Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation

References

• BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
   PubMed Web of Science ®Google Scholar
• DemicheliR, RetskyMW, HrusheskyWJ, BaumM, GukasID. The effects of surgery on tumor growth: a century of investigations. Ann Oncol. 2008;19(11):1821–1828. doi:10.1093/annonc/mdn38618550576
   PubMed Web of Science ®Google Scholar
• RetskyM, DemicheliR, HrusheskyW, BaumM, GukasI. Surgery triggers outgrowth of latent distant disease in breast cancer: an inconvenient truth? Cancers. 2010;2(2):305–337. doi:10.3390/cancers202030524281072
   PubMedGoogle Scholar
• HorowitzM, NeemanE, SharonE, Ben-EliyahuS. Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol. 2015;12(4):213–226. doi:10.1038/nrclinonc.2014.22425601442
   PubMed Web of Science ®Google Scholar
• Conrick-MartinI, KellMR, BuggyDJ. Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function. J Clin Anesth. 2012;24(1):3–7. doi:10.1016/j.jclinane.2011.09.00122284311
   PubMed Web of Science ®Google Scholar
• GreenfeldK, AvrahamR, BenishM, et al. Immune suppression while awaiting surgery and following it: dissociations between plasma cytokine levels, their induced production, and NK cell cytotoxicity. Brain Behav Immun. 2007;21(4):503–513. doi:10.1016/j.bbi.2006.12.00617293081
   PubMed Web of Science ®Google Scholar
• Perez-SayansM, Somoza-MartinJM, Barros-AngueiraF, DizPG, Gandara ReyJM, Garcia-GarciaA. Beta-adrenergic receptors in cancer: therapeutic implications. Oncol Res. 2010;19(1):45–54. doi:10.3727/096504010x1282837255186721141740
   PubMed Web of Science ®Google Scholar
• PeetersCF, de WaalRM, WobbesT, WestphalJR, RuersTJ. Outgrowth of human liver metastases after resection of the primary colorectal tumor: a shift in the balance between apoptosis and proliferation. Int J Cancer. 2006;119(6):1249–1253. doi:10.1002/ijc.2192816642475
   PubMed Web of Science ®Google Scholar
• SvendsenMNWK, NielsenHJ. VEGF and tumour angiogenesis. Impact of surgery, wound healing, inflammation and blood transfusion. Scand J Gastroenterol. 2002;37(4):373–379. doi:10.1080/00365520231731597111989825
   PubMed Web of Science ®Google Scholar
• ZengXY, XieH, YuanJ, et al. M2-like tumor-associated macrophages-secreted EGF promotes epithelial ovarian cancer metastasis via activating EGFR-ERK signaling and suppressing lncRNA LIMT expression. Cancer Biol Ther. 2019;20(7):956–966. doi:10.1080/15384047.2018.156456731062668
   PubMed Web of Science ®Google Scholar
• YamaguchiKTY, AokiS. Significant detection of circulating cancer cells in the blood by reverse transcriptase-polymerase chain reaction during colorectal cancer resection. Ann Surg. 2000;232(1):58–65. doi:10.1097/00000658-200007000-0000910862196
   PubMed Web of Science ®Google Scholar
• GongAG, LiN, LauKM, et al. Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of astragali radix and angelica sinensis radix: an evaluation by using calycosin-knock out herbal extract. J Ethnopharmacol. 2015;168:150–157. doi:10.1016/j.jep.2015.03.03325796405
   PubMed Web of Science ®Google Scholar
• HuG, YangP, ZengY, ZhangS, SongJ. Danggui Buxue decoction promotes angiogenesis by up-regulation of VEGFR1/2 expressions and down-regulation of sVEGFR1/2 expression in myocardial infarction rat. J Chin Med Assoc. 2018;81(1):37–46. doi:10.1016/j.jcma.2017.06.01528882731
   PubMed Web of Science ®Google Scholar
• ZhouJ, LiX, DengP, et al. Chinese herbal formula, modified Danggui Buxue Tang, attenuates apoptosis of hematopoietic stem cells in immune-mediated aplastic anemia mouse model. J Immunol Res. 2017;2017:9786972. doi:10.1155/2017/978697228951880
   PubMed Web of Science ®Google Scholar
• LiF, TangR, ChenLB, ZhangKS, HuangXP, DengCQ. Effects of astragalus combined with angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide in mice. Biol Pharm Bull. 2017;40(5):598–609. doi:10.1248/bpb.b16-0080228458344
   PubMed Web of Science ®Google Scholar
• CuiMD, PanZH, PanLQ. Danggui Buxue extract-loaded liposomes in thermosensitive gel enhance In Vivo Dermal Wound Healing via activation of the VEGF/PI3K/Akt and TGF-beta/Smads signaling pathway. Evid Based Complement Alternat Med. 2017;2017:8407249. doi:10.1155/2017/840724929292400
   PubMed Web of Science ®Google Scholar
• GaoQT, CheungJKH, LiJ, et al. A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. FEBS Lett. 2007;581(26):5087–5093. doi:10.1016/j.febslet.2007.09.05317923124
   PubMed Web of Science ®Google Scholar
• DuQC, YangKZ, SunXF. Efficacy of auxiliary therapy with Danggui Buxue Decoction No.1 in treating patients of non-small cell lung cancer at peri-operational stage. Chin J Integr Med. 2009;15(3):184–188. doi:10.1007/s11655-009-0184-y19568710
   PubMed Web of Science ®Google Scholar
• MiaoZSFPY. Effect of Danggui Buxue Decoction on proliferation and its molecular mechanism in tumor vascularvendothelial cells. Chinese J Exp Traditional Med Formulae. 2013;19(2):163–167. doi:10.13422/j.cnki.syfjx.2013.02.055
   Google Scholar
• YueSJ, XinLT, FanYC, et al. Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach. Sci Rep. 2017;7:40318. doi:10.1038/srep4031828074863
   PubMed Web of Science ®Google Scholar
• DongTT, ZhaoKJ, GaoQT, et al. Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: determination of drug ratio in having optimized properties. J Agric Food Chem. 2006;54(7):2767–2774. doi:10.1021/jf053163l16569074
   PubMed Web of Science ®Google Scholar
• LinPL, LiZC, XieRF, WangYH, ZhouX. Compatibility study of Danggui Buxue Tang on chemical ingredients, angiogenesis and endothelial function. Sci Rep. 2017;7:45111. doi:10.1038/srep4511128327640
   PubMed Web of Science ®Google Scholar
• B GNF, SafferEA. Influence of the interval between primary tumor removal and chemotherapy on kinetics and growth of metastases. Cancer Res. 1983;43(4):1488–1492.6831397
   PubMed Web of Science ®Google Scholar
• GangGJ-H, HanJ-H, LiaoF, et al. Chinese herbal decoction Shiquan Dabu Tang inhibits tumor growth and angiogenesis of metastasis after primary tumor surgical removal in mice. J Chinese Integrative Med. 2012;10(04):436–447. doi:10.3736/jcim20120413
   Google Scholar
• Jin-Fang-DuW-Q-Y, ZhouY, SunJ, ShiX-L. Effects of Shiquan Dabu Decoction on metastatic tumor growth and NK cells after resection of primary tumor of colon cancer. Shanghai J Traditional Chinese Med. 2017;51(12):79–83.
