HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases

References

• BurroughsSK, KaluzS, WangD, WangK, Van MeirEG, WangB. Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. Future Med Chem. 2013;5(5):553–572. doi:10.4155/fmc.13.1723573973
   PubMed Web of Science ®Google Scholar
• KruschewskiM, FoitzikT, Perez-CantóA, HübotterA, BuhrHJ. Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system. Dig Dis Sci. 2001;46(11):2336–2343. doi:10.1023/a:101233472750911713932
   PubMed Web of Science ®Google Scholar
• SemenzaGL, WangGL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12(12):5447–5454. doi:10.1128/mcb.12.12.54471448077
   PubMed Web of Science ®Google Scholar
• WilkinsSE, AbboudMI, HancockRL, SchofieldCJ. Targeting Protein-Protein Interactions in the HIF System. ChemMedChem. 2016;11(8):773–786. doi:10.1002/cmdc.20160001226997519
   PubMed Web of Science ®Google Scholar
• GuruSK, PathaniaAS, KumarS, et al. Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade. Cancer Res. 2015;75(14):2886–2896. doi:10.1158/0008-5472.CAN-14-231225977334
   PubMed Web of Science ®Google Scholar
• ChenX, LiuJ, HeB, et al. Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model. Hum Reprod. 2015;30(9):2160–2170. doi:10.1093/humrep/dev15626113661
   PubMed Web of Science ®Google Scholar
• RenQZ, QianZH, JiaSH, XuZZ. Vascular endothelial growth factor expression up-regulated by endometrial ischemia in secretory phase plays an important role in endometriosis. Fertil Steril. 2011;95(8):2687–2689. doi:10.1016/j.fertnstert.2011.05.00121616486
   PubMed Web of Science ®Google Scholar
• SoedaA, ParkM, LeeD, et al. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene. 2009;28(45):3949–3959. doi:10.1038/onc.2009.25219718046
   PubMed Web of Science ®Google Scholar
• JingSW, WangYD, KurodaM, et al. HIF-1α contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression. Acta Med Okayama. 2012;66(5):399–407. doi:10.18926/AMO/4896423093058
   PubMed Web of Science ®Google Scholar
• XiongY, LiuY, XiongW, et al. Hypoxia-inducible factor 1α-induced epithelial–mesenchymal transition of endometrial epithelial cells may contribute to the development of endometriosis. Hum Reprod. 2016;31(6):1327–1338. doi:10.1093/humrep/dew08127094478
   PubMed Web of Science ®Google Scholar
• LiuH, ZhangZ, XiongW, et al. Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis. Reproduction. 2017;153(6):809–820. doi:10.1530/REP-16-064328348069
   PubMed Web of Science ®Google Scholar
• BaeMK, KimSH, JeongJW, et al. Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1. Oncol Rep. 2006;15(6):1557–1562.16685395
   PubMed Web of Science ®Google Scholar
• XinM, HeJ, YangW, YinX, WangJ. Wenshen Yangxue decoction improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model. Pharm Biol. 2018;56(1):573–579. doi:10.1080/13880209.2018.151097331070529
   PubMed Web of Science ®Google Scholar
• JögiA, EhingerA, HartmanL, AlknerS. Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer. PLoS One. 2019;14(12):e0226150. doi:10.1371/journal.pone.022615031821370
   PubMed Web of Science ®Google Scholar
• KewleyRJ, WhitelawML, Chapman-SmithA. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol. 2004;36(2):189–204. doi:10.1016/s1357-2725(03)00211-514643885
   PubMed Web of Science ®Google Scholar
• DuanC. Hypoxia-inducible factor 3 biology: complexities and emerging themes. Am J Physiol Cell Physiol. 2016;310(4):C260–C269. doi:10.1152/ajpcell.00315.201526561641
   PubMed Web of Science ®Google Scholar
• PezzutoA, CaricoE. Role of HIF-1 in Cancer Progression: novel Insights. A Review. Curr Mol Med. 2018;18(6):343–351. doi:10.2174/156652401866618110912184930411685
   PubMed Web of Science ®Google Scholar
• JiangBH, ZhengJZ, LeungSW, RoeR, SemenzaGL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem. 1997;272(31):19253–19260. doi:10.1074/jbc.272.31.192539235919
   PubMed Web of Science ®Google Scholar
• JiangBH, LiuLZ. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat. 2008;11(3):63–76. doi:10.1016/j.drup.2008.03.00118440854
   PubMed Web of Science ®Google Scholar
• ReilingJH, SabatiniDM. Stress and mTORture signaling. Oncogene. 2006;25(48):6373–6383. doi:10.1038/sj.onc.120988917041623
   PubMed Web of Science ®Google Scholar
• KuroyanagiG, TokudaH, YamamotoN, Matsushima-NishiwakiR, KozawaO. Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts. Int J Mol Med. 2015;36(3):881–889. doi:10.3892/ijmm.2015.227426151374
   PubMed Web of Science ®Google Scholar
• LiuM, PengP, WangJ, et al. RACK1-mediated translation control promotes liver fibrogenesis. Biochem Biophys Res Commun. 2015;463(3):255–261. doi:10.1016/j.bbrc.2015.05.04026002467
   PubMed Web of Science ®Google Scholar
• ZhangC, LiuXR, CaoYC, et al. Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice. Reprod Fertil Dev. 2017;29(4):768–777. doi:10.1071/RD1523026748416
   PubMed Web of Science ®Google Scholar
• AyusoMI, Hernández-JiménezM, MartínME, SalinasM, AlcázarA. New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. J Biol Chem. 2010;285(45):34355–34363. doi:10.1074/jbc.M110.13510320736160
   PubMed Web of Science ®Google Scholar
• DreasA, MikulskiM, MilikM, FabritiusCH, BrzózkaK, Mitogen-activated ProteinRT. Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: recent Progress in the Development of MNK Inhibitors. Curr Med Chem. 2017;24(28):3025–3053.28164761
   PubMed Web of Science ®Google Scholar
