Pristimerin Suppresses Trophoblast Cell Epithelial–Mesenchymal Transition via miR-542-5p/EGFR Axis

References

• ChouinardM, MayrandM-H, AyoubA, Healy-ProfitósJ, AugerN. Ectopic pregnancy and outcomes of future intrauterine pregnancy. Fertility Sterility. 2019;112(1):112–119. doi:10.1016/j.fertnstert.2019.03.01931056305
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology. ACOG practice bulletin no. 210: fecal incontinence. Obstet Gynecol. 2019;133(4):e260–e273. doi:10.1097/AOG.000000000000318730913197
   PubMed Web of Science ®Google Scholar
• BradyPC. New evidence to guide ectopic pregnancy diagnosis and management. Obstetrical Gynecological Survey. 2017;72(10):618–625. doi:10.1097/OGX.000000000000049229059454
   PubMed Web of Science ®Google Scholar
• CreangaAA, SyversonC, SeedK, CallaghanWM. Pregnancy-related mortality in the United States, 2011–2013. Obstet Gynecol. 2017;130(2):366–373. doi:10.1097/AOG.000000000000211428697109
   PubMed Web of Science ®Google Scholar
• MolF, MolBW, AnkumWM, van der VeenF, HajeniusPJ. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis. Human Reproduction Update. 2008;14(4):309–319. doi:10.1093/humupd/dmn01218522946
   PubMed Web of Science ®Google Scholar
• UludagSZ, KutukMS. Comparison of systemic and local methotrexate treatments in cesarean scar pregnancies: time to change conventional treatment and follow-up protocols. European J Obstetrics, Gynecology, Reproductive Biology. 2016;206:131–135. doi:10.1016/j.ejogrb.2016.09.010
   PubMed Web of Science ®Google Scholar
• BrinkerAM, MaJ, LipskyPE, RaskinI. Medicinal chemistry and pharmacology of genus tripterygium (celastraceae). Phytochemistry. 2007;68(6):732–766. doi:10.1016/j.phytochem.2006.11.02917250858
   PubMed Web of Science ®Google Scholar
• YousefBA, HassanHM, ZhangLY, JiangZZ. Pristimerin exhibits in vitro and in vivo anticancer activities through inhibition of nuclear factor-small ka, CyrillicB signaling pathway in colorectal cancer cells. Phytomedicine. 2018;40:140–147. doi:10.1016/j.phymed.2018.01.00829496166
   PubMed Web of Science ®Google Scholar
• LiuYB, GaoX, DeebD, ArbabAS, GautamSC. Pristimerin induces apoptosis in prostate cancer cells by down-regulating Bcl-2 through ROS-dependent ubiquitin-proteasomal degradation pathway. J Carcinogenesis Mutagenesis. 2013;3(Suppl 6):005.
   Google Scholar
• WuCC, ChanML, ChenWY, TsaiCY, ChangFR, WuYC. Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. Molecular Cancer Therapeutics. 2005;4(8):1277. doi:10.1158/1535-7163.MCT-05-002716093444
   PubMed Web of Science ®Google Scholar
• TiedemannRE, SchmidtJ, KeatsJJ, et al. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood. 2009;113(17):4027–4037.19096011
   PubMed Web of Science ®Google Scholar
• XieG, YuX, LiangH, et al. Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling. Oncol Lett. 2016;11(5):3111–3116. doi:10.3892/ol.2016.433527123073
   PubMed Web of Science ®Google Scholar
• YousefBA, HassanHM, ZhangLY, JiangZZ. Anticancer potential and molecular targets of pristimerin: a mini- review. Current Cancer Drug Targets. 2017;17(2). doi:10.2174/1568009616666160112105824
   PubMed Web of Science ®Google Scholar
• MaXL, LiX, TianFJ, et al. Upregulation of RND3 affects trophoblast proliferation, apoptosis, and migration at the maternal-fetal interface. Front Cell Dev Biol. 2020;8:153.32232044
   PubMed Web of Science ®Google Scholar
• ZhangY, HeXY, QinS, et al. Upregulation of PUM1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther. 2020;28(2):631–641. doi:10.1016/j.ymthe.2019.11.02531862314
   PubMed Web of Science ®Google Scholar
• TianFJ, HeXY, WangJ, et al. Elevated tristetraprolin impairs trophoblast invasion in women with recurrent miscarriage by destabilization of HOTAIR. Mol Ther Nucleic Acids. 2018;12:600–609. doi:10.1016/j.omtn.2018.07.00130195796
   PubMedGoogle Scholar
• PaulmuruganR, OronskyB, BrouseCF, ReidT, KnoxS, ScicinskiJ. Real time dynamic imaging and current targeted therapies in the war on cancer: a new paradigm. Theranostics. 2013;3(6):437–447. doi:10.7150/thno.565823781290
   PubMed Web of Science ®Google Scholar
• FabianM, SonenbergN, FilipowiczW. Regulation of mRNA translation and stability by microRNAs. Annual Review Biochemistry. 2010;79:351–379. doi:10.1146/annurev-biochem-060308-103103
   PubMed Web of Science ®Google Scholar
• PasquinelliA. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship, Nature reviews. Genetics. 2012;13(4):271–282.22411466
