223
Views
19
CrossRef citations to date
0
Altmetric
Original Research

Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1

, , , &
Pages 87-97 | Published online: 11 Jan 2021

References

  • DongJ, ChenH. Cardiotoxicity of anticancer therapeutics. Front Cardiovasc Med. 2018;5:9. doi:10.3389/fcvm.2018.0000929473044
  • HerrmannJ. From trends to transformation: where cardio-oncology is to make a difference. Eur Heart J. 2019;40(48):3898–3900. doi:10.1093/eurheartj/ehz78131761931
  • PucciC, MartinelliC, CiofaniG. Innovative approaches for cancer treatment: current perspectives and new challenges. Ecancermedicalscience. 2019;13:961. doi:10.3332/ecancer.2019.96131537986
  • El-AgamySE, Abdel-AzizAK, EsmatA, et al. Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. Cancer Chemother Pharmacol. 2019;84(1):1–14. doi:10.1007/s00280-019-03827-030955080
  • RivankarS. An overview of doxorubicin formulations in cancer therapy. J Cancer Res Ther. 2014;10(4):853–858. doi:10.4103/0973-1482.13926725579518
  • KoleiniN, KardamiE. Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity. Oncotarget. 2017;8(28):46663–46680. doi:10.18632/oncotarget.1694428445146
  • ShabalalaS, MullerCJF, LouwJ, et al. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 2017;180(160):160–170. doi:10.1016/j.lfs.2017.05.00328478263
  • WuZ, ZhaoX, MiyamotoA, et al. Effects of steroidal saponins extract from ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response. Pharm Biol. 2019;57(1):176–183. doi:10.1080/13880209.2019.157746730860934
  • AltieriP, BarisioneC, LazzariniE, et al. Testosterone antagonizes doxorubicin-induced senescence of cardiomyocytes. J Am Heart Assoc. 2016;5(1):e002383. doi:10.1161/JAHA.115.00238326746999
  • HsuCH, AltschulerSJ, WuLF. Patterns of early p21 dynamics determine proliferation-senescence cell fate after chemotherapy. Cell. 2019;178(2):361–373 e312. doi:10.1016/j.cell.2019.05.04131204100
  • Kilic ErenM, KilincliA, ErenO. Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation. PLoS One. 2015;10(4):e0124837. doi:10.1371/journal.pone.012483725924011
  • GhoshAK, RaiR, ParkKE, et al. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence. Oncotarget. 2016;7(45):72443–72457. doi:10.18632/oncotarget.1249427736799
  • KeravisT, LugnierC. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol. 2012;165(5):1288–1305. doi:10.1111/j.1476-5381.2011.01729.x22014080
  • HatzelmannA, MorcilloEJ, LungarellaG, et al. The preclinical pharmacology of roflumilast–a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2010;23(4):235–256. doi:10.1016/j.pupt.2010.03.01120381629
  • AntoniuSA. New therapeutic options in the management of COPD - focus on roflumilast. Int J Chron Obstruct Pulmon Dis. 2011;6:147–155. doi:10.2147/COPD.S733621468165
  • ChapmanRW, HouseA, JonesH, et al. Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats. Eur J Pharmacol. 2007;571(2–3):215–221. doi:10.1016/j.ejphar.2007.05.07417610865
  • MataM, SarriaB, BuenestadoA, et al. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax. 2005;60(2):144–152. doi:10.1136/thx.2004.02569215681504
  • WohlsenA, HirrleA, TenorH, et al. Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices. Eur J Pharmacol. 2010;635(1–3):177–183. doi:10.1016/j.ejphar.2010.03.00520303939
  • van EmpelVP, BertrandAT, HofstraL, et al. Myocyte apoptosis in heart failure. Cardiovasc Res. 2005;67(1):21–29. doi:10.1016/j.cardiores.2005.04.01215896727
  • TakahashiT, TangT, LaiNC, et al. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006;114(5):388–396. doi:10.1161/CIRCULATIONAHA.106.63251316864723