• RuvinskyI, SharonN, LererT, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 2005;19(18):2199–2211. doi:10.1101/gad.35160516166381
   PubMed Web of Science ®Google Scholar
• Yee KohM, Spivak-KroizmanTR, PowisG. HIF-1 regulation: not so easy come, easy go. Trends Biochem Sci. 2008;33(11):526–534. doi:10.1016/j.tibs.2008.08.00218809331
   PubMed Web of Science ®Google Scholar
• LangKJ, KappelA, GoodallGJ. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell. 2002;13(5):1792–1801. doi:10.1091/mbc.02-02-001712006670
   PubMed Web of Science ®Google Scholar
• ZhouJ, CallapinaM, GoodallGJ, BrüneB. Functional integrity of nuclear factor kappaB, phosphatidylinositol 3ʹ-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha. Cancer Res. 2004;64(24):9041–9048. doi:10.1158/0008-5472.CAN-04-143715604270
   PubMed Web of Science ®Google Scholar
• SchepensB, TintonSA, BruynoogheY, BeyaertR, CornelisS. The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia. Nucleic Acids Res. 2005;33(21):6884–6894. doi:10.1093/nar/gki100016396835
   PubMed Web of Science ®Google Scholar
• MakinoY, KanopkaA, WilsonWJ, TanakaH, PoellingerL. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem. 2002;277(36):32405–32408. doi:10.1074/jbc.C20032820012119283
   PubMed Web of Science ®Google Scholar
• GalbánS, KuwanoY, PullmannR, et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008;28(1):93–107. doi:10.1128/MCB.00973-0717967866
   PubMed Web of Science ®Google Scholar
• TaguchiA, YanagisawaK, TanakaM, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res. 2008;68(14):5540–5545. doi:10.1158/0008-5472.CAN-07-646018632605
   PubMed Web of Science ®Google Scholar
• LiuLZ, LiC, ChenQ, et al. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression. PLoS One. 2011;6(4):e19139. doi:10.1371/journal.pone.001913921544242
   PubMed Web of Science ®Google Scholar
• HaqueM, KousoulasKG. The Kaposi’s sarcoma-associated herpesvirus ORF34 protein binds to HIF-1α and causes its degradation via the proteasome pathway. J Virol. 2013;87(4):2164–2173. doi:10.1128/JVI.02460-1223221556
   PubMed Web of Science ®Google Scholar
• WuD, CaoW, XiangD, HuYP, LuoB, ChenP. Exercise induces tissue hypoxia and HIF-1α redistribution in the small intestine. J Sport Health Sci. 2020;9(1):82–89. doi:10.1016/j.jshs.2019.05.00231921483
   PubMed Web of Science ®Google Scholar
• HaqueM, KousoulasKG. The Kaposi’s Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains. J Virol. 2019;93(17):e00764–19. doi:10.1128/JVI.00764-1931189709
   PubMed Web of Science ®Google Scholar
• ZhaoJ, DuF, ShenG, ZhengF, XuB. The role of hypoxia-inducible factor-2 in digestive system cancers. Cell Death Dis. 2015;6(1):e1600.25590810
   PubMed Web of Science ®Google Scholar
• MikawaT, LLeonartME, Takaori-KondoA. Dysregulated glycolysis as an oncogenic event. Cell Mol Life Sci. 2015;72(10):1881–1892. doi:10.1007/s00018-015-1840-325609364
   PubMed Web of Science ®Google Scholar
• GaoS, LuL, BaiY, ZhangP, SongW, DuanC. Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family. FASEB J. 2014;28(4):1880–1890. doi:10.1096/fj.12-22015224174425
   PubMed Web of Science ®Google Scholar
• HenzeAT, AckerT. Feedback regulators of hypoxia-inducible factors and their role in cancer biology. Cell Cycle. 2010;9(14):2749–2763. doi:10.4161/cc.9.14.1259120603601
   PubMed Web of Science ®Google Scholar
• WillamC, MassonN, TianYM, et al. Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proc Natl Acad Sci U S A. 2002;99(16):10423–10428. doi:10.1073/pnas.16211939912149454
   PubMed Web of Science ®Google Scholar
• SchödelJ, GramppS, MaherER, et al. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. Eur Urol. 2016;69(4):646–657. doi:10.1016/j.eururo.2015.08.00726298207
   PubMed Web of Science ®Google Scholar
• WangW, XuB, XuanH, et al. Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease. J Vasc Surg. 2018;68(5):1538–1550. doi:10.1016/j.jvs.2017.09.03029242064
   PubMed Web of Science ®Google Scholar
• SemenzaGL. Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization. J Investig Med. 2016;64(2):361–363. doi:10.1097/JIM.0000000000000206
   PubMed Web of Science ®Google Scholar
• Carbia-NagashimaA, GerezJ, Perez-CastroC, et al. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell. 2007;131(2):309–323. doi:10.1016/j.cell.2007.07.04417956732
   PubMed Web of Science ®Google Scholar
• ChengJ, KangX, ZhangS, YehET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007;131(3):584–595. doi:10.1016/j.cell.2007.08.04517981124
   PubMed Web of Science ®Google Scholar
• LiuYV, SemenzaGL. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle. 2007;6(6):656–659. doi:10.4161/cc.6.6.398117361105
   PubMed Web of Science ®Google Scholar
• HoxhajG, ManningBD. The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nat Rev Cancer. 2020;20(2):74–88. doi:10.1038/s41568-019-0216-731686003
   PubMed Web of Science ®Google Scholar
• FlügelD, GörlachA, MichielsC, KietzmannT. Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol Cell Biol. 2007;27(9):3253–3265. doi:10.1128/MCB.00015-0717325032
   PubMed Web of Science ®Google Scholar
• LiuW, LiY, LuoB. Current perspective on the regulation of FOXO4 and its role in disease progression. Cell Mol Life Sci. 2020;77(4):651–663. doi:10.1007/s00018-019-03297-w31529218
   PubMed Web of Science ®Google Scholar
• HirotaK. Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine. Biomedicines. 2020;8(2):32.
