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Original Research

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

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Pages 3937-3952 | Published online: 16 Sep 2021

References

  • PreshawP, AlbaA, HerreraD, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21–31. doi:10.1007/s00125-011-2342-y22057194
  • ChenX, WuG, FengZ, et al. Advanced biomaterials and their potential applications in the treatment of periodontal disease. Crit Rev Biotechnol. 2016;36(4):760–775. doi:10.3109/07388551.2015.103569326004052
  • BaranovN, PopaM, AtanaseLI, IchimDL. Polysaccharide-based drug delivery systems for the treatment of periodontitis. Molecules. 2021;26(9):2735. doi:10.3390/molecules2609273534066568
  • TominariT, SanadaA, IchimaruR, et al. Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts. Sci Rep. 2021;11(1):1–12. doi:10.1038/s41598-021-92744-533414495
  • HerreraD, MatesanzP, Bascones-MartínezA, SanzM. Local and systemic antimicrobial therapy in periodontics. J Evid Based Dent Pract. 2012;12(3):50–60. doi:10.1016/S1532-3382(12)70013-1
  • AhmedMG, HarishN, CharyuluRN, PrabhuP. Formulation of chitosan-based ciprofloxacin and diclofenac film for periodontitis therapy. Trop J Pharm Res. 2009;8(1):33–41. doi:10.4314/tjpr.v8i1.14710
  • GreensteinG, PolsonA. The role of local drug delivery in the management of periodontal diseases: a comprehensive review. J Periodontol. 1998;69(5):507–520. doi:10.1902/jop.1998.69.5.5079623893
  • KhanG, YadavSK, PatelRR, NathG, BansalM, MishraB. Development and evaluation of biodegradable chitosan films of metronidazole and levofloxacin for the management of periodontitis. Aaps Pharmscitech. 2016;17(6):1312–1325. doi:10.1208/s12249-015-0466-y26689408
  • ZamanM, HanifM, ShaheryarZA. Development of tizanidine HCL-meloxicam loaded mucoadhesive buccal films: in-vitro and in-vivo evaluation. PLoS One. 2018;13(3):e0194410. doi:10.1371/journal.pone.019441029566073
  • ThuH-E, ZulfakarMH, NgS-F. Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing. Int J Pharm. 2012;434(1–2):375–383. doi:10.1016/j.ijpharm.2012.05.04422643226
  • StevenJ, FountainW, CuiZ, MumperRJ. Transmucosal delivery of testosterone in rabbits using novel bi‐layer mucoadhesive wax‐film composite disks. J Pharm Sci. 2002;91(9):2016–2025. doi:10.1002/jps.1019812210048
  • KumarR. Fast dissolving films: a unique strategy for drug delivery. Asian J Pharm Res. 2014;4(1):47–55.
  • LimSY, DafyddM, OngJ, et al. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. Int J Pharm. 2020;573:118860. doi:10.1016/j.ijpharm.2019.11886031759104
  • AshriLY, Amal El SayehF, IbrahimMA, AlshoraDH. Optimization and evaluation of chitosan buccal films containing tenoxicam for treating chronic periodontitis: in vitro and in vivo studies. J Drug Deliv Sci Technol. 2020;57:101720. doi:10.1016/j.jddst.2020.101720
  • Paczkowska-WalendowskaM, DvořákJ, RosiakN, et al. Buccal resveratrol delivery system as a potential new concept for the periodontitis treatment. Pharmaceutics. 2021;13(3):417. doi:10.3390/pharmaceutics1303041733804630
  • KangKS, VeederGT, MirrasoulPJ, KanekoT, CottrellIW. Agar-like polysaccharide produced by a pseudomonas species: production and basic properties. Appl Environ Microbiol. 1982;43(5):1086–1091. doi:10.1128/aem.43.5.1086-1091.198216346007
  • MahmoodH, KhanIU, AsifM, et al. In vitro and in vivo evaluation of gellan gum hydrogel films: assessing the co impact of therapeutic oils and ofloxacin on wound healing. Int J Biol Macromol. 2020;166:483–495. doi:10.1016/j.ijbiomac.2020.10.20633130262
  • Rowe, Raymond C., Paul J. Sheskey, and Marian E. Quinn. Handbook of pharmaceutical excipients. London: Pharmaceutical Press; 2009.
