Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

References

• DeSantisCE, MaJM, GaudetMM, et al. Breast cancer statistics, 2019. CA Cancer J Clin. 2019;69(6):438–451. doi:10.3322/caac.2158331577379
   PubMed Web of Science ®Google Scholar
• HarbeckN, Penault-LlorcaF, CortesJ, et al. Breast cancer. Nat Rev Dis Primers. 2019;5(1):66. doi:10.1038/s41572-019-0111-231548545
   PubMed Web of Science ®Google Scholar
• YunTK. Update from Asia: asian Studies on Cancer Chemoprevention. Ann N Y Acad Sci. 1999;889:157–192. doi:10.1111/j.1749-6632.1999.tb08734.x10668493
   PubMed Web of Science ®Google Scholar
• Chapa-OliverAM, Mejia-TenienteL. Capsaicin: from Plants to a Cancer-Suppressing Agent. Molecules. 2016;21(8):931. doi:10.3390/molecules21080931
   PubMed Web of Science ®Google Scholar
• BortA, SanchezBG, SpinolaE, Mateos-GomezPA, Rodriguez-HencheN, Diaz-LaviadaI. The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ. PLoS One. 2019;14(1):e0211420. doi:10.1371/journal.pone.021142030695053
   PubMed Web of Science ®Google Scholar
• SharmaSK, VijAS, SharmaM. Mechanisms and clinical uses of capsaicin. Eur J Pharmacol. 2013;720(1–3):55–62. doi:10.1016/j.ejphar.2013.10.05324211679
   PubMed Web of Science ®Google Scholar
• FattoriV, HohmannMS, RossaneisAC, Pinho-RibeiroFA, VerriWA. Capsaicin: current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules. 2016;21:(7):844. doi:10.3390/molecules21070844
   Web of Science ®Google Scholar
• ClarkR, LeeSH. Anticancer Properties of Capsaicin Against Human Cancer. Anticancer Res. 2016;36(3):837–843. PMID: 2697696926976969
   PubMed Web of Science ®Google Scholar
• ZhangSP, WangD, HuangJY, HuYM, XuYF. Application of capsaicin as a potential new therapeutic drug in human cancers. J Clin Pharm Ther. 2020;45(1):16–28. doi:10.1111/jcpt.1303931545523
   PubMed Web of Science ®Google Scholar
• MinkeB. TRP channels and Ca2+ signaling. Cell Calcium. 2006;40(3):261–275. doi:10.1016/j.ceca.2006.05.00216806461
   PubMed Web of Science ®Google Scholar
• YangZH, WangXH, WangHP, HuLQ, ZhengXM, LiSW. Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization. Urology. 2010;75(3):735–741. doi:10.1016/j.urology.2009.03.04219592070
   PubMed Web of Science ®Google Scholar
• SanchezAM, SanchezMG, Malagarie-CazenaveS, OleaN, Diaz-LaviadaI. Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis. 2006;11(1):89–99. doi:10.1007/s10495-005-3275-z16374544
   PubMed Web of Science ®Google Scholar
• StogiosPJ, ChenL, PriveGG. Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator. Protein Sci. 2006;16(2):336–342. doi:10.1110/ps.06266090717189472
   PubMed Web of Science ®Google Scholar
• LiuXS, GenetMD, HainesJE, et al. ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Mol Cancer Res. 2015;13(8):1206–1217. doi:10.1158/1541-7786.MCR-15-016925995384
   PubMed Web of Science ®Google Scholar
• MaedaT, HobbsRM, MerghoubT, et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature. 2005;433(7023):278–285. doi:10.1038/nature0320315662416
   PubMed Web of Science ®Google Scholar
• MaedaT, HobbsRM, PandolfiPP. The transcription factor pokemon: a new key player in cancer pathogenesis: figure 1. Cancer Res. 2005;65(19):8575–8578. doi:10.1158/0008-5472.CAN-05-105516204018
   PubMed Web of Science ®Google Scholar
• JeonBN, YooJY, ChoiWI, LeeCE, YoonHG, HurMW. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor suppressor RB gene via binding competition with sp1 and recruitment of co-repressors. J Biol Chem. 2008;283(48):33199–33210. doi:10.1074/jbc.M80293520018801742
   PubMed Web of Science ®Google Scholar