   PubMed Web of Science ®Google Scholar
• OkadaN, IshigamiY, SuzukiT, et al. Importins and exportins in cellular differentiation. J Cell Mol Med. 2008;12(5B):1863–1871. doi:10.1111/j.1582-4934.2008.00437.x18657223
   PubMed Web of Science ®Google Scholar
• ChachamiG, ParaskevaE, MingotJM, BraliouGG, GörlichD, SimosG. Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. Biochem Biophys Res Commun. 2009;390(2):235–240. doi:10.1016/j.bbrc.2009.09.09319788888
   PubMed Web of Science ®Google Scholar
• AlbadariN, DengS, LiW. The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opin Drug Discov. 2019;14(7):667–682. doi:10.1080/17460441.2019.161337031070059
   PubMed Web of Science ®Google Scholar
• MylonisI, ChachamiG, SamiotakiM, et al. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. J Biol Chem. 2006;281(44):33095–33106. doi:10.1074/jbc.M60505820016954218
   PubMed Web of Science ®Google Scholar
• YangG, XuS, PengL, LiH, ZhaoY, HuY. The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells. Mol Med Rep. 2016;13(3):2583–2589. doi:10.3892/mmr.2016.483626846577
   PubMed Web of Science ®Google Scholar
• FlaggSC, MartinCB, TaabazuingCY, HolmesBE, KnappMJ. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). J Inorg Biochem. 2012;113:25–30. doi:10.1016/j.jinorgbio.2012.03.00222687491
   PubMed Web of Science ®Google Scholar
• HwangSH, BangS, KimW, ChungJ. Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K). J Biol Chem. 2020;295(8):2336–2347. doi:10.1074/jbc.RA119.01159631959630
   PubMed Web of Science ®Google Scholar
• LiSH, ChunYS, LimJH, HuangLE, ParkJW. von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase. Int J Biochem Cell Biol. 2011;43(5):795–804. doi:10.1016/j.biocel.2011.02.00421316481
   PubMed Web of Science ®Google Scholar
• FauquierL, AzzagK, ParraMAM, et al. CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity. Sci Rep. 2018;8(1):12629. doi:10.1038/s41598-018-31102-430135524
   PubMed Web of Science ®Google Scholar
• BraicuC, BuseM, BusuiocC, et al. A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer. Cancers. 2019;11(10):1618. doi:10.3390/cancers11101618
   PubMed Web of Science ®Google Scholar
• LiuX, CaiX, HuB, et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291(49):25692–25705. doi:10.1074/jbc.M116.74547127777301
   PubMed Web of Science ®Google Scholar
• BaldewijnsMM, ThijssenVL, Van den EyndenGG, et al. High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. Br J Cancer. 2007;96(12):1888–1895. doi:10.1038/sj.bjc.660379617505508
   PubMed Web of Science ®Google Scholar
• CatalánV, Gómez-AmbrosiJ, RodríguezA, et al. Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J Nutr Biochem. 2011;22(7):634–641. doi:10.1016/j.jnutbio.2010.04.01520961744
   PubMed Web of Science ®Google Scholar
• Bosch-MarceM, OkuyamaH, WesleyJB, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res. 2007;101(12):1310–1318. doi:10.1161/CIRCRESAHA.107.15334617932327
   PubMed Web of Science ®Google Scholar
• VeerojuS, MamazhakypovA, RaiN, et al. Effect of p53 activation on experimental right ventricular hypertrophy. PLoS One. 2020;15(6):e0234872. doi:10.1371/journal.pone.023487232559203
   PubMed Web of Science ®Google Scholar
• YoshidaT, ZhangH, IwaseT, ShenJ, SemenzaGL, CampochiaroPA. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. FASEB J. 2010;24(6):1759–1767. doi:10.1096/fj.09-14566420065104
   PubMed Web of Science ®Google Scholar
• HadjipanayiE, SchillingAF. Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regeneration. Organogenesis. 2013;9(4):261–272. doi:10.4161/org.2597023974216
   PubMed Web of Science ®Google Scholar
• ChaST, ChenPS, JohanssonG, et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis [published correction appears in Cancer Res. 2019 Jul 15;79(14):3790]. Cancer Res. 2010;70(7):2675–2685. doi:10.1158/0008-5472.CAN-09-244820233879
   PubMed Web of Science ®Google Scholar
• BabaY, NoshoK, ShimaK, et al. HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 2010;176(5):2292–2301. doi:10.2353/ajpath.2010.09097220363910
   PubMed Web of Science ®Google Scholar
• IoannouM, PapamichaliR, KouvarasE, et al. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung. 2009;187(5):321–329. doi:10.1007/s00408-009-9169-z19707816
   PubMed Web of Science ®Google Scholar
• GravdalK, HalvorsenOJ, HaukaasSA, AkslenLA. Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer [published correction appears in Cancer Res. 2009 Jul 15;69(14):6005]. Cancer Res. 2009;69(11):4708–4715. doi:10.1158/0008-5472.CAN-08-441719487287
   PubMed Web of Science ®Google Scholar
