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Original Research

Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs)

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Pages 5087-5096 | Published online: 18 Nov 2020

References

  • MackJJ, Iruela-ArispeML. NOTCH regulation of the endothelial cell phenotype. Curr Opin Hematol. 2018;25(3):212. doi:10.1097/MOH.000000000000042529547401
  • SuburoAM, D’AmorePA. Development of the endothelium. Handb Exp Pharmacol. 2006;71.16999217
  • ThenappanT, OrmistonML, RyanJJ, ArcherSL. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018;360:j5492. doi:10.1136/bmj.j549229540357
  • ZhangJ, ZhaoWS, WangX, XuL, YangXC. Palmitic acid increases endothelin-1 expression in vascular endothelial cells through the induction of endoplasmic reticulum stress and protein kinase C signaling. Cardiology. 2018;140(3):133. doi:10.1159/00049009329996135
  • NavaE, LlorensS. The local regulation of vascular function: from an inside-outside to an outside-inside model. Front Physiol. 2019;10:729. doi:10.3389/fphys.2019.0072931244683
  • Del CampoL, Sanchez-LopezA, SalaicesM, et al. Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: therapeutic effect of dietary nitrite. Aging Cell. 2019;18:e12936. doi:10.1111/acel.1293630884114
  • XueC, ZhangT, XieX, et al. Substrate stiffness regulates arterial-venous differentiation of endothelial progenitor cells via the Ras/Mek pathway. Biochim Biophys Acta Mol Cell Res. 2017;1864(10):1799. doi:10.1016/j.bbamcr.2017.07.00628732675
  • MozosI, LucaCT. Crosstalk between oxidative and nitrosative stress and arterial stiffness. Curr Vasc Pharmacol. 2017;15(5):446. doi:10.2174/157016111566617020111542828155616
  • MehtaPK, GriendlingKK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292(1):C82. doi:10.1152/ajpcell.00287.200616870827
  • KaschinaE, NamsolleckP, UngerT. AT2 receptors in cardiovascular and renal diseases. Pharmacol Res. 2017;125(Pt A):39–47. doi:10.1016/j.phrs.2017.07.00828694144
  • LuzzattoL, NannelliC, NotaroR. Glucose-6-phosphate dehydrogenase deficiency. Hematol Oncol Clin North Am. 2016;30(2):373. doi:10.1016/j.hoc.2015.11.00627040960
  • KangZ, QiaoN, LiuG, ChenH, TangZ, LiY. Copper-induced apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction in male germ cells. Toxicol in Vitro. 2019;61:104639. doi:10.1016/j.tiv.2019.10463931491480
  • HamaguchiM, SenoT, YamamotoA, et al. Loxoprofen Sodium, a non-selective NSAID, reduces atherosclerosis in mice by reducing inflammation. J Clin Biochem Nutr. 2010;47(2):138.20838569
  • ZhaoD, ChenZ, HuS, et al. Efficacy and safety of loxoprofen hydrogel transdermalpatch versus loxoprofen tablet in Chinese patients with myalgia: a double-blind, double-dummy, parallel-group, randomized, controlled, non-inferiority trial. Clin Drug Investig. 2019;39(4):369. doi:10.1007/s40261-019-00756-x
  • SekiguchiM, ShirasakaM, KonnoS, KikuchiS. Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. BMC Musculoskelet Disord. 2008;9(1):15. doi:10.1186/1471-2474-9-1518234123
  • AzumaA, KudohS, NakashimaM, NagatakeT. Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium. Pharmacology. 2011;87(3–4):204. doi:10.1159/00032453221430410
  • YamakawaN, SuemasuS, KimotoA, et al. Low direct cytotoxicity of loxoprofen on gastric mucosal cells. Biol Pharm Bull. 2010;33(3):398–403. doi:10.1248/bpb.33.39820190399
  • KurataC, UeharaA, SugiT, YamazakiK. Syncope caused by nonsteroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors. Jpn Circ J. 1999;63(12):1002–1003. doi:10.1253/jcj.63.100210614849
  • ZhangH, YangN, WangT, DaiB, ShangY. Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NFkappaB signaling pathway. Mol Med Rep. 2018;17:2915.29257249
  • SturtzelC. Endothelial cells. Adv Exp Med Biol. 2017;1003:71.28667554
  • JiangF. Autophagy in vascular endothelial cells. Clin Exp Pharmacol Physiol. 2016;43(11):1021. doi:10.1111/1440-1681.1264927558982