   PubMed Web of Science ®Google Scholar
• RDT, SBY, TangY, O’GormanWE, ChenC-Z. The potential functions of primary microRNAs in target recognition and repression. EMBO J. 2010;29(19):3272–3285. doi:10.1038/emboj.2010.20820808284
   PubMed Web of Science ®Google Scholar
• BartelDP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215–233. doi:10.1016/j.cell.2009.01.00219167326
   PubMed Web of Science ®Google Scholar
• MatsuiM, ChuY, ZhangH, et al. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Research. 2013;41(22):10086–10109. doi:10.1093/nar/gkt77723999091
   PubMed Web of Science ®Google Scholar
• HuangV, PlaceR, PortnoyV, et al. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Research. 2012;40(4):1695–1707. doi:10.1093/nar/gkr93422053081
   PubMed Web of Science ®Google Scholar
• XiaoM, LiJ, LiW, et al. MicroRNAs activate gene transcription epigenetically as an enhancer trigger. RNA Biology. 2017;14(10):1326–1334. doi:10.1080/15476286.2015.111248726853707
   PubMed Web of Science ®Google Scholar
• TurnerM, JiaoA, SlackF. Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans. Cell Cycle. 2014;13(5):772–781. doi:10.4161/cc.2767924398561
   PubMed Web of Science ®Google Scholar
• NishiK, NishiA, NagasawaT, Ui-TeiK. Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus. RNA. 2013;19(1):17–35. doi:10.1261/rna.034769.11223150874
   PubMed Web of Science ®Google Scholar
• ZisoulisD, KaiZ, ChangR, PasquinelliA. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature. 2012;486(7404):541–544. doi:10.1038/nature1113422722835
   PubMed Web of Science ®Google Scholar
• Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Molecular Medicine. 2014;20(8):460–469. doi:10.1016/j.molmed.2014.06.005
   PubMed Web of Science ®Google Scholar
• Li Z, Hu C, Zhen Y, Pang B, Yi H, Chen X. Pristimerin inhibits glioma progression by targeting AGO2 and PTPN1 expression via miR-542-5p. Biosci Rep. 2019;39:5.
   Web of Science ®Google Scholar
• TuY, TanF, ZhouJ, PanJ. Pristimerin targeting NF-kappaB pathway inhibits proliferation, migration, and invasion in esophageal squamous cell carcinoma cells. Cell Biochem Funct. 2018;36(4):228–240. doi:10.1002/cbf.333529781107
   PubMed Web of Science ®Google Scholar
• JiangX, XuY, YuanL, et al. TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance. Acta pharmacologica Sinica. 2020. doi:10.1038/s41401-020-0457-8
   Web of Science ®Google Scholar
• LiuJ, ZhaoM. Prioritization of susceptibility genes for ectopic pregnancy by gene network analysis. International J Molecular Sciences. 2016;17:2.
   Web of Science ®Google Scholar
• NilssonU, JohnsT, WilmannT, et al. Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth. Obstet Gynecol. 2013;122(4):737–744. doi:10.1097/AOG.0b013e3182a1ba5624084529
   PubMed Web of Science ®Google Scholar
• DengQ, BaiS, GaoW, TongL. Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways. Int Immunopharmacol. 2015;29(2):302–313. doi:10.1016/j.intimp.2015.11.00126548348
   PubMed Web of Science ®Google Scholar
• El-AgamyDS, El-HarbiKM, KhoshhalS, et al. Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways. Cancer Manag Res. 2019;11:47–61. doi:10.2147/CMAR.S18669630588110
   PubMed Web of Science ®Google Scholar
• HosseiniM, Ali-HassanzadehM, NadimiE, Karbalay-DoustS, NoorafshanA, Gharesi-FardB. Stereological study of the placental structure in abortion-prone mice model (CBA/J×DBA/2J). Ann Anatomy. 2020;230:151508. doi:10.1016/j.aanat.2020.151508
   PubMed Web of Science ®Google Scholar
• KHL. Systematic dissection of the metabolic-apoptotic interface in aml reveals heme biosynthesis to be a regulator of drug sensitivity. Cell Metabolism Undefined. 2019 undefined.
   Google Scholar
• JMS, HTX. YF, Induction of cell-cycle arrest and apoptosis in human cholangiocarcinoma cells by pristimerin. J Cellular Biochemistry Undefined. 2019 undefined.
   Google Scholar
• LinY, LiuT, CuiT, et al. RNAInter in 2020: RNA interactome repository with increased coverage and annotation. Nucleic Acids Research. 2020;48:D189–D197. doi:10.1093/nar/gkz80431906603
   PubMed Web of Science ®Google Scholar
• WangD, NaQ, SongG, WangL. Human umbilical cord mesenchymal stem cell-derived exosome-mediated transfer of microRNA-133b boosts trophoblast cell proliferation, migration and invasion in preeclampsia by restricting SGK1. Cell Cycle. 2020;1–15.