• DangDT, ChunSY, BurkittK, et al. Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition. Cancer Res. 2008;68(6):1872–1880. doi:10.1158/0008-5472.CAN-07-158918339868
   PubMed Web of Science ®Google Scholar
• SimonMC. Coming up for air: HIF-1 and mitochondrial oxygen consumption. Cell Metab. 2006;3(3):150–151. doi:10.1016/j.cmet.2006.02.00716517402
   PubMed Web of Science ®Google Scholar
• ZhaoF, MancusoA, BuiTV, et al. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming. Oncogene. 2010;29(20):2962–2972. doi:10.1038/onc.2010.6720228846
   PubMed Web of Science ®Google Scholar
• GriffithsEA, PritchardSA, McGrathSM, et al. Increasing expression of hypoxia-inducible proteins in the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence. Br J Cancer. 2007;96(9):1377–1383. doi:10.1038/sj.bjc.660374417437013
   PubMed Web of Science ®Google Scholar
• PattersonDM, GaoD, TrahanDN, et al. Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma. Angiogenesis. 2011;14(3):255–266. doi:10.1007/s10456-011-9210-821484514
   PubMed Web of Science ®Google Scholar
• MenradH, WernoC, SchmidT, et al. Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology. 2010;51(6):2183–2192. doi:10.1002/hep.2359720513003
   PubMed Web of Science ®Google Scholar
• LiuL, SunL, ZhangH, et al. Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. Int J Cancer. 2009;124(7):1707–1715. doi:10.1002/ijc.2413519123465
   PubMed Web of Science ®Google Scholar
• CorzoCA, CondamineT, LuL, et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207(11):2439–2453. doi:10.1084/jem.2010058720876310
   PubMed Web of Science ®Google Scholar
• QiuY, HuangX, HeW. The regulatory role of HIF-1 in tubular epithelial cells in response to kidney injury. Histol Histopathol. 2020;35(4):321–330. doi:10.14670/HH-18-18231691948
   PubMed Web of Science ®Google Scholar
• NakayamaK, KataokaN. Regulation of Gene Expression under Hypoxic Conditions. Int J Mol Sci. 2019;20(13):3278. doi:10.3390/ijms20133278
   PubMed Web of Science ®Google Scholar
• WestraJ, BrouwerE, BosR, et al. Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2007;1108:340–348. doi:10.1196/annals.1422.03517893997
   PubMed Web of Science ®Google Scholar
• FiresteinGS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356–361. doi:10.1038/nature0166112748655
   PubMed Web of Science ®Google Scholar
• HuF, ShiL, MuR, et al. Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis [published correction appears in PLoS One. 2013;8(8). 10.1371/annotation/f61a5d49-25e7-47ce-8509-6478df526886]. PLoS One. 2013;8(8):e72650. doi:10.1371/journal.pone.007265023967327
   PubMed Web of Science ®Google Scholar
• KonistiS, KiriakidisS, PaleologEM. Hypoxia–a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat Rev Rheumatol. 2012;8(3):153–162. doi:10.1038/nrrheum.2011.20522293762
   PubMed Web of Science ®Google Scholar
• DameC, KirschnerKM, BartzKV, WallachT, HusselsCS, ScholzH. Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood. 2006;107(11):4282–4290. doi:10.1182/blood-2005-07-288916467207
   PubMed Web of Science ®Google Scholar
• ZhengKY, GuoAJ, BiCW, et al. The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts. Planta Med. 2011;77(9):894–899. doi:10.1055/s-0030-125062721157678
   PubMed Web of Science ®Google Scholar
• FandreyJ. Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol. 2004;286(6):R977–R988. doi:10.1152/ajpregu.00577.200315142852
   PubMed Web of Science ®Google Scholar
• LeeFS. Genetic causes of erythrocytosis and the oxygen-sensing pathway. Blood Rev. 2008;22(6):321–332. doi:10.1016/j.blre.2008.04.00318538455
   PubMed Web of Science ®Google Scholar
• ChenXQ, WangSJ, DuJZ, ChenXC. Diversities in hepatic HIF-1, IGF-I/IGFBP-1, LDH/ ICD, and their mRNA expressions induced by CoCl(2) in Qinghai-Tibetan plateau mammals and sea level mice. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R516–R526. doi:10.1152/ajpregu.00397.200616990490
   PubMed Web of Science ®Google Scholar
• AnQ, ShiCX, GuoH, et al. Development and characterization of octreotide-modified curcumin plus docetaxel micelles for potential treatment of non-small-cell lung cancer. Pharm Dev Technol. 2019;24(9):1164–1174. doi:10.1080/10837450.2019.164723631340709
   PubMed Web of Science ®Google Scholar
• ZhuG, JiangC, YanX, ZhaoS, XuD, CaoY. Shaofu Zhuyu Decoction Regresses Endometriotic Lesions in a Rat Model. Evid Based Complement Alternat Med. 2018;2018:3927096. doi:10.1155/2018/392709629636775
   PubMed Web of Science ®Google Scholar
• WangY, ZhangL, JinH, WangD. Based on HIF-1α/Wnt/β-Catenin Pathway to Explore the Effect of Qingshen Granules on Chronic Renal Failure Patients: A Randomized Controlled Trial. Evid Based Complement Alternat Med. 2019;2019:7656105. doi:10.1155/2019/765610531354858
