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Review

Profile of epratuzumab and its potential in the treatment of systemic lupus erythematosus

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Pages 2303-2310 | Published online: 17 Nov 2014

References

  • Bootsma H Spronk P Derksen R Prevention of relapses in systemic lupus erythematosus Lancet 1995 345 8965 1595 1599 7783536
  • Tsokos GC Systemic lupus erythematosus N Engl J Med 2011 365 22 2110 2121 22129255
  • Rahman A Isenberg DA Systemic lupus erythematosus N Engl J Med 2008 358 9 929 939 18305268
  • Gatto M Zen M Ghirardello A Emerging and critical issues in the pathogenesis of lupus Autoimmun Rev 2013 12 4 523 536 23000207
  • Touma Z Gladman DD Tulloch-Reid D Burden of autoantibodies and association with disease activity and damage in systemic lupus erythematosus Clin Exp Rheumatol 2010 28 4 525 531 20659409
  • Chan O Shlomchik MJ A new role for B-cells in systemic autoimmunity: B-cells promote spontaneous T cell activation in MRL-lpr/lpr mice J Immunol 1998 160 1 51 59 9551955
  • Harris DP Haynes L Sayles PC Reciprocal regulation of polarized cytokine production by effector B and T cells Nat Immunol 2000 1 6 475 482 11101868
  • Touma Z Urowitz MB Gladman DD Systemic lupus erythematosus: an update on current pharmacotherapy and future directions Expert Opin Biol Ther 2013 13 5 723 737 23339281
  • Ding HJ Gordon C New biologic therapy for systemic lupus erythematosus Curr Opin Pharmacol 2013 13 3 405 512 23664092
  • Rovin BH Furie R Latinis K Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study Arthritis Rheum 2012 64 4 1215 1226 22231479
  • Merrill JT Neuwelt CM Wallace DJ Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial Arthritis Rheum 2010 62 1 222 233 20039413
  • Mysler EF Spindler AJ Guzman R Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double-blind, phase III study Arthritis Rheum 2013 65 9 2368 2379 23740801
  • Mok MY The immunological basis of B-cell therapy in systemic lupus erythematosus Int J Rheum Dis 2010 13 1 3 11 20374380
  • Traczewski P Rudnicka L Treatment of systemic lupus erythematosus with epratuzumab Br J Clin Pharmacol 2011 71 2 175 182 21219397
  • Leadbetter EA Rifkin IR Hohlbaum AM Beaudette BC Shlomchik MJ Marshak-Rothstein A Chromatin-IgG complexes activate B-cells by dual engagement of IgM and Toll-like receptors Nature 2002 416 6881 603 607 11948342
  • Fattah Z Isenberg DA Recent developments in the treatment of patients with systemic lupus erythematosus: focusing on biologic therapies Expert Opin Biol Ther 2014 14 3 311 326 24387632
  • Nitschke L The role of CD22 and other inhibitory co-receptors in B-cell activation Curr Opin Immunol 2005 17 3 290 297 15886119
  • Looney RJ Anolik J Sanz I A perspective on B-cell-targeting therapy for SLE Mod Rheumatol 2010 20 1 1 10 19669389
  • Dorner T Jacobi AM Lipsky PE B-cells in autoimmunity Arthritis Res Ther 2009 11 5 247 19849820
  • Ding C Foote S Jones G B-cell-targeted therapy for systemic lupus erythematosus: an update BioDrugs 2008 22 4 239 249 18611066
  • Tedder TF Tuscano J Sato S Kehrl JH CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling Annu Rev Immunol 1997 15 481 504 9143697
  • Otipoby KL Andersson KB Draves KE CD22 regulates thymus-independent responses and the lifespan of B-cells Nature 1996 384 6610 634 637 8967951
  • Dorner T Kaufmann J Wegener WA Teoh N Goldenberg DM Burmester GR Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus Arthritis Res Ther 2006 8 3 R74 16630358
