Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology

References

• BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.30207593
   PubMed Web of Science ®Google Scholar
• Alessio BiagioniLM, SkalameraI, PapucciL. Update on gastric cancer treatments and gene therapies. Cancer Metastasis Rev. 2019. doi:10.1007/s10555-019-09803-7
   PubMed Web of Science ®Google Scholar
• LiSS, CostantinoCL, MullenJT. Morbidity and Mortality of Total Gastrectomy: a Comprehensive Analysis of 90-Day Outcomes. J Gastrointest Surg. 2019;23(7):1340–1348.31062268
   PubMed Web of Science ®Google Scholar
• ThriftAP, El-SeragHB. Burden of Gastric Cancer. Clin Gastroenterol Hepatol. 2019;2:124.
   Google Scholar
• TuY. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217–1220.21989013
   PubMed Web of Science ®Google Scholar
• EmadiA, GoreSD. Arsenic trioxide – an old drug rediscovered. Blood Rev. 2010;24(4–5):191–199.20471733
   PubMed Web of Science ®Google Scholar
• WangZY, ChenZ. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008;111(5):2505–2515.18299451
   PubMed Web of Science ®Google Scholar
• LiWL, ZhengHC, BukuruJ, De KimpeN. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol. 2004;92(1):1–21.15099842
   PubMed Web of Science ®Google Scholar
• WangJ, WongYK, LiaoF. What has traditional Chinese medicine delivered for modern medicine? Expert Rev Mol Med. 2018;20:e4.29747718
   PubMed Web of Science ®Google Scholar
• Schmeda-HirschmannG, QuispeC, AranaGV, TheodulozC, UrraFA, CárdenasC. Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: bufonidae). Toxicon. 2016;121::119–129. doi:10.1016/j.toxicon.2016.09.004
   PubMed Web of Science ®Google Scholar
• MaL, WangB, LongY, LiH. Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis. Front Med. 2017;11(2):191–202. doi:10.1007/s11684-017-0512-028349301
   PubMed Web of Science ®Google Scholar
• ChonS-H, BerlthF, PlumPS, et al. Gastric cancer treatment in the world: germany. Translational Gastroenterology Hepatol. 2017;2(5):53. doi:10.21037/tgh.2017.05.07
   PubMed Web of Science ®Google Scholar
• YanZ, LaiZ, LinJ. Anticancer Properties of Traditional Chinese Medicine. Comb Chem High Throughput Screen. 2017;20(5):423–429. doi:10.2174/138620732066617011614181828093974
   PubMed Web of Science ®Google Scholar
• XiaoH, SunX, LiuR, et al. Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy. Pharmacol Res. 2020;151:104559.31759089
   PubMed Web of Science ®Google Scholar
• Chaoqun ZhouWD, XiangG, LinX. Gentiopicroside Reduces Pain, Pruritus, and Corticosteroid Addictive Dermatitis. Nat Prod Commun. 2019;14(9):1–4.
   Web of Science ®Google Scholar
• YaoT, CuiQ, LiuZ, WangC, ZhangQ, WangG. Metabolomic evidence for the therapeutic effect of Gentiopicroside in a corticosterone-induced model of depression. Biomed Pharmacother. 2019;120:109549.31655313
   PubMed Web of Science ®Google Scholar
• XiaohaoL, Hao ShenCY. Gentiopicroside exerts convincing antitumor effects in human ovarian carcinoma cells (SKOV3) by inducing cell cycle arrest, mitochondrial mediated apoptosis and inhibition of cell migration. JBUON. 2019;24(1):280–284.30941981
   PubMed Web of Science ®Google Scholar
• Xian-Ju HuangJL, MeiZ-Y. Gentiopicroside and sweroside from Veratrilla baillonii Franch induced phosphorylation of Akt and suppressed Pck1 expression in hepatoma cells. Biochem Cell Biol. 2016;94(3):270–278.27248905
   PubMed Web of Science ®Google Scholar
• ChouCC. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells. Eur J Pharmaceutical Sci. 2003;1(19):403–412.
   Web of Science ®Google Scholar
• ShiXQ, YueSJ, TangYP, et al. A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction. J Ethnopharmacol. 2019;235::227–242.
   Web of Science ®Google Scholar
• ZhouC, LiuL, ZhuangJ, et al. A Systems Biology-Based Approach to Uncovering Molecular Mechanisms Underlying Effects of Traditional Chinese Medicine Qingdai in Chronic Myelogenous Leukemia, Involving Integration of Network Pharmacology and Molecular Docking Technology. Med Sci Monit. 2018;24::4305–4316.
   Web of Science ®Google Scholar
• WangT, LiHT, WeiSZ, et al. Use of Network Pharmacology and Molecular Docking to Investigate the Mechanism by Which Ginseng Ameliorates Hypoxia. Biomed Environ Sci. 2018;31(11):855–858.30558707
   PubMed Web of Science ®Google Scholar
• GongB, KaoY, ZhangC, SunF. Systematic Investigation of Scutellariae Barbatae Herba for Treating Hepatocellular Carcinoma Based on Network Pharmacology. Evid Based Complement Alternat Med. 2018;2018:4365739.30584453
   PubMed Web of Science ®Google Scholar
• HamoshA, ScottAF, AmbergerJS, BocchiniCA. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 2005;33:D514–D517.15608251
   PubMed Web of Science ®Google Scholar
• StelzerG, RosenN, PlaschkesI, et al. The GeneCards Suite: from Gene Data Mining to Disease Genome Sequence Analyses. Curr Protoc Bioinformatics. 2016;54:30.27322403
   PubMedGoogle Scholar
• ShannonP, MarkielA, OzierO, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504.14597658
   PubMed Web of Science ®Google Scholar
• TrottO. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455–461.19499576
   PubMed Web of Science ®Google Scholar
• LiuX, WuJ, ZhangD, WangK, DuanX. A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. Evid Based Complement Alternat Med. 2018;2018:6517034.29619072
   PubMed Web of Science ®Google Scholar
• ZhangYF, HuangY, NiYH. Systematic elucidation of the mechanism of geraniol via network pharmacology. Drug Des Devel Ther. 2019;13::1069–1075.
   Web of Science ®Google Scholar
• YuG, WangW, WangX. Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis. BMC Complement Altern Med. 2018;18(1):292.30382864
   PubMed Web of Science ®Google Scholar
• BiYH, ZhangLH, ChenSJ. Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology. Evid Based Complement Alternat Med. 2018;2018:4509892.29636777
   PubMed Web of Science ®Google Scholar
• MengZ, LiuX, WuJ, et al. Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology. Evid Based Complement Alternat Med. 2019;2019:4637839.31275410
   PubMed Web of Science ®Google Scholar
• HuZQ, WangH, FuY, MaK, MaXY. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutrition and Cancer. 2020;1–12. doi:10.1080/01635581.2020.1801777
   Web of Science ®Google Scholar