  • KwakHJ, ParkKM, ChoiHE, et al. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. Cell Signal. 2008;20(5):803–814. doi:10.1016/j.cellsig.2007.12.01118276108
  • MassieBM, ShahNB. The heart failure epidemic: magnitude of the problem and potential mitigating approaches. Curr Opin Cardiol. 1996;11(3):221–226. doi:10.1097/00001573-199605000-000018835863
  • McGregorE, DunnMJ. Proteomics of the heart: unraveling disease. Circ Res. 2006;98(3):309–321. doi:10.1161/01.RES.0000201280.20709.2616484627
  • XinW, LuX, LiX, et al. Attenuation of endoplasmic reticulum stress-related myocardial apoptosis by SERCA2a gene delivery in ischemic heart disease. Mol Med. 2011;17(3–4):201–210. doi:10.2119/molmed.2010.0019721152695
  • RachmatJ, SastroasmoroS, SuyatnaFD, et al. Ischemic preconditioning reduces apoptosis in open heart surgery. Asian Cardiovasc Thorac Ann. 2014;22(3):276–283. doi:10.1177/021849231348122324585902
  • MaejimaY, AdachiS, ItoH, et al. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell. 2008;7(2):125–136. doi:10.1111/j.1474-9726.2007.00358.x18031568
  • NiemannB, ChenY, TeschnerM, et al. Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria. J Am Coll Cardiol. 2011;57(5):577–585. doi:10.1016/j.jacc.2010.09.04021272749
  • HayflickL, MoorheadPS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25(3):585–621. doi:10.1016/0014-4827(61)90192-613905658
  • SpyridopoulosI, IsnerJM, LosordoDW. Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1). Basic Res Cardiol. 2002;97(2):117–124. doi:10.1007/s00395020000112002258
  • MartinezDE, BorniegoML, BattchikovaN, et al. SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis. J Exp Bot. 2015;66(1):161–174. doi:10.1093/jxb/eru40925371504
  • PassosJF, NelsonG, WangC, et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol. 2010;6(1):347. doi:10.1038/msb.2010.520160708
  • SamarakoonR, HigginsSP, HigginsCE, et al. The TGF-beta1/p53/PAI-1 signaling axis in vascular senescence: role of caveolin-1. Biomolecules. 2019;9(8):341. doi:10.3390/biom9080341
  • LeeSH, LeeJH, LeeHY, et al. Sirtuin signaling in cellular senescence and aging. BMB Rep. 2019;52(1):24–34. doi:10.5483/BMBRep.2019.52.1.29030526767
  • HwangJW, YaoH, CaitoS, et al. Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med. 2013;61:95–110. doi:10.1016/j.freeradbiomed.2013.03.01523542362
  • LiuMH, ShanJ, LiJ, et al. Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes. Exp Ther Med. 2016;12(2):1113–1118. doi:10.3892/etm.2016.343727446329
  • DolinskyVW. The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction. Biol Chem. 2017;398(9):955–974.28253192
  • RuanY, DongC, PatelJ, et al. SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways. Cell Physiol Biochem. 2015;35(3):1116–1124. doi:10.1159/00037393725766524
  • DallonsM, SchepkensC, DupuisA, et al. New insights about doxorubicin-induced toxicity to cardiomyoblast-derived H9C2 cells and dexrazoxane cytoprotective effect: contribution of in vitro1H-NMR metabonomics. Front Pharmacol. 2020;11:79. doi:10.3389/fphar.2020.0007932153402
  • EnayetallahAE, PuppalaD, ZiemekD, et al. Assessing the translatability of in vivo cardiotoxicity mechanisms to in vitro models using causal reasoning. BMC Pharmacol Toxicol. 2013;14(1):46. doi:10.1186/2050-6511-14-4624010585
  • MolinaCE, LeroyJ, RichterW, et al. Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias. J Am Coll Cardiol. 2012;59(24):2182–2190. doi:10.1016/j.jacc.2012.01.06022676938
  • EschenhagenT. PDE4 in the human heart - major player or little helper? Br J Pharmacol. 2013;169(3):524–527. doi:10.1111/bph.1216823489196