Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model

References

• TerkeltaubR. Update on gout: new therapeutic strategies and options. Nat Rev Rheumatol. 2010;6(1):30–38. doi:10.1038/nrrheum.2009.23620046204
   PubMed Web of Science ®Google Scholar
• SoA, ThorensB. Uric acid transport and disease. J Clin Invest. 2010;120(6):1791–1799. doi:10.1172/JCI4234420516647
   PubMed Web of Science ®Google Scholar
• RussoE, ViazziF, PontremoliR, et al. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) project. J Nephrol. 2021. doi:10.1007/s40620-021-00985-4
   Web of Science ®Google Scholar
• HahnK, KanbayM, LanaspaMA, JohnsonRJ, EjazAA. Serum uric acid and acute kidney injury: a mini review. J Adv Res. 2017;8(5):529–536. doi:10.1016/j.jare.2016.09.00628748118
   PubMed Web of Science ®Google Scholar
• MalobertiA, GiannattasioC, BombelliM, et al. Hyperuricemia and risk of cardiovascular outcomes: the experience of the URRAH (Uric Acid Right for Heart Health) project. High Blood Press Cardiovasc Prev. 2020;27(2):121–128. doi:10.1007/s40292-020-00368-z32157643
   PubMed Web of Science ®Google Scholar
• RockKL, KataokaH, LaiJJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013;9(1):13–23. doi:10.1038/nrrheum.2012.14322945591
   PubMed Web of Science ®Google Scholar
• LuW, XuY, ShaoX, et al. Uric acid produces an inflammatory response through activation of NF-kappaB in the hypothalamus: implications for the pathogenesis of metabolic disorders. Sci Rep. 2015;5:12144. doi:10.1038/srep1214426179594
   PubMed Web of Science ®Google Scholar
• DesaiJ, SteigerS, AndersHJ. Molecular pathophysiology of gout. Trends Mol Med. 2017;23(8):756–768. doi:10.1016/j.molmed.2017.06.00528732688
   PubMed Web of Science ®Google Scholar
• MaiuoloJ, OppedisanoF, GratteriS, MuscoliC, MollaceV. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8–14. doi:10.1016/j.ijcard.2015.08.10926316329
   PubMed Web of Science ®Google Scholar
• WangCW, DaoRL, ChungWH. Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions. Curr Opin Allergy Clin Immunol. 2016;16(4):339–345. doi:10.1097/ACI.000000000000028627362322
   PubMed Web of Science ®Google Scholar
• HarroldL. New developments in gout. Curr Opin Rheumatol. 2013;25(3):304–309. doi:10.1097/BOR.0b013e32835fd5e523466959
   PubMed Web of Science ®Google Scholar
• BeckerMA, SchumacherHR, EspinozaLR, et al. The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther. 2010;12(2):R63. doi:10.1186/ar297820370912
   PubMed Web of Science ®Google Scholar
• MackenzieIS, FordI, NukiG, et al. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet (London, England). 2020;396(10264):1745–1757. doi:10.1016/S0140-6736(20)32234-0
   PubMed Web of Science ®Google Scholar
• BardinT, RichetteP. FAST: new look at the febuxostat safety profile. Lancet (London, England). 2020;396(10264):1704–1705. doi:10.1016/S0140-6736(20)32343-6
   Web of Science ®Google Scholar
• WangX, WangY-G. Progress in treatment of gout using chinese and western medicine. Chin J Integr Med. 2020;26(1):8–13. doi:10.1007/s11655-019-3058-y30659455
   PubMed Web of Science ®Google Scholar
• ChiX, ZhangH, ZhangS, MaK. Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms. Chin Med. 2020;15:17. doi:10.1186/s13020-020-0297-y32082411
   PubMed Web of Science ®Google Scholar
• ZhaoF, GuochunL, YangY, ShiL, XuL, YinL. A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout. J Ethnopharmacol. 2015;168:1–16. doi:10.1016/j.jep.2015.03.03525824593
   PubMed Web of Science ®Google Scholar
• ZhangH, WeiJ, XueR, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism. 2010;59(2):285–292. doi:10.1016/j.metabol.2009.07.02919800084
   PubMed Web of Science ®Google Scholar
• WuLG, ChenM, WuY. Effect of berberine on hyperuricemia. Chin J Integr Tradit West Med. 2010;30(6):659–662.
   Google Scholar
• WangY, YangR, ShanL, YuanJ. Efficacy and safety of berberine combined with benzbromarone in the treatment of hyperuricemia with gout. Chin J Mod Drug Appl. 2018;12(7):3–6.
