References
- WongWL, SuX, LiX, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106–116. doi:10.1016/s2214-109x(13)70145-125104651
- MartinDF, MaguireMG, FineSL, et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology. 2012;119(7):1388–1398. doi:10.1016/j.ophtha.2012.03.05322555112
- NebbiosoM, LambiaseA, CeriniA, LimoliPG, La CavaM, GrecoA. Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules. Int J Mol Sci. 2019;20(7):1693. doi:10.3390/ijms20071693
- KleinR, KleinBEK, LintonKLP. Prevalence of age-related maculopathy: the beaver dam eye study. Ophthalmology. 2020;127(4):S122–s132. doi:10.1016/j.ophtha.2020.01.03332200811
- CherepanoffS, McMenaminP, GilliesMC, KettleE, SarksSH. Bruch’s membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol. 2010;94(7):918–925. doi:10.1136/bjo.2009.16556319965817
- HanusJ, AndersonC, WangS. RPE necroptosis in response to oxidative stress and in AMD. Ageing Res Rev. 2015;24(Pt B):286–298. doi:10.1016/j.arr.2015.09.00226369358
- TakayamaK, KanekoH, KataokaK, et al. Nuclear factor (erythroid-derived)-related factor 2-associated retinal pigment epithelial cell protection under blue light-induced oxidative stress. Oxid Med Cell Longev. 2016;2016:8694641. doi:10.1155/2016/869464127774118
- SattaS, MahmoudAM, WilkinsonFL, Yvonne AlexanderM, WhiteSJ. The role of Nrf2 in cardiovascular function and disease. Oxid Med Cell Longev. 2017;2017:9237263. doi:10.1155/2017/923726329104732
- FelszeghyS, ViiriJ, PaternoJJ, et al. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2019;20:1–12. doi:10.1016/j.redox.2018.09.01130253279
- BroadheadGK, GriggJR, ChangAA, McCluskeyP. Dietary modification and supplementation for the treatment of age-related macular degeneration. Nutr Rev. 2015;73(7):448–462. doi:10.1093/nutrit/nuv00526081455
- XiC, DanQ, TianMingH, WeiW. Efficacy in the treatment of dry age-related macular degeneration by traditional Chinese medicine: a meta analysis. Lishizhen Med Materia Medica Res. 2019;30(09):2273–2276.
- FangY, LiuX, SuJ, RehmanK. Network pharmacology analysis of traditional Chinese medicine formula Shuang Di Shou Zhen tablets treating nonexudative age-related macular degeneration. Evid Based Complement Altern Med. 2021;2021:6657521. doi:10.1155/2021/6657521
- SaiL, DongL. Clinical application and discrimination of Qiju Dihuang Wan and Mingmu Dihuang Wan. China J Tradition Chin Med Pharm. 2013;28(07):2186–2188.
- XuX, HangL, HuangB, WeiY, ZhengS, LiW. Efficacy of ethanol extract of Fructus lycii and its constituents lutein/zeaxanthin in protecting retinal pigment epithelium cells against oxidative stress: in vivo and in vitro models of age-related macular degeneration. J Ophthalmol. 2013;2013:862806. doi:10.1155/2013/86280624163760
- ZhuX, WangK, ZhouF, ZhuL. Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca(2+)/CaMKII-dependent activation of AMPK. Arch Pharm Res. 2018;41(10):1009–1018. doi:10.1007/s12272-018-1059-630117083
- YueSJ, XinLT, FanYC, et al. Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach. Sci Rep. 2017;7:40318. doi:10.1038/srep4031828074863
- TaoW, XuX, WangX, et al. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J Ethnopharmacol. 2013;145(1):1–10. doi:10.1016/j.jep.2012.09.05123142198
- GeQ, ChenL, TangM, et al. Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology. Eur J Pharmacol. 2018;833:50–62. doi:10.1016/j.ejphar.2018.05.02129782863
- ZhaiJ, SongZ, WangY, et al. Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research. Phytomedicine. 2019;59:152776. doi:10.1016/j.phymed.2018.11.03631004886
- LiuH, WangJ, ZhouW, WangY, YangL. Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice. J Ethnopharmacol. 2013;146(3):773–793. doi:10.1016/j.jep.2013.02.00423415946
- WaltersWP, MurckoMA. Prediction of ‘drug-likeness’. Adv Drug Deliv Rev. 2002;54(3):255–271. doi:10.1016/s0169-409x(02)00003-011922947
- ZhangXF, ChenJ, YangJL, ShiYP. UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. Talanta. 2018;180:389–395. doi:10.1016/j.talanta.2017.12.07829332828
- LamP, CheungF, TanHY, WangN, YuenMF, FengY. Hepatoprotective effects of Chinese medicinal herbs: a focus on anti-inflammatory and anti-oxidative activities. Int J Mol Sci. 2016;17(4):465. doi:10.3390/ijms1704046527043533