• ChoiWI, JeonBN, YunCO, et al. Proto-oncogene FBI-1 Represses Transcription of p21CIP1 by Inhibition of Transcription Activation by p53 and Sp1. J Biol Chem. 2009;284(19):12633–12644. doi:10.1074/jbc.M80979420019244234
   PubMed Web of Science ®Google Scholar
• YangYT, CuiJJ, XueF, et al. Resveratrol represses pokemon expression in human glioma cells. Mol Neurobiol. 2016;53(2):1266–1278. doi:10.1007/s12035-014-9081-225875864
   PubMed Web of Science ®Google Scholar
• QuHY, QuDN, ChenFH, ZhangZY, LiuBG, LiuHF. ZBTB7 overexpression contributes to malignancy in breast cancer. Cancer Invest. 2010;28(6):672–678. doi:10.3109/0735790100363100720394500
   PubMed Web of Science ®Google Scholar
• AggarwalA, HunterWJ, AggarwalH, et al. Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers. Exp Mol Pathol. 2010;89(2):140–148. doi:10.1016/j.yexmp.2010.05.00220471975
   PubMed Web of Science ®Google Scholar
• ZuXY, MaJ, LiuHX, et al. Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Breast Cancer Res. 2011;13(2):R26. doi:10.1186/bcr284321392388
   PubMed Web of Science ®Google Scholar
• MaoAY, ChenMJ, QinQH, et al. ZBTB7A promotes migration, invasion and metastasis of human breast cancer cells through NF-κB-induced epithelial–mesenchymal transition in vitro and in vivo. J Biochem. 2019;166(6):485–493. doi:10.1093/jb/mvz06231385585
   PubMed Web of Science ®Google Scholar
• AnandakumarP, KamarajS, JaganS, RamakrishnanG, DevakiT. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013;17(2):254–259. doi:10.1016/j.intimp.2013.05.01523747734
   PubMed Web of Science ®Google Scholar
• LiY, LiS, MengX, GanRY, ZhangJJ, LiHB. Dietary natural products for prevention and treatment of breast cancer. Nutrients. 2017;9(7):728. doi:10.3390/nu9070728
   PubMed Web of Science ®Google Scholar
• ZhuMM, YuX, ZhengZM, HuangJM, YangXP, ShiHF. Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway. Phytother Res. 2020;34(4):817–824. doi:10.1002/ptr.656331782192
   PubMed Web of Science ®Google Scholar
• IslamA, YangYT, WuWH, ChuehPJ, LinMH. Capsaicin attenuates cell migration via SIRT1 targeting and inhibition to enhance cortactin and β-catenin acetylation in bladder cancer cells. Am J Cancer Res. 2019;9(6):1172–1182. PMID: 3128595031285950
   PubMed Web of Science ®Google Scholar
• QianKY, WangG, CaoR, et al. Capsaicin suppresses cell proliferation, induces cell cycle arrest and ros production in bladder cancer cells through FOXO3A-mediated pathways. Molecules. 2016;21(10):1406. doi:10.3390/molecules21101406
   Web of Science ®Google Scholar
• ClarkR, LeeJ, LeeSH. Synergistic Anticancer activity of capsaicin and 3,3′-diindolylmethane in human colorectal cancer. J Agric Food Chem. 2015;63(17):4297–4304. doi:10.1021/jf506098s25876645
   PubMed Web of Science ®Google Scholar
• YangKM, PyoJO, KimGY, et al. Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines. Cell Mol Biol Lett. 2009;14(3):497–510. doi:10.2478/s11658-009-0016-219381455
   PubMed Web of Science ®Google Scholar
• ChouCC, WuYC, WangYF, ChouMJ, KuoSJ, ChenD-R. Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol Rep. 2009;21(3):665–671. PMID: 1921262419212624
   PubMed Web of Science ®Google Scholar
• ThoennissenNH, O’KellyJ, LuD, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. 2010;29(2):285–296. doi:10.1038/onc.2009.33519855437
   PubMed Web of Science ®Google Scholar
• ItoK, NakazatoT, YamatoK, et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 2004;64(3):1071–1078. doi:10.1158/0008-5472.CAN-03-167014871840
   PubMed Web of Science ®Google Scholar
• PesslerF, PendergrastPS, HernandezN. Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.. Mol Cell Biol. 1997;17(7):3786–3798. doi:10.1128/MCB.17.7.37869199312
   PubMed Web of Science ®Google Scholar
