Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

References

• FerlayJ, ColombetM, SoerjomataramI, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–1953. doi:10.1002/ijc.3193730350310
   PubMed Web of Science ®Google Scholar
• TorreLA, BrayF, SiegelRL, FerlayJ, Lortet-TieulentJ, JemalA. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.2126225651787
   PubMed Web of Science ®Google Scholar
• ZhouGW, XiongY, ChenS, XiaF, LiQ, HuJ. Anti-PD-1/PD-L1 antibody therapy for pretreated advanced nonsmall-cell lung cancer: A meta-analysis of randomized clinical trials. Medicine. 2016;95(35):e4611. doi:10.1097/MD.000000000000461127583876
   PubMed Web of Science ®Google Scholar
• MassarelliE, PapadimitrakopoulouV, WelshJ, TangC, TsaoAS. Immunotherapy in lung cancer. Transl Lung Cancer Res. 2014;3(1):53–63. doi:10.3978/j.issn.2218-6751.2014.01.0125806281
   PubMedGoogle Scholar
• ElmoreS. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495–516. doi:10.1080/0192623070132033717562483
   PubMed Web of Science ®Google Scholar
• D’ArcyMS. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019;43(6):582–592. doi:10.1002/cbin.1113730958602
   PubMed Web of Science ®Google Scholar
• PistrittoG, TrisciuoglioD, CeciC, GarufiA, D’OraziG. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. 2016;8(4):603–619. doi:10.18632/aging.10093427019364
   PubMedGoogle Scholar
• KaczanowskiS. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging. Phys Biol. 2016;13(3):031001. doi:10.1088/1478-3975/13/3/03100127172135
   PubMed Web of Science ®Google Scholar
• GoldarS, KhanianiMS, DerakhshanSM, BaradaranB. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 2015;16(6):2129–2144.25824729
   PubMedGoogle Scholar
• WangX, LuX, ZhuR, et al. Betulinic acid induces apoptosis in differentiated pc12 cells via ros-mediated mitochondrial pathway. Neurochem Res. 2017;42(4):1130–1140. doi:10.1007/s11064-016-2147-y28124213
   PubMed Web of Science ®Google Scholar
• EstaquierJ, ValletteF, VayssiereJL, MignotteB. The mitochondrial pathways of apoptosis. Adv Exp Med Biol. 2012;942:157–183.22399422
   PubMed Web of Science ®Google Scholar
• KnightT, LuedtkeD, EdwardsH, TaubJW, GeY. A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics. Biochem Pharmacol. 2019;162:250–261. doi:10.1016/j.bcp.2019.01.01530668936
   PubMed Web of Science ®Google Scholar
• ZhaoN, WangH, MuC, WangQ, CaiZ. [Celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34(12):1111–1115.Chinese.30626478
   PubMedGoogle Scholar
• WangS, HuY, YanY, ChengZ, LiuT. Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway. BMC Complement Altern Med. 2018;18(1):235. doi:10.1186/s12906-018-2300-z30092797
   PubMed Web of Science ®Google Scholar
• ZhangZQ, ChenJC, ZhouL, QiuMH. Two new cholestane bisdesmosides from Reineckia carnea. Helv Chim Acta. 2009;90(3):616–622. doi:10.1002/hlca.200790063
   Web of Science ®Google Scholar
• FuXJ, ZouK, ZhangX, ChengJF. Study on the anti-inflammatory effects and mechanisms of ethyl acetate extract of Reineckia carnea. Lishizhen Med Materia Medica Rese. 2013;24(4):822–825.
   Google Scholar
• ZengW, BiYT. Antioxidant Activity of Five Extracts from Reineckea carnea to SH-SY5Y cell. Lishizhen Med Materia Medica Research. 2014;25(7):1549–1551.
   Google Scholar
• LiuH, YangJQ, XiongL, MaHM, XuXJ. Preliminary study on the apoptosis mechanisms of lung cancer A549 cell induced by Reineckia carnea ethanol extracts. Chinese J Hospital Pharmacy. 2013;33(19):1580–1584.