   PubMed Web of Science ®Google Scholar
• LeiQ, QiangF, ChaoD, et al. Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways. Int J Mol Med. 2014;34(6):1629–1639. doi:10.3892/ijmm.2014.196525318952
   PubMed Web of Science ®Google Scholar
• LiZ, YouQ, ZhangX. Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: development and Therapeutic Applications. J Med Chem. 2019;62(12):5725–5749. doi:10.1021/acs.jmedchem.8b0159630682255
   PubMed Web of Science ®Google Scholar
• HuY, WangS, WuX, et al. Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma. J Ethnopharmacol. 2013;149(3):601–612. doi:10.1016/j.jep.2013.07.03023916858
   PubMed Web of Science ®Google Scholar
• TanC, ZhangL, ChengX, et al. Curcumin inhibits hypoxia-induced migration in K1 papillary thyroid cancer cells.Experimental Biology and Medicine. 2015;240(7):925–935. doi:10.1177/153537021455566525349216
   PubMed Web of Science ®Google Scholar
• SiddiquiFA, PrakasamG, ChattopadhyayS. Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition. Sci Rep. 2018;8(1):8323. doi:10.1038/s41598-018-25524-329844464
   PubMed Web of Science ®Google Scholar
• OuyangS, YaoYH, ZhangZM, LiuJS, XiangH. Curcumin inhibits hypoxia inducible factor-1α-induced inflammation and apoptosis in macrophages through an ERK dependent pathway. Eur Rev Med Pharmacol Sci. 2019;23(4):1816–1825. doi:10.26355/eurrev_201902_1714530840308
   PubMed Web of Science ®Google Scholar
• NorooznezhadF, Rodriguez-MerchanEC, AsadiS, NorooznezhadAH. Curcumin: hopeful treatment of hemophilic arthropathy via inhibition of inflammation and angiogenesis. Expert Review of Hematology. 2020;13(1):5–11. doi:10.1080/17474086.2020.168586731657968
   PubMed Web of Science ®Google Scholar
• FayedHA, BarakatBM, ElshaerSS, Abdel-NaimAB, MenzeET. Antiosteoporotic activities of isoquercitrin in ovariectomized rats: role of inhibiting hypoxia inducible factor-1 alpha. Eur J Pharmacol. 2019;865:172785. doi:10.1016/j.ejphar.2019.17278531712059
   PubMed Web of Science ®Google Scholar
• WangL, MaQ. Clinical benefits and pharmacology of scutellarin: A comprehensive review. Pharmacol Ther. 2018;190:105–127. doi:10.1016/j.pharmthera.2018.05.00629742480
   PubMed Web of Science ®Google Scholar
• ZhuZ-Y, WangF, JiaC-H, XieM-L. Apigenin-induced HIF-1α inhibitory effect improves abnormal glucolipid metabolism in AngⅡ/hypoxia-stimulated or HIF-1α-overexpressed H9c2 cells. Phytomedicine. 2019;62:152713. doi:10.1016/j.phymed.2018.10.01031078968
   PubMed Web of Science ®Google Scholar
• FitzpatrickSF, TambuwalaMM, BruningU, et al. An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia. J Immunol. 2011;186(2):1091‑1096. doi:10.4049/jimmunol.1002256
   PubMed Web of Science ®Google Scholar
• XiaoW-D, ChenW, SunL-H, WangW-S, ZhouS-W, YangH. The protective effect of enteric glial cells on intestinal epithelial barrier function is enhanced by inhibiting inducible nitric oxide synthase activity under lipopolysaccharide stimulation. Mol Cell Neurosci. 2011;46(2):527–534. doi:10.1016/j.mcn.2010.12.00721182950
   PubMed Web of Science ®Google Scholar
• HuL, CuiR, LiuH, WangF. Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells. Oncotarget. 2017;8(50):88008–88020. doi:10.18632/oncotarget.2133029152137
   PubMedGoogle Scholar
• ShenS. Inhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia. Int J Ophthalmol. 2019;12(10):1539–1547. doi:10.18240/ijo.2019.10.0431637188
   PubMed Web of Science ®Google Scholar
• ZhangD, XuL, CaoF, et al. Celastrol regulates multiple nuclear transcription factors belonging to HSP90’s clients in a dose- and cell type-dependent way. Cell Stress Chaperones. 2010;15(6):939–946. doi:10.1007/s12192-010-0202-120480272
   PubMed Web of Science ®Google Scholar
• LiC, WangQ, ShenS, WeiX, LiG. Oridonin inhibits VEGF-A-associated angiogenesis and epithelial-mesenchymal transition of breast cancer in vitro and in vivo. Oncol Lett. 2018;16(2):2289–2298. doi:10.3892/ol.2018.894330008931
   PubMed Web of Science ®Google Scholar
• LiW, XueD, XueM, et al. Fucoidan inhibits epithelial-to-mesenchymal transition via regulation of the HIF-1α pathway in mammary cancer cells under hypoxia. Oncol Lett. 2019;18(1):330–338. doi:10.3892/ol.2019.1028331289504
   PubMed Web of Science ®Google Scholar
• KimA, MaJY. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells. Front Pharmacol. 2018;9:1455. doi:10.3389/fphar.2018.0145530618749
   PubMed Web of Science ®Google Scholar
• ChenQ, LinW, YinZ, et al. Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1α/Akt Pathway in Liver Cancer. Evid Based Complement Alternat Med. 2019;2019:9602935. doi:10.1155/2019/960293531057657