• LeeDK, KangJE, ParkHJ, et al. FBI-1 Enhances Transcription of the Nuclear Factor-κB (NF-κB)-responsive E-selectin Gene by Nuclear Localization of the p65 Subunit of NF-κB. J Biol Chem. 2005;280(30):27783–27791. doi:10.1074/jbc.M50490920015917220
   PubMed Web of Science ®Google Scholar
• LeeDK, SuhD, EdenbergHJ, HurMW. POZ Domain Transcription Factor, FBI-1, Represses Transcription of ADH5/FDH by Interacting with the Zinc Finger and Interfering with DNA Binding Activity of Sp1. J Biol Chem. 2002;277(30):26761–26768. doi:10.1074/jbc.M20207820012004059
   PubMed Web of Science ®Google Scholar
• PendergrastPS, WangC, HernandezN, HuangS. FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles. Mol Biol Cell. 2002;13(3):915–929. doi:10.1091/mbc.01-08-038311907272
   PubMed Web of Science ®Google Scholar
• ZhuXS, DaiYC, ChenZX, XieJP, ZengW, LinYY. Knockdown of Pokemon protein expression inhibits hepatocellular carcinoma cell proliferation by suppression of AKT activity. Oncol Res. 2013;20(8):377–381. doi:10.3727/096504013X1365768938301223924858
   PubMed Web of Science ®Google Scholar
• YuanBQ, XianRH, WuXQ, et al. Endoplasmic reticulum chaperone glucose regulated protein 170–Pokemon complexes elicit a robust antitumor immune response in vivo. Immunobiology. 2012;217(7):738–742. doi:10.1016/j.imbio.2012.01.00622317751
   PubMed Web of Science ®Google Scholar
• MakVCY, WongOGW, SiuMKY, et al. FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling. Am J Pathol. 2006;16(2):2038–2048. doi:10.1016/j.ajpath.2015.03.011
   Web of Science ®Google Scholar
• JiangFQ, ZhengQF, ChangLP, LiX, WangXS, GuXQ. Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. J Cancer. 2019;10(8):1833–1845. doi:10.7150/jca.2947131205540
   PubMed Web of Science ®Google Scholar
• ChenL, ZhongJ, LiuJH, et al. Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1. J Breast Cancer. 2019;22(1):15–28. doi:10.4048/jbc.2019.22.e1130941230
   PubMed Web of Science ®Google Scholar
• XiaoX, ShenYY, YinLY, et al. Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha. Life Sci. 2019;239:117042. doi:10.1016/j.lfs.2019.11704231715186
   PubMed Web of Science ®Google Scholar
• NiaziMKK, SenarasC, PennellM, AroleV, TozbikianG, GurcanMN. Relationship between the Ki67 index and its area based approximation in breast cancer. BMC Cancer. 2018;18(1):867. doi:10.1186/s12885-018-4735-530176814
   PubMed Web of Science ®Google Scholar
• Cabrera‐GaleanaP, Muñoz‐MontañoW, Lara‐MedinaF, et al. Ki67 Changes Identify Worse Outcomes in Residual Breast Cancer Tumors After Neoadjuvant Chemotherapy. Oncologist. 2018;23(6):670–678. doi:10.1634/theoncologist.2017-039629490940
   PubMed Web of Science ®Google Scholar
• BradyHJ, Gil-Gómez G. Molecules in focus Bax. The pro-apoptotic Bcl-2 family member, Bax. Int J Biochem Cell Biol. 1998;30(6):647–650. doi:10.1016/S1357-2725(98)00006-59695020
   PubMed Web of Science ®Google Scholar
• Del PoetaG, VendittiA, Del PrincipeMI, et al. Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML). Blood. 2003;101(6):2125–2131. doi:10.1182/blood-2002-06-171412424199
   PubMed Web of Science ®Google Scholar
• PorterAG, JänickeRU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999;6(2):99–104. doi:10.1038/sj.cdd.440047610200555
   PubMed Web of Science ®Google Scholar
• LaCasseEC, BairdS, KornelukRG, MacKenzieAE. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1998;17(25):3247–3259. doi:10.1038/sj.onc.12025699916987
   PubMed Web of Science ®Google Scholar
• FuldaS, TargetingVD. IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov. 2012;11(2):109–124. doi:10.1038/nrd362722293567
   PubMed Web of Science ®Google Scholar