  • Wallace DJ Goldenberg DM Epratuzumab for systemic lupus erythematosus Lupus 2013 22 4 400 405 23553783
  • Goldenberg DM Epratuzumab in the therapy of oncological and immunological diseases Expert Rev Anticancer Ther 2006 6 10 1341 1353 17069520
  • Dorner T Goldenberg DM Targeting CD22 as a strategy for treating systemic autoimmune diseases Ther Clin Risk Manag 2007 3 5 953 959 18473018
  • Edwards JC Cambridge G B-cell targeting in rheumatoid arthritis and other autoimmune diseases Nat Rev Immunol 2006 6 5 394 403 16622478
  • Rossi EA Goldenberg DM Michel R Rossi DL Wallace DJ Chang CH Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab Blood 2013 122 17 3020 3029 23821660
  • Jacobi AM Goldenberg DM Hiepe F Radbruch A Burmester GR Dorner T Differential effects of epratuzumab on peripheral blood B-cells of patients with systemic lupus erythematosus versus normal controls Ann Rheum Dis 2008 67 4 450 457 17673490
  • Carnahan J Wang P Kendall R Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties Clin Cancer Res 2003 9 10 Pt 2 3982S 3990S 14506197
  • Carnahan J Stein R Qu Z Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab Mol Immunol 2007 44 6 1331 1341 16814387
  • Beum PV Kennedy AD Williams ME Lindorfer MA Taylor RP The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes J Immunol 2006 176 4 2600 2609 16456022
  • Williams ME Densmore JJ Pawluczkowycz AW Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia J Immunol 2006 177 10 7435 7443 17082663
  • Wallace DJ Kalunian K Petri MA Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study Ann Rheum Dis 2014 73 1 183 190 23313811
  • Leonard JP Coleman M Ketas JC Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin’s lymphoma J Clin Oncol 2003 21 16 3051 3059 12837807
  • Steinfeld SD Tant L Burmester GR Epratuzumab (humanised anti-CD22 antibody) in primary Sjogren’s syndrome: an open-label phase I/II study Arthritis Res Ther 2006 8 4 R129 16859536
  • Strand V Petri M Kalunian K Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006 Rheumatology (Oxford) 2014 53 3 502 511 24273022
  • Wallace DJ Gordon C Strand V Efficacy and safety of epratuzumab in patients with moderate/severe flaring systemic lupus erythematosus: results from two randomized, double-blind, placebo-controlled, multicentre studies (ALLEVIATE) and follow-up Rheumatology (Oxford) 2013 52 7 1313 1322 23542611
  • Petri M Hobbs K Gordon C Randomized controlled trials (RCTS) of epratuzumab (anti-CD22 MAB targeting B-cells) reveal clinically meaningful improvements in patients (pts) with moderate/severe SLE flares Ann Rheum Dis 2008 67 Suppl II 53
  • Wallace D Hobbs K Houssiau F Randomized controlled trials of epratuzumab (anti-CD22 MAB targeting B-cells) reveal clinically meaningful reductions in corticosteroid use with favorable safety profile in moderate and severe flaring SLE patients Ann Rheum Dis 2008 67 Suppl II 212 17526555
  • Urowitz MB Gladman DD Tom BD Ibanez D Farewell VT Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus J Rheumatol 2008 35 11 2152 2158 18793004
  • Navarra SV Guzman RM Gallacher AE Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial Lancet 2011 377 9767 721 731 21296403
  • Davies RJ Sangle SR Jordan NP Rituximab in the treatment of resistant lupus nephritis: therapy failure in rapidly progressive crescentic lupus nephritis Lupus 2013 22 6 574 582 23632989
  • Lightstone L Minimising steroids in lupus nephritis – will B-cell depletion pave the way? Lupus 2013 22 4 390 399 23553782