   PubMed Web of Science ®Google Scholar
• WangHW, LiouKT, WangYH, et al. Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol. 2011;138(1):22–33. doi:10.1016/j.jep.2011.06.03321784143
   PubMed Web of Science ®Google Scholar
• GongX, GuoQ, ZhaoH. Bu Yang Huan Wu decoction prevents reperfusion injury following ischemic stroke in rats via inhibition of HIF-1 α, VEGF and promotion β-ENaC expression. J Ethnopharmacol. 2019;228:70–81. doi:10.1016/j.jep.2018.09.01730218809
   PubMed Web of Science ®Google Scholar
• ZhengKY, ZhangZX, GuoAJ, et al. Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells. Eur J Pharmacol. 2012;679(1–3):34–39. doi:10.1016/j.ejphar.2012.01.02722309741
   PubMed Web of Science ®Google Scholar
• GuoXQ, QiL, YangJ, et al. Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts. Cell Tissue Res. 2017;367(2):197–211. doi:10.1007/s00441-016-2535-227942852
   PubMed Web of Science ®Google Scholar
• LiL, WuLF, WeiD. Effects of tanshinone IIA on proliferation, apoptosis and expression of HIF-1α, VEGF and wild-type P53 in human hepatoma Hep G2 cells under hypoxia. Chin j Pathophysiol. 2014;30:2155–2160.
   Google Scholar
• WeiB, LiWW, JiJ, HuQH, JiH. The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats. Atherosclerosis. 2014;235(2):318–327. doi:10.1016/j.atherosclerosis.2014.05.92424911635
   PubMed Web of Science ®Google Scholar
• XiangY, YaoX, WangX, et al. Houshiheisan promotes angiogenesis via HIF-1α/VEGF and SDF-1/CXCR4 pathways: in vivo and in vitro. Biosci Rep. 2019;39(10):BSR20191006. doi:10.1042/BSR2019100631652450
   PubMed Web of Science ®Google Scholar
• JangH. Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression. Oncol Rep. 2017;38(6):3430–3438. doi:10.3892/or.2017.602129039561
   PubMed Web of Science ®Google Scholar
• ZhangY, ChenC, ZhangJ. Effects and significance of formononetin on expression levels of HIF-1α and VEGF in mouse cervical cancer tissue. Oncol Lett. 2019;18(3):2248–2253. doi:10.3892/ol.2019.1056731452725
   PubMed Web of Science ®Google Scholar
• XingY, MiC, WangZ, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166–180. doi:10.1016/j.phrs.2018.08.00430103001
   PubMed Web of Science ®Google Scholar
• LiS, LiJ, DaiW, et al. Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death. Br J Cancer. 2017;117(10):1518–1528. doi:10.1038/bjc.2017.32328926527
   PubMed Web of Science ®Google Scholar
• ZhangJ, SuH, LiQ, LiJ, ZhaoQ. Genistein decreases A549 cell viability via inhibition of the PI3K/AKT/HIF-1α/VEGF and NF-κB/COX-2 signaling pathways. Mol Med Rep. 2017;15(4):2296–2302. doi:10.3892/mmr.2017.626028259980
   PubMed Web of Science ®Google Scholar
• KimGD. Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells [published correction appears in Prev Nutr Food Sci. 2018 Mar;23 (1): 84–85]. Prev Nutr Food Sci. 2017;22(4):320–326. doi:10.3746/pnf.2017.22.4.32029333385
   PubMedGoogle Scholar
• WangJ, GaoT, WangF, XueJ, YeH, XieM. Luteolin improves myocardial cell glucolipid metabolism by inhibiting hypoxia inducible factor-1α expression in angiotensin II/hypoxia-induced hypertrophic H9c2 cells. Nutr Res. 2019;65:63–70. doi:10.1016/j.nutres.2019.02.00430954346
   PubMed Web of Science ®Google Scholar
• JinH, LianN, BianM, et al. Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. Chem Biol Interact. 2018;285:14–20. doi:10.1016/j.cbi.2018.02.02529476730
   PubMed Web of Science ®Google Scholar
• FengJ, ZhangXL, LiYY, CuiYY, ChenYH. Pinus massoniana Bark Extract: structure-Activity Relationship and Biomedical Potentials. Am J Chin Med. 2016;44(8):1559–1577. doi:10.1142/S0192415X1650087727852122
   PubMed Web of Science ®Google Scholar
• HammerstoneJF, LazarusSA, MitchellAE, RuckerR, SchmitzHH. Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem. 1999;47(2):490–496. doi:10.1021/jf980760h10563922
   PubMed Web of Science ®Google Scholar
• FengJ, WangC, LiuT, et al. Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis. J Cell Mol Med. 2019;23(9):6479–6493. doi:10.1111/jcmm.1454331328391
   PubMed Web of Science ®Google Scholar
• LeeDH, LeeYJ. Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis. J Cell Biochem. 2008;105(2):546–553. doi:10.1002/jcb.2185118655183
   PubMed Web of Science ®Google Scholar
• AnsóE, ZuazoA, IrigoyenM, UrdaciMC, RouzautA, Martínez-IrujoJJ. Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. Biochem Pharmacol. 2010;79(11):1600–1609. doi:10.1016/j.bcp.2010.02.00420153296
   PubMed Web of Science ®Google Scholar
• WangK, LiuR, LiJ, et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011;7(9):966–978. doi:10.4161/auto.7.9.1586321610320
   PubMed Web of Science ®Google Scholar
