155
Views
14
CrossRef citations to date
0
Altmetric
Original Research

Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition

ORCID Icon, , , ORCID Icon, , , , , & ORCID Icon show all
Pages 5315-5324 | Published online: 01 Dec 2020

References

  • WirschingHG, GalanisE, WellerM. Glioblastoma. Handb Clin Neurol. 2016;134:381–397. doi:10.1016/B978-0-12-802997-8.00023-226948367
  • EllisonDW. Multiple molecular data sets and the classification of adult diffuse gliomas. N Engl J Med. 2015;372(26):2555–2557. doi:10.1056/NEJMe150681326061754
  • ParkDM, SathornsumeteeS, RichJN. Medical oncology: treatment and management of malignant gliomas. Nat Rev Clin Oncol. 2010;7(2):75–77. doi:10.1038/nrclinonc.2009.22120118976
  • Hombach-KlonischS, MehrpourM, ShojaeiS, et al. Glioblastoma and chemoresistance to alkylating agents: involvement of apoptosis, autophagy, and unfolded protein response. Pharmacol Ther. 2018;184:13–41. doi:10.1016/j.pharmthera.2017.10.01729080702
  • TavanaE, MollazadehH, MohtashamiE, et al. Quercetin: a promising phytochemical for the treatment of glioblastoma multiforme. BioFactors. 2020;46(3):356–366. doi:10.1002/biof.160531880372
  • AfshariA, MollazadehH, MohtashamiE, et al. Protective role of natural products in glioblastoma multiforme: a focus on nitric oxide pathway. Curr Med Chem. 2020;27. doi:10.2174/0929867327666200130104757.
  • SuthammarakW, NumpraphrutP, CharoensakdiR, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev. 2016;2016:1293036. doi:10.1155/2016/129303627703599
  • MurakamiM. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016;37(4):939–948. doi:10.3892/ijmm.2016.2517.26951885
  • WuC, HsiaoS, MurakamiM, et al. Alpha-mangostin reverses multidrug resistance by attenuating the function of the multidrug resistance-linked ABCG2 transporter. Mol Pharm. 2017;14(8):2805–2814. doi:10.1021/acs.molpharmaceut.7b0033428641010
  • GhasemzadehA, JaafarHZE, BaghdadiA, Tayebi-MeigooniA. Alpha-mangostin-rich extracts from mangosteen pericarp: optimization of green extraction protocol and evaluation of biological activity. Molecules. 2018;23(8):8. doi:10.3390/molecules23081852
  • ZhangX, LiuJ, YongH, QinY, LiuJ, JinC. Development of antioxidant and antimicrobial packaging films based on chitosan and mangosteen (Garcinia mangostana L.) rind powder. Int J Biol Macromol. 2020;145:1129–1139. doi:10.1016/j.ijbiomac.2019.10.03831730981
  • LeeY, KimS, OhY, et al. γ inhibition of oxidative neurotoxicity and scopolamine-induced memory impairment by -mangostin: and evidence. Oxid Med Cell Longev. 2019;2019:3640753. doi:10.1155/2019/364075331019651
  • ChaeH-S, OhS-R, LeeH-K, JooSH, ChinY-W. Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell. Food Chem. 2012;134(1):397–400. doi:10.1016/j.foodchem.2012.02.075
  • YinQ, WuY, PanS, et al. Activation of Cholinergic anti-inflammatory pathway in peripheral immune cells involved in therapeutic actions of α-mangostin on collagen-induced arthritis in rats. Drug Des Devel Ther. 2020;14:1983–1993. doi:10.2147/dddt.S249865
  • ChiuY, WuJ, YehC, YadavV, HuangH, WangLJA. Garcinia mangostanaγ-mangostin isolated from L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling. Aging. 2020;12(8):6630–6643. doi:10.18632/aging.10300332302289
  • WidyarmanAS, LaySH, WendhitaIP, TjakraEE, MurdonoFI, BinarthaCTO. Indonesian mangosteen fruit (Garcinia mangostana L.) peel extract inhibits Streptococcus mutans and Porphyromonas gingivalis in biofilms In vitro. Contemp Clin Dent. 2019;10(1):123–128. doi:10.4103/ccd.ccd_758_1832015654
  • TarasukM, SongprakhonP, ChimmaP, SratongnoP, Na-BangchangK, YenchitsomanusP. Alpha-mangostin inhibits both dengue virus production and cytokine/chemokine expression. Virus Res. 2017;240:180–189. doi:10.1016/j.virusres.2017.08.01128864423
  • HuangCF, TengYH, LuFJ, et al. β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017;32(11):2360–2370. doi:10.1002/tox.2244928722351
  • LeeK, RyuH, OhS, et al. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Exp Dermatol. 2017;26(7):585–591. doi:10.1111/exd.1323327714857