• ZhaoXK, NingQM, SunXN, TianDA. Pokemon reduces Bcl-2 expression through NF-kappa Bp65: A possible mechanism of hepatocellular carcinoma. Asian Pac J Trop Med. 2011;4(6):492–497. doi:10.1016/S1995-7645(11)60133-821771706
   PubMed Web of Science ®Google Scholar
• ZhangYQ, XiaoCX, LinBY, et al. Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS One. 2013;8(7):e68981. doi:10.1371/journal.pone.006898123874836
   PubMed Web of Science ®Google Scholar
• HoeselB, SchmidJA. The complexity of NF-kappaB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. doi:10.1186/1476-4598-12-8623915189
   PubMed Web of Science ®Google Scholar
• XiaYF, ShenS, VermaIM. NF-kappaB, an active player in human cancers. Cancer Immunol Res. 2014;2(9):823–830. doi:10.1158/2326-6066.CIR-14-011225187272
   PubMed Web of Science ®Google Scholar
• BegAA, BaltimoreD. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science. 1996;274(5288):782–784. doi:10.1126/science.274.5288.7828864118
   PubMed Web of Science ®Google Scholar
• WangCY, MayoMW, KornelukRG, GoeddelDV, BaldwinASJ. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281(5383):1680–1683. doi:10.1126/science.281.5383.16809733516
   PubMed Web of Science ®Google Scholar
• ZhangNN, SunQS, ChenZ, LiuF, JiangYY. Homeostatic regulatory role of Pokemon in NF-kappaB signaling: stimulating both p65 and IkappaBalpha expression in human hepatocellular carcinoma cells. Mol Cell Biochem. 2013;372(1–2):57–64. doi:10.1007/s11010-012-1445-123054188
   PubMed Web of Science ®Google Scholar
• Ramos PittolJM, OrubaA, MittlerG, SaccaniS, van EssenD. Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PLoS Biol. 2018;16(5):e2004526. doi:10.1371/journal.pbio.200452629813070
   PubMed Web of Science ®Google Scholar
• LeeCH, JeonYT, KimSH, SongYS. NF-kappaB as a potential molecular target for cancer therapy. Biofactors. 2007;29(1):19–35. doi:10.1002/biof.552029010317611291
   PubMed Web of Science ®Google Scholar
• PerkinsND. The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer. 2012;12(2):121–132. doi:10.1038/nrc320422257950
   PubMed Web of Science ®Google Scholar
• SurhYJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003;3(10):768–780. doi:10.1038/nrc118914570043
   PubMed Web of Science ®Google Scholar
• PatelPS, VarneyML, DaveBJ, SinghRK. Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation. J Interferon Cytokine Res. 2002;22(4):427–435. doi:10.1089/1079990025295221712034025
   PubMed Web of Science ®Google Scholar
• LeeGR, JangSH, KimCJ, et al. Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway. Clin Exp Metastasis. 2014;31(8):897–907. doi:10.1007/s10585-014-9678-x25217963
   PubMed Web of Science ®Google Scholar
• AnandakumarP, KamarajS, JaganS, et al. Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm Res. 2012;61(11):1169–1175. doi:10.1007/s00011-012-0511-122735861
   PubMed Web of Science ®Google Scholar
• GuoY, LiuN, LiuK, GaoM. Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression. Biosci Rep. 2019;39(8):BSR20190819. doi:10.1042/BSR2019081931324733
   PubMed Web of Science ®Google Scholar
• WangYW, ZhouYN, JiaG, et al. Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: involvement of NF-κB signaling pathway. Biochem Pharmacol. 2014;88(3):322–333. doi:10.1016/j.bcp.2014.01.04124522113
   PubMed Web of Science ®Google Scholar
• XuB, ZhangAM, LiF, CuiM, HanJ, CaoQ. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-κB/p53/Ki67 signaling pathway. Biosci Rep. 2018;38(3):BSR20171529. doi:10.1042/BSR2017152929588340
   PubMed Web of Science ®Google Scholar
• KarinM. Nuclear factor-kappaB in cancer development and progression. Nature. 2006;441(7092):431–436. doi:10.1038/nature0487016724054
   PubMed Web of Science ®Google Scholar