The Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway

References

• SiegelRL, MillerKD, JemalA. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30. doi:10.3322/caac.2144229313949
   PubMed Web of Science ®Google Scholar
• LitwinMS, TanHJ. The diagnosis and treatment of prostate cancer: a review. JAMA. 2017;317(24):2532–2542. doi:10.1001/jama.2017.724828655021
   PubMed Web of Science ®Google Scholar
• MansinhoA, MacedoD, FernandesI, CostaL. Castration-resistant prostate cancer: mechanisms, targets and treatment. Adv Exp Med Biol. 2018;1096:117–133. doi:10.1007/978-3-319-99286-0_730324351
   PubMed Web of Science ®Google Scholar
• ZhangJ, LiS, ZhangS, et al. Effect of icariside II and metformin on penile erectile function, histological structure, mitochondrial autophagy, glucose-lipid metabolism, angiotensin ii and sex hormone in type 2 diabetic rats with erectile dysfunction. J Sex Med. 2020;8(2):168–177. doi:10.1016/j.esxm.2020.01.006
   Web of Science ®Google Scholar
• ZhangJ, LiS, LiS, et al. Effect of icariside II and metformin on penile erectile function, glucose metabolism, reaction oxygen species, superoxide dismutase, and mitochondrial autophagy in type 2 diabetic rats with erectile dysfunction. Transl Androl Urol. 2020;9(2):355. doi:10.21037/tau.2020.02.0732420141
   PubMed Web of Science ®Google Scholar
• ChenM, WuJ, LuoQ, et al. The anticancer properties of herba epimedii and its main bioactive components icariin and icariside II. Nutrients. 2016;8(9):563. doi:10.3390/nu8090563
   PubMed Web of Science ®Google Scholar
• SachanR, KunduA, JeonY, et al. Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells. Phytomedicine. 2018;51:139–150. doi:10.1016/j.phymed.2018.10.01230466611
   PubMed Web of Science ®Google Scholar
• GouXJ, BaiHH, LiuLW, et al. Asiatic acid interferes with invasion and proliferation of breast cancer cells by inhibiting WAVE3 activation through PI3K/AKT signaling pathway. Biomed Res Int. 2020;2020:1874387. doi:10.1155/2020/187438732104680
   PubMed Web of Science ®Google Scholar
• YangJ, PiC, WangG. Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. Biomed Pharmacother. 2018;103:699–707. doi:10.1016/j.biopha.2018.04.07229680738
   PubMed Web of Science ®Google Scholar
• KumarS, AshishJ, WonCS, et al. Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens. Nat Cell Biol. 2020;22(8):973–985. doi:10.1038/s41556-020-0549-132753672
   PubMed Web of Science ®Google Scholar
• ZhaoX, ChenC, WeiY, et al. Novel mutations of COL4A3, COL4A4, and COL4A5 genes in Chinese patients with Alport Syndrome using next generation sequence technique. Mol Genet Genomic Med. 2019;7:e653. doi:10.1002/mgg3.65330968591
   PubMed Web of Science ®Google Scholar
• SuCC, HsiehKL, LiuPL, et al. AICAR induces apoptosis and inhibits migration and invasion in prostate cancer cells through an AMPK/mTOR-dependent pathway. Int J Mol Sci. 2019;20(7):1647. doi:10.3390/ijms20071647
   PubMed Web of Science ®Google Scholar
• LeeHJ, Venkatarame Gowda SaralammaV, KimSM, et al. Pectolinarigenin induced cell cycle arrest, autophagy, and apoptosis in gastric cancer cell via PI3K/AKT/mTOR signaling pathway. Nutrients. 2018;10(8):1043. doi:10.3390/nu10081043
   PubMed Web of Science ®Google Scholar
• FettkeH, KwanEM, BukczynskaP, et al. Prognostic impact of total plasma cell-free DNA concentration in androgen receptor pathway inhibitor–treated metastatic castration-resistant prostate cancer. Eur Urol Focus. 2020. doi:10.1016/j.euf.2020.07.001
   PubMedGoogle Scholar
• HuangD, CuiLQ, AhmedS, et al. An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs. Food Chem Toxicol. 2019;123:574–594. doi:10.1016/j.fct.2018.10.05230408543
