Potential roles of GPR120 and its agonists in the management of diabetes

References

• Hu FB Globalization of diabetes: the role of diet, lifestyle, and genes Diabetes Care 2011 34 6 1249 1257 21617109
   PubMed Web of Science ®Google Scholar
• Beltran-Sanchez H Harhay MO Harhay MM McElligott S Prevalence and trends of metabolic syndrome in the adult US population, 1999–2010 J Am Coll Cardiol 2013 62 8 697 703 23810877
   PubMed Web of Science ®Google Scholar
• Oh DY Talukdar S Bae EJ GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 2010 142 5 687 698 20813258
   PubMed Web of Science ®Google Scholar
• Ichimura A Hirasawa A Poulain-Godefroy O Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human Nature 2012 483 7389 350 354 22343897
   PubMed Web of Science ®Google Scholar
• Matsuzaka T Shimano H Molecular mechanisms involved in hepatic steatosis and insulin resistance J Diabetes Investig 2011 2 3 170 175
   Web of Science ®Google Scholar
• Danforth EJr Failure of adipocyte differentiation causes type II diabetes mellitus? Nat Genet 2000 26 1 13 10973236
   PubMed Web of Science ®Google Scholar
• Yan Y Jiang W Spinetti T Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation Immunity 2013 38 6 1154 1163 23809162
   PubMed Web of Science ®Google Scholar
• Li X Yu Y Funk CD Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4) FASEB J 2013 27 12 4987 4997 24005906
   PubMed Web of Science ®Google Scholar
• Raptis DA Limani P Jang JH Gpr120 on Kupffer cells mediates hepatoprotective effects of omega3-fatty acids J Hepatol 2014 60 3 625 632 24262133
   PubMed Web of Science ®Google Scholar
• Li Y Zhang H Jiang C Hyperhomocysteinemia promotes insulin resistance by inducing endoplasmic reticulum stress in adipose tissue J Biol Chem 2013 288 14 9583 9592 23417716
   PubMed Web of Science ®Google Scholar
• Hirasawa A Tsumaya K Awaji T Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 2005 11 1 90 94 15619630
   PubMed Web of Science ®Google Scholar
• Tanaka T Katsuma S Adachi T Free fatty acids induce cholecystokinin secretion through GPR120 Naunyn Schmiedebergs Arch Pharmacol 2008 377 4–6 523 527 17972064
   PubMed Web of Science ®Google Scholar
• Tanaka T Yano T Adachi T Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells Naunyn Schmiedebergs Arch Pharmacol 2008 377 4–6 515 522 18320172
   PubMed Web of Science ®Google Scholar
• Shah BP Liu P Yu T Hansen DR Gilbertson TA TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1 Am J Physiol Cell Physiol 2012 302 1 C210 C219 21998136
   PubMed Web of Science ®Google Scholar
• Taneera J Lang S Sharma A A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets Cell Metab 2012 16 1 122 134 22768844
   PubMed Web of Science ®Google Scholar
• Kebede MA Alquier T Latour MG Poitout V Lipid receptors and islet function: therapeutic implications? Diabetes Obes Metab 2009 11 Suppl 4 10 20 19817784
   PubMed Web of Science ®Google Scholar
• Burns RN Moniri NH Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor Biochem Biophys Res Commun 2010 396 4 1030 1035 20471368
   PubMed Web of Science ®Google Scholar
• Watson SJ Brown AJ Holliday ND Differential signaling by splice variants of the human free fatty acid receptor GPR120 Mol Pharmacol 2012 81 5 631 642 22282525
   PubMed Web of Science ®Google Scholar
• Moore K Zhang Q Murgolo N Hosted T Duffy R Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants Comp Biochem Physiol B Biochem Mol Biol 2009 154 4 419 426 19723586
   PubMed Web of Science ®Google Scholar
• Shimpukade B Hudson BD Hovgaard CK Milligan G Ulven T Discovery of a potent and selective GPR120 agonist J Med Chem 2012 55 9 4511 4515 22519963
   PubMed Web of Science ®Google Scholar
• Holliday ND Watson SJ Brown AJ Drug discovery opportunities and challenges at g protein coupled receptors for long chain free fatty acids Front Endocrinol (Lausanne) 2012 2 112 22649399
   PubMedGoogle Scholar
• Suzuki T Igari S Hirasawa A Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists J Med Chem 2008 51 23 7640 7644 19007110
   PubMed Web of Science ®Google Scholar
• Sun Q Hirasawa A Hara T Structure-activity relationships of GPR120 agonists based on a docking simulation Mol Pharmacol 2010 78 5 804 810 20685848