   Google Scholar
• MigliaccioA, YangF, SongL, et al. Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 Cells Xenograft tumor growth. PLoS One. 2015;10(5). doi:10.1371/journal.pone.0128277
   Web of Science ®Google Scholar
• ChengL, ShiL, WuJ, et al. A hederagenin saponin isolated from Clematis ganpiniana induces apoptosis in breast cancer cells via the mitochondrial pathway. Oncol Lett. 2017;15(2):1737–1743. doi:10.3892/ol.2017.749429434869
   PubMed Web of Science ®Google Scholar
• WooJ-H, AhnJ-H, JangDS, LeeK-T, ChoiJ-H. Effect of kumatakenin isolated from cloves on the apoptosis of cancer cells and the alternative activation of tumor-associated macrophages. J Agric Food Chem. 2017;65(36):7893–7899. doi:10.1021/acs.jafc.7b0154328763204
   PubMed Web of Science ®Google Scholar
• ZhangJ, LiuL, WangJ, RenB, ZhangL, LiW. Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells. J Ethnopharmacol. 2018;221:91–99. doi:10.1016/j.jep.2018.04.01429660466
   PubMed Web of Science ®Google Scholar
• ZhangD, SunG, PengL, TianJ, ZhangH. Calycosin inhibits viability, induces apoptosis, and suppresses invasion of cervical cancer cells by upregulating tumor suppressor miR-375. Arch Biochem Biophys. 2020;691:108478. doi:10.1016/j.abb.2020.10847832712290
   PubMed Web of Science ®Google Scholar
• El-KottAF, Al-KahtaniMA, ShatiAA. Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR. Clin Exp Pharmacol Physiol. 2019;46(10):944–954. doi:10.1111/1440-1681.1313331276230
   PubMed Web of Science ®Google Scholar
• Y TCF, HuHT, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016;11(45). doi:10.1186/s13020-016-0116-7
   Web of Science ®Google Scholar
• HanahanD, WeinbergRA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.01321376230
   PubMed Web of Science ®Google Scholar
• AdamsJM, CoryS. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene. 2007;26(9):1324–1337. doi:10.1038/sj.onc.121022017322918
   PubMed Web of Science ®Google Scholar
• CampbellKJ, TaitSWG. Targeting BCL-2 regulated apoptosis in cancer. Open Biol. 2018;8(5):May. doi:10.1098/rsob.180002
   Web of Science ®Google Scholar
• L ZGY, LiDC. MiR-136 triggers apoptosis in human gastric cancer cells by targeting AEG-1 and BCL2. Eur Rev Med Pharmacol Sci. 2018;22(21):7251–7256. doi:10.26355/eurrev_201811_1625930468468
   PubMed Web of Science ®Google Scholar
• LokSW, WhittleJR, VaillantF. A phase ib dose-escalation and expansion study of the BCL2 Inhibitor venetoclax combined with tamoxifen in ER and BCL2-Positive metastatic breast cancer. Cancer Discov. 2019;9(3):354–369. doi:10.1158/2159-8290.CD-18-115130518523
   PubMed Web of Science ®Google Scholar
• ZhangH, DongR, ZhangP, WangY. Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl-2/Bax and GSK3β/β-catenin signaling pathways. Oncol Rep. 2019;41(5):3069–3079. doi:10.3892/or.2019.707030896826
   PubMed Web of Science ®Google Scholar
• TaiYTLS, NiloffE, WeismanC, StrobelT, CannistraSA. BAX protein expression and clinical outcome in epithelial ovarian cancer. J Clin Oncol. 1998;16(8):2583–2590. doi:10.1200/JCO.1998.16.8.25839704707
   PubMed Web of Science ®Google Scholar
• XuX, LaiY, HuaZC. Apoptosis and apoptotic body: disease message and therapeutic target potentials. Biosci Rep. 2019;39(1). doi:10.1042/BSR20180992
   Web of Science ®Google Scholar
• KnightT, LuedtkeD, EdwardsH, TaubJW, GeY. A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics. Biochem Pharmacol. 2019;162:250–261. doi:10.1016/j.bcp.2019.01.01530668936
   PubMed Web of Science ®Google Scholar