Quercetin Inhibits Adenomyosis by Attenuating Cell Proliferation, Migration and Invasion of Ectopic Endometrial Stromal Cells

References

• BirdCC, McElinTW, Manalo-EstrellaP. The elusive adenomyosis of the uterus–revisited. Am J Obstet Gynecol. 1972;112(5):583–593. doi:10.1016/0002-9378(72)90781-85059589
   PubMed Web of Science ®Google Scholar
• Di DonatoN, MontanariG, BenfenatiA, et al. Prevalence of adenomyosis in women undergoing surgery for endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;181:289–293. doi:10.1016/j.ejogrb.2014.08.01625201608
   PubMed Web of Science ®Google Scholar
• PontisA, D’AlterioMN, PirarbaS, de AngelisC, TinelliR, AngioniS. Adenomyosis: a systematic review of medical treatment. Gynecol Endocrinol. 2016;32(9):696–700. doi:10.1080/09513590.2016.119720027379972
   PubMed Web of Science ®Google Scholar
• FarquharC, BrosensI. Medical and surgical management of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20(4):603–616. doi:10.1016/j.bpobgyn.2006.01.01216563872
   PubMed Web of Science ®Google Scholar
• HaradaT, KhineYM, KaponisA, NikellisT, DecavalasG, TaniguchiF. The impact of adenomyosis on women’s fertility. Obstet Gynecol Surv. 2016;71(9):557–568. doi:10.1097/OGX.000000000000034627640610
   PubMed Web of Science ®Google Scholar
• VercelliniP, ConsonniD, DridiD, BraccoB, FrattaruoloMP, SomiglianaE. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014;29(5):964–977. doi:10.1093/humrep/deu04124622619
   PubMed Web of Science ®Google Scholar
• GordtsS, GrimbizisG, CampoR. Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril. 2018;109(3):380–388e381. doi:10.1016/j.fertnstert.2018.01.00629566850
   PubMed Web of Science ®Google Scholar
• GuoSW, GroothuisPG. Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? Hum Reprod Update. 2018;24(5):577–598. doi:10.1093/humupd/dmy02029893860
   PubMed Web of Science ®Google Scholar
• YangX, ZhangX, LinB, FengX, AiliA. Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis. Int J Hyperthermia. 2019;36(1):486–492. doi:10.1080/02656736.2019.159517930994010
   PubMed Web of Science ®Google Scholar
• RadzinskyVE, KhamoshinaMB, NosenkoEN, et al. Treatment strategies for pelvic pain associated with adenomyosis. Gynecol Endocrinol. 2016;32(sup2):19–22. doi:10.1080/09513590.2016.123267327759444
   PubMed Web of Science ®Google Scholar
• AngioniS, CofeliceV, PontisA, TinelliR, SocolovR. New trends of progestins treatment of endometriosis. Gynecol Endocrinol. 2014;30(11):769–773. doi:10.3109/09513590.2014.95064625144122
   PubMed Web of Science ®Google Scholar
• BergeronC, AmantF, FerenczyA. Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20(4):511–521. doi:10.1016/j.bpobgyn.2006.01.01616563870
   PubMed Web of Science ®Google Scholar
• ImaokaI, AscherSM, SugimuraK, et al. MR imaging of diffuse adenomyosis changes after GnRH analog therapy. J Magn Reson Imaging. 2002;15(3):285–290. doi:10.1002/jmri.1006011891973
   PubMed Web of Science ®Google Scholar
• KhanF, NiazK, MaqboolF, et al. Molecular targets underlying the anticancer effects of quercetin: an update. Nutrients. 2016;8(9):529. doi:10.3390/nu8090529
   PubMed Web of Science ®Google Scholar
• BootsAW, HaenenGR, BastA. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2–3):325–337. doi:10.1016/j.ejphar.2008.03.00818417116
   PubMed Web of Science ®Google Scholar
• HirparaKV, AggarwalP, MukherjeeAJ, JoshiN, BurmanAC. Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability. Anticancer Agents Med Chem. 2009;9(2):138–161. doi:10.2174/18715200978731385519199862
   PubMed Web of Science ®Google Scholar
• LiY, YaoJ, HanC, et al. Quercetin, inflammation and immunity. Nutrients. 2016;8(3):167. doi:10.3390/nu803016726999194
   PubMed Web of Science ®Google Scholar
• HanM, SongY, ZhangX. Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/nuclear factor-kappa B pathway. Pharmacogn Mag. 2016;12(Suppl 2):S237–244. doi:10.4103/0973-1296.18215427279714
   PubMed Web of Science ®Google Scholar
• ShenQ, ZouS, ShengB, ZhaoM, SunLZ, ZhuX. Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas. Drug Des Devel Ther. 2019;13:3161–3170.