  • Condon MB Ashby D Pepper RJ Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids Ann Rheum Dis 2013 72 8 1280 1286 23740227
  • Gunnarsson I Jonsdottir T Rituximab treatment in lupus nephritis – where do we stand? Lupus 2013 22 4 381 389 23553781
  • Moroni G Raffiotta F Trezzi B Rituximab vs mycophenolate and vs cyclophosphamide pulses for induction therapy of active lupus nephritis: a clinical observational study Rheumatology (Oxford) 2014 53 9 1570 1577 24505125
  • Rovin BH Targeting B-cells in lupus nephritis: should cautions optimism remain? Nephrol Dial Transplant 2014 28 1 7 9 22844105
  • Touma Z Gladman DD Urowitz MB Clinical measures, metrics and indices Wallace DJ Hahn BH Dubois’ Lupus Erythematosus 8th ed Lippincott Williams and Wilkins Saunders 2012
  • Strand V Gladman D Isenberg D Petri M Smolen J Tugwell P Outcome measures to be used in clinical trials in systemic lupus erythematosus J Rheumatol 1999 26 2 490 497 9972993
  • Touma Z Urowitz MB Gladman DD Outcome measures in systemic lupus erythematosus Indian Journal of Rheumatology 2013 8 Supp 1 S46 S53
  • Bombardier C Gladman DD Urowitz MB Caron D Chang CH Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE Arthritis Rheum 1992 35 6 630 640 1599520
  • Symmons DP Coppock JS Bacon PA Development and assessment of a computerized index of clinical disease activity in systemic lupus erythematosus. Members of the British Isles Lupus Assessment Group (BILAG) Q J Med 1988 69 259 927 937 3271336
  • Isenberg DA Rahman A Allen E BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group’s disease activity index for patients with systemic lupus erythematosus Rheumatology (Oxford) 2005 44 7 902 906 15814577
  • Gladman DD Ibanez D Urowitz MB Systemic lupus erythematosus disease activity index 2000 J Rheumatol 2002 29 2 288 291 11838846
  • Touma Z Urowitz MB Ibanez D Gladman DD SLEDAI-2K 10 days versus SLEDAI-2K 30 days in a longitudinal evaluation Lupus 2011 20 1 67 70 21233149
  • Touma Z Gladman DD Ibanez D Urowitz MB Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50 J Rheumatol 2011 38 2 275 284 21123323
  • Touma Z Urowitz MB Taghavi-Zadeh S Ibanez D Gladman DD Systemic lupus erythematosus disease activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months Rheumatology (Oxford) 2012 51 10 1814 1819 22718868
  • Touma Z Gladman DD Ibanez D Urowitz MB SLEDAI-2K Responder Index 50 captures 50% improvement in disease activity over 10 years Lupus 2012 21 12 1305 1311 22800940
  • Furie RA Petri MA Wallace DJ Novel evidence-based systemic lupus erythematosus responder index Arthritis Rheum 2009 61 9 1143 1151 19714615
  • Thanou A Chakravarty E James JA Merrill J Which outcome measures in SLE clinical trials best reflect medical judgment? Lupus Science and Medicine 2014 1 1 e000005 25396057
  • Petri M Pike MC Kelley L Kilgallen B Gordon C Systemic Lupus Erythematosus Responder Index Assessment of Responders in EMBLEM, a Phase IIb Study in Patients with Moderate to Severe Systemic Lupus Erythematosus Arthritis and Rheumatism 2011 63 Suppl 10 1378
  • Sridharan ST Zhou T Immermann F Lehmann M Masferrer JL Honczarenko M Low placebo responses and clinical components of the biomarkers of lupus disease (BOLD) study may provide useful insights for SLE clinical trial design Arthritis Rheumatol 2011 63 Suppl S543
  • Pike MC Kelley L Data quality challenges in systemic lupus erythematosus trials: how can this be optimized? Curr Rheumatol Rep 2012 14 4 324 333 22580894