882
Views
12
CrossRef citations to date
0
Altmetric
Original Research

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives

, &
Pages 3119-3129 | Published online: 17 Jul 2021

References

  • SEMDSA. Guidelines for the management of type 2 diabetes mellitus. JEMDSA. 2017;22(suppl1):S1–S196.
  • OgurtsovaK, RochaJD, HuangY, LinnenkampU, GuariguataL. Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pr. 2017;128:40–50. doi:10.1016/j.diabres.2017.03.024
  • KarurangaS, ChoNH, OhlroggeAW, et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi:10.1016/j.diabres.2018.02.02329496507
  • BaynesHW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab. 2015;6(5):1–9. doi:10.4172/2155-6156.1000541
  • WilliamS. Insulin and drugs used to treat diabetes. In: ThomasdLL, DavidAW, VictoriaFR, ZitWS, editors. Foye’s Principles of Medicinal Chemistry. 7th edi ed. Lippincott Williams & Wilkins; 2012:877–903.
  • ChavanB, GadekarA, MehtaP, VawhalP, KolsureA, ChabukswarA. Synthesis & medicinal significance of chalcones- review. Asian J Biomed Pharm Sci. 2016;6:56.
  • SatyanarayanaM, TiwariP, TripathiBK, SrivastavaAK, PratapR. Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines. Bioorganic Med Chem. 2004;12(5):883–889. doi:10.1016/j.bmc.2003.12.026
  • XiaoJ, KaiG, YamamotoK, ChenX. Advance in dietary polyphenols as α-glucosidases inhibitors: a review on structure-activity relationship aspect. Crit Rev Food Sci Nutr. 2013;53(8):818–836. doi:10.1080/10408398.2011.56137923768145
  • MahapatraD, BhartiS, AsatiV. Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives. Eur J Med Chem. 2015;101:496–524. doi:10.1016/j.ejmech.2015.06.05226188621
  • ParkH, BakE, WooG, et al. Licochalcone E has an antidiabetic effect. J Nutr Biochem. 2012;23(7):759–767. doi:10.1016/j.jnutbio.2011.03.02121840191
  • ChinthalaY, ThakurS, TirunagariS, et al. Synthesis, docking and ADMET studies of novel chalcone triazoles for anti-cancer and anti-diabetic activity. Eur J Med Chem. 2015;93:564–573. doi:10.1016/j.ejmech.2015.02.02725743216
  • SobhiGM, RiyadhM, AbdallaM. Solvent-drop grinding method: efficient synthesis, DPPH radical scavenging and anti-diabetic activities of chalcones, bis-chalcones, azolines, and bis-azolines. Curr Org Synth. 2015;12(2):220–228. doi:10.2174/1570179412666150122230447
  • SunH, WangD, SongX, et al. Natural prenylchalconaringenins and prenylnaringenins as antidiabetic agents: α-glucosidase and α-amylase inhibition and in Vivo antihyperglycemic and antihyperlipidemic effects. J Agric Food Chem. 2017;65(8):1574–1581. doi:10.1021/acs.jafc.6b0544528132506
  • YadavP, LalK, KumarA, GuruS, JaglanS, BhushanS. Green synthesis and anticancer potential of chalcone linked-1, 2, 3-triazoles. Eur J Med Chem. 2017;126:944–953. doi:10.1016/j.ejmech.2016.11.03028011424
  • GoingCC, TailorD, KumarV, et al. Quantitative proteomic profiling reveals key pathways in the anti-cancer action of methoxychalcone derivatives in triple negative breast cancer. J Proteome Res. 2018;17(10):3574–3585. doi:10.1021/acs.jproteome.8b0063630200768
  • UgwuD, EzemaB, OkoroU, et al. Synthesis and pharmacological applications of chalcones: review. Int J Chem Sci. 2015;13(1).
  • SuwitoH, PudjiastutiP, FananiM, et al. Design and synthesis of chalcone derivatives as inhibitors of the ferredoxin—Ferredoxin-NADP+ reductase interaction of plasmodium falciparum: pursuing new antimalarial agents. Molecules. 2014;19(12):21473–21488. doi:10.3390/molecules19122147325532844
  • RossiM, CarusoF, CrespiE, et al. Probing antioxidant activity of 2′-hydroxychalcones: crystal and molecular structures, in vitro antiproliferative studies and in vivo effects on glucose regulation. Biochimie. 2013;95(10):1954–1963. doi:10.1016/j.biochi.2013.07.00223851195
  • BuiT, NguyenN, DangP, NguyenH, NguyenM. Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors. Springerplus. 2016;5(1):1789. doi:10.1186/s40064-016-3485-627795931
  • KhanS, AsiriA. Green synthesis, characterization and biological evaluation of novel chalcones as anti bacterial agents. Arab J Chem. 2017;10:S2890–S2895. doi:10.1016/j.arabjc.2013.11.018
  • SahuN, BalbhadraS, ChoudharyJ, KohliD. Exploring pharmacological significance of chalcone scaffold: a review. Curr Med. 2012;19(2):209–225.
  • ZhuangC, ZhangW, ShengC, ZhangW, XingC, MiaoZ. Chalcone: a privileged structure in medicinal chemistry. Chem Rev. 2017;117(12):7762–7810. doi:10.1021/acs.chemrev.7b0002028488435
  • KumarV, KumarS, HassanM, et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. J Med Chem. 2011;54(12):4147–4159. doi:10.1021/jm200234821539383
  • GomesM, MuratovE, PereiraM, PeixotoJC. Chalcone derivatives: promising starting points for drug design. Molecules. 2017;22(8):1210. doi:10.3390/molecules22081210
  • Institute for Laboratory Animal Research. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC; 2011.
  • DeedsM, AndersonJ, ArmstrongA, et al. Single dose streptozotocin induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011;45(3):131–140. doi:10.1258/la.2010.01009021478271
  • EddouksM, ChattopadhyayD, ZeggwaghNA. Animal models as tools to investigate antidiabetic and anti-inflammatory plants. Evid-Based Comple Alter Med. 2012;1–14. doi:10.1155/2012/142087
  • SinghMP, PathakK. Animal models for biological screening of anti-diabetic drugs. Eur J Exper Bio. 2015;5(5):37–48.
  • OECD/OCDE. No. 425. Acute oral toxicity: up-and-down procedure. OECD guidelines for the testing of chemicals. 2008;1–27.
  • GaurR, YadavK, VermaR, YadavN, BhakuniR. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine. 2014;21(4):415–422. doi:10.1016/j.phymed.2013.10.01524262065