A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

References

• ZhaoYL, WangJB, ShanLM, JinC, MaL, XiaoXH. Effect of Radix isatidis polysaccharides on immunological function and expression of immune related cytokines in mice. Chin J Integr Med. 2008;14(3):207–211. doi:10.1007/s11655-008-0207-218853118
   PubMed Web of Science ®Google Scholar
• ChanYS, ChengLN, WuJH, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245–254. doi:10.1007/s10787-010-0062-420981575
   PubMedGoogle Scholar
• HuN, WangC, DaiX, et al. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-kappaB signaling pathway. J Ethnopharmacol. 2020;248:112361. doi:10.1016/j.jep.2019.11236131683033
   PubMed Web of Science ®Google Scholar
• LiuJF, JiangZY, WangRR, et al. Isatisine A, a novel alkaloid with an unprecedented skeleton from leaves of Isatis indigotica. Org Lett. 2007;9(21):4127–4129. doi:10.1021/ol701540y17850153
   PubMed Web of Science ®Google Scholar
• ZhouW, ZhangXY. Research progress of Chinese herbal medicine Radix isatidis (banlangen). Am J Chin Med. 2013;41(4):743–764. doi:10.1142/S0192415X1350050X23895149
   PubMed Web of Science ®Google Scholar
• HoYL, ChangYS. Studies on the antinociceptive, anti-inflammatory and anti pyretic effects of Isatis indigotica root. Phytomedicine. 2002;9(5):419–424. doi:10.1078/0944711026057166112222662
   PubMed Web of Science ®Google Scholar
• NieLX, WuYL, DaiZ, MaSC. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J Ethnopharmacol. 2020;251:112550. doi:10.1016/j.jep.2020.11255031918015
   PubMed Web of Science ®Google Scholar
• YanJ, LiuS, LiBP, LiuZQ, GuoDF. Fingerprint chromatograms and chemical components of compound indigowoad root granule by APCI-MS and LC-APCI-MS. J Chin Mass Spectromet Soc. 2017;38(3):320–327. doi:10.7538/zpxb.youxian.2016.0057
   Google Scholar
• ShinEK, KimDH, LimH, ShinHK, KimJK. The anti-inflammatory effects of a methanolic extract from Radix Isatidis in murine macrophages and mice. Inflammation. 2010;33(2):110–118. doi:10.1007/s10753-009-9164-919888641
   PubMed Web of Science ®Google Scholar
• LiZ, LiL, ZhouH, et al. Radix isatidis polysaccharides inhibit influenza a virus and influenza A virus-induced inflammation via suppression of host TLR3 signaling in vitro. Molecules. 2017;22(1). doi:10.3390/molecules22010116
   Web of Science ®Google Scholar
• RuanD, LiuW, ShiY, et al. Protective effects of aqueous extract of radix isatidis on lipopolysaccharide-induced sepsis in C57BL/6J mice. J Med Food. 2020;23(1):79–89. doi:10.1089/jmf.2019.447631765267
   PubMed Web of Science ®Google Scholar
• XiaoP, HuangH, ChenJ, LiX. In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion. J Ethnopharmacol. 2014;157:55–61. doi:10.1016/j.jep.2014.09.00525256688
   PubMed Web of Science ®Google Scholar
• JiangL, LuY, JinJ, et al. n-Butanol extract from Folium isatidis inhibits lipopolysaccharide-induced inflammatory cytokine production in macrophages and protects mice against lipopolysaccharide-induced endotoxic shock. Drug Des Devel Ther. 2015;9:5601–5609. doi:10.2147/DDDT.S89924
   Web of Science ®Google Scholar
• YangZ-F, WangY-T, QinS, et al. The effects of a hot water soluble extract (S-03) isolated from Isatis indigotica Root on Influenza A and B viruses in vitro. Chin J Virol. 2011;27(3):6.