- NeelamK, DeyS, SimR, LeeJ, Au EongKG. Fructus lycii: a natural dietary supplement for amelioration of retinal diseases. Nutrients. 2021;13:1. doi:10.3390/nu13010246
- YeM, MoonJ, YangJ, et al. The standardized Lycium chinense fruit extract protects against Alzheimer’s disease in 3xTg-AD mice. J Ethnopharmacol. 2015;172:85–90. doi:10.1016/j.jep.2015.06.02626102549
- LiuL, LaoW, JiQS, YangZH, YuGC, ZhongJX. Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis. Int J Ophthalmol. 2015;8(1):11–16. doi:10.3980/j.issn.2222-3959.2015.01.0225709900
- GongW, ZhangN, ChengG, et al. Rehmannia glutinosa libosch extracts prevent bone loss and architectural deterioration and enhance osteoblastic bone formation by regulating the IGF-1/PI3K/mTOR pathway in streptozotocin-induced diabetic rats. Int J Mol Sci. 2019;20(16):3964. doi:10.3390/ijms20163964
- YuanH, NiX, ZhengM, HanX, SongY, YuM. Effect of catalpol on behavior and neurodevelopment in an ADHD rat model. Biomed Pharmacother. 2019;118:109033. doi:10.1016/j.biopha.2019.10903331545235
- LiuC, MaR, WangL, et al. Rehmanniae Radix in osteoporosis: a review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology. J Ethnopharmacol. 2017;198:351–362. doi:10.1016/j.jep.2017.01.02128111216
- KeD, XiaoxiaG, FengW, PeiXiW, MeiQX. Research progress on quality and efficacy evaluation of Rehmanniae Radix Praeparata based on pharmacodynamic material basis. Chin Tradition Herbal Drugs. 2019;50(06):1477–1484.
- XueChunW, WeiZ, YaTuG, YiBoG. Protective effects of rehmannia glutinosa,wolfberry and the mixed extracts on light-induced retinal injury of mice. Recent Adv Ophthalmol. 2021;41(01):12–17. doi:10.13389/j.cnki.rao.2021.0003
- ParkerS, MayB, ZhangC, ZhangAL, LuC, XueCC. A pharmacological review of bioactive constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch. Phytother Res. 2016;30(9):1445–1473. doi:10.1002/ptr.565327279421
- ZhuQ, LiuM, HeY, YangB. Quercetin protect cigarette smoke extracts induced inflammation and apoptosis in RPE cells. Artif Cells, Nanomed Biotechnol. 2019;47(1):2010–2015. doi:10.1080/21691401.2019.160821731122072
- MoineE, BoukhallatM, CiaD, et al. New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration. Free Radic Biol Med. 2020. doi:10.1016/j.freeradbiomed.2020.10.316
- DuW, AnY, HeX, ZhangD, HeW. Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage. Oxid Med Cell Longev. 2018;2018:1610751. doi:10.1155/2018/161075130584457
- YuanZ, DuW, HeX, ZhangD, HeW. Tribulus terrestris ameliorates oxidative stress-induced ARPE-19 cell injury through the PI3K/Akt-Nrf2 signaling pathway. Oxid Med Cell Longev. 2020;2020:7962393. doi:10.1155/2020/796239332774685
- SchonhoffCM, GastonB, MannickJB. Nitrosylation of cytochrome c during apoptosis. J Biol Chem. 2003;278(20):18265–18270. doi:10.1074/jbc.M21245920012646553
- LiP, NijhawanD, WangX. Mitochondrial activation of apoptosis. Cell. 2004;116(2):S57–59,52 p following S59. doi:10.1016/s0092-8674(04)00031-515055583
- WengS, MaoL, GongY, SunT, GuQ. Role of quercetin in protecting ARPE‑19 cells against H2O2‑induced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition. Mol Med Rep. 2017;16(3):3461–3468. doi:10.3892/mmr.2017.696428713895
- Xie W, Yu W, Zhou M, et al. Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. Mol Vis. 2011;17:3512–3522.22219646
- DuL, ChenJ, XingYQ. Eupatilin prevents H(2)O(2)-induced oxidative stress and apoptosis in human retinal pigment epithelial cells. Biomed Pharmacother. 2017;85:136–140. doi:10.1016/j.biopha.2016.11.10827930977
- JustilienV, PangJJ, RenganathanK, et al. SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci. 2007;48(10):4407–4420. doi:10.1167/iovs.07-043217898259
- KaarnirantaK, UusitaloH, BlasiakJ, et al. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020;79:100858. doi:10.1016/j.preteyeres.2020.10085832298788
- SaitoY, KuseY, InoueY, NakamuraS, HaraH, ShimazawaM. Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival. Redox Biol. 2018;19:354–363. doi:10.1016/j.redox.2018.09.00430216854