213
Views
51
CrossRef citations to date
0
Altmetric
Original Research

Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery

, , , , &
Pages 1107-1123 | Published online: 19 Aug 2014

References

  • Folkman J Angiogenesis in cancer, vascular, rheumatoid and other disease Nat Med 1995 1 1 27 31 7584949
  • Verheul HM Pinedo HM Inhibition of angiogenesis in cancer patients Expert Opin Emerg Drugs 2005 10 2 403 412 15934875
  • Pasquier E Kavallaris M Andre N Metronomic chemotherapy: new rationale for new directions Nat Rev Clin Oncol 2010 7 8 455 465 20531380
  • Faivre S Delbaldo C Vera K Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer J Clin Oncol 2006 24 1 25 35 16314617
  • Verheul HM Pinedo HM Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition Nat Rev Cancer 2007 7 6 475 485 17522716
  • Elice F Rodeghiero F Falanga A Rickles FR Thrombosis associated with angiogenesis inhibitors Best Pract Res Clin Haematol 2009 22 1 115 128 19285278
  • Rajotte D Arap W Hagedorn M Koivunen E Pasqualini R Ruoslahti E Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display J Clin Invest 1998 102 2 430 437 9664085
  • Staton CA Stribbling SM Tazzyman S Hughes R Brown NJ Lewis CE Current methods for assaying angiogenesis in vitro and in vivo Int J Exp Pathol 2004 85 5 233 248 15379956
  • Serbedzija GN Flynn E Willett CE Zebrafish angiogenesis: a new model for drug screening Angiogenesis 1999 3 4 353 359 14517415
  • Lyons MS Bell B Stainier D Peters KG Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases Dev Dyn 1998 212 1 133 140 9603430
  • Liang D Chang JR Chin AJ The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development Mech Dev 2001 108 1–2 29 43 11578859
  • Chan J Bayliss PE Wood JM Roberts TM Dissection of angiogenic signaling in zebrafish using a chemical genetic approach Cancer Cell 2002 1 3 257 267 12086862
  • Cross LM Cook MA Lin S Chen JN Rubinstein AL Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay Arterioscler Thromb Vasc Biol 2003 23 5 911 912 12740225
  • Kimmel CB Ballard WW Kimmel SR Ullmann B Schilling TF Stages of embryonic development of the zebrafish Dev Dyn 1995 203 3 253 310 8589427
  • Nicoli S Presta M The zebrafish/tumor xenograft angiogenesis assay Nat Protoc 2007 2 11 2918 2923 18007628
  • Nagel R DarT: The embryo test with the Zebrafish Danio rerio – a general model in ecotoxicology and toxocology ALTEX 2002 19 Supp 1 38 48 12096329
  • Gridelli C Bareschino MA Schettino C Rossi A Maione P Ciardiello F Erlotinib in non-small cell lung cancer treatment: current status and future development Oncologist 2007 12 7 840 849 17673615
  • Eskens FA de Jonge MJ Bhargava P Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1, -2, and -3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors Clin Cancer Res 2011 17 22 7156 7163 21976547
  • Pal SK Bergerot PG Figlin RA Tivozanib: current status and future directions in the treatment of solid tumors Expert Opin Investig Drugs 2012 21 12 1851 1859
  • Hu-Lowe DD Zou HY Grazzini ML Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3 Clin Cancer Res 2008 14 22 7272 7283 19010843
  • Morabito A Piccirillo MC Falasconi F Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions Oncologist 2009 14 4 378 390 19349511
  • Kumar R Knick VB Rudolph SK Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol Cancer Ther 2007 6 7 2012 2021 17620431
  • Polverino A Coxon A Starnes C AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts Cancer Res 2006 66 17 8715 8721 16951187
  • Ng SS Gütschow M Weiss M Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues Cancer Res 2003 63 12 3189 3194 12810647
  • Danesi R Del Bianchi S Soldani P Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane Br J Cancer 1993 68 5 932 938 7692920
  • Minischetti M Vacca A Ribatti D TNP-470 and recombinant human interferon-alpha2a inhibit angiogenesis synergistically Br J Haematol 2000 109 4 829 837 10929037
