Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin α_vβ₅ Signaling Pathway

References

• RossR. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362(6423):801–809. doi:10.1038/362801a08479518
   PubMed Web of Science ®Google Scholar
• NigroJ, OsmanN, DartAM, LittlePJ. Insulin resistance and atherosclerosis. Endocr Rev. 2006;27(3):242–259. doi:10.1210/er.2005-000716492903
   PubMed Web of Science ®Google Scholar
• HanssonGK, LibbyP. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006;6(7):508–519. doi:10.1038/nri188216778830
   PubMed Web of Science ®Google Scholar
• WeberC, NoelsH. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 2011;17(11):1410–1422. doi:10.1038/nm.253822064431
   PubMed Web of Science ®Google Scholar
• WoollardKJ, GeissmannF. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol. 2010;7(2):77–86. doi:10.1038/nrcardio.2009.22820065951
   PubMed Web of Science ®Google Scholar
• SwirskiFK, NahrendorfM. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339(6116):161–166. doi:10.1126/science.123071923307733
   PubMed Web of Science ®Google Scholar
• MurrayPJ, WynnTA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723–737. doi:10.1038/nri307321997792
   PubMed Web of Science ®Google Scholar
• BiY, ChenJ, HuF, LiuJ, LiM, ZhaoZL. M2 macrophages as a potential target for antiatherosclerosis treatment. Neural Plast. 2019;2019:6724903. doi:10.1155/2019/672490330923552
   PubMed Web of Science ®Google Scholar
• Shapouri-MoghaddamA, MohammadianS, VaziniH, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–6440. doi:10.1002/jcp.26429
   PubMed Web of Science ®Google Scholar
• OzakiH, NagaseH, UrakawaN. Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles. J Pharmacol Exp Ther. 1984;231(1):153–158.6149301
   PubMed Web of Science ®Google Scholar
• ShangX, MiaoX, YangF, et al. The genus as an important cardiac folk medicine: a review of the ethnobotany, phytochemistry and pharmacology. Front Pharmacol. 2019;10:25. doi:10.3389/fphar.2019.0002530778296
   PubMed Web of Science ®Google Scholar
• JiangB-W, ZhangW-J, WangY, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020;121:109615. doi:10.1016/j.biopha.2019.10961531707343
   PubMed Web of Science ®Google Scholar
• ZhangZH, LiMY, WangZ, et al. Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer. Phytomedicine. 2020;68:153172. doi:10.1016/j.phymed.2020.15317232004989
   PubMed Web of Science ®Google Scholar
• YuJ, QiuY, YangJ, et al. DNMT1-PPARgamma pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice. Sci Rep. 2016;6:30053. doi:10.1038/srep3005327530451
   PubMed Web of Science ®Google Scholar
• StrausDS, PascualG, LiM, et al. 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A. 2000;97(9):4844–4849. doi:10.1073/pnas.97.9.484410781090
   PubMed Web of Science ®Google Scholar
• OdegaardJI, Ricardo-GonzalezRR, GoforthMH, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447(7148):1116–1120. doi:10.1038/nature0589417515919
   PubMed Web of Science ®Google Scholar
• RicoteM, LiAC, WillsonTM, KellyCJ, GlassCK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 1998;391(6662):79–82. doi:10.1038/341789422508
   PubMed Web of Science ®Google Scholar
• LiMY, ZhangZH, WangZ, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-kappaB signaling through activation of PPARgamma. Pharmacol Res. 2019;147:104355. doi:10.1016/j.phrs.2019.10435531386886
   PubMed Web of Science ®Google Scholar
• ZhongM, ZhangX, ShiX, ZhengC. Halofuginone inhibits LPS-induced attachment of monocytes to HUVECs. Int Immunopharmacol. 2020;87:106753. doi:10.1016/j.intimp.2020.10675332707492
   PubMed Web of Science ®Google Scholar
• Chen-C-C, LiH-Y, LeuY-L, ChenY-J, WangC-J, WangS-H. Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice. Antioxidants (Basel). 2020;9(4). doi:10.3390/antiox9040275
   Google Scholar
• ShkrobomSI. [Changes in the systemic hemodynamics of patients with chronic cerebrovascular insufficiency]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(7):976–981. Russian.6158210
   PubMedGoogle Scholar
• FalkE, NakanoM, BentzonJF, FinnAV, VirmaniR. Update on acute coronary syndromes: the pathologists’ view. Eur Heart J. 2013;34(10):719–728. doi:10.1093/eurheartj/ehs41123242196
   PubMed Web of Science ®Google Scholar
• Chinetti-GbaguidiG, ColinS, StaelsB. Macrophage subsets in atherosclerosis. Nat Rev Cardiol. 2015;12(1):10–17. doi:10.1038/nrcardio.2014.17325367649
   PubMed Web of Science ®Google Scholar
• YuX-H, FuY-C, ZhangD-W, YinK, TangC-K. Foam cells in atherosclerosis. Clin Chim Acta. 2013;424:245–252. doi:10.1016/j.cca.2013.06.00623782937
   PubMed Web of Science ®Google Scholar
• MurrayPJ. Macrophage polarization. Annu Rev Physiol. 2017;79:541–566. doi:10.1146/annurev-physiol-022516-03433927813830
   PubMed Web of Science ®Google Scholar
• SeoJW, YangEJ, YooKH, ChoiIH. Macrophage differentiation from monocytes is influenced by the lipid oxidation degree of low density lipoprotein. Mediators Inflamm. 2015;2015:235797. doi:10.1155/2015/23579726294848
   PubMed Web of Science ®Google Scholar
• MaréchalL, LavioletteM, Rodrigue-WayA, et al. The CD36-PPARγ pathway in metabolic disorders. Int J Mol Sci. 2018;19(5):1529. doi:10.3390/ijms19051529
   Web of Science ®Google Scholar
• ChawlaA. Control of macrophage activation and function by PPARs. Circ Res. 2010;106(10):1559–1569. doi:10.1161/CIRCRESAHA.110.21652320508200
   PubMed Web of Science ®Google Scholar
• YaoQ, LiuJ, ZhangZ, et al. Peroxisome proliferator-activated receptor gamma (PPARgamma) induces the gene expression of integrin alphaVbeta5 to promote macrophage M2 polarization. J Biol Chem. 2018;293(43):16572–16582. doi:10.1074/jbc.RA118.00316130181212
   PubMed Web of Science ®Google Scholar
• GaoQ, WeiA, ChenF, et al. Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020;160:105059. doi:10.1016/j.phrs.2020.10505932621955
   PubMed Web of Science ®Google Scholar
• OppiS, Nusser-SteinS, BlyszczukP, et al. Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARgamma signature. Eur Heart J. 2020;41(9):995–1005. doi:10.1093/eurheartj/ehz66731529020
   PubMed Web of Science ®Google Scholar