   Google Scholar
• ZhangCE, XiongY, DongQ, et al. Comparison of reversed-phase liquid chromatography and hydrophilic interaction chromatography for the fingerprint analysis of Radix isatidis. J Sep Sci. 2014;37(9–10):1141–1147. doi:10.1002/jssc.20130115924595986
   PubMed Web of Science ®Google Scholar
• HeLW, LiuHQ, ChenYQ, YangJY, WangTL, LiW. Total synthesis and anti-viral activities of an extract of Radix isatidis. Molecules. 2014;19(12):20906–20912. doi:10.3390/molecules19122090625514229
   PubMed Web of Science ®Google Scholar
• WangXL, ChenMH, WangF, et al. [Chemical consitituents from root of Isatis indigotica]. Zhongguo Zhong Yao Za Zhi. 2013;38(8):1172–1182. Chinese.23944031
   PubMedGoogle Scholar
• WangT, WangX, ZhuoY, et al. Antiviral activity of a polysaccharide from Radix Isatidis (Isatis indigotica Fortune) against hepatitis B virus (HBV) in vitro via activation of JAK/STAT signal pathway. J Ethnopharmacol. 2020;257:112782. doi:10.1016/j.jep.2020.11278232217096
   PubMed Web of Science ®Google Scholar
• DengYP, LiuYY, LiuZ, et al. Antiviral activity of Folium isatidis derived extracts in vitro and in vivo. Am J Chin Med. 2013;41(4):957–969. doi:10.1142/S0192415X1350064X23895163
   PubMed Web of Science ®Google Scholar
• LiB, ChenWS, ZhangHM, ZhangWD, YangGJ, QiaoCZ. [A new alkaloids isolated from tetraploidy banlangen]. Yao Xue Xue Bao. 2003;38(6):430–432. Chinese.14513802
   PubMedGoogle Scholar
• ShiY, ZhengC, LiJ, YangL, WangZ, WangR. Separation and quantification of four main chiral glucosinolates in radix isatidis and its granules using high-performance liquid chromatography/diode array detector coupled with circular dichroism detection. Molecules. 2018;23(6):1305. doi:10.3390/molecules23061305
   Web of Science ®Google Scholar
• HouX, ZhangX, BiJ, ZhuA, HeL. Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway. J Nat Med. 2021;75:602–611. doi:10.1007/s11418-021-01506-033755912
   PubMed Web of Science ®Google Scholar
• LvH, YuZ, ZhengY, et al. Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-kappaB and activating HO-1/Nrf2 pathways. Int J Biol Sci. 2016;12(1):72–86. doi:10.7150/ijbs.1318826722219
   PubMed Web of Science ®Google Scholar
• XiaoH, XuJ. Isaindigotone as an inhibitor of the lipopolysaccharide induced inflammatory reaction of BV2 cells and corresponding mechanisms. Mol Med Rep. 2019;19(4):2890–2896. doi:10.3892/mmr.2019.990930720138
   PubMed Web of Science ®Google Scholar
• ZhangX, SongY, WuY, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011;129(10):2502–2511. doi:10.1002/ijc.2590921207415
   PubMed Web of Science ®Google Scholar
• AqeelT, GurumalluSC, BhaskarA, HashimiSM, JavaraiahR. Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats. J Trace Elem Med Biol. 2020;61:126552. doi:10.1016/j.jtemb.2020.12655232446210
   PubMed Web of Science ®Google Scholar
• HopkinsAL. Network pharmacology. Nat Biotechnol. 2007;25(10):1110–1111. doi:10.1038/nbt1007-111017921993
   PubMed Web of Science ®Google Scholar
• SeeleyJJ, GhoshS. Molecular mechanisms of innate memory and tolerance to LPS. J Leukoc Biol. 2017;101(1):107–119. doi:10.1189/jlb.3MR0316-118RR27780875
   PubMed Web of Science ®Google Scholar
• HafnerAM, CorthesyB, MerkleHP. Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant. Adv Drug Deliv Rev. 2013;65(10):1386–1399. doi:10.1016/j.addr.2013.05.01323751781
   PubMed Web of Science ®Google Scholar
• DainaA, MichielinO, ZoeteV. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7:42717. doi:10.1038/srep4271728256516
   PubMed Web of Science ®Google Scholar
• DainaA, MichielinO, ZoeteV. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 2019;47(W1):W357–W364. doi:10.1093/nar/gkz38231106366
   PubMed Web of Science ®Google Scholar
• PietrofesaRA, WoodruffP, HwangWT, et al. The synthetic lignan secoisolariciresinol diglucoside prevents asbestos-induced NLRP3 inflammasome activation in murine macrophages. Oxid Med Cell Longev. 2017;2017:7395238. doi:10.1155/2017/739523829075366
   PubMed Web of Science ®Google Scholar
• ChhillarH, ChopraP, AshfaqMA. Lignans from linseed (Linum usitatissimum L.) and its allied species: retrospect, introspect and prospect. Crit Rev Food Sci Nutr. 2020;1–23. doi:10.1080/10408398.2020.1784840
   Web of Science ®Google Scholar
• HeM, MinJW, KongWL, HeXH, LiJX, PengBW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016;115:74–85. doi:10.1016/j.fitote.2016.09.01127693342
   PubMed Web of Science ®Google Scholar
• StelzerG, RosenN, PlaschkesI, et al. The GeneCards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics. 2016;54:1 30 1–1 30 33. doi:10.1002/cpbi.527322403
