210
Views
52
CrossRef citations to date
0
Altmetric
Original Research

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

, , , , , , & show all
Pages 4901-4913 | Published online: 13 Nov 2020

References

  • HajishengallisG. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30–44.25534621
  • BindermanI, GadbanN, YaffeA. Extracellular ATP is a key modulator of alveolar bone loss in periodontitis. Arch Oral Biol. 2017;81:131–135. doi:10.1016/j.archoralbio.2017.05.00228528307
  • TanabeS, BodetC, GrenierD. Treponema denticola lipooligosaccharide activates gingival fibroblasts and upregulates inflammatory mediator production. J Cell Physiol. 2008;216:727–731. doi:10.1002/jcp.2144718366071
  • NaruishiK, NagataT. Biological effects of interleukin-6 on Gingival Fibroblasts: cytokine regulation in periodontitis. J Cell Physiol. 2018;233:6393–6400. doi:10.1002/jcp.2652129574949
  • JorgensenI, MiaoEA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev. 2015;265:130–142. doi:10.1111/imr.1228725879289
  • MeyleJ, DommischH, GroegerS, GiacamanRA, CostalongaM, HerzbergM. The innate host response in caries and periodontitis. J Clin Periodontol. 2017;44:1215–1225. doi:10.1111/jcpe.1278128727164
  • HershD, MonackDM, SmithMR, GhoriN, FalkowS, ZychlinskyA. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A. 1999;96:2396–2401. doi:10.1073/pnas.96.5.239610051653
  • ChengR, FengY, ZhangR, LiuW, LeiL, HuT. The extent of pyroptosis varies in different stages of apical periodontitis. Biochimica Et Biophysica Acta Mol Basis Dis. 2018;1864:226–237. doi:10.1016/j.bbadis.2017.10.025
  • XueF, ShuR, XieY. The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry. Arch Oral Biol. 2015;60:948–958. doi:10.1016/j.archoralbio.2015.03.00525841070
  • HerathTD, DarveauRP, SeneviratneCJ, WangCY, WangY, JinL. Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS One. 2013;8:e58496.23554896
  • KimDY, JunJ-H, LeeH-L. N-acetylcysteine prevents LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts. Arch Pharm Res. 2007;30:1283–1292. doi:10.1007/BF0298026918038907
  • LianD, DaiL, XieZ. Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide. Mol Immunol. 2018;103:209–219. doi:10.1016/j.molimm.2018.10.00130312877
  • García‐HernándezAL, Muñoz‐SaavedraÁE, González‐AlvaP, et al. Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes. Oral Dis. 2019;25:596–608.30422379
  • LiH, ZhongX, LiW, WangQ. Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model. J Appl Oral Sci. 2019;27:e20180713. doi:10.1590/1678-7757-2018-071331691738
  • NguyenT, NioiP, PickettCB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009;284:13291–13295. doi:10.1074/jbc.R90001020019182219
  • HuQ, ZhangT, YiL, ZhouX, MiM. Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. BioFactors (Oxford, England). 2018;44:123–136. doi:10.1002/biof.1395
  • YanZ, QiW, ZhanJ, et al. Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation. J Cell Mol Med. 2020. doi:10.1111/jcmm.15905
  • GaoZ, SuiJ, FanR, QuW, DongX, SunD. Emodin protects against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via Nrf2/HO-1 signaling. Drug Des Devel Ther. 2020;14:1971–1982. doi:10.2147/DDDT.S247103
  • QiF, SunJ-H, YanJ-Q, LiC-M, LvX-C. Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. Microb Pathog. 2018;120:37–41. doi:10.1016/j.micpath.2018.04.04929704670
  • ReynoldsMA. Modifiable risk factors in periodontitis: at the intersection of aging and disease. Periodontol 2000. 2014;64:7–19. doi:10.1111/prd.1204724320953
  • KondoS, TakanoT, OnoY, SaitoH, MatsumotoT. Eldecalcitol reduces osteoporotic fractures by unique mechanisms. J Steroid Biochem Mol Biol. 2015;148:232–238. doi:10.1016/j.jsbmb.2015.01.01625625663
