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Original Research

Analysis of Clinical Trials of New Drugs for Liver Diseases in China

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Pages 3181-3191 | Published online: 20 Jul 2021

References

  • McBrideG. Hepatitis B virus-induced liver cancer in Asian Americans: a preventable disease. J Natl Cancer Inst. 2008;100(8):528–529. doi:10.1093/jnci/djn12018398090
  • YanYP, SuHX, JiZH, ShaoZJ, PuZS. Epidemiology of hepatitis B virus infection in China: current status and challenges. J Clin Transl Hepatol. 2014;2(1):15–22. doi:10.14218/JCTH.2013.0003026356070
  • ZhouY, WanY, YeZW, HeZ, LiuQ, ShiY. How hepatitis B virus causes cirrhosis and liver cancer. Med Hypotheses. 2017;108:52–53. doi:10.1016/j.mehy.2017.08.00529055401
  • GanemD, PrinceAM. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med. 2004;350(11):1118–1129. doi:10.1056/NEJMra03108715014185
  • LinL, YanL, LiuY, YuanF, LiH, NiJ. Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study. J Hematol Oncol. 2019;12(1):96. doi:10.1186/s13045-019-0783-931511035
  • LinL, YanL, LiuY, QuC, NiJ, LiH. The burden and trends of primary liver cancer caused by specific etiologies from 1990 to 2017 at the global, regional, national, age, and sex level results from the Global Burden of Disease Study 2017. Liver Cancer. 2020;9(5):563–582. doi:10.1159/00050856833083281
  • PalumboE. New drugs for chronic hepatitis B: a review. Am J Ther. 2008;15(2):167–172. doi:10.1097/MJT.0b013e318155a19118356637
  • HadziyannisSJ, PapatheodoridisGV. Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others). J Hepatol. 2003;39(Suppl 1):S172–176. doi:10.1016/S0168-8278(03)00334-914708699
  • FanningGC, ZoulimF, HouJ, BertolettiA. Therapeutic strategies for hepatitis B virus infection: towards a cure. Nat Rev Drug Discov. 2019;18(11):827–844. doi:10.1038/s41573-019-0037-031455905
  • SasaiM, YamamotoM. Pathogen recognition receptors: ligands and signaling pathways by Toll-like receptors. Int Rev Immunol. 2013;32(2):116–133. doi:10.3109/08830185.2013.77439123570313
  • JanssenHLA, BrunettoMR, KimYJ, et al. Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B. J Hepatol. 2018;68(3):431–440. doi:10.1016/j.jhep.2017.10.02729104121
  • MannsMP. Current state of interferon therapy in the treatment of chronic hepatitis B. Semin Liver Dis. 2002;22(Suppl 1):7–13. doi:10.1055/s-2002-3569512447724
  • AraseY, TsubotaA, SuzukiY, et al. A pilot study of thymosin alpha1 therapy for chronic hepatitis B patients. Intern Med. 2003;42(10):941–946. doi:10.2169/internalmedicine.42.94114606705
  • SarucM, OzdenN, TurkelN, et al. Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B. J Pharm Sci. 2003;92(7):1386–1395. doi:10.1002/jps.1040112820143
  • ClarkDN, HuJ. Unveiling the roles of HBV polymerase for new antiviral strategies. Future Virol. 2015;10(3):283–295. doi:10.2217/fvl.14.11325893003
  • LiuXJ, LiuC, ZhuLY, et al. Hepalatide ameliorated progression of nonalcoholic steatohepatitis in mice. Biomed Pharmacother. 2020;126:110053. doi:10.1016/j.biopha.2020.11005332200254
  • KiserJJ, FlexnerC. Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53(1):427–449. doi:10.1146/annurev-pharmtox-011112-14025423140245
  • SpenglerU. Direct antiviral agents (DAAs) - A new age in the treatment of hepatitis C virus infection. Pharmacol Ther. 2018;183:118–126. doi:10.1016/j.pharmthera.2017.10.00929024739
  • SorianoV, VispoE, de MendozaC, et al. Hepatitis C therapy with HCV NS5B polymerase inhibitors. Expert Opin Pharmacother. 2013;14(9):1161–1170. doi:10.1517/14656566.2013.79554323621117
  • GittoS, GamalN, AndreoneP. NS5A inhibitors for the treatment of hepatitis C infection. J Viral Hepat. 2017;24(3):180–186. doi:10.1111/jvh.1265727925362
  • TaoX, WangN, WangJ, et al. Preclinical evaluation of Amphihevir, a first-in-class clinical Hepatitis C virus NS4B inhibitor. Antimicrob Agents Chemother. 2019;63(12). doi:10.1128/AAC.01237-19.
  • LinL, ChenY, YanL, et al. Analysis of clinical trials of new drugs in China as of 2019. Drug Discov Today. 2020;25(12):2080–2088. doi:10.1016/j.drudis.2020.09.03033017690
  • A 4-drug combination (Viekira Pak) for hepatitis C. JAMA. 2015;313:1857–1858.25965236
  • OparA. Excitement grows for potential revolution in hepatitis C virus treatment. Nat Rev Drug Discov. 2010;9(7):501–503. doi:10.1038/nrd321420592732
  • KowdleyKV, GordonSC, ReddyKR, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370:1879–1888.24720702
  • HalfonP, SarrazinC. Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important? Liver Int. 2012;32(Suppl 1):79–87. doi:10.1111/j.1478-3231.2011.02716.x
  • ZhangJ, LiW, YuanQ, et al. Transcriptome analyses of the anti-proliferative effects of 20(S)-ginsenoside Rh2 on HepG2 cells. Front Pharmacol. 2019;10:1331. doi:10.3389/fphar.2019.0133131780945
  • SongBK, KimKM, ChoiKD, ImWT. Production of the Rare Ginsenoside Rh2-MIX (20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3) by enzymatic conversion combined with acid treatment and evaluation of its anti-cancer activity. J Microbiol Biotechnol. 2017;27(7):1233–1241. doi:10.4014/jmb.1701.0107728478658
  • LiQ, HuaiL, ZhangC, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013;97(5):617–623. doi:10.1007/s12185-013-1317-923550021
  • ZhuJ, LiZ, ZhangG, et al. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. PLoS One. 2011;6(8):e23720. doi:10.1371/journal.pone.002372021887305
  • HaoH, ZhangQ, ZhuH, et al. Icaritin promotes tumor T-cell infiltration and induces antitumor immunity in mice. Eur J Immunol. 2019;49(12):2235–2244. doi:10.1002/eji.20194822531465113