• LiW, CaoL, ChenX, LeiJ, MaQ. Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway. Oncol Rep. 2016;35(3):1718–1726. doi:10.3892/or.2015.450426707376
   PubMed Web of Science ®Google Scholar
• WangY, TanX, LiS, YangS. The total flavonoid of Eucommia ulmoides sensitizes human glioblastoma cells to radiotherapy via HIF-α/MMP-2 pathway and activates intrinsic apoptosis pathway. Onco Targets Ther. 2019;12:5515–5524. doi:10.2147/OTT.S21049731371989
   PubMed Web of Science ®Google Scholar
• XieT, WangJR, DaiCG, FuXA, DongJ, HuangQ. Vitexin, an inhibitor of hypoxia-inducible factor-1α, enhances the radiotherapy sensitization of hyperbaric oxygen on glioma. Clin Transl Oncol. 2020;22(7):1086–1093. doi:10.1007/s12094-019-02234-431677055
   PubMed Web of Science ®Google Scholar
• WangH, ZhaoL, ZhuLT, et al. Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. Mol Carcinog. 2014;53:E107–E118. doi:10.1002/mc.2205223761018
   PubMed Web of Science ®Google Scholar
• PrangsaengtongO, JantareeP, LirdprapamongkolK, SvastiJ, KoizumiK. Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition. Biol Pharm Bull. 2018;41(11):1659–1666. doi:10.1248/bpb.b18-0032930381665
   PubMed Web of Science ®Google Scholar
• ZhouY, XuQ, ShangJ, LuL, ChenG. Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling. J Cell Physiol. 2019;234(10):17876–17885. doi:10.1002/jcp.2841830851060
   PubMed Web of Science ®Google Scholar
• WenZ, HuangC, XuY, et al. α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways. Eur J Pharmacol. 2016;771:93–98. doi:10.1016/j.ejphar.2015.12.02026688571
   PubMed Web of Science ®Google Scholar
• WangH, ZhangC, XuL, et al. Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway. Oncotarget. 2016;7(15):20193–20208. doi:10.18632/oncotarget.793526958938
   PubMedGoogle Scholar
• LiY, ZhengJY, LiuJQ, et al. Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: therapeutical Effects of Clematichinenoside AR on Arthritis. Front Immunol. 2016;7:532. doi:10.3389/fimmu.2016.0053228003810
   PubMed Web of Science ®Google Scholar
• ZhaoP, HanSN, ArumugamS, et al. Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation. Am J Physiol Gastrointest Liverv. 2019;317(4):G387–G397. doi:10.1152/ajpgi.00054.2019
   PubMed Web of Science ®Google Scholar
• ZhaoR, SunL, LinS, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity. Oncol Rep. 2013;29(4):1379–1386. doi:10.3892/or.2013.227223404207
   PubMed Web of Science ®Google Scholar
• LiJ, YangYL, LiLZ, et al. Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: therapeutic effects of ginsenoside Rb1. Biochim Biophys Acta Mol Basis Dis. 2017;1863(11):2835–2847. doi:10.1016/j.bbadis.2017.07.01728736181
   PubMed Web of Science ®Google Scholar
• LiuT, ZhaoL, HouH, DingL, ChenW, LiX. Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals. Tumour Biol. 2017;39(5):1010428317692225. doi:10.1177/101042831769222528459376
   PubMedGoogle Scholar
• LiuT, ZhaoL, ZhangY, et al. Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells. PLoS One. 2014;9(9):e103887. doi:10.1371/journal.pone.010388725197976
   PubMed Web of Science ®Google Scholar
• HeS, LuG, HouH, et al. Saikosaponin-d suppresses the expression of cyclooxygenase-2 through the phospho-signal transducer and activator of transcription 3/hypoxia-inducible factor-1α pathway in hepatocellular carcinoma cells. Mol Med Rep. 2014;10(5):2556–2562. doi:10.3892/mmr.2014.257425231214
   PubMed Web of Science ®Google Scholar
• LawPC, AuyeungKK, ChanLY, KoJK. Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complement Altern Med. 2012;12:160. doi:10.1186/1472-6882-12-16022992293
   PubMed Web of Science ®Google Scholar
• JiaLY, WuXJ, GaoY, et al. Inhibitory Effects of Total Triterpenoid Saponins Isolated from the Seeds of the Tea Plant (Camellia sinensis) on Human Ovarian Cancer Cells. Molecules. 2017;22(10):1649. doi:10.3390/molecules22101649
   PubMed Web of Science ®Google Scholar
• Tyszka-CzocharaM, Bukowska-StrakovaK, Kocemba-PilarczykKA, MajkaM. Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines. Nutrients. 2018;10(7):841. doi:10.3390/nu10070841
   PubMed Web of Science ®Google Scholar
• LuoLX, LiY, LiuZQ, et al. Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells. Front Pharmacol. 2017;8:199. doi:10.3389/fphar.2017.0019928443025
   PubMed Web of Science ®Google Scholar
• MaJ, XueM, ZhangS, et al. Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB-2-HIF-1α axis. Oncol Rep. 2019;41(2):1051–1058. doi:10.3892/or.2018.689430535465
   PubMed Web of Science ®Google Scholar
• LinS, TsaiSC, LeeCC, WangBW, LiouJY, ShyuKG. Berberine inhibits HIF-1alpha expression via enhanced proteolysis. Mol Pharmacol. 2004;66(3):612–619.15322253
