Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway

References

• BhaskaranSP, HuangT, RajendranBK. et al. Ethnic-specific BRCA1/2 variation within Asia population: evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations. J Med Genet.2020:jmedgenet-2020-107299. doi:10.1136/jmedgenet-2020-107299
   PubMed Web of Science ®Google Scholar
• Temurer AfsarZ, AycicekB, TutuncuY, CavdarU, SennarogluE. Relationships between microvascular complications of diabetes mellitus and levels of macro and trace elements. Minerva Endocrinol. 2020.
   PubMedGoogle Scholar
• BhatiaD, ChoiME. Autophagy in kidney disease: advances and therapeutic potential. Prog Mol Biol Transl Sci. 2020;172:107–133.32620239
   PubMed Web of Science ®Google Scholar
• CaiR, JiangJ. LncRNA ANRIL silencing alleviates high glucose-induced inflammation, oxidative stress, and apoptosis via upregulation of MME in podocytes. Inflammation. 2020;43(6):2147–2155. doi:10.1007/s10753-020-01282-132617859
   PubMed Web of Science ®Google Scholar
• HuangL, LinT, ShiM, ChenX, WuP. Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/beta-catenin signaling. Am J Physiol Renal Physiol. 2020;319(3):F458–F468. doi:10.1152/ajprenal.00128.202032715762
   PubMed Web of Science ®Google Scholar
• HsuPC, ChengCF, HsiehPC, et al. Chrysophanol regulates cell death, metastasis, and reactive oxygen species production in oral cancer cell lines. Evid Based Complement Alternat Med. 2020;2020:5867064. doi:10.1155/2020/586706432595733
   PubMed Web of Science ®Google Scholar
• DouF, DingY, WangC, et al. Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-beta/Smad signaling pathway. Biochem Pharmacol. 2020;180:114079. doi:10.1016/j.bcp.2020.11407932511988
   PubMed Web of Science ®Google Scholar
• ChuX, ZhouS, SunR, et al. Chrysophanol relieves cognition deficits and neuronal loss through inhibition of inflammation in diabetic mice. Neurochem Res. 2018;43(4):972–983. doi:10.1007/s11064-018-2503-129497904
   PubMed Web of Science ®Google Scholar
• DuanXJ, ZhangX, LiLR, ZhangJY, ChenYP. MiR-200a and miR-200b restrain inflammation by targeting ORMDL3 to regulate the ERK/MMP-9 pathway in asthma. Exp Lung Res. 2020;46(9):321–331. doi:10.1080/01902148.2020.177881632820688
   PubMed Web of Science ®Google Scholar
• ShiY, HuangC, ZhaoY, et al. RIPK3 blockade attenuates tubulointerstitial fibrosis in a mouse model of diabetic nephropathy. Sci Rep. 2020;10(1):10458. doi:10.1038/s41598-020-67054-x32591618
   PubMed Web of Science ®Google Scholar
• FanZ, QiX, YangW, XiaL, WuY. Melatonin ameliorates renal fibrosis though the inhibition of NF-kappaB and TGF-beta1/Smad3 pathways in db/db diabetic mice. Arch Med Res. 2020;51(6):524–534. doi:10.1016/j.arcmed.2020.05.00832473749
   PubMed Web of Science ®Google Scholar
• RaoN, WangX, XieJ, et al. Stem cells from human exfoliated deciduous teeth ameliorate diabetic nephropathy in vivo and in vitro by inhibiting advanced glycation end product-activated epithelial-mesenchymal transition. Stem Cells Int. 2019;2019:2751475. doi:10.1155/2019/275147531871464
   PubMed Web of Science ®Google Scholar
• LinS, YuL, NiY, et al. Fibroblast growth factor 21 attenuates diabetes-induced renal fibrosis by negatively regulating TGF-beta-p53-Smad2/3-mediated epithelial-to-mesenchymal transition via activation of AKT. Diabetes Metab J. 2020;44(1):158–172. doi:10.4093/dmj.2018.023531701691
   PubMed Web of Science ®Google Scholar
• NalinN, DhanhaniAA, AlBawardiA, et al. The effect of angiotensin II on diabetic glomerular hyperpermeability: in vivo permeability studies in rats. Am J Physiol Renal Physiol. 2020. doi:10.1152/ajprenal.00259.2020
   PubMed Web of Science ®Google Scholar
• ThistedL, OstergaardMV, PedersenAA, et al. Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy. Sci Rep. 2020;10(1):16130. doi:10.1038/s41598-020-73046-832999377
   PubMed Web of Science ®Google Scholar
• XueP, ZhaoJ, ZhengA, et al. Chrysophanol alleviates myocardial injury in diabetic db/db mice by regulating the SIRT1/HMGB1/NF-kappaB signaling pathway. Exp Ther Med. 2019;18(6):4406–4412.31772635
   PubMed Web of Science ®Google Scholar
• WangG, ZhouY, ChenW, et al. miR-21-5p promotes lung adenocarcinoma cell proliferation, migration and invasion via targeting WWC2. Cancer Biomark. 2020;28(4):549–559. doi:10.3233/CBM-20148932623387
   PubMed Web of Science ®Google Scholar
• JahaniM, KhanahmadH, NikpourP. Evaluation of the effects of valproic acid treatment on cell survival and epithelial-mesenchymal transition-related features of human gastric cancer cells. J Gastrointest Cancer. 2020. doi:10.1007/s12029-019-00332-8
