Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway

References

• BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• BrodyH. Colorectal cancer. Nature. 2015;521(7551):S1. doi:10.1038/521S1a25970450
   PubMed Web of Science ®Google Scholar
• DekkerE, TanisPJ, VleugelsJLA, KasiPM, WallaceMB. Colorectal cancer. Lancet. 2019;394(10207):1467–1480. doi:10.1016/s0140-6736(19)32319-031631858
   PubMed Web of Science ®Google Scholar
• The LancetO. Colorectal cancer: a disease of the young? Lancet Oncol. 2017;18(4):413. doi:10.1016/s1470-2045(17)30202-4
   Web of Science ®Google Scholar
• PatelSG, AhnenDJ. Colorectal cancer in the young. Curr Gastroenterol Rep. 2018;20(4):15. doi:10.1007/s11894-018-0618-929616330
   PubMedGoogle Scholar
• Costas-ChavarriA, NandakumarG, TeminS, et al. Treatment of patients with early-stage colorectal cancer: ASCO resource-stratified guideline. J Glob Oncol. 2019;5(5):1–19. doi:10.1200/jgo.18.00214
   Web of Science ®Google Scholar
• ZellwegerM, Abdelnour-BerchtoldE, KruegerT, RisHB, PerentesJY, GonzalezM. Surgical treatment of pulmonary metastasis in colorectal cancer patients: current practice and results. Crit Rev Oncol Hematol. 2018;127:105–116. doi:10.1016/j.critrevonc.2018.05.00129891107
   PubMed Web of Science ®Google Scholar
• ChakedisJ, SchmidtCR. Surgical treatment of metastatic colorectal cancer. Surg Oncol Clin N Am. 2018;27(2):377–399. doi:10.1016/j.soc.2017.11.01029496096
   PubMed Web of Science ®Google Scholar
• KimJH. Chemotherapy for colorectal cancer in the elderly. World J Gastroenterol. 2015;21(17):5158–5166. doi:10.3748/wjg.v21.i17.515825954089
   PubMed Web of Science ®Google Scholar
• SileriP, D’UgoS, BenavoliD, et al. Metachronous splenic metastasis from colonic carcinoma five years after surgery: a case report and literature review. South Med J. 2009;102(7):733–735. doi:10.1097/SMJ.0b013e3181a93c3919487993
   PubMed Web of Science ®Google Scholar
• KoiM, CarethersJM. The colorectal cancer immune microenvironment and approach to immunotherapies. Future Oncol. 2017;13(18):1633–1647. doi:10.2217/fon-2017-014528829193
   PubMed Web of Science ®Google Scholar
• WrobelP, AhmedS. Current status of immunotherapy in metastatic colorectal cancer. Int J Colorectal Dis. 2019;34(1):13–25. doi:10.1007/s00384-018-3202-830465238
   PubMed Web of Science ®Google Scholar
• FuX, SunF, WangF, et al. Aloperine protects mice against DSS-induced colitis by PP2A-mediated PI3K/Akt/mTOR signaling suppression. Mediators Inflamm. 2017;2017:5706152. doi:10.1155/2017/570615229056830
   PubMed Web of Science ®Google Scholar
• TolkachevON, MonakhovaTE, SheichenkoVI, KabanovVS, FesenkoOG, ProskurninaNF. Alkaloids of a new type from Sophora alopecuroides L. Chem Nat Compd. 1975;11(1):29–34. doi:10.1007/BF00567025
   Google Scholar
• YuHI, ShenHC, ChenSH, et al. Autophagy modulation in human thyroid cancer cells following aloperine treatment. Int J Mol Sci. 2019;20(21):5315. doi:10.3390/ijms20215315
   Web of Science ®Google Scholar
• LiuJS, HuoCY, CaoHH, et al. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. Phytomedicine. 2019;61:152843. doi:10.1016/j.phymed.2019.15284331039533
   PubMed Web of Science ®Google Scholar
• LingZ, GuanH, YouZ, et al. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Onco Targets Ther. 2018;11:2735–2743. doi:10.2147/ott.s16526229785122
   PubMed Web of Science ®Google Scholar
• TianD, LiY, LiX, TianZ. Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells. Mol Med Rep. 2018;18(4):3699–3710. doi:10.3892/mmr.2018.941930132540
   PubMed Web of Science ®Google Scholar
• CiesielskaA, StączekP. Selection and validation of reference genes for qRT-PCR analysis of gene expression in microsporum canis growing under different adhesion-inducing conditions. Sci Rep. 2018;8(1):1197. doi:10.1038/s41598-018-19680-929352152
   PubMed Web of Science ®Google Scholar
• MüllerMF, IbrahimAE, ArendsMJ. Molecular pathological classification of colorectal cancer. Virchows Arch. 2016;469(2):125–134. doi:10.1007/s00428-016-1956-327325016
   PubMed Web of Science ®Google Scholar
• ZhangL, ZhengY, DengH, LiangL, PengJ. Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. Int J Mol Med. 2014;33(6):1613–1620. doi:10.3892/ijmm.2014.171824682388
   PubMed Web of Science ®Google Scholar
• ChenLL, YangL. Regulation of circRNA biogenesis. RNA Biol. 2015;12(4):381–388. doi:10.1080/15476286.2015.102027125746834
   PubMed Web of Science ®Google Scholar
• LiS, TengS, XuJ, et al. Microarray is an efficient tool for circRNA profiling. Brief Bioinform. 2019;20(4):1420–1433. doi:10.1093/bib/bby00629415187
   PubMed Web of Science ®Google Scholar
• ConnSJ, PillmanKA, ToubiaJ, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell. 2015;160(6):1125–1134. doi:10.1016/j.cell.2015.02.01425768908
   PubMed Web of Science ®Google Scholar
• HansenTB, JensenTI, ClausenBH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–388. doi:10.1038/nature1199323446346
   PubMed Web of Science ®Google Scholar
• XuL, FengX, HaoX, et al. CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth. J Exp Clin Cancer Res. 2019;38(1):98. doi:10.1186/s13046-019-1041-230795787
   PubMed Web of Science ®Google Scholar
• YeCY, ChenL, LiuC, ZhuQH, FanL. Widespread noncoding circular RNAs in plants. New Phytol. 2015;208(1):88–95. doi:10.1111/nph.1358526204923
   PubMed Web of Science ®Google Scholar
• WangY, YangM, WeiS, QinF, ZhaoH, SuoB. Identification of circular RNAs and their targets in leaves of triticum aestivum l. under dehydration stress. Front Plant Sci. 2016;7:2024. doi:10.3389/fpls.2016.0202428105043
   PubMed Web of Science ®Google Scholar
• ChenRX, ChenX, XiaLP, et al. N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 2019;10(1):4695. doi:10.1038/s41467-019-12651-231619685
   PubMed Web of Science ®Google Scholar
• FletcherJS, SpringerMG, ChoiK, et al. STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Oncogene. 2019;38(15):2876–2884. doi:10.1038/s41388-018-0600-x30542122
   PubMed Web of Science ®Google Scholar
• MohammadRM, MuqbilI, LoweL, et al. Broad targeting of resistance to apoptosis in cancer. Semin Cancer Biol. 2015;35:S78–s103. doi:10.1016/j.semcancer.2015.03.00125936818
   PubMed Web of Science ®Google Scholar
• GoldarS, KhanianiMS, DerakhshanSM, BaradaranB. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 2015;16(6):2129–2144. doi:10.7314/apjcp.2015.16.6.212925824729
   PubMedGoogle Scholar