   PubMed Web of Science ®Google Scholar
• WhighamC, MacDonaldT, WalkerS, HannanN, TongS, Kaitu’u-LinoT. The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development. Placenta. 2019;84:28–31. doi:10.1016/j.placenta.2019.02.00230745114
   PubMed Web of Science ®Google Scholar
• WuC, OrozcoC, BoyerJ, et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biology. 2009;10(11):R130. doi:10.1186/gb-2009-10-11-r13019919682
   PubMed Web of Science ®Google Scholar
• FagerbergL, HallströmB, OksvoldP, et al. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Molecular Cellular Proteomics. 2014;13(2):397–406. doi:10.1074/mcp.M113.03560024309898
   PubMed Web of Science ®Google Scholar
• Rosa*MBA, Sorrentino†A, Sthandier*O, et al.The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation.PNAS  2007;104(50):19849–19854.doi:10.1073/pnas.0706963104
   Google Scholar
• SchmeierS, MacPhersonCR, EssackM, et al. Deciphering the transcriptional circuitry of microRNA genes expressed during human monocytic differentiation. BMC Genomics. 2009;10:595. doi:10.1186/1471-2164-10-59520003307
   PubMed Web of Science ®Google Scholar
• SinghR, KaushikS, WangY. Autophagy regulates lipid metabolism. Nature. 2009;458(7242):1131–1135. doi:10.1038/nature0797619339967
   PubMed Web of Science ®Google Scholar
• MuX, ShiW, SunL, LiH, JiangZ, ZhangL. Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation. Molecules. 2012;17(6):6854. doi:10.3390/molecules1706685422669041
   PubMed Web of Science ®Google Scholar
• Shi Z, She K, Li H, Yuan X, Han X, Wang Y. MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia. Chemico-Biological Interactions. 2019;298:8–14. doi:10.1016/j.cbi.2018.10.01230367833
   PubMed Web of Science ®Google Scholar
• CLD, ColsonA, HubinontC, DebieveF. Impaired vascular endothelial growth factor expression and secretion during in vitro differentiation of human primary term cytotrophoblasts. Angiogenesis. 2020;23(2):221–230. doi:10.1007/s10456-019-09702-z31894427
   PubMed Web of Science ®Google Scholar
• ZhangQ, AgostonAT, PhamTH. Acidic bile salts induce epithelial to mesenchymal transition via vegf signaling in non-neoplastic barrett’s cells. Gastroenterology. 2019;156(1):130–144.e10. doi:10.1053/j.gastro.2018.09.04630268789
   PubMed Web of Science ®Google Scholar
• CJG, XieF, ZhangB. High glucose promotes epithelial-mesenchymal transition of uterus endometrial cancer cells by increasing ER/GLUT4-mediated vegf secretion. Cellular Physiology Biochemistry. 2018;50(2):706–720. doi:10.1159/00049423730308493
   PubMedGoogle Scholar
• Horikawa N, Abiko K, Matsumura N, et al. Expression of vascular endothelial growth factor in ovarian cancer inhibits tumor immunity through the accumulation of myeloid-derived suppressor cells. Clinical Cancer Research. 2017;23(2):587–599.27401249
   PubMed Web of Science ®Google Scholar
• HPTN. N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays. Human Reproduction. 2017;32(11):2254–2268.29040564
   PubMed Web of Science ®Google Scholar
• TakiM, AbikoK, BabaT. Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation. Nature Communications. 2018;9(1):1685. doi:10.1038/s41467-018-03966-7
   PubMed Web of Science ®Google Scholar
• BuZ, WangK, DaiW, SunY. Endometrial thickness significantly affects clinical pregnancy and live birth rates in frozen-thawed embryo transfer cycles. Gynecological Endocrinology. 2016;32(7):524–528. doi:10.3109/09513590.2015.113661626942778
   PubMed Web of Science ®Google Scholar
• SimeonovM, SapirO, LandeY, et al. The entire range of trigger-day endometrial thickness in fresh IVF cycles is independently correlated with live birth rate. Reprod Biomed Online. 2020;41:239–247. doi:10.1016/j.rbmo.2020.04.00832532669
   PubMed Web of Science ®Google Scholar
• Bai R, Kusama K, Nakamura K, et al. Down-regulation of transcription factor OVOL2 contributes to epithelial-mesenchymal transition in a noninvasive type of trophoblast implantation to the maternal endometrium. FASEB J. 2018;32(6):3371–3384.29394105
   PubMed Web of Science ®Google Scholar
• ZhangJ, MoHQ, TianFJ, et al. EIF5A1 promotes trophoblast migration and invasion via ARAF-mediated activation of the integrin/ERK signaling pathway. Cell Death Dis. 2018;9(9):926. doi:10.1038/s41419-018-0971-530206208
   PubMed Web of Science ®Google Scholar
• TianFJ, ChengYX, LiXC, et al. The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface. J Pathol. 2016;239(1):36–47. doi:10.1002/path.469427071480
   PubMed Web of Science ®Google Scholar