   Google Scholar
• CaiSW. Clinical effect and safety of combination medicine for elderly patients with hypertension and gout. China Reflexolocy. 2017;26(11):84–89.
   Google Scholar
• HuangGL. Effect of amlodipine and berberine in mild and midrange hypertension patients complicated with hyperuricemia arthrolithiasis. China Pharm. 2013;22(5):32–33.
   Google Scholar
• GuarinoG, StrolloF, CarboneL, et al. Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. J Biol Regul Homeost Agents. 2017;31(2):495–502.28685558
   PubMed Web of Science ®Google Scholar
• NazH, NazS, MirajR, et al. The effect of berberine, a drug from chinese folk medicine, on serum and urinary uric acid levels in rats with hyperuricemia. Cureus. 2021;13(2):e13186.33717730
   PubMed Web of Science ®Google Scholar
• WeidangW, XingyanZ, ZihongW, et al. Inhibition of berberine on organ anion transporters and its bidirectional trans-membrane transport. Drug Eval Res. 2017;40(6):778–782.
   Google Scholar
• LiuYF, WenCY, ChenZ, WangY, HuangY, TuSH. Effects of berberine on NLRP3 and IL-1beta expressions in monocytic THP-1 cells with monosodium urate crystals-induced inflammation. Biomed Res Int. 2016;2016:2503703.27689075
   PubMed Web of Science ®Google Scholar
• DineshP, RasoolM. Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats. Int Immunopharmacol. 2017;44:26–37. doi:10.1016/j.intimp.2016.12.03128068647
   PubMed Web of Science ®Google Scholar
• NiWJ, DingHH, TangLQ. Berberine as a promising anti-diabetic nephropathy drug: an analysis of its effects and mechanisms. Eur J Pharmacol. 2015;760:103–112. doi:10.1016/j.ejphar.2015.04.01725912800
   PubMed Web of Science ®Google Scholar
• WanX, ChenX, LiuL, et al. Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of nfκb signaling pathway in rats. PLoS One. 2013;8(3):e59794. doi:10.1371/journal.pone.005979423555784
   PubMed Web of Science ®Google Scholar
• LiZ, ZhangW. Protective effect of berberine on renal fibrosis caused by diabetic nephropathy. Mol Med Rep. 2017;16(2):1055–1062. doi:10.3892/mmr.2017.670729067464
   PubMed Web of Science ®Google Scholar
• YongT, LiD, LiM, et al. Anti-hyperuricemic effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic acid in hyperuricemic mice through XOD. Molecules. 2018;23:10. doi:10.3390/molecules23102671
   Web of Science ®Google Scholar
• Animal Care Committee. Rodent Anesthesia and Analgesia Formulary and General Drug Information; 2016. Available from: https://animalcare.ubc.ca/sites/default/files/documents/Guideline%20-%20Rodent%20Anesthesia%20Analgesia%20Formulary%20%282016%29.pdf. Accessed 530, 2021.
   Google Scholar
• RussM, OttS, BedarfJR, KirschfinkM, HieblB, UngerJK. Increased compensatory kidney workload results in cellular damage in a short time porcine model of mixed acidemia - Is acidemia a ‘first hit’ in acute kidney injury? PLoS One. 2019;14(6):e0218308. doi:10.1016/j.semarthrit.2020.04.00731206554
   PubMed Web of Science ®Google Scholar
• BustinSA, BenesV, GarsonJA, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55(4):611–622. doi:10.1373/clinchem.2008.11279719246619
   PubMed Web of Science ®Google Scholar
• MitchellJ. RT-PCR Protocols. Methods in Molecular Biology, Vol. 193: O’Connell J, ed. Humana Press, 2002. ISBN 0 89603 875 0. J Clin Pathol. 2003;56(5):400. doi:10.1136/jcp.56.5.400-a
   Google Scholar
• MahmoodT, YangP-C. Western blot: technique, theory, and trouble shooting. N Am J Med Sci. 2012;4(9):429–434. doi:10.4103/1947-2714.10099823050259
   PubMedGoogle Scholar
• DouY, HuangR, LiQ, et al. Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways. Biomed Pharmacother. 2021;137:111312. doi:10.1016/j.biopha.2021.11131233524788
   PubMed Web of Science ®Google Scholar
• SyrbuSI, CohenMB. An enhanced antigen-retrieval protocol for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues. Methods Mol Biol. 2011;717:101–110.21370027