   PubMed Web of Science ®Google Scholar
• Cen B Xiong Y Ma L Pei G Direct and differential interaction of beta-arrestins with the intracellular domains of different opioid receptors Mol Pharmacol 2001 59 4 758 764 11259620
   PubMed Web of Science ®Google Scholar
• Hudson BD Shimpukade B Mackenzie AE The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism Mol Pharmacol 2013 84 5 710 725 23979972
   PubMed Web of Science ®Google Scholar
• Parker HE Habib AM Rogers GJ Gribble FM Reimann F Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells Diabetologia 2009 52 2 289 298 19082577
   PubMed Web of Science ®Google Scholar
• Wu Q Wang H Zhao X Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma Oncogene 2013 32 49 5541 5550 23851494
   PubMed Web of Science ®Google Scholar
• Iakoubov R Izzo A Yeung A Whiteside CI Brubaker PL Protein kinase Czeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells Endocrinology 2007 148 3 1089 1098 17110421
   PubMed Web of Science ®Google Scholar
• Miyauchi S Hirasawa A Iga T Distribution and regulation of protein expression of the free fatty acid receptor GPR120 Naunyn Schmiedebergs Arch Pharmacol 2009 379 4 427 434 19145429
   PubMed Web of Science ®Google Scholar
• Janssen S Laermans J Iwakura H Tack J Depoortere I Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein PLoS One 2012 7 6 e40168 22768248
   PubMed Web of Science ®Google Scholar
• Lu X Zhao X Feng J Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice Am J Physiol Gastrointest Liver Physiol 2012 303 3 G367 G376 22678998
   PubMed Web of Science ®Google Scholar
• Gong Z Yoshimura M Aizawa S G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro Am J Physiol Endocrinol Metab 2014 306 1 E28 E35 24222669
   PubMed Web of Science ®Google Scholar
• Matsumura S Mizushige T Yoneda T GPR expression in the rat taste bud relating to fatty acid sensing Biomed Res 2007 28 1 49 55 17379957
   PubMed Web of Science ®Google Scholar
• Matsumura S Eguchi A Mizushige T Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice Neurosci Lett 2009 450 2 186 190 19071193
   PubMed Web of Science ®Google Scholar
• Cartoni C Yasumatsu K Ohkuri T Taste preference for fatty acids is mediated by GPR40 and GPR120 J Neurosci 2010 30 25 8376 8382 20573884
   PubMed Web of Science ®Google Scholar
• Martin C Passilly-Degrace P Chevrot M Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity J Lipid Res 2012 53 11 2256 2265 22904345
   PubMed Web of Science ®Google Scholar
• Ozdener MH Subramaniam S Sundaresan S CD36- and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice Gastroenterology 2014 146 4 995 1005 24412488
   PubMed Web of Science ®Google Scholar
• Galindo MM Voigt N Stein J G protein-coupled receptors in human fat taste perception Chem Senses 2012 37 2 123 139 21868624
   PubMed Web of Science ®Google Scholar
• Morgan NG Dhayal S G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell Biochem Pharmacol 2009 78 12 1419 1427 19660440
   PubMed Web of Science ®Google Scholar
• Gotoh C Hong YH Iga T The regulation of adipogenesis through GPR120 Biochem Biophys Res Commun 2007 354 2 591 597 17250804
   PubMed Web of Science ®Google Scholar
• Cornall LM Mathai ML Hryciw DH McAinch AJ Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner Cell Physiol Biochem 2011 28 5 949 958 22178946
   PubMedGoogle Scholar
• Katsuma S Hatae N Yano T Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1 J Biol Chem 2005 280 20 19507 19515 15774482
   PubMed Web of Science ®Google Scholar
• Hara T Hirasawa A Sun Q Novel selective ligands for free fatty acid receptors GPR120 and GPR40 Naunyn Schmiedebergs Arch Pharmacol 2009 380 3 247 255 19471906
   PubMed Web of Science ®Google Scholar
• Briscoe CP Peat AJ McKeown SC Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules Br J Pharmacol 2006 148 5 619 628 16702987
   PubMed Web of Science ®Google Scholar
• Roduit R Nolan C Alarcon C A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli Diabetes 2004 53 4 1007 1019 15047616
   PubMed Web of Science ®Google Scholar
