoarthritis. Drug Des Devel Ther. 2019;13:3559–3568. doi:doi:10.2147/DDDT.S216596
  • WojdasiewiczP, PoniatowskiLA, SzukiewiczD. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014;2014:561459. doi:doi:10.1155/2014/56145924876674
  • YamaguchiT, OchiaiN, SasakiY, et al. Efficacy of hyaluronic acid or steroid injections for the treatment of a rat model of rotator cuff injury. J Orthop Res. 2015;33(12):1861–1867. doi:doi:10.1002/jor.2297626147720
  • ZhangL, XingR, HuangZ, et al. Inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in knee osteoarthritis. Mediators Inflamm. 2019;2019:2165918. doi:doi:10.1155/2019/216591831582897