  • GryglewskiRJ, ChlopickiS, UraczW, MarcinkiewiczE. Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation. Med Sci Monit. 2001;7:1.11208485
  • SuzukiY, SanoH, TomczykM, BrzoskaT, UranoT. Activities of wild-type and variant tissue-type plasminogen activators retained on vascular endothelial cells. FEBS Open Bio. 2016;6(5):469. doi:10.1002/2211-5463.12057
  • XuH, DuS, FangB, et al. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019;116(17):8457. doi:10.1073/pnas.190211911630948641
  • WangC, LuoH, XuY, TaoL, ChangC, ShenX. Salvianolic acid B-alleviated angiotensin II induces cardiac fibrosis by suppressing NF-κB pathway in vitro. Med Sci Monit. 2018;24:7654. doi:10.12659/MSM.90893630365482
  • SiW, XieW, DengW, et al. Angiotensin II increases angiogenesis by NF-κB–mediated transcriptional activation of angiogenic factor AGGF1. FASEB J. 2018;32(9):5051. doi:10.1096/fj.201701543RR29641288
  • DoughanAK, HarrisonDG, DikalovSI. Molecular mechanisms of angiotensin II–mediated mitochondrial dysfunction. Circ Res. 2008;102(4):488–496. doi:10.1161/CIRCRESAHA.107.16280018096818
  • DurikM, Seva PessoaB, RoksAJ. The renin–angiotensin system, bone marrow and progenitor cells. Clin Sci (Lond). 2012;123(4):205. doi:10.1042/CS2011066022548406
  • YangM, KahnAM. Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells. Am J Hypertens. 2006;19(6):587. doi:10.1016/j.amjhyper.2005.11.01716733230
  • RajagopalanS, KurzS, MunzelT, et al. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.. J Clin Invest. 1996;97(8):1916. doi:10.1172/JCI1186238621776
  • DrummondGR, SobeyCG. Endothelial NADPH oxidases: which NOX to target in vascular disease? Trends Endocrinol Metab. 2014;25(9):452–463. doi:10.1016/j.tem.2014.06.01225066192
  • LiH, LiuQ, WangN, XuJ. Correlation of different NADPH oxidase homologues with late endothelial progenitor cell senescence induced by angiotensin II: effect of telmisartan. Intern Med. 2011;50(16):1631. doi:10.2169/internalmedicine.50.525021841319
  • TsunekiH, TokaiE, SuzukiT, et al. Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells. Eur J Pharmacol. 2013;701(1–3):218. doi:10.1016/j.ejphar.2012.12.02723348709
  • NoguchiM, KimotoA, GierseJK, et al. Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. Biological & Pharmaceutical Bulletin. 2005;28(11):2075–2079. doi:10.1248/bpb.28.207516272692
  • HamaguchiM, SenoT, YamamotoA, et al. Loxoprofen sodium, a non-selective NSAID, reduces atherosclerosis in mice by reducing inflammation. J Clin Biochem Nutr. 2010;47(2):138–147. doi:10.3164/jcbn.10-3320838569
  • RiendeauD, SalemM, StyhlerA, OuelletM, ManciniJA, LiCS. Li CS: evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201–1203. doi:10.1016/j.bmcl.2003.12.04714980665
  • FélétouM, HuangY, VanhouttePM. Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol. 2011;164(3):894–912.21323907
  • FosslienE. Cardiovascular complications of non-steroidal anti-inflammatory drugs. Ann Clin Lab Sci. 2005;35(4):347–385.16254252
  • CaloLA, SchiavoS, DavisPA, et al. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. J Hypertens. 2010;28:111.19797979
  • TianM, LinX, WuL, LuJ, ZhangY, ShiJ. Angiotensin II triggers autophagy and apoptosis in PC12 cell line: an in vitro Alzheimer’s disease model. Brain Res. 2019;1718:46.31054884
  • AnandU, YiangouY, SinisiM, et al. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015;11:38.26111701
  • RajagopalanS, HarrisonDG. Reversing endothelial dysfunction with ACE inhibitors. A new trend. Circulation. 1996;94(3):240–243.8759059
  • DesideriG, GrassiD, CroceG, et al. Different effects of angiotensin-converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087.19079593
  • EvangelistaS, AntioxidantMS. cardioprotective properties of the sulphydryl angiotensin-converting enzyme inhibitor zofenopril. J Int Med Res. 2005;33(1):42–54.15651714