• Horia E Watkins BA Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells Carcinogenesis 2007 28 4 809 815 17052999
   PubMed Web of Science ®Google Scholar
• Zapata-Gonzalez F Rueda F Petriz J Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids J Leukoc Biol 2008 84 4 1172 1182 18632990
   PubMed Web of Science ®Google Scholar
• Latour MG Alquier T Oseid E GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo Diabetes 2007 56 4 1087 1094 17395749
   PubMed Web of Science ®Google Scholar
• Zhang Y Xu M Zhang S The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1 J Mol Endocrinol 2007 38 6 651 661 17556534
   PubMed Web of Science ®Google Scholar
• Itoh Y Kawamata Y Harada M Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 2003 422 6928 173 176 12629551
   PubMed Web of Science ®Google Scholar
• Stoddart LA Brown AJ Milligan G Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5′-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist Mol Pharmacol 2007 71 4 994 1005 17200419
   PubMed Web of Science ®Google Scholar
• Williams RH Champagne J Effects of cholecystokinin, secretin, and pancreatic polypeptide on secretion of gastric inhibitory polypeptide, insulin, and glucagon Life Sci 1979 25 11 947 956 513942
   PubMed Web of Science ®Google Scholar
• Rossetti L Shulman GI Zawalich WS Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding Diabetes 1987 36 10 1212 1215 3308589
   PubMed Web of Science ®Google Scholar
• Fried M Schwizer W Beglinger C Physiological role of cholecystokinin on postprandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor antagonist loxiglumide Diabetologia 1991 34 10 721 726 1959704
   PubMed Web of Science ®Google Scholar
• Luo J Swaminath G Brown SP A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents PLoS One 2012 7 10 e46300 23056280
   PubMed Web of Science ®Google Scholar
• Woessmann W Mivechi NF Role of ERK activation in growth and erythroid differentiation of K562 cells Exp Cell Res 2001 264 2 193 200 11262176
   PubMed Web of Science ®Google Scholar
• Verheijen MH Wolthuis RM Defize LH den Hertog J Bos JL Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells Oncogene 1999 18 31 4435 4439 10442634
   PubMed Web of Science ®Google Scholar
• De Vita G Berlingieri MT Visconti R Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects Cancer Res 2000 60 14 3916 3920 10919669
   PubMed Web of Science ®Google Scholar
• Hardy S Langelier Y Prentki M Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects Cancer Res 2000 60 22 6353 6358 11103797
   PubMed Web of Science ®Google Scholar
• Soto-Guzman A Robledo T Lopez-Perez M Salazar EP Oleic acid induces ERK1/2 activation and AP-1 DNA binding activity through a mechanism involving Src kinase and EGFR transactivation in breast cancer cells Mol Cell Endocrinol 2008 294 1–2 81 91 18775472
   PubMed Web of Science ®Google Scholar
• Butler AE Janson J Bonner-Weir S Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 1 102 110 12502499
   PubMed Web of Science ®Google Scholar
• Thomas HE McKenzie MD Angstetra E Campbell PD Kay TW Beta cell apoptosis in diabetes Apoptosis 2009 14 12 1389 1404 19322660
   PubMed Web of Science ®Google Scholar
• Wrede CE Dickson LM Lingohr MK Briaud I Rhodes CJ Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1) J Biol Chem 2002 277 51 49676 49684 12393870
   PubMed Web of Science ®Google Scholar
• Wijesekara N Krishnamurthy M Bhattacharjee A Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion J Biol Chem 2010 285 44 33623 33631 20709750
   PubMed Web of Science ®Google Scholar
• Dezaki K Sone H Yada T Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis Pharmacol Ther 2008 118 2 239 249 18433874
   PubMed Web of Science ®Google Scholar
• Vatansever-Ozen S Tiryaki-Sonmez G Bugdayci G Ozen G The effects of exercise on food intake and hunger: relationship with acylated ghrelin and leptin J Sports Sci Med 2011 10 2 283 291 24149873
   PubMed Web of Science ®Google Scholar
• Levin F Edholm T Schmidt PT Ghrelin stimulates gastric emptying and hunger in normal-weight humans J Clin Endocrinol Metab 2006 91 9 3296 3302 16772353
   PubMed Web of Science ®Google Scholar
