80
Views
11
CrossRef citations to date
0
Altmetric
Original Research

Activation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study

ORCID Icon, , , , &
Pages 5155-5166 | Published online: 24 Nov 2020

References

  • BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
  • AbbasAE. Surgical management of lung cancer: history, evolution, and modern advances. Curr Oncol Rep. 2018;20(12):98.30421260
  • MiglioreM, HalezerogluS, MuellerMR. Making precision surgical strategies a reality: are we ready for a paradigm shift in thoracic surgical oncology? Future Oncol. 2020;16(16s):1–5.
  • LohserJ, SlingerP. Lung injury after one-lung ventilation: a review of the pathophysiologic mechanisms affecting the ventilated and the collapsed lung. Anesth Analg. 2015;121(2):302–318. doi:10.1213/ANE.000000000000080826197368
  • de la GalaF, PiñeiroP, GaruttiI, et al. Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: a prospective observational study. Eur J Anaesthesiol. 2015;32(12):872–880. doi:10.1097/EJA.000000000000023326513310
  • WangJ, WuA, WuY. Endothelial glycocalyx layer: a possible therapeutic target for acute lung injury during lung resection. Biomed Res Int. 2017;130:5969657. doi:10.1155/2017/5969657
  • OkaharaS, ShimizuK, SuzukiS, IshiiK, MorimatsuH. Associations between intraoperative ventilator settings during one-lung ventilation and postoperative pulmonary complications: a prospective observational study. BMC Anesthesiol. 2018;18(1):13. doi:10.1186/s12871-018-0476-x29370755
  • KimBG, LeePH, LeeSH, ParkCS, JangAS. Impact of ozone on claudins and tight junctions in the lungs. Environ Toxicol. 2018;33(7):798–806. doi:10.1002/tox.2256629673049
  • HuaT, YangM, ZhouY, ChenL, WuH, LiuR. Alda-1 prevents pulmonary epithelial barrier dysfunction following severe hemorrhagic shock through clearance of reactive aldehydes. Biomed Res Int. 2019;2019:2476252. doi:10.1155/2019/247625231467875
  • WangY, LinL, JiY, et al. Prognostic value of the advanced lung cancer inflammation index in early-stage non-small cell lung cancer patients undergoing video-assisted thoracoscopic pulmonary resection. Ann Palliat Med. 2020;9(3):721–729. doi:10.21037/apm.2020.03.1832312059
  • BaoN, TangB. Organ-protective effects and the underlying mechanism of dexmedetomidine. Mediators Inflamm. 2020;2020:6136105. doi:10.1155/2020/613610532454792
  • HuangSQ, ZhangJ, ZhangXX, et al. Can dexmedetomidine improve arterial oxygenation and intrapulmonary shunt during one-lung ventilation in adults undergoing thoracic surgery? A meta-analysis of randomized, placebo-controlled trials. Chin Med J (Engl). 2017;130(14):1707–1714. doi:10.4103/0366-6999.20989128685722
  • AsriS, HosseinzadehH, EydiM, MarahemM, DehghaniA, SoleimanpourH. Effect of dexmedetomidine combined with inhalation of isoflurane on oxygenation following one-lung ventilation in thoracic surgery. Anesth Pain Med. 2020;10(1):e95287. doi:10.5812/aapm.9528732309196
  • KarP, DurgaP, GopinathR. The effect of epidural dexmedetomidine on oxygenation and shunt fraction in patients undergoing thoracotomy and one lung ventilation: a randomized controlled study. J Anaesthesiol Clin Pharmacol. 2016;32(4):458–464.28096575
  • WangJ, YiX, JiangL, et al. Protective effects of dexmedetomidine on lung in rats with one-lung ventilation. Exp Ther Med. 2019;17(1):187–192.30651781
  • ShiL, GuoC, XieY, LiuY, WuF. Dexmedetomidine attenuates lung injury in obstructive jaundice rats through PI3K/Akt/HIF-1α signaling pathway. Arch Med Res. 2019;50(5):233–240. doi:10.1016/j.arcmed.2019.08.00631589938
  • KozianA, SchillingT, FredénF, et al. One-lung ventilation induces hyperperfusion and alveolar damage in the ventilated lung: an experimental study. Br J Anaesth. 2008;100(4):549–559. doi:10.1093/bja/aen02118308740
  • LongME, GongKQ, EddyWE, et al. MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury. JCI Insight. 2019;4(23).
  • LiY, HuangJ, FoleyNM, et al. B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration. Sci Rep. 2016;6:31284. doi:10.1038/srep3128427515382
  • OdaJ, YamashitaK, InoueT, et al. Acute lung injury and multiple organ dysfunction syndrome secondary to intra-abdominal hypertension and abdominal decompression in extensively burned patients. J Trauma. 2007;62(6):1365–1369. doi:10.1097/TA.0b013e3180487d3c17563650
  • YiL, ZhouZ, ZhengY, et al. Suppressive effects of GSS on lipopolysaccharide-induced endothelial cell injury and ALI via TNF-α and IL-6. Mediators Inflamm. 2019;2019:4251394. doi:10.1155/2019/425139432082076
  • FunakoshiT, IshibeY, OkazakiN, et al. Effect of re-expansion after short-period lung collapse on pulmonary capillary permeability and pro-inflammatory cytokine gene expression in isolated rabbit lungs. Br J Anaesth. 2004;92(4):558–563. doi:10.1093/bja/aeh10114977797
  • YangCL, TsaiPS, HuangCJ. Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury. Acta Anaesthesiol Taiwan. 2008;46(4):151–159. doi:10.1016/S1875-4597(09)60002-319097961
