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Original Research

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

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Pages 277-287 | Published online: 25 Jan 2021

References

  • WichaP, TocharusJ, JanyouA, et al. Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model. PLoS One. 2017;12(12):e0189211. doi:10.1371/journal.pone.018921129220411
  • WuR, LiX, XuP, et al. TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain. 2017;10(1):20. doi:10.1186/s13041-017-0296-928592261
  • GongL, TangY, AnR, et al. RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death Dis. 2017;8(10):e3080. doi:10.1038/cddis.2017.46528981095
  • ChenZ, YangJ, ZhongJ, et al. MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression. Exp Neurol. 2020;327:113223. doi:10.1016/j.expneurol.2020.11322332032565
  • JungJE, KimGS, ChenH, et al. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol. 2010;41(2–3):172–179. doi:10.1007/s12035-010-8102-z20157789
  • HarstonGW, RaneN, ShayaG, et al. Imaging biomarkers in acute ischemic stroke trials: a systematic review. AJNR Am J Neuroradiol. 2015;36(5):839–843. doi:10.3174/ajnr.A420825634718
  • ZhuJR, LuHD, GuoC, et al. Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation. Acta Pharmacol Sin. 2018;39(11):1706–1715. doi:10.1038/s41401-018-0160-130266998
  • HwangCJ, YunHM, JungYY, et al. Reducing effect of IL-32α in the development of stroke through blocking of NF-κB, but enhancement of STAT3 pathways. Mol Neurobiol. 2015;51(2):648–660. doi:10.1007/s12035-014-8739-024854197
  • LiuH, WuX, LuoJ, et al. Pterostilbene attenuates astrocytic inflammation and neuronal oxidative injury after ischemia-reperfusion by inhibiting NF-κB phosphorylation. Front Immunol. 2019;10:2408. doi:10.3389/fimmu.2019.0240831681297
  • PangMJ, YangZ, ZhangXL, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016;37(12):1623–1640. doi:10.1038/aps.2016.9827694907
  • GuoS, FengB, ZhuR, MaJ, WangW. Preparative isolation of three anthraquinones from rumex japonicus by high-speed counter-current chromatography. Molecules. 2011;16(2):1201–1210. doi:10.3390/molecules1602120121273951
  • HanYT, ChenXH, GaoH, YeJL, WangCB. Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2. Acta Pharmacol Sin. 2016;37(2):264–275. doi:10.1038/aps.2015.11526707141
  • LiRR, LiuXF, FengSX, et al. Pharmacodynamics of five anthraquinones (aloe-emodin, emodin, rhein, chrysophanol, and physcion) and reciprocal pharmacokinetic interaction in rats with cerebral ischemia. Molecules. 2019;24(10). doi:10.3390/molecules24101898.
  • FengSX, LiJS, QuLB, ShiYM, ZhaoD. Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. Phytother Res. 2013;27(10):1489–1494. doi:10.1002/ptr.489023180574
  • YanH, RaoJ, YuanJ, et al. Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway. Cell Death Dis. 2017;8(12):3211. doi:10.1038/s41419-017-0047-y29238035
  • LeeJH, JeongJH, JeongYG, et al. Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property. Anat Cell Biol. 2019;52(4):486–497. doi:10.5115/acb.19.14131949989
  • ChenJ, LiY, WangL, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32(4):1005–1011. doi:10.1161/01.STR.32.4.100511283404
  • YeY, JinT, ZhangX, et al. Meisoindigo protects against focal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB signaling pathway. Front Cell Neurosci. 2019;13:553. doi:10.3389/fncel.2019.0055331920554
  • LiX, ChuS, LiuY, ChenN. Neuroprotective effects of anthraquinones from rhubarb in central nervous system diseases. Evid Based Complement Alternat Med. 2019;2019:3790728.31223328
