Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway

References

• Dabrowska-BenderM, MilewskaM, GolabekA, DudaZalewskaA, StaniszewskaA. The impact of ischemic cerebral stroke on the quality of life of patients based on clinical, social, and psychoemotional factors. J Stroke Cerebrovasc Dis. 2017;26:101–107. doi:10.1016/j.jstrokecerebrovasdis.2016.08.03627746082
   PubMed Web of Science ®Google Scholar
• JinR, YangG, LiG. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87:779–789. doi:10.1189/jlb.110976620130219
   PubMed Web of Science ®Google Scholar
• LakhanSE, KirchgessnerA, HoferM. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med. 2009;7:97. doi:10.1186/1479-5876-7-9719919699
   PubMed Web of Science ®Google Scholar
• WardlawJM, ZoppoG, YamaguchiT, BergeE. Acute stroke intervention: a systematic review. JAMA. 2015;14:1451–1462.
   Google Scholar
• LaluMM, FergussonDA, ChengW, et al. Identifying stroke therapeutics from preclinical models: a protocol for a novel application of network meta-analysis. F1000Research. 2019;8:11–26. doi:10.12688/f1000research.15869.130906535
   PubMedGoogle Scholar
• SunD, WangW, WangX, et al. bFGF plays an europrotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats. Cell Death Dis. 2018;9:172. doi:10.1038/s41419-017-0229-729416039
   PubMed Web of Science ®Google Scholar
• MiaoY, LiaoJK. Potential serum biomarkers in the pathophysiological processes of stroke. Expert Rev Neurother. 2014;2:173–185. doi:10.1586/14737175.2014.875471
   Web of Science ®Google Scholar
• ZhouYP, LiGC. Kaempferol protects cell damage in in vitro ischemia reperfusion model in rat neuronal PC12 cells. Biomed Res Int. 2020;23:2461079.
   Google Scholar
• XuW, ZhengJ, GaoL, LiT, ZhangJ, ShaoA. Neuroprotective effects of stem cells in ischemic stroke. Stem Cells Int. 2017;2017:4653936. doi:10.1155/2017/465393628757878
   PubMed Web of Science ®Google Scholar
• LiangY, XuJ, WangY, et al. Inhibition of miRNA-125b decreases cerebral ischemia/reperfusion injury by targeting CK2α/NADPH oxidase signaling. Cell Physiol Biochem. 2018;45:1818–1826. doi:10.1159/00048787329510389
   PubMedGoogle Scholar
• Del ZoppoGJ, SaverJL, JauchEC, AdamsHP Jr Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke. 2009;40:2945–2948. doi:10.1161/STROKEAHA.109.19253519478221
   PubMed Web of Science ®Google Scholar
• SandercockP, WardlawJM, LindleyetalRI, DennisM, CohenG, MurrayG. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (The Third International Stroke Trial [IST-3]): a randomised controlled trial. Lancet. 2012;379:2352–2363.22632908
   PubMed Web of Science ®Google Scholar
• ZhangY, WangYT, LuoJX, et al. Effect of WSP, a Chinese Herbal Formula, on Th17/Treg ratio and HBeAg seroconversion in telbivudine-treated HBeAg-positive chronic Hepatitis B patients with high baseline ALT levels (20–30 times the ULN). Evid Based Complement Alternat Med. 2019;2019:7260369.30949222
   PubMed Web of Science ®Google Scholar
• ManMQ, HuLZ, EliasPM. Herbal medicines prevent the development of atopic dermatitis by multiple mechanisms. Chin J Integr Med. 2019;25:151–160. doi:10.1007/s11655-015-2438-126740223
   PubMed Web of Science ®Google Scholar
• HangYR, LiuCL, JiaK. The clinical efficacy of xiaoyaosan combined with dairenxin in the treatment of post-stroke depression and its effect on neurotransmitter levels. Inf Tradit Chin Med. 2019;36:84–87.
   Google Scholar
• WangJY. Effect analysis of xiaoyaosan in the treatment of 68 patients with post-stroke depression. A Clu Con Med Theo. 2019;17:206–208.
   Google Scholar
• SunQY. A randomized, parallel controlled study of xiaoyao SAN combined with fluoxetine in the treatment of post-stroke depression. J Inter Med Appl Tradit Chin Med. 2017;31:66–67.
   Google Scholar
• YangX, SuHP, YangHF. Clinical efficacy and mechanism of xiaoyaosan combined with sertraline in patients with post-stroke depression. World Tradit Chin Med. 2018;13:60–63.