  • DingD, XuS, ZhangH, et al. 3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy. Exp Ther Med. 2018;15(4):3516–3522.29545877
  • ZhangQ, WuD, YangY, LiuT, LiuH. Dexmedetomidine alleviates hyperoxia-induced acute lung injury via inhibiting NLRP3 inflammasome activation. Cell Physiol Biochem. 2017;42(5):1907–1919. doi:10.1159/00047960928873369
  • YanagiS, TsubouchiH, MiuraA, MatsumotoN, NakazatoM. Breakdown of epithelial barrier integrity and overdrive activation of alveolar epithelial cells in the pathogenesis of acute respiratory distress syndrome and lung fibrosis. Biomed Res Int. 2015;2015:573210. doi:10.1155/2015/57321026523279
  • LiY, YangW, Quinones-HinojosaA, et al. Interference with protease-activated receptor 1 alleviates neuronal cell death induced by lipopolysaccharide-stimulated microglial cells through the PI3K/Akt pathway. Sci Rep. 2016;6:38247. doi:10.1038/srep3824727910893
  • WeiY, HongH, ZhangX, et al. Salidroside inhibits inflammation through PI3K/Akt/HIF signaling after focal cerebral ischemia in rats. Inflammation. 2017;40(4):1297–1309. doi:10.1007/s10753-017-0573-x28478514
  • JoshiS, SinghAR, ZulcicM, DurdenDL. A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis. Mol Cancer Res. 2014;12(10):1520–1531.25103499
  • EltzschigHK, BrattonDL, ColganSP. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov. 2014;13(11):852–869. doi:10.1038/nrd442225359381
  • WangC, WangZ, ZhangX, et al. Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression. Neurosci Lett. 2012;529(1):45–50. doi:10.1016/j.neulet.2012.08.07822999929
  • LiangS, WangY, LiuY. Dexmedetomidine alleviates lung ischemia-reperfusion injury in rats by activating PI3K/Akt pathway. Eur Rev Med Pharmacol Sci. 2019;23(1):370–377.30657579
  • LiJ, GuoM, LiuY, et al. Both GSK-3β/CRMP2 and CDK5/CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in neonatal rats. Toxicol Sci. 2019;171(1):193–210. doi:10.1093/toxsci/kfz135
  • ZhangW, ZhangJQ, MengFM, XueFS. Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. J Anesth. 2016;30(5):826–833. doi:10.1007/s00540-016-2214-127412350
  • YangJ, WangY, LiuH, BiJ, LuY. C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression. Toxicol Mech Methods. 2017;27(4):293–297. doi:10.1080/15376516.2017.127881228052715
  • TanHT, HagnerS, RuchtiF, et al. Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice. Allergy. 2019;74(2):294–307. doi:10.1111/all.1361930267575
  • WittekindtOH. Tight junctions in pulmonary epithelia during lung inflammation. Pflugers Arch. 2017;469(1):135–147. doi:10.1007/s00424-016-1917-327921210
  • YouK, XuX, FuJ, et al. Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1. Respir Res. 2012;13(1):36. doi:10.1186/1465-9921-13-3622559818
  • WangH, WangT, YuanZ, et al. Role of receptor for advanced glycation end products in regulating lung fluid balance in lipopolysaccharide-induced acute lung injury and infection-related acute respiratory distress syndrome. Shock (Augusta, Ga). 2018;50(4):472–482. doi:10.1097/SHK.0000000000001032
  • HartmannG, TschöpM, FischerR, et al. High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine. 2000;12(3):246–252. doi:10.1006/cyto.1999.053310704252
  • ChenQ, YiB, MaJ, et al. α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury. Oncotarget. 2016;7(35):55990–56001. doi:10.18632/oncotarget.1080927463003
  • GongZ, LongX, WeiH, et al. Dexmedetomidine combined with protective lung ventilation strategy provides lung protection in patients undergoing radical resection of esophageal cancer with one-lung ventilation. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;40(7):1013–1017.32701242
  • LiuY, ZhuX, ZhouD, HanF, YangX. Dexmedetomidine for prevention of postoperative pulmonary complications in patients after oral and maxillofacial surgery with fibular free flap reconstruction: a prospective, double-blind, randomized, placebo-controlled trial. BMC Anesthesiol. 2020;20(1):127. doi:10.1186/s12871-020-01045-332460699
  • MineoTC, SellitriF, VanniG, GallinaFT, AmbrogiV. Immunological and inflammatory impact of non-intubated lung metastasectomy. Int J Mol Sci. 2017;18(7):1466. doi:10.3390/ijms18071466
  • LavonH, MatznerP, BenbenishtyA, et al. Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers. Br J Anaesth. 2018;120(1):188–196. doi:10.1016/j.bja.2017.11.00429397129
  • SuX, FanY, YangL, et al. Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery. J Transl Med. 2018;16(1):347. doi:10.1186/s12967-018-1727-930537999
  • ZhengL, JiaR, ZhaoJ. Dexmedetomidine regulates proliferation, apoptosis, migration, and invasion in ovarian cancer cells via MiR-155-HIF-1α axis. Med Sci Monit. 2019;25:10164–10172. doi:10.12659/MSM.91911231887107
  • WallT, SherwinA, MaD, BuggyDJ. Influence of perioperative anaesthetic and analgesic interventions on oncological outcomes: a narrative review. Br J Anaesth. 2019;123(2):135–150. doi:10.1016/j.bja.2019.04.06231255291