   PubMedGoogle Scholar
• ZhouJ, WangT, DouY, et al. Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: involvement of NF-κB pathway and NLRP3 inflammasome. Int Immunopharmacol. 2018;64:264–274. doi:10.1016/j.intimp.2018.09.00830218953
   PubMed Web of Science ®Google Scholar
• ForliS, HueyR, PiqueME, SannerMF, GoodsellDS, OlsonAJ. Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nat Protoc. 2016;11(5):905–919. doi:10.1038/nprot.2016.05127077332
   PubMed Web of Science ®Google Scholar
• CurtisMJ, AlexanderS, CirinoG, et al. Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. Br J Pharmacol. 2018;175(7):987–993. doi:10.1111/bph.1415329520785
   PubMed Web of Science ®Google Scholar
• SunY, LenonGB, YangAWH. Phellodendri cortex: a phytochemical, pharmacological, and pharmacokinetic review. Evid Based Complement Alternat Med. 2019;2019:7621929. doi:10.1155/2019/762192931057654
   PubMed Web of Science ®Google Scholar
• LuJ, DalbethN, YinH, LiC, MerrimanTR, WeiWH. Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019;15(7):413–426. doi:10.1038/s41584-019-0222-x31118497
   PubMed Web of Science ®Google Scholar
• ObermayrRP, TemmlC, GutjahrG, KnechtelsdorferM, OberbauerR, Klauser-BraunR. Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol. 2008;19(12):2407–2413. doi:10.1681/ASN.200801008018799720
   PubMed Web of Science ®Google Scholar
• KirtaneAJ, LederDM, WaikarSS, et al. Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates. J Am Coll Cardiol. 2005;45(11):1781–1786. doi:10.1016/j.jacc.2005.02.06815936606
   PubMed Web of Science ®Google Scholar
• JungSW, KimSM, KimYG, LeeSH, MoonJY. Uric acid and inflammation in kidney disease. Am J Physiol Renal Physiol. 2020;318(6):F1327–f1340. doi:10.1152/ajprenal.00272.201932223310
   PubMed Web of Science ®Google Scholar
• BakkerPJ, ButterLM, KorsL, et al. Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation. Kidney Int. 2014;85(5):1112–1122. doi:10.1038/ki.2013.50324352154
   PubMed Web of Science ®Google Scholar
• KomadaT, MuruveDA. The role of inflammasomes in kidney disease. Nat Rev Nephrol. 2019;15(8):501–520.31164720
   PubMed Web of Science ®Google Scholar
• NowakKL, ChoncholM, IkizlerTA, et al. IL-1 inhibition and vascular function in CKD. J Am Soc Nephrol. 2017;28(3):971–980. doi:10.1681/ASN.201604045327647856
   PubMed Web of Science ®Google Scholar
• WuH, CraftML, WangP, et al. IL-18 contributes to renal damage after ischemia-reperfusion. J Am Soc Nephrol. 2008;19(12):2331–2341. doi:10.1681/ASN.200802017018815244
   PubMed Web of Science ®Google Scholar
• AfsarB, CovicA, OrtizA, AfsarRE, KanbayM. The future of IL-1 targeting in kidney disease. Drugs. 2018;78(11):1073–1083. doi:10.1007/s40265-018-0942-229968152
   PubMed Web of Science ®Google Scholar
• LiZ, GengY-N, JiangJ-D, KongW-J. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus. Evid Based Compl Altern Med. 2014;2014:289264.
   PubMed Web of Science ®Google Scholar
• LiS, LiuC, GuoL, et al. Ultrafiltration liquid chromatography combined with high-speed countercurrent chromatography for screening and isolating potential alpha-glucosidase and xanthine oxidase inhibitors from Cortex Phellodendri. J Sep Sci. 2014;37(18):2504–2512. doi:10.1002/jssc.20140047524975280
   PubMed Web of Science ®Google Scholar
• KongLD, CaiY, HuangWW, ChengCH, TanRX. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J Ethnopharmacol. 2000;73(1–2):199–207. doi:10.1016/S0378-8741(00)00305-611025157
   PubMed Web of Science ®Google Scholar
• KeenanRT. The biology of urate. Semin Arthritis Rheum. 2020;50(3s):S2–s10.32620198
   PubMed Web of Science ®Google Scholar
• DongY, ZhaoT, AiW, et al. Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016-2019). Expert Opin Ther Pat. 2019;29(11):871–879. doi:10.1080/13543776.2019.167672731593642
   PubMed Web of Science ®Google Scholar