   PubMed Web of Science ®Google Scholar
• MaoL, ChenQ, GongK, et al. Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells. Oncol Rep. 2018;39(5):2436–2442. doi:10.3892/or.2018.631829565467
   PubMed Web of Science ®Google Scholar
• Carrasco-PozoC, TanKN, RodriguezT, AveryVM. The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor. Int J Mol Sci. 2019;20(21):5384. doi:10.3390/ijms20215384
   PubMed Web of Science ®Google Scholar
• ZhangF, LuS, HeJ, et al. Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α. Theranostics. 2018;8(3):610–626. doi:10.7150/thno.2223729344293
   PubMed Web of Science ®Google Scholar
• XiaY, KangTW, JungYD, ZhangC, LianS. Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia. J Agric Food Chem. 2019;67(28):7844–7854. doi:10.1021/acs.jafc.9b0302731241937
   PubMed Web of Science ®Google Scholar
• ChenYL, ZhengYY, DaiYC, ZhangYL, TangZP. Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis. World J Gastroenterol. 2019;25(21):2603–2622. doi:10.3748/wjg.v25.i21.260331210713
   PubMed Web of Science ®Google Scholar
• YangW, ZhangL, ChenS, et al. Longshengzhi Capsules Improve Ischemic Stroke Outcomes and Reperfusion Injury via the Promotion of Anti-Inflammatory and Neuroprotective Effects in MCAO/R Rats. Evid Based Complement Alternat Med. 2020;2020:9654175. doi:10.1155/2020/965417532215051
   PubMed Web of Science ®Google Scholar
• Luo, ZhengC. Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke. Phytomedicine. 2018;44:20–31. doi:10.1016/j.phymed.2018.04.02529895489
   PubMed Web of Science ®Google Scholar
• LiYN, WangXJ, LiB, et al. Tongxinluo inhibits cyclooxygenase-2, inducible nitric oxide synthase, hypoxia-inducible factor-2α/vascular endothelial growth factor to antagonize injury in hypoxia-stimulated cardiac microvascular endothelial cells. Chin Med J. 2015;128(8):1114–1120. doi:10.4103/0366-6999.15511925881609
   PubMed Web of Science ®Google Scholar
• ZengJ, YanR, PanH, et al. Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions. BMC Complement Altern Med. 2018;18(1):250. doi:10.1186/s12906-018-2309-330200948
   PubMed Web of Science ®Google Scholar
• YiJ, YangJ, et al. Weiqi Decoction Attenuated Chronic Atrophic Gastritis with Precancerous Lesion through Regulating Microcirculation Disturbance and HIF-1α Signaling Pathway. Evid Based Complement Alternat Med. 2019;2019:2651037. doi:10.1155/2019/265103731320912
   PubMed Web of Science ®Google Scholar
• PangHQ, YueSJ, TangYP, et al. Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia. Front Pharmacol. 2018;9:165. doi:10.3389/fphar.2018.0016529551975
   PubMed Web of Science ®Google Scholar
• ShiX, TangY, ZhuH, et al. Comparative tissue distribution profiles of five major bio-active components in normal and blood deficiency rats after oral administration of Danggui Buxue Decoction by UPLC-TQ/MS. J Pharm Biomed Anal. 2014;88:207–215. doi:10.1016/j.jpba.2013.08.04324076576
   PubMed Web of Science ®Google Scholar
• HouF, LiW, ShiQ, et al. Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1α and epithelial mesenchymal transition. BMC Complement Altern Med. 2016;16(1):428. doi:10.1186/s12906-016-1419-z27806701
   PubMed Web of Science ®Google Scholar
• ZhangLY, OuM, HuangYZ, QiaoYY, ZhangDJ. Effect of Yifei Huoxue Granule on the proliferation of rat pulmonary artery smooth muscle cells upon exposure to chronic hypoxic conditions in vitro. Chin J Integr Med. 2012;18(7):507–513. doi:10.1007/s11655-012-1150-722772913
   PubMed Web of Science ®Google Scholar
• ZhangL, LiuQ, LuL, ZhaoX, GaoX. Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway. J Pharmacol Exp Ther. 2011;338(2):485–491. doi:10.1124/jpet.111.18099221576377
   PubMed Web of Science ®Google Scholar
• LiQ, LiangX, YangY, ZengX, ZhongX, HuangC. Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1α/mitochondria/ROS pathway. FEBS Open Bio. 2020;10(1):118–126. doi:10.1002/2211-5463.12760
   PubMed Web of Science ®Google Scholar
• ZhangJP, LiuAH, HouRR, et al. Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. Eur J Pharmacol. 2009;607(1):6–14. doi:10.1016/j.ejphar.2009.01.04619326475
   PubMed Web of Science ®Google Scholar
• WangZ, ZhangZ, ZhaoJ, YongC, MaoY. Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1α. Int Heart J. 2019;60(4):964–973. doi:10.1536/ihj.18-51931257333
   PubMed Web of Science ®Google Scholar
• DaiGH, LiuN, ZhuJW, et al. Qi-Shen-Yi-Qi Dripping Pills Promote Angiogenesis of Ischemic Cardiac Microvascular Endothelial Cells by Regulating MicroRNA-223-3p Expression. Evid Based Complement Alternat Med. 2016;2016:5057328. doi:10.1155/2016/505732827057198
   PubMed Web of Science ®Google Scholar