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Original Research

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

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Pages 39-47 | Published online: 18 Dec 2013

References

  • Asuthkar S Rao JS Gondi CS Drugs in preclinical and early-stage clinical development for pancreatic cancer Expert Opin Investig Drugs 2012 21 143 152
  • The Editorial Board of the Cancer Statistics in Japan Cancer Statistics in Japan 2012 Tokyo, Japan Foundation for Promotion Cancer Research 2012
  • Hidalgo M Pancreatic cancer N Engl J Med 2010 362 1605 1617 20427809
  • Jemal A Bray F Center MM Ferlay J Ward E Forman D Global cancer statistics CA Cancer J Clin 2011 61 69 90 21296855
  • Lionetto R Pugliese V Bruzzi P Rosso R No standard treatment is available for advanced pancreatic cancer Eur J Cancer 1995 31 882 887 7646915
  • Philip PA Benedetti J Corless CL Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest oncology group-directed intergroup trial S0205 J Clin Oncol 2010 28 3605 3610 20606093
  • Arumugam T Ramachandran V Fournier KF Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer Cancer Res 2009 69 5820 5828 19584296
  • Qiu MT Ding XX Hu JW Tian HY Yin R Xu L Fixed-dose rate infusion and standard rate infusion of gemcitabine in patients with advanced non-small-cell lung cancer: a meta-analysis of six trials Cancer Chemother Pharmacol 2012 70 861 873 23053260
  • Conroy T Desseigne F Ychou M FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer N Engl J Med 2011 364 1817 1825 21561347
  • Von Hoff DD Ramanathan RK Borad MJ Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial J Clin Oncol 2011 29 4548 4554 21969517
  • Ko AH Venook AP Bergsland EK A Phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer Cancer Chemother Pharmacol 2010 66 1051 1057 20130876
  • Sakamoto H Kitano M Suetomi Y Maekawa K Takeyama Y Kudo M Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas Ultrasound Med Biol 2008 34 525 532 18045768
  • Feig C Gopinathan A Neesse A Chan DS Cook N Tuveson DA The pancreas cancer microenvironment Clin Cancer Res 2012 18 4266 4276 22896693
  • Izuishi K Kato K Ogura T Kinoshita T Esumi H Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy Cancer Res 2000 60 6201 6207 11085546
  • Awale S Lu J Kalauni SK Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation Cancer Res 2006 66 1751 1757 16452235
  • Awale S Nakashima EMN Kalauni SK Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation Bioorg Med Chem Lett 2006 16 581 583 16288865
  • Win NN Awale S Esumi H Tezuka Y Kadota S Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar Bioorg Med Chem Lett 2008 18 4688 4691 18640837
  • Win NN Awale S Esumi H Tezuka Y Kadota S Novel anticancer agents, kayeassamins C–I from the flower of Kayea assamica of Myanmar Bioorg Med Chem 2008 16 8653 8660 18725180
  • Win NN Awale S Esumi H Tezuka Y Kadota S Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium J Nat Prod 2007 70 1582 1587 17896818
  • Win NN Awale S Esumi H Tezuka Y Kadota S Panduratins D–I, novel secondary metabolites from rhizomes of Boesenbergia pandurata Chem Pharm Bull 2008 56 491 496 18379096
  • Awale S Linn TZ Than MM Swe T Saiki I Kadota S The healing art of traditional medicines in Myanmar J Trad Med 2006 23 47 68
  • Awale S Ueda J Athikomkulchai S Antiausterity agents from Uvaria dac and their preferential cytotoxic activity against human pancreatic cancer cell lines in a nutrient-deprived condition J Nat Prod 2012 75 1177 1183 22676269
  • Guertin DA Sabatini DM Defining the role of mTOR in cancer Cancer Cell 2007 12 9 22 17613433
  • Conroy T Gavoille C Samalin E Ychou M Ducreux M The role of the FOLFIRINOX regimen for advanced pancreatic cancer Curr Oncol Rep 2013 15 182 189 23341367
  • Saif MW Advancements in the management of pancreatic cancer: 2013 JOP 2013 14 112 118 23474549
  • Schönthal AH Endoplasmic reticulum stress and autophagy as targets for cancer therapy Cancer Lett 2009 275 163 169 18692955
  • Schönthal AH Gliomas: Aggravating endoplasmic reticulum stress by combined application of bortezomib and celexoib as a novel therapeutic strategy for glioblastoma Hayat MA Tumors of the Central Nervous System Dordrecht, The Netherlands Springer 2011 1
  • Yang ZJ Chee CE Huang S Sinicrope FA The role of autophagy in cancer: therapeutic implications Mol Cancer Ther 2011 10 1533 1541 21878654
  • Sato K Tsuchihara K Fujii S Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation Cancer Res 2007 67 9677 9684 17942897
  • Choi KS Autophagy and cancer Exp Mol Med 2012 44 109 120 22257886
  • Gozuacik D Kimchi A Autophagy as a cell death and tumor suppressor mechanism Oncogene 2004 23 2891 2906 15077152
  • Esumi H Lu J Kurashima Y Hanaoka T Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation Cancer Sci 2004 95 685 690 15298733
  • Lu J Kunimoto S Yamazaki Y Kaminishi M Esumi H Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells’ tolerance to nutrient starvation Cancer Sci 2004 95 547 552 15182438
  • Yardley DA Combining mTOR inhibitors with chemotherapy and other targeted therapies in advanced breast cancer: rationale, clinical experience, and future directions Breast Cancer Basic Res Treat 2013 7 7 22