   PubMed Web of Science ®Google Scholar
• YenCF, HuangSJ, LeeCL, WangHS, LiaoSK. Molecular characteristics of the endometrium in uterine adenomyosis and its biochemical microenvironment. Reprod Sci. 2017;24(10):1346–1361. doi:10.1177/193371911769114128183227
   PubMed Web of Science ®Google Scholar
• IsmiilND, RastyG, GhorabZ, et al. Adenomyosis is associated with myometrial invasion by FIGO 1 endometrial adenocarcinoma. Int J Gynecol Pathol. 2007;26(3):278–283. doi:10.1097/01.pgp.0000235064.93182.ec17581412
   PubMed Web of Science ®Google Scholar
• YuanH, ZhangS. Malignant transformation of adenomyosis: literature review and meta-analysis. Arch Gynecol Obstet. 2019;299(1):47–53. doi:10.1007/s00404-018-4991-230519753
   PubMed Web of Science ®Google Scholar
• HabibaM, PluchinoN, PetignatP, BianchiP, BrosensIA, BenagianoG. Adenomyosis and endometrial cancer: literature review. Gynecol Obstet Invest. 2018;83(4):313–328. doi:10.1159/00048732029874641
   PubMed Web of Science ®Google Scholar
• IzumiY, YamamotoT, MatsunagaN, et al. Endometrial cancer arising from adenomyosis: case report and literature review of MRI findings. Radiol Case Rep. 2020;15(4):427–430. doi:10.1016/j.radcr.2020.01.02532099587
   PubMedGoogle Scholar
• KoikeN, TsunemiT, UekuriC, et al. Pathogenesis and malignant transformation of adenomyosis (review). Oncol Rep. 2013;29(3):861–867. doi:10.3892/or.2012.218423242072
   PubMed Web of Science ®Google Scholar
• NieJ, LiuX. Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis. Mol Med Rep. 2017;16(4):5370–5376. doi:10.3892/mmr.2017.723828849202
   PubMed Web of Science ®Google Scholar
• StevensonGW, BilskyEJ, NegusSS. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain. 2006;7(6):408–416. doi:10.1016/j.jpain.2006.01.44716750797
   PubMed Web of Science ®Google Scholar
• ZhaoL, ZhouS, ZouL, ZhaoX. The expression and functionality of stromal caveolin 1 in human adenomyosis. Hum Reprod. 2013;28(5):1324–1338. doi:10.1093/humrep/det04223442759
   PubMed Web of Science ®Google Scholar
• WeimarCH, MacklonNS, Post UiterweerED, BrosensJJ, GellersenB. The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function. Hum Reprod Update. 2013;19(5):542–557.23827985
   PubMed Web of Science ®Google Scholar
• ErdoganS, TurkekulK, DibirdikI, et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. Biomed Pharmacother. 2018;107:793–805. doi:10.1016/j.biopha.2018.08.06130142541
   PubMed Web of Science ®Google Scholar
• ZhaoJ, FangZ, ZhaZ, et al. Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer. Eur J Pharmacol. 2019;847:11–18. doi:10.1016/j.ejphar.2019.01.00630639311
   PubMed Web of Science ®Google Scholar
• WuTC, ChanST, ChangCN, YuPS, ChuangCH, YehSL. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549cells. Chem Biol Interact. 2018;292:101–109. doi:10.1016/j.cbi.2018.07.01030016632
   PubMed Web of Science ®Google Scholar
• YamadaN, Matsushima-NishiwakiR, KozawaO. Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-alpha: attenuation of AKT signaling pathway. Arch Biochem Biophys. 2020;682:108296. doi:10.1016/j.abb.2020.10829632032576
   PubMed Web of Science ®Google Scholar
• Shahi ThakuriP, GuptaM, SinghS, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. 2020;20(1):4. doi:10.1186/s12885-019-6479-231898540
   PubMed Web of Science ®Google Scholar
• XuW, XuH, FangM, WuX, XuY. MKL1 links epigenetic activation of MMP2 to ovarian cancer cell migration and invasion. Biochem Biophys Res Commun. 2017;487(3):500–508. doi:10.1016/j.bbrc.2017.04.00628385531
   PubMed Web of Science ®Google Scholar
• HungCY, LeeCH, ChiouHL, et al. Praeruptorin-B inhibits 12-O-tetradecanoylphorbol-13-acetate-induced cell invasion by targeting AKT/NF-kappaB via matrix metalloproteinase-2/-9 expression in human cervical cancer cells. Cell Physiol Biochem. 2019;52(6):1255–1266.31026389
   PubMedGoogle Scholar
• KrishnanK, BruceB, HewittS, ThomasD, KhannaC, HelmanLJ. Ezrin mediates growth and survival in Ewing’s sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin Exp Metastasis. 2006;23(3–4):227–236. doi:10.1007/s10585-006-9033-y17028919
   PubMed Web of Science ®Google Scholar
• MaY, ReynoldsLE, LiA, et al. Fascin 1 is dispensable for developmental and tumour angiogenesis. Biol Open. 2013;2(11):1187–1191. doi:10.1242/bio.2013603124244855
   PubMed Web of Science ®Google Scholar
• LiuL, LuoN, GuoJ, XieY, ChenL, ChengZ. Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: imply the possible treatment of adenomyosis. J Pharmacol Sci. 2018;137(1):5–11. doi:10.1016/j.jphs.2017.12.00129752208
   PubMed Web of Science ®Google Scholar
• LiuL, ChenL, JiangC, et al. Berberine inhibits the LPS-induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Exp Ther Med. 2017;14(6):6125–6130.29285168
   PubMed Web of Science ®Google Scholar
• WanL, ZouY, WanLH, et al. Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3zeta downregulation. Arch Gynecol Obstet. 2015;292(6):1301–1309. doi:10.1007/s00404-015-3766-226054824
   PubMed Web of Science ®Google Scholar