   Google Scholar
• YangJQ, MaHM, LiuH, XuXJ, WangZ, LiuQ. Study on in vitro anti-tumor activity of Reineckia carnea extract. J Chinese Med Materials. 2013;36(4):618–621.
   Google Scholar
• MinH-Y, JangH-J, ParkKH, et al. The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II. Cell Death Dis. 2019;10(11):810. doi:10.1038/s41419-019-2041-z31649278
   PubMed Web of Science ®Google Scholar
• ChenC-R, ZhangJ, WuK-W, et al. Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1. Die Pharmazie. 2015;70(3):199–204.25980181
   PubMed Web of Science ®Google Scholar
• HuK, YaoX. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytother Res. 2003;17(6):620–626. doi:10.1002/ptr.121112820229
   PubMed Web of Science ®Google Scholar
• KangLP, MaBP, WangY, ZhangJ, XiongCQ, TangDW. Study on separation and identification of steroidal of Dioscorea nipponica Makino. Chinese Pharmaceutical J. 2005;(20):23–25.
   Google Scholar
• WangSF, WuMY, CaiCZ, LiM, LuJH. Autophagy modulators from traditional Chinese medicine: mechanisms and therapeutic potentials for cancer and neurodegenerative diseases. J Ethnopharmacol. 2016;194:861–876. doi:10.1016/j.jep.2016.10.06927793785
   PubMed Web of Science ®Google Scholar
• TaoX, YinL, XuL, PengJ. Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections. Pharmacol Res. 2018;137:259–269. doi:10.1016/j.phrs.2018.09.02230315966
   PubMed Web of Science ®Google Scholar
• PangG, WangF, ZhangLW. Dose matters: direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment. Carbohydr Polym. 2018;195:243–256. doi:10.1016/j.carbpol.2018.04.10029804974
   PubMed Web of Science ®Google Scholar
• LangnerE, LemieszekMK, RzeskiW. Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro. J Food Biochem. 2019;43(4):e12802. doi:10.1111/jfbc.1280231353575
   PubMed Web of Science ®Google Scholar
• VercesiAE, CastilhoRF, KowaltowskiAJ, et al. Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radic Biol Med. 2018;129:1–24. doi:10.1016/j.freeradbiomed.2018.08.03430172747
   PubMed Web of Science ®Google Scholar
• VargheseE, SamuelSM, SadiqZ, et al. Anti-cancer agents in proliferation and cell death: the calcium connection. Int J Mol Sci. 2019;20(12):3017. doi:10.3390/ijms20123017
   Web of Science ®Google Scholar
• La RovereRM, RoestG, BultynckG, ParysJB. Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy. Cell Calcium. 2016;60(2):74–87. doi:10.1016/j.ceca.2016.04.00527157108
   PubMed Web of Science ®Google Scholar
• ChristensenME, JansenES, SanchezW, WaterhouseNJ. Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release. Methods. 2013;61(2):138–145. doi:10.1016/j.ymeth.2013.03.02023545197
   PubMed Web of Science ®Google Scholar
• OberstA, BenderC, GreenDR. Living with death: the evolution of the mitochondrial pathway of apoptosis in animals. Cell Death Differ. 2008;15(7):1139–1146. doi:10.1038/cdd.2008.6518451868
   PubMed Web of Science ®Google Scholar
• TianHY, LiZX, LiHY, WangHJ, ZhuXW, DouZH. Effects of 14 single herbs on the induction of caspase-3 in tumor cells: a brief review. Chin J Integr Med. 2013;19(8):636–640. doi:10.1007/s11655-013-1539-y23893135
   PubMed Web of Science ®Google Scholar
• CrowleyLC, WaterhouseNJ. Detecting cleaved caspase-3 in apoptotic cells by flow cytometry. Cold Spring Harb Protoc. 2016;2016:11. doi:10.1101/pdb.prot087312
   Google Scholar