  • LinC, LinC, YingT, et al. β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade. J Cell Physiol. 2020;235(11):8446–8460. doi:10.1002/jcp.2968832324277
  • Jalili-NikM, SadeghiM, MohtashamiE, et al. Zerumbone promotes cytotoxicity in human malignant glioblastoma cells through reactive oxygen species (ROS) generation. Oxid Med Cell Longev. 2020;2020:3237983. doi:10.1155/2020/323798332454937
  • KimS. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G/G cell-cycle arrest. Tumour Biol. 2017;39(11):1010428317731451. doi:10.1177/101042831773145129110583
  • PhanTKT, ShahbazzadehF, PhamTTH, KiharaT. Alpha-mangostin inhibits the migration and invasion of A549 lung cancer cells. PeerJ. 2018;6:e5027. doi:10.7717/peerj.502729967723
  • ScolamieroG, PazziniC, BonafeF, GuarnieriC, MuscariC. Effects of alpha-mangostin on viability, growth and cohesion of multicellular spheroids derived from human breast cancer cell lines. Int J Med Sci. 2018;15(1):23–30. doi:10.7150/ijms.2200229333084
  • YanXT, SunYS, RenS, et al. Dietary alpha-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis. Int J Mol Sci. 2018;19:5. doi:10.3390/ijms19051335
  • KimSM, Han JM, Le TH, Sohng JK, Jung HJ. Anticancer and antiangiogenic activities of novel α-mangostin glycosides in human hepatocellular carcinoma cells via downregulation of c-Met and HIF-1α. Int J Mol Sci. 2020;21(11). doi:10.3390/ijms21114043
  • KimS, et al. β-Mangostin inhibits the metastatic power of cervical cancer cells attributing to suppression of JNK2/AP-1/Snail cascade. J Cell Physiol. 2020. doi:10.1002/jcp.29688
  • WeiM, WuY, LiuH, XieC. Xie C. Genipin induces autophagy and suppresses cell growth of oral squamous cell carcinoma via PI3K/AKT/MTOR pathway. Drug Des Devel Ther. 2020;14:395–405. doi:10.2147/dddt.S222694
  • LiuH. A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells. Acta Pharmacol Sin. 2020. doi:10.1038/s41401-019-0354-1
  • ZhuY, LiuX, ZhaoP, ZhaoH, GaoW, WangL. pharmacology WLJFi. Celastrol suppresses glioma vasculogenic mimicry formation and angiogenesis by blocking the PI3K/Akt/mTOR signaling pathway. Front Pharmacol. 2020;11:25. doi:10.3389/fphar.2020.0002532116702
  • SitharaT, DhanyaBP, ArunKB. Zerumbone, a cyclic sesquiterpene from Zingiber zerumbet induces apoptosis, cell cycle arrest, and antimigratory effects in SW480 colorectal cancer cells. J Agric Food Chem. 2018;66(3):602–612. doi:10.1021/acs.jafc.7b0447229276946
  • AfshariA, MollazadehH, HenneyN, JamialahmadT, SahebkarA. Effects of statins on brain tumors: a review. Semin Cancer Biol. 2020. doi:10.1016/j.semcancer.2020.08.002
  • WuJ, NiY, YangQ. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes. Sci Total Environ. 2020;734:139425. doi:10.1016/j.scitotenv.2020.13942532450402
  • JiangH, FanD, ZhouG, LiX, DengH. Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo. J Exp Clin Cancer Res. 2010;29(1):34. doi:10.1186/1756-9966-29-3420412566
  • WangG, ZhangT, SunW. Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. Free Radic Biol Med. 2017;106:24–37. doi:10.1016/j.freeradbiomed.2017.02.01528188923
  • RajRK. beta-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line. J Biomed Mater Res A. 2020. doi:10.1002/jbm.a.36953
  • VairavelM, DevarajE, ShanmugamR. An eco-friendly synthesis of Enterococcus sp.-mediated gold nanoparticle induces cytotoxicity in human colorectal cancer cells. Environ Sci Pollut Res Int. 2020;27(8):8166–8175. doi:10.1007/s11356-019-07511-x31900772
  • SharmaV, JosephC, GhoshS, AgarwalA, MishraMK, SenE. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther. 2007;6(9):2544–2553. doi:10.1158/1535-7163.Mct-06-078817876051
  • LiuH. Chidamide inhibits glioma cells by increasing oxidative stress via the miRNA-338-5p regulation of Hedgehog signaling. Oxid Med Cell Longev. 2020;2020:7126976. doi:10.1155/2020/712697632256960
  • JangE, KimIY, KimH. Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca homeostasis. Biochem Pharmacol. 2020;178:114098. doi:10.1016/j.bcp.2020.11409832540484
  • ChangC. Aspirin induced glioma apoptosis through noxa upregulation. Int J Mol Sci. 2020;21:12. doi:10.3390/ijms21124219