   PubMed Web of Science ®Google Scholar
• KhanM, MaryamA, QaziJI, MaT. Targeting apoptosis and multiple signaling pathways with icariside ii in cancer cells. Int J Biol Sci. 2015;11(9):1100–1112. doi:10.7150/ijbs.1159526221076
   PubMed Web of Science ®Google Scholar
• GaoP, HuangX, LiaoT, et al. Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation. Biosci Trends. 2019;13(2):160–167. doi:10.5582/bst.2018.0129330944266
   PubMed Web of Science ®Google Scholar
• LyuQ, TouF, SuH, et al. The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. Biochem Biophys Res Commun. 2015;462(1):38–45. doi:10.1016/j.bbrc.2015.04.10225935480
   PubMed Web of Science ®Google Scholar
• LvY, LiuZ, HuangJ, et al. LncRNA nuclear-enriched abundant transcript 1 regulates hypoxia-evoked apoptosis and autophagy via mediation of microRNA-181b. Mol Cell Biochem. 2020;464(1–2):193–203. doi:10.1007/s11010-019-03660-231853799
   PubMed Web of Science ®Google Scholar
• YangJ, LanJ, DuH, et al. Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells. Eur J Pharmacol. 2019;846:12–22. doi:10.1016/j.ejphar.2018.12.02630579933
   PubMed Web of Science ®Google Scholar
• FanC, YangY, LiuY, et al. Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling. Sci Rep. 2016;6(1):21145. doi:10.1038/srep2114526892033
   PubMed Web of Science ®Google Scholar
• ZhaoGS, GaoZR, ZhangQ, et al. TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis. J Exp Clin Cancer Res. 2018;37(1):188. doi:10.1186/s13046-018-0856-630092789
   PubMed Web of Science ®Google Scholar
• XiongYC, WangJ, ChengY, et al. Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH. Mol Cell Biochem. 2020;1–9.
   Web of Science ®Google Scholar
• ChenHE, LinJF, TsaiTF, et al. Allyl isothiocyanate induces autophagy through the up-regulation of beclin-1 in human prostate cancer cells. Am J Chin Med. 2018:1–19. doi:10.1142/S0192415X18500830.
   Web of Science ®Google Scholar
• AhmedM, LaiTH, ZadaS, et al. Functional linkage of RKIP to the epithelial to mesenchymal transition and autophagy during the development of prostate cancer. Cancers (Basel). 2018;10(8):273. doi:10.3390/cancers10080273
   PubMed Web of Science ®Google Scholar
• LiuM, BamoduOA, HuangWC, et al. 4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway. Toxicol Appl Pharmacol. 2017;325:48–60. doi:10.1016/j.taap.2017.04.00328408137
   PubMed Web of Science ®Google Scholar
• TsaiJH, HsuLS, HuangHC, et al. 1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione induces G1 cell cycle arrest and autophagy in heLa cervical cancer cells. Int J Mol Sci. 2016;17(8):1274. doi:10.3390/ijms17081274
   PubMed Web of Science ®Google Scholar
• GuanH, PiaoH, QianZ, et al. 2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway. Mol Biosyst. 2017;13(10):1993–2005. doi:10.1039/c7mb00001d28752163
   PubMedGoogle Scholar
• YuZ, ChenY, LiangC. Eriocalyxin B induces apoptosis and autophagy involving Akt/mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Med Sci Monit. 2019;25:8534–8543. doi:10.12659/MSM.91733331714902
   PubMed Web of Science ®Google Scholar
• GiotiK, PapachristodoulouA, BenakiD, et al. Silymarin enriched extract (silybum marianum) additive effect on doxorubicin-mediated cytotoxicity in PC-3 prostate cancer cells. Planta Med. 2019;85(11/12):997–1007. doi:10.1055/a-0954-670431288278
   PubMed Web of Science ®Google Scholar
• RahmaniM, NkwochaJ, HawkinsE, et al. Cotargeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells. Cancer Res. 2018;78(11):3075–3086. doi:10.1158/0008-5472.CAN-17-302429559471
   PubMed Web of Science ®Google Scholar