251
Views
13
CrossRef citations to date
0
Altmetric
Clinical Trial Report

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial

, , , , & ORCID Icon
Pages 3559-3565 | Published online: 26 Aug 2020

References

  • FischerS, VinallJ, PavlovaM, et al. Role of anxiety in young children’s pain memory development after surgery. Pain. 2019;160:965–972.30586022
  • SolaC, LefauconnierA, BringuierS, et al. Childhood preoperative anxiolysis: is sedation and distraction better than either alone? A prospective randomized study. Paediatr Anaesth. 2017;27:827–834.28620924
  • DaveNM. Premedication and induction of anaesthesia in pediatric patients. Indian JAnaesth 2019;63:713–720.
  • SottasCE, AndersonBJ. Dexmedetomidine: the new all-in-one drug in pediatric anesthesia? Curr Opin Anaesthesiol. 2017;30:441–451.28537937
  • Abdel-GhaffarHS, KamalSM, El SherifFA, et al. Comparison of nebulized dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy. Br JAnaesth 2018;121:445–452.
  • LinY, ZhangR, ShenW, et al. Dexmedetomidine versus other sedatives for non-painful pediatric examinations: a systematic review and meta-analysis of randomized controlled trials. J Clin Anesth. 2020;62:109736.32018129
  • JunJH, KimKN, KimJY, et al. The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis. Can JAnaesth 2017;64:947–961.
  • PasinL, FebresD, TestaV, et al. Dexmedetomidine vs midazolam as preanesthetic medication in children: a meta-analysis of randomized controlled trials. Paediatr Anaesth. 2015;25:468–476.25559766
  • MahmoudM, MasonKP. Dexmedetomidine: review, update, and future considerations of pediatric perioperative and periprocedural applications and limitations. Br JAnaesth 2015;115:171–182.
  • PoonaiN, CantonK, AliS, et al. Intranasal ketamine for anesthetic premedication in children: a systematic review. Pain Manag. 2018;8:495–503.30394192
  • PoonaiN, CantonK, AliS, et al. Intranasal ketamine for procedural sedation and analgesia in children: a systematic review. PLoS One. 2017;12:e0173253.28319161
  • PandisN, ChungB, SchererRW, et al. CONSORT 2010 statement: extension checklist for reporting within person randomized trials. BMJ. 2017;357:j2835.28667088
  • YangF, LiuY, YuQ, et al. Analysis of 17,948 pediatric patients undergoing procedural sedation with a combination of intranasal dexmedetomidine and ketamine. Paediatr Anaesth 2019;29:85–91.
  • KelesS, KocaturkO. Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study. Drug Des Devel Ther. 2018;12:647–653.
  • LinY, ChenY, HuangJ, et al. Efficacy of premedication with intranasal dexmedetomidine on inhalational induction and postoperative emergence agitation in pediatric undergoing cataract surgery with sevoflurane. J Clin Anesth. 2016;33:289–295.27555179
  • RingblomJ, WåhlinI, ProczkowskaM. A psychometric evaluation of the pediatric anesthesia emergence delirium scale. Paediatr Anaesth. 2018;28:332–337.29508484
  • AksuC, ŞenMC, AkayMA, et al. Erector spinae plane block vs quadratus lumborum block for pediatric lower abdominal surgery: a double-blinded, prospective, and randomized trial. J Clin Anesth. 2019;57:24–28.30851499
  • AldreteJA. The post-anesthesia recovery score revisited. J Clin Anesth. 1995;7:89–91.7772368
  • ZanatyOM, El MetainySA. A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery. Anesth Analg. 2015;121:167–171.25822924
  • ParashchankaA, SchelfoutS, CoppensM. Role of novel drugs in sedation outside the operating room: dexmedetomidine, ketamine and remifentanil. Curr Opin Anaesthesiol. 2014;27:442–447.24762954
  • MillerJW, BalyanR, DongM, et al. Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study. Br JAnaesth 2018;120:1056–1065.
  • ShetaSA, Al-SarheedMA, AbdelhalimAA. Intranasal dexmedetomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: a double-blinded randomized controlled trial. Paediatr Anaesth 2014;24:181–189.
  • UusaloP, GuillaumeS, SirenS, et al. Pharmacokinetics and sedative effects of intranasal dexmedetomidine in ambulatory pediatric patients. Anesth Analg. 2020;130:949–957.31206433