   Google Scholar
• WangC, WuC, YanZG, ChengX. Ameliorative effect of Xiaoyao- jieyu-san on post-stroke depression and its potential mechanisms. J Nat Med. 2019;73:76–84. doi:10.1007/s11418-018-1243-530194657
   PubMed Web of Science ®Google Scholar
• ShiBY, LiuR, RaoZL, et al. Protective mechanism of xiaoyaosan on nerve injury induced by LPS in rats. Chin J Exp Form. 2019;025:50–56.
   Google Scholar
• WangMM, BiYM, ZengSM, et al. Modified Xiaoyao San ameliorates depressive-like behaviors by triggering autophagosome formation to alleviate neuronal apoptosis. Biomed Pharmacother. 2019;111:1057–1065. doi:10.1016/j.biopha.2018.12.14130841419
   PubMed Web of Science ®Google Scholar
• PengW, ShenH, LinB, et al. Docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from Litsea cubeba targeting cathepsin K and MEK1. Med Chem Res. 2018;27:2062–2070. doi:10.1007/s00044-018-2215-8
   Web of Science ®Google Scholar
• ZhengTT, ShiY, ZhangJ, et al. MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway. Biomed Pharmacother. 2019;117:109117. doi:10.1016/j.biopha.2019.10911731226635
   PubMed Web of Science ®Google Scholar
• WangSM, LongSQ, XiaoSJ, WuWY, HannSS. Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces lung cancer cell apoptosis via STAT3/Bcl-2/Caspase-3 pathway. Evid Based Complement Alternat Med. 2018;2018:1–14.
   Web of Science ®Google Scholar
• WangYE, XuK, YueWH, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chin Herbal Med. 2018:S1674638418300327.
   Web of Science ®Google Scholar
• ZhangQ, PengW, WeiSJ, et al. Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts. Biomed Pharmacother. 2019;118:109367. doi:10.1016/j.biopha.2019.10936731545276
   PubMed Web of Science ®Google Scholar
• WuF, QiuJ, FanY, et al. Apelin-13 attenuates ER stress-mediated neuronal apoptosis by activating Gαi/Gαq -CK2 signaling in ischemic stroke. Exp Neurol. 2018;302:136–144. doi:10.1016/j.expneurol.2018.01.00629337146
   PubMed Web of Science ®Google Scholar
• UzdenskyAB. Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins. Apoptosis. 2019;24(Suppl 2):687–702. doi:10.1007/s10495-019-01556-631256300
   PubMed Web of Science ®Google Scholar
• KalpageHA, BazylianskaV, RecanatiMA, et al. Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis. FASEB J. 2019;33:1540–1553. doi:10.1096/fj.201801417R30222078
   PubMed Web of Science ®Google Scholar
• PengW, QiuXQ, ShuZH, et al. Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa. J Ethnopharmacol. 2015;174:317–21. 5. doi:10.1016/j.jep.2015.08.03226320683
   PubMed Web of Science ®Google Scholar
• ValkoM, LeibfritzD, MoncolJ, CroninMTD, MazurM, TelserJ. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84. doi:10.1016/j.biocel.2006.07.00116978905
   PubMed Web of Science ®Google Scholar
• WangMQ, HuR, WangYJ, et al. Atractylenolide III attenuates muscle wasting in chronic kidney disease via the oxidative stress-mediated PI3K/AKT/mTOR pathway. Oxid Med Cell Longev. 2019:1875471.31178951
   PubMed Web of Science ®Google Scholar
• LeiSQ, SuWT, XiaZY, et al. Hyperglycemia-induced oxidative stress abrogates remifentanil preconditioning- mediated cardioprotection in diabetic rats by impairing caveolin-3Modulated PI3K/Akt and JAK2/STAT3 signaling. Oxid Med Cell Longev. 2019;2019:9836302. doi:10.1155/2019/983630231583053
   PubMed Web of Science ®Google Scholar
• LiHL, TangZY, ChuP, et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med. 2018;120:228–238. doi:10.1016/j.freeradbiomed.2018.03.01429559323
   PubMed Web of Science ®Google Scholar
• ZhangQ, LiuJ, ZhangMM, et al. Apoptosis induction of fibroblast-like synoviocytes is an important molecular-mechanism for herbal medicine along with its active components in treating rheumatoid arthritis. Biomolecules. 2019;9:795. doi:10.3390/biom9120795
   PubMed Web of Science ®Google Scholar
• ZhangK, TuMJ, GaoW, et al. Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell apoptosis. Nano Lett. 2019;19:2812–2823. doi:10.1021/acs.nanolett.8b0472930908916
   PubMed Web of Science ®Google Scholar