   Web of Science ®Google Scholar
• ZhangX, ZouY, LiuY, et al. Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells. Mol Immunol. 2020;125:15–22. doi:10.1016/j.molimm.2020.06.01332619930
   PubMed Web of Science ®Google Scholar
• PengJ, WuHJ, ZhangHF, FangSQ, ZengR. miR-143-3p inhibits proliferation and invasion of hepatocellular carcinoma cells by regulating its target gene FGF1. Clin Transl Oncol. 2020. doi:10.1007/s12094-020-02440-5
   Web of Science ®Google Scholar
• Hernandez-PadillaL, Reyes de la CruzH, Campos-GarciaJ. Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner. Apoptosis. 2020;25(9–10):632–647. doi:10.1007/s10495-020-01619-z32617785
   PubMed Web of Science ®Google Scholar
• DengM, XueYJ, XuLR, et al. Chrysophanol suppresses hypoxia-induced epithelial-mesenchymal transition in colorectal cancer cells. Anat Rec (Hoboken). 2019;302(9):1561–1570. doi:10.1002/ar.2408130737895
   PubMedGoogle Scholar
• JinS, LiJ, BaratiM, et al. Loss of NF-E2 expression contributes to the induction of profibrotic signaling in diabetic kidneys. Life Sci. 2020;254:117783. doi:10.1016/j.lfs.2020.11778332413404
   PubMed Web of Science ®Google Scholar
• ZhengXP, NieQ, FengJ, et al. Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin. BMC Nephrol. 2020;21(1):174. doi:10.1186/s12882-020-01833-632398108
   PubMed Web of Science ®Google Scholar
• CappelliC, TellezA, JaraC, et al. The TGF-beta profibrotic cascade targets ecto-5ʹ-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease. Biochim Biophys Acta Mol Basis Dis. 2020;1866(7):165796. doi:10.1016/j.bbadis.2020.16579632289379
   PubMed Web of Science ®Google Scholar
• VerzolaD, MilanesiS, ViazziF, et al. Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy. Sci Rep. 2020;10(1):6343. doi:10.1038/s41598-020-62875-232286342
   PubMed Web of Science ®Google Scholar
• MoonSJ, KimJH, ChoiYK, LeeCH, HwangJH. Ablation of Gadd45beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction. J Cell Mol Med. 2020;24(15):8814–8825. doi:10.1111/jcmm.1551932570293
   PubMed Web of Science ®Google Scholar
• ZhangW, LiX, TangY, et al. miR-155-5p implicates in the pathogenesis of renal fibrosis via targeting SOCS1 and SOCS6. Oxid Med Cell Longev. 2020;2020:6263921.32587662
   PubMed Web of Science ®Google Scholar
• JiangY, ZhuY, ZhenT, et al. Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model. Sci Rep. 2020;10(1):10682. doi:10.1038/s41598-020-67690-332606425
   PubMed Web of Science ®Google Scholar
• SunJ, WangJ, LuW, et al. MiR-325-3p inhibits renal inflammation and fibrosis by targeting CCL19 in diabetic nephropathy. Clin Exp Pharmacol Physiol. 2020. doi:10.1111/1440-1681.13371
   Web of Science ®Google Scholar
• YangJ, DongH, WangY, et al. Cordyceps cicadae polysaccharides ameliorated renal interstitial fibrosis in diabetic nephropathy rats by repressing inflammation and modulating gut microbiota dysbiosis. Int J Biol Macromol. 2020;163:442–456. doi:10.1016/j.ijbiomac.2020.06.15332592781
   PubMed Web of Science ®Google Scholar
• PengR, ChenY, WeiL, et al. Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer. Gastric Cancer. 2020;23(6):988–1002. doi:10.1007/s10120-020-01088-y32617693
   PubMed Web of Science ®Google Scholar
• SariE, OztayF, TasciAE. Vitamin D modulates E-cadherin turnover by regulating TGF-beta and Wnt signalings during EMT-mediated myofibroblast differentiation in A459 cells. J Steroid Biochem Mol Biol. 2020;202:105723. doi:10.1016/j.jsbmb.2020.10572332603782
   PubMed Web of Science ®Google Scholar
• BakshiHA, ZoubiMSA, FaruckHL, et al. Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage. Nutrients. 2020;12(6):1901. doi:10.3390/nu12061901
   PubMed Web of Science ®Google Scholar
• UmarS, SoniR, DurgapalSD, SomanS, BalakrishnanS. A synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at G0/G1 stage, induces apoptosis, and inhibits metastasis via ROS-mediated p53 and AKT signaling pathways in A549 cells. J Biochem Mol Toxicol. 2020;e22553.32578917
   PubMed Web of Science ®Google Scholar
• SmithHL, SouthgateH, TweddleDA, CurtinNJ. DNA damage checkpoint kinases in cancer. Expert Rev Mol Med. 2020;22:e2. doi:10.1017/erm.2020.332508294
   PubMed Web of Science ®Google Scholar
• LiuJY, FuWQ, ZhengXJ, et al. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Acta Pharmacol Sin. 2020.
   Web of Science ®Google Scholar
• WangJN, YangQ, YangC, et al. Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production. Redox Biol. 2020;32:101479. doi:10.1016/j.redox.2020.10147932143149
   PubMed Web of Science ®Google Scholar