  • FinkelT, HolbrookNJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239–247. doi:10.1038/3504168711089981
  • ZhangY, ChengZ, WangC, et al. Neuroprotective effects of kukoamine a against radiation-induced rat brain injury through inhibition of oxidative stress and neuronal apoptosis. Neurochem Res. 2016;41(10):2549–2558. doi:10.1007/s11064-016-1967-027241194
  • YangCY, LinMT. Oxidative stress in rats with heatstroke-induced cerebral ischemia. Stroke. 2002;33(3):790–794. doi:10.1161/hs0102.10020811872905
  • SunMS, JinH, SunX, et al. Free radical damage in ischemia-reperfusion injury: an obstacle in acute ischemic stroke after revascularization therapy. Oxid Med Cell Longev. 2018;2018:3804979. doi:10.1155/2018/380497929770166
  • KalogerisT, BaoY, KorthuisRJ. Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol. 2014;2:702–714. doi:10.1016/j.redox.2014.05.00624944913
  • SunS, HuF, WuJ, ZhangS. Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons. Redox Biol. 2017;11:577–585. doi:10.1016/j.redox.2016.12.02928110213
  • WuL, JiangC, KangY, et al. Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: involvement of the PI3K/AKT pathway. Int J Mol Med. 2020;45(4):993–1004. doi:10.3892/ijmm.2020.448332124937
  • ZhangY, ZhangY, JinXF, et al. The role of astragaloside IV against cerebral ischemia/reperfusion injury: suppression of apoptosis via promotion of P62-LC3-autophagy. Molecules. 2019;24(9).
  • ZhaoL, ZhuangJ, WangY, et al. Propofol ameliorates H9c2 cells apoptosis induced by oxygen glucose deprivation and reperfusion injury via inhibiting high levels of mitochondrial fusion and fission. Front Pharmacol. 2019;10:61. doi:10.3389/fphar.2019.0006130809145
  • Del ZoppoG, GinisI, HallenbeckJM, et al. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 2000;10(1):95–112. doi:10.1111/j.1750-3639.2000.tb00247.x10668900
  • LiuH, WeiX, KongL, et al. NOD2 is involved in the inflammatory response after cerebral ischemia-reperfusion injury and triggers NADPH oxidase 2-derived reactive oxygen species. Int J Biol Sci. 2015;11(5):525–535. doi:10.7150/ijbs.1092725892960
  • ZhangW, SongJ, LiW, et al. Salvianolic acid D alleviates cerebral ischemia-reperfusion injury by suppressing the cytoplasmic translocation and release of HMGB1-triggered NF-κB activation to inhibit inflammatory response. Mediators Inflamm. 2020;2020:9049614. doi:10.1155/2020/904961432410871
  • RidderDA, SchwaningerM. NF-kappaB signaling in cerebral ischemia. Neuroscience. 2009;158(3):995–1006. doi:10.1016/j.neuroscience.2008.07.00718675321
  • SuX, WangH, ZhaoJ, PanH, MaoL. Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat. Mediators Inflamm. 2011;2011:807142. doi:10.1155/2011/80714221772666
  • JungHS, JooJD, KimDW, et al. Effect of milrinone on the inflammatory response and NF-kB activation in renal ischemia-reperfusion injury in mice. Korean J Anesthesiol. 2014;66(2):136–142. doi:10.4097/kjae.2014.66.2.13624624272
  • SelimNM, ElgazarAA, Abdel-HamidNM, et al. Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2: in silico and molecular studies. Antioxidants (Basel). 2019;8(9).
  • WangC, YangYH, ZhouL, et al. Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-κB to suppress inflammation and apoptosis. J Pharm Pharmacol. 2020;72(9):1176–1185. doi:10.1111/jphp.1329332436614
  • GaoD, JingS, ZhangQ, WuG. Pterostilbene protects against acute renal ischemia reperfusion injury and inhibits oxidative stress, inducible nitric oxide synthase expression and inflammation in rats via the Toll-like receptor 4/nuclear factor-κB signaling pathway. Exp Ther Med. 2018;15(1):1029–1035. doi:10.3892/etm.2017.547929403551