  • BambekeV. Quinolones in 2005: an update. Clin Microbiol Infect. 2005;11(4):256–280.15760423
  • DholakiaM, ThakkarV, PatelN, GandhiT. Development and characterisation of thermo reversible mucoadhesive moxifloxacin hydrochloride in situ ophthalmic gel. J Pharm Bioallied Sci. 2012;4(Suppl 1):S42. doi:10.4103/0975-7406.9413823066202
  • PintoE, Vale-SilvaL, CavaleiroC, SalgueiroL. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2009;58(11):1454–1462. doi:10.1099/jmm.0.010538-019589904
  • ArafaMG, GhalwashD, El-KershDM, ElmazarM. Propolis-based niosomes as oromuco-adhesive films: a randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep. 2018;8(1):1–14. doi:10.1038/s41598-018-37157-729311619
  • ManconiM, PetrettoG, D’hallewinG, et al. Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases. Colloids Surf B Biointerfaces. 2018;171:115–122. doi:10.1016/j.colsurfb.2018.07.02130025373
  • São PedroA, Cabral-AlbuquerqueE, FerreiraD, SarmentoB. Chitosan: an option for development of essential oil delivery systems for oral cavity care?Carbohydr Polym. 2009;76(4):501–508. doi:10.1016/j.carbpol.2008.12.016
  • BalouiriM, SadikiM, IbnsoudaSK. Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal. 2016;6(2):71–79. doi:10.1016/j.jpha.2015.11.00529403965
  • ShahzadY, MaqboolM, HussainT, et al. Natural and semisynthetic polymers blended orodispersible films of citalopram. Nat Prod Res. 2020;34(1):16–25. doi:10.1080/14786419.2018.155269830663358
  • IrfanM, RabelS, BukhtarQ, QadirMI, JabeenF, KhanA. Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharm J. 2016;24(5):537–546. doi:10.1016/j.jsps.2015.02.02427752225
  • Abu-HuwaijR, ObaidatRM, SweidanK, Al-HiariY. Formulation and in vitro evaluation of xanthan gum or carbopol 934-based mucoadhesive patches, loaded with nicotine. Aaps Pharmscitech. 2011;12(1):21–27. doi:10.1208/s12249-010-9534-521161460
  • PrezottiFG, CuryBSF, EvangelistaRC. Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs. Carbohydr Polym. 2014;113:286–295. doi:10.1016/j.carbpol.2014.07.02125256487
  • EroğluH, SargonMF, ÖnerL. Chitosan formulations for steroid delivery: effect of formulation variables on in vitro characteristics. Drug Dev Ind Pharm. 2007;33(3):265–271. doi:10.1080/0363904060071313417454059
  • ColleyH, SaidZ, Santocildes-RomeroM, et al. Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa. Biomaterials. 2018;178:134–146. doi:10.1016/j.biomaterials.2018.06.00929929183
  • PendekalMS, TegginamatPK. Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine. Acta Pharm Sinica B. 2012;2(3):318–324. doi:10.1016/j.apsb.2011.12.012
  • MukherjeeD, BharathS. Design and characterization of double layered mucoadhesive system containing bisphosphonate derivative. ISRN Pharm. 2013;2013. doi:10.1155/2013/604690
  • SuvakantaD. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217–223.20524422
  • CarstensenJT. Modeling and Data Treatment in the Pharmaceutical Sciences. CRC Press; 1996.
  • BourneD, BankerG, RhodesC. Modern Pharmaceutics. New York: Informa Healthcare; 2002:67–92.