• Delhanty PJ van der Lely AJ Ghrelin and glucose homeostasis Peptides 2011 32 11 2309 2318 21396419
   PubMed Web of Science ®Google Scholar
• Dezaki K Sone H Koizumi M Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance Diabetes 2006 55 12 3486 3493 17130496
   PubMed Web of Science ®Google Scholar
• Mela DJ Sacchetti DA Sensory preferences for fats: relationships with diet and body composition Am J Clin Nutr 1991 53 4 908 915 2008871
   PubMed Web of Science ®Google Scholar
• Drewnowski A Brunzell JD Sande K Iverius PH Greenwood MR Sweet tooth reconsidered: taste responsiveness in human obesity Physiol Behav 1985 35 4 617 622 4070436
   PubMed Web of Science ®Google Scholar
• Cai H Cong WN Daimon CM Altered lipid and salt taste responsivity in ghrelin and GOAT null mice PLoS One 2013 8 10 e76553 24124572
   PubMed Web of Science ®Google Scholar
• Shin YK Martin B Golden E Modulation of taste sensitivity by GLP-1 signaling J Neurochem 2008 106 1 455 463 18397368
   PubMed Web of Science ®Google Scholar
• Stewart JE Feinle-Bisset C Golding M Oral sensitivity to fatty acids, food consumption and BMI in human subjects Br J Nutr 2010 104 1 145 152 20196892
   PubMed Web of Science ®Google Scholar
• Chen CS Bench EM Allerton TD Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue Am J Physiol Regul Integr Comp Physiol 2013 305 11 R1346 R1355 24154509
   PubMed Web of Science ®Google Scholar
• Godinot N Yasumatsu K Barcos ME Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice Neuroscience 2013 25020 25030
   Web of Science ®Google Scholar
• Martin C Passilly-Degrace P Gaillard D The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference PLoS One 2011 6 8 e24014 21901153
   PubMed Web of Science ®Google Scholar
• Liu D Wang L Meng Q Kuang H Liu X G-protein coupled receptor 120 is involved in glucose metabolism in fat cells Cell Mol Biol 2012 Suppl 58 OL1757 OL1762 23046868
   PubMedGoogle Scholar
• Auwerx J Cock TA Knouff C PPAR-gamma: a thrifty transcription factor Nucl Recept Signal 2003 1 e006 16604178
   PubMedGoogle Scholar
• Hoogeveen EK Kostense PJ Jakobs C Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study Circulation 2000 101 13 1506 1511 10747342
   PubMed Web of Science ®Google Scholar
• Martos R Valle M Morales R Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children Metabolism 2006 55 1 72 77 16324922
   PubMed Web of Science ®Google Scholar
• Golbahar J Aminzadeh MA Kassab SE Omrani GR Hyperhomocysteinemia induces insulin resistance in male Sprague-Dawley rats Diabetes Res Clin Pract 2007 76 1 1 5 16963146
   PubMed Web of Science ®Google Scholar
• Ozcan U Yilmaz E Ozcan L Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 2006 313 5790 1137 1140 16931765
   PubMed Web of Science ®Google Scholar
• Suetsugu H Iimuro Y Uehara T Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury Gut 2005 54 6 835 842 15888794
   PubMed Web of Science ®Google Scholar
• Giakoustidis DE Giakoustidis AE Iliadis S Attenuation of liver ischemia/reperfusion induced apoptosis by epigallocatechin-3-gallate via down-regulation of NF-kappaB and c-Jun expression J Surg Res 2010 159 2 720 728 19394642
   PubMed Web of Science ®Google Scholar
• Seki E Brenner DA Karin M A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches Gastroenterology 2012 143 2 307 320 22705006
   PubMed Web of Science ®Google Scholar
• Donath MY Schumann DM Faulenbach M Islet inflammation in type 2 diabetes: from metabolic stress to therapy Diabetes Care 2008 31 Suppl 2 S161 S164 18227479
   PubMed Web of Science ®Google Scholar
• Imai Y Dobrian AD Morris MA Nadler JL Islet inflammation: a unifying target for diabetes treatment? Trends Endocrinol Metab 2013 24 7 351 360 23484621
   PubMed Web of Science ®Google Scholar
• Waguri T Goda T Kasezawa N Yamakawa-Kobayashi K The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk Biomed Res 2013 34 2 69 74 23594480
   PubMed Web of Science ®Google Scholar
• McGarry JD Dobbins RL Fatty acids, lipotoxicity and insulin secretion Diabetologia 1999 42 2 128 138 10064091
   PubMed Web of Science ®Google Scholar
• Randle PJ Garland PB Hales CN Newsholme EA The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1963 1 7285 785 789 13990765