   PubMedGoogle Scholar
• Huang daW, ShermanBT, LempickiRA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57. doi:10.1038/nprot.2008.21119131956
   PubMed Web of Science ®Google Scholar
• FujiharaM, MuroiM, TanamotoK, SuzukiT, AzumaH, IkedaH. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther. 2003;100(2):171–194. doi:10.1016/j.pharmthera.2003.08.00314609719
   PubMed Web of Science ®Google Scholar
• LeeHN, ShinSA, ChooGS, et al. Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. Int J Mol Med. 2018;41(2):888–898. doi:10.3892/ijmm.2017.329629207037
   PubMed Web of Science ®Google Scholar
• HasanM, RuksznisC, WangY, LeiferCA. Antimicrobial peptides inhibit polyinosinic-polycytidylic acid-induced immune responses. J Immunol. 2011;187(11):5653–5659. doi:10.4049/jimmunol.110214422048772
   PubMed Web of Science ®Google Scholar
• TariqS, WaniS, RasoolW, et al. A comprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens. Microb Pathog. 2019;134:103580. doi:10.1016/j.micpath.2019.10358031195112
   PubMed Web of Science ®Google Scholar
• Trong LeN, Viet HoD, Quoc DoanT, et al. In vitro antimicrobial activity of essential oil extracted from leaves of leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam. Plants (Basel). 2020;9(4). doi:10.3390/plants9040453
   Google Scholar
• Trong LeN, Viet HoD, Quoc DoanT, et al. Biological activities of essential oils from leaves of Paramignya trimera (Oliv.) guillaum and Limnocitrus littoralis (Miq.) swingle. Antibiotics (Basel). 2020;9(4). doi:10.3390/antibiotics9040207
   Web of Science ®Google Scholar
• SannaG, MadedduS, SerreliG, et al. Antiviral effect of Hornstedtia bella Skornick essential oil from the whole plant against vaccinia virus (VV). Nat Prod Res. 2020;1–7. doi:10.1080/14786419.2020.1824228.
   Web of Science ®Google Scholar
• LeNT, DonaduMG, HoDV, et al. Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam. J Infect Dev Ctries. 2020;14(9):1054–1064. doi:10.3855/jidc.1246933031096
   PubMed Web of Science ®Google Scholar
• LeeJH, WoodTK, LeeJ. Roles of indole as an interspecies and interkingdom signaling molecule. Trends Microbiol. 2015;23(11):707–718. doi:10.1016/j.tim.2015.08.00126439294
   PubMed Web of Science ®Google Scholar
• SowndhararajanK, DeepaP, KimM, ParkSJ, KimS. An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis. Biomed Pharmacother. 2018;97:958–968. doi:10.1016/j.biopha.2017.10.14529136774
   PubMed Web of Science ®Google Scholar
• MakNK, LeungCY, WeiXY, et al. Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells. Biochem Pharmacol. 2004;67(1):167–174. doi:10.1016/j.bcp.2003.08.02014667939
   PubMed Web of Science ®Google Scholar
• ChenK, XiaoF, HuD, et al. SARS-CoV-2 nucleocapsid protein interacts with RIG-I and represses RIG-mediated IFN-beta production. Viruses. 2020;13(1):47. doi:10.3390/v13010047
   Web of Science ®Google Scholar
• TisoncikJR, KorthMJ, SimmonsCP, FarrarJ, MartinTR, KatzeMG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76(1):16–32. doi:10.1128/MMBR.05015-1122390970
   PubMed Web of Science ®Google Scholar
• GoubauD, DeddoucheS, SousaCRE. Cytosolic sensing of viruses. Immunity. 2013;38(5):855–869. doi:10.1016/j.immuni.2013.05.00723706667
   PubMed Web of Science ®Google Scholar
• XuH, HeL, ChenJ, et al. Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy. J Ethnopharmacol. 2019;239:111901. doi:10.1016/j.jep.2019.11190131051218
   PubMed Web of Science ®Google Scholar
• CuiX, QianDW, JiangS, ShangEX, ZhuZH, DuanJA. Scutellariae radix and coptidis rhizoma improve glucose and lipid metabolism in T2DM rats via regulation of the metabolic profiling and MAPK/PI3K/Akt signaling pathway. Int J Mol Sci. 2018;19(11):3634. doi:10.3390/ijms19113634
   PubMed Web of Science ®Google Scholar
• ZhangCH, ShengJQ, SarsaiyaS, et al. The anti-diabetic activities, gut microbiota composition, the anti-inflammatory effects of Scutellaria-coptis herb couple against insulin resistance-model of diabetes involving the toll-like receptor 4 signaling pathway. J Ethnopharmacol. 2019;237:202–214. doi:10.1016/j.jep.2019.02.04030807814
   PubMed Web of Science ®Google Scholar
• ChoY, ChallaS, MoquinD, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 2009;137(6):1112–1123. doi:10.1016/j.cell.2009.05.03719524513
   PubMed Web of Science ®Google Scholar
• LevineB, MizushimaN, VirginHW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323–335. doi:10.1038/nature0978221248839
   PubMed Web of Science ®Google Scholar