  • DressmanJ, FleisherD, AmidonG. Physicochemical model for dose-dependent drug absorption. J Pharm Sci. 1984;73(9):1274–1279. doi:10.1002/jps.26007309226548523
  • NastitiCMRR, PontoT, MohammedY, RobertsMS, BensonHAE. Novel nanocarriers for targeted topical skin delivery of the antioxidant resveratrol. Pharmaceutics. 2020;12(2):108. doi:10.3390/pharmaceutics12020108
  • JirovetzL, BuchbauerG, StoilovaI, StoyanovaA, KrastanovA, SchmidtE. Chemical composition and antioxidant properties of clove leaf essential oil. J Agric Food Chem. 2006;54(17):6303–6307. doi:10.1021/jf060608c16910723
  • OulkheirS, AghrouchM, El MourabitF, et al. Antibacterial activity of essential oils extracts from cinnamon, thyme, clove and geranium against a gram negative and gram positive pathogenic bacteria. J Dis Med Plants. 2017;3(2):1.
  • SchedletzkyH, WiedemannB, HeisigP. The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus. J Antimicrobial Chemother. 1999;43(suppl_2):31–37. doi:10.1093/jac/43.suppl_2.31
  • MirzaeeiS, MansurianM, Asare-AddoK, NokhodchiA. Metronidazole-and amoxicillin-loaded PLGA and PCL nanofibers as potential drug delivery systems for the treatment of periodontitis: in vitro and in vivo evaluations. Biomedicines. 2021;9(8):975. doi:10.3390/biomedicines908097534440179
  • NairAB, KumriaR, HarshaS, AttimaradM, Al-DhubiabBE, AlhaiderIA. In vitro techniques to evaluate buccal films. J Control Release. 2013;166(1):10–21. doi:10.1016/j.jconrel.2012.11.01923219961
  • KarkiS, KimH, NaS-J, ShinD, JoK, LeeJ. Thin films as an emerging platform for drug delivery. Asian J Pharm Sci. 2016;11(5):559–574. doi:10.1016/j.ajps.2016.05.004
  • BoatengJ, PopescuA. Composite bi-layered erodible films for potential ocular drug delivery. Colloids Surf B Biointerfaces. 2016;145:353–361. doi:10.1016/j.colsurfb.2016.05.01427214785
  • MalanaMA, ZafarZI, ZuhraR. Effect of cross linker concentration on swelling kinetics of a synthesized ternary co-polymer system. J Chem Soc Pak. 2012;34(4):793.
  • HameedM, RasulA, WaqasMK, et al. Formulation and evaluation of a clove oil-encapsulated nanofiber formulation for effective wound-healing. Molecules. 2021;26(9):2491. doi:10.3390/molecules2609249133923335
  • PawarPK, KataraR, MajumdarDK. Design and evaluation of moxifloxacin hydrochloride ocular insert. Acta Pharm. 2012;62(1):93–104. doi:10.2478/v10007-012-0002-522472452
  • PawarM. Preparation and in vitro/ex vivo evaluation of moxifloxacin-loaded PLGA nanosuspensions for ophthalmic application. Sci Pharm. 2013;81(2):591–606. doi:10.3797/scipharm.1204-1623833723
  • FuR, LiC, YuC, et al. A novel electrospun membrane based on moxifloxacin hydrochloride/poly (vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application. Drug Deliv. 2016;23(3):818–829. doi:10.3109/10717544.2014.91867624892630
  • DeyabM. Hydroxyethyl cellulose as efficient organic inhibitor of zinc–carbon battery corrosion in ammonium chloride solution: electrochemical and surface morphology studies. J Power Sources. 2015;280:190–194. doi:10.1016/j.jpowsour.2015.01.107
  • Silva‐CorreiaJ, OliveiraJM, CaridadeS, et al. Gellan gum‐based hydrogels for intervertebral disc tissue‐engineering applications. J Tissue Eng Regen Med. 2011;5(6):e97–e107. doi:10.1002/term.36321604382
  • LeeM-W, TsaiH-F, WenS-M, HuangC-H. Photocrosslinkable gellan gum film as an anti-adhesion barrier. Carbohydr Polym. 2012;90(2):1132–1138. doi:10.1016/j.carbpol.2012.06.06422840050
  • MohammedMJ, Al-BayatiFA. Isolation and identification of antibacterial compounds from Thymus kotschyanus aerial parts and Dianthus caryophyllus flower buds. Phytomedicine. 2009;16(6–7):632–637. doi:10.1016/j.phymed.2008.12.02619200700
  • PatelU, ChotaiN, NagdaC. Design and evaluation of polymeric ocular drug delivery system for controlled delivery of moxifloxacin hydrochloride: in vitro and in vivo evaluation. Acta Pharm Sci. 2010;52(4):523–535.