   PubMed Web of Science ®Google Scholar
• Cao H Gerhold K Mayers JR Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 2008 134 6 933 944 18805087
   PubMed Web of Science ®Google Scholar
• Kabayama K Sato T Kitamura F TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3 Glycobiology 2005 15 1 21 29 15306563
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS The role of TNFalpha and TNF receptors in obesity and insulin resistance J Intern Med 1999 245 6 621 625 10395191
   PubMed Web of Science ®Google Scholar
• Gorgens SW Eckardt K Elsen M Tennagels N Eckel J Chitinase-3-like protein 1 protects skeletal muscle from TNFalpha-induced inflammation and insulin resistance Biochem J 2014 459 3 479 488 24512683
   PubMed Web of Science ®Google Scholar
• Jager J Gremeaux T Cormont M Le Marchand-Brustel Y Tanti JF Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression Endocrinology 2007 148 1 241 251 17038556
   PubMed Web of Science ®Google Scholar
• Wen H Ting JP O’Neill LA A role for the NLRP3 inflammasome in metabolic diseases – did Warburg miss inflammation? Nat Immunol 2012 13 4 352 357 22430788
   PubMed Web of Science ®Google Scholar
• Wilkin TJ The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes Diabetologia 2001 44 7 914 922 11508279
   PubMed Web of Science ®Google Scholar
• Sherry NA Tsai EB Herold KC Natural history of beta-cell function in type 1 diabetes Diabetes 2005 54 Suppl 2 S32 S39 16306337
   PubMed Web of Science ®Google Scholar
• Greenbaum CJ Insulin resistance in type 1 diabetes Diabetes Metab Res Rev 2002 18 3 192 200 12112937
   PubMed Web of Science ®Google Scholar
• Buteau J Foisy S Joly E Prentki M Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 2003 52 1 124 132 12502502
   PubMed Web of Science ®Google Scholar
• Yusta B Baggio LL Estall JL GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress Cell Metab 2006 4 5 391 406 17084712
   PubMed Web of Science ®Google Scholar
• Lavine JA Raess PW Stapleton DS Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival Endocrinology 2010 151 8 3577 3588 20534724
   PubMed Web of Science ®Google Scholar
• Lavine JA Raess PW Davis DB Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function Mol Endocrinol 2008 22 12 2716 2728 18845673
   PubMedGoogle Scholar
• Kim SJ Winter K Nian C Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression J Biol Chem 2005 280 23 22297 22307 15817464
   PubMed Web of Science ®Google Scholar
• Whalley NM Pritchard LE Smith DM White A Processing of proglucagon to GLP-1 in pancreatic alpha-cells: is this a paracrine mechanism enabling GLP-1 to act on beta-cells? J Endocrinol 2011 211 1 99 106 21795304
   PubMed Web of Science ®Google Scholar
• Ashcroft FM Proks P Smith PA Stimulus-secretion coupling in pancreatic beta cells J Cell Biochem 1994 55 Suppl 54 65 7929618
   PubMed Web of Science ®Google Scholar
• Luan B Zhao J Wu H Deficiency of a beta- arrestin-2 signal complex contributes to insulin resistance Nature 2009 457 7233 1146 1149 19122674
   PubMed Web of Science ®Google Scholar
• Zhang M Zhu Y Mu K Loss of beta-arrestin2 mediates pancreatic-islet dysfunction in mice Biochem Biophys Res Commun 2013 435 3 345 349 23660189
   PubMed Web of Science ®Google Scholar
• Bellenger J Bellenger S Bataille A High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition Diabetes 2011 60 4 1090 1099 21330635
   PubMed Web of Science ®Google Scholar
• Ehses JA Perren A Eppler E Increased number of islet-associated macrophages in type 2 diabetes Diabetes 2007 56 9 2356 2370 17579207
   PubMed Web of Science ®Google Scholar
• Maedler K Sergeev P Ris F Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets J Clin Invest 2002 110 6 851 860 12235117
   PubMed Web of Science ®Google Scholar
• Parazzoli S Harmon JS Vallerie SN Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets J Biol Chem 2012 287 38 32246 32253 22822059
   PubMed Web of Science ®Google Scholar
• Tran PO Gleason CE Robertson RP Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function Diabetes 2002 51 6 1772 1778 12031964
   PubMed Web of Science ®Google Scholar