  • BarbalhoSM, GoulartRDA, GaspariniRG. Associations between inflammatory bowel diseases and vitamin D. Crit Rev Food Sci Nutr. 2019;59:1347–1356. doi:10.1080/10408398.2017.140633329236523
  • Abo El-MagdNF, ErakySM. The molecular mechanism underlining the preventive effect of vitamin D against hepatic and renal acute toxicity through the NrF2/BACH1/HO-1 pathway. Life Sci. 2020;244:117331. doi:10.1016/j.lfs.2020.11733131972209
  • BletsaA, AbdallaH, LøesS, BerggreenE. Lymphatic growth factors are expressed in human gingiva and upregulated in gingival fibroblasts after stimulation. J Periodontol. 2018;89:606–615. doi:10.1002/JPER.17-040029520843
  • WangY, GaoW, ShiX, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547:99–103. doi:10.1038/nature2239328459430
  • SinghA, VenkannagariS, OhKH, et al. Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem Biol. 2016;11:3214–3225.27552339
  • PihlstromBL, MichalowiczBS, JohnsonNW. Periodontal diseases. Lancet (London, England). 2005;366:1809–1820. doi:10.1016/S0140-6736(05)67728-8
  • GuoH, CallawayJB, TingJP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21:677–687.26121197
  • OlsenI, YilmazÖ. Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases. J Oral Microbiol. 2016;8:30385. doi:10.3402/jom.v8.3038526850450
  • AralK, BerdeliE, CooperPR, et al. Differential expression of inflammasome regulatory transcripts in periodontal disease. J Periodontol. 2019.
  • JablonskaE, JablonskiJ. Effect of IL-18 on the release of IL-6 and its soluble receptors: sIL-6R α and sgp130 by human neutrophils. Immunol Invest. 2002;31:159–167. doi:10.1081/IMM-12001623712472176
  • ArancibiaR, MaturanaC, SilvaD. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. J Dent Res. 2013;92:740–745. doi:10.1177/002203451349481623788611
  • FengW, LiuB, LiuD. Long-term administration of high-fat diet corrects abnormal bone remodeling in the tibiae of interleukin-6-deficient mice. J Histochem Cytochem. 2016;64:42–53. doi:10.1369/002215541561193126416243
  • BickelM. The role of interleukin-8 in inflammation and mechanisms of regulation. J Periodontol. 1993;64:456–460.8315568
  • CochranD. Inflammation and bone loss in periodontal disease. J Periodontol. 2008;79:1569–1576. doi:10.1902/jop.2008.08023318673012
  • GravesD, CochranD. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol. 2003;74:391–401. doi:10.1902/jop.2003.74.3.39112710761
  • LiJP, LiFY, XuA, et al. Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts. J Periodontol. 2012;83:816–824.22087807
  • TsukamotoH, TakeuchiS, KubotaK. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKϵ-IRF3 axis activation. J Biol Chem. 2018;293:10186–10201. doi:10.1074/jbc.M117.79663129760187
  • BaeJ, ParkH. Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly. J Biol Chem. 2011;286:39528–39536. doi:10.1074/jbc.M111.27881221880711
  • NapaK, BaederA, WittJ, et al. P. gingivalisLPS from negatively alters gingival cell mitochondrial bioenergetics. Int J Dent. 2017;2017:2697210. doi:10.1155/2017/269721028592970
  • PlumLA, DeLucaHF. Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov. 2010;9:941–955.21119732
  • WangQ, LiH, XieH. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013;135:43–50. doi:10.1016/j.jsbmb.2013.01.00823333931
  • BerridgeMJ. Vitamin D: a custodian of cell signalling stability in health and disease. Biochem Soc Trans. 2015;43:349–358.26009175
  • ChenL, YangR, QiaoW, et al. 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. Aging Cell. 2019;18:e12951. doi:10.1111/acel.1295130907059
  • LobodaA, DamulewiczM, PyzaE, JozkowiczA, DulakJ. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73:3221–3247.27100828
  • LiuX, ZhangX, DingY, et al. Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxid Redox Signal. 2017;26:28–43. doi:10.1089/ars.2015.661527308893