  • BelliniMZ, Oliva-NetoP, MoraesÂM. Properties of films obtained from biopolymers of different origins for skin lesions therapy. Braz Arch Biol Tech. 2015;58(2):289–299. doi:10.1590/S1516-8913201500305
  • ChaiwaritT, RuksiriwanichW, JantanasakulwongK, JantrawutP. Use of orange oil loaded pectin films as antibacterial material for food packaging. Polymers. 2018;10(10):1144. doi:10.3390/polym10101144
  • EedaraBB, RangnekarB, DoyleC, CavallaroA, DasSC. The influence of surface active l-leucine and 1, 2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) in the improvement of aerosolization of pyrazinamide and moxifloxacin co-spray dried powders. Int J Pharm. 2018;542(1–2):72–81. doi:10.1016/j.ijpharm.2018.03.00529524618
  • Al OmariMMH, JaafariDS, Al-Sou’odKA, BadwanAA. Chapter seven - moxifloxacin hydrochloride. In: BrittainHG, editor. Profiles of Drug Substances, Excipients and Related Methodology. Vol. 39. Academic Press; 2014:299–431.
  • NayakN, BharaniS, ThakurR. Formulation and evaluation of pH triggered in situ ophthalmic gel of Moxifloxacin hydrochloride. Int J Pharm PharmSci. 2012;4(2):452–459.
  • FernandesFP, FortesAC, da Cruz FonsecaSG, BreitkreutzJ, FerrazHG. Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide. Int J Polym Sci. 2018;2018. doi:10.1155/2018/2403802
  • GiramPS, ShitoleA, NandeSS, SharmaN, GarnaikB. Fast dissolving moxifloxacin hydrochloride antibiotic drug from electrospun eudragit L-100 nonwoven nanofibrous mats. Mater Sci Eng C. 2018;92:526–539. doi:10.1016/j.msec.2018.06.031
  • LiuQ, OuyangW-C, ZhouX-H, JinT, WuZ-W. Antibacterial activity and drug loading of moxifloxacin-loaded poly(vinyl alcohol)/chitosan electrospun nanofibers. Front Mater. 2021;8:36.
  • TahirMA, AliME, LamprechtA. Nanoparticle formulations as recrystallization inhibitors in transdermal patches. Int J Pharm. 2020;575:118886. doi:10.1016/j.ijpharm.2019.11888631790804
  • AlvesTF, RiosAC, da Silva PontesK, et al. Bilayer mucoadhesive buccal film for mucosal ulcers treatment: development, characterization, and single study case. Pharmaceutics. 2020;12(7):657. doi:10.3390/pharmaceutics12070657
  • ShiledarRR, TagalpallewarAA, KokareCR. Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydr Polym. 2014;101:1234–1242. doi:10.1016/j.carbpol.2013.10.07224299896
  • TrevisolTC, ScartazziniL, ValérioA, Guelli Ulson de SouzaSMA, BierhalzACK, ValleJAB. Diclofenac release from alginate/carboxymethyl cellulose mono and bilayer films for wound dressing applications. Cellulose. 2020;27(11):6629–6642. doi:10.1007/s10570-020-03217-3
  • AbruzzoA, NicolettaFP, DalenaF, CerchiaraT, LuppiB, BigucciF. Bilayered buccal films as child-appropriate dosage form for systemic administration of propranolol. Int J Pharm. 2017;531(1):257–265. doi:10.1016/j.ijpharm.2017.08.07028811117