  • Davis DW Takamori R Raut CP Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668 Clin Cancer Res 2005 11 2 Pt 1 678 689 15701856
  • Kumar K Bhargava P Roy U In vitro refolding of triosephosphate isomerase from L. donovani Appl Biochem Biotechnol 2011 164 7 1207 1214 21365180
  • Wilhelm SM Dumas J Adnane L Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity Int J Cancer 2011 129 1 245 255 21170960
  • Kerr JS Wexler RS Mousa SA Novel small molecule alpha v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors Anticancer Res 1999 19 2A 959 968 10368639
  • Brüsselbach S Nettelbeck DM Sedlacek HH Müller R Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells Int J Cancer 1998 77 1 146 152 9639406
  • Melkonian G Munoz N Chung J Tong C Marr R Talbot P Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by cytochalasin D and suramin J Exp Zool 2002 292 3 241 254 11857458
  • Bauer KS Dixon SC Figg WD Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent Biochem Pharmacol 1998 55 11 1827 1834 9714301
  • Wilhelm SM Carter C Tang L BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis Cancer Res 2004 64 19 7099 7109 15466206
  • Pignochino Y Grignani G Cavalloni G Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways Mol Cancer 2009 8 118 20003259
  • Martinho O Silva-Oliveira R Miranda-Gonçalves V In vitro and in vivo analysis of RTK inhibitor efficacy and identification of its novel targets in glioblastomas Transl Oncol 2013 6 2 187 196 23544171
  • Newcomb EW Ali MA Schnee T Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy Neuro Oncol 2005 7 3 225 235 16053697
  • Hurwitz H Fehrenbacher L Novotny W Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N Engl J Med 2004 350 23 2335 2342 15175435
  • Ferrara N Hillan KJ Gerber HP Novotny W Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer Nat Rev Drug Discov 2004 3 5 391 400 15136787
  • Geberth M Foerster F Klare P Efficacy and safety of first-line bevacizumab (BEV) combined with paclitaxel (PAC) according to age: subpopulation analysis of a large, multicenter, non-interventional study in patients (Pts) with HER2-negative metastatic breast cancer (MBC) Cancer Res 2009 69 24 Suppl 3 6085
  • Tozer GM Kanthou C Baguley BC Disrupting tumour blood vessels Nat Rev Cancer 2005 5 6 423 435 15928673
  • Bilenker JH Flaherty KT Rosen M Phase I trial of combretastatin a-4 phosphate with carboplatin Clin Cancer Res 2005 11 4 1527 1533 15746056
  • Motzer RJ Hutson TE Tomczak P Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma J Clin Oncol 2009 27 22 3584 3590 19487381
  • Escudier B Eisen T Stadler WM Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial J Clin Oncol 2009 27 20 3312 3318 19451442
  • Bhargava P Robinson MO Development of second-generation VEGFR tyrosine kinase inhibitors: current status Curr Oncol Rep 2011 13 2 103 111 21318618
  • Auerbach R Auerbach W Polakowski I Assays for angiogenesis: a review Pharmacol Ther 1991 51 1 1 11 1722898
  • Norrby K Drug testing with angiogenesis models Expert Opin Drug Discov 2008 3 5 533 549 23484925
  • Norrby K In vivo models of angiogenesis J Cell Mol Med 2006 10 3 588 612 16989723
  • Busquet F Nagel R von Landenberg F Mueller SO Huebler N Broschard TH Development of a new screening assay to identify proteratogenic substances using zebrafish danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT) Toxicol Sci 2008 104 1 177 188 18375544
  • Mriouah J Boura C Thomassin M Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models Trends Biotechnol 2012 30 12 649 658 23021636
  • Chu TF Rupnick MA Kerkela R Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib Lancet 2007 370 9604 2011 2019 18083403
  • Senderowicz AM Small molecule modulators of cyclin-dependent kinases for cancer therapy Oncogene 2000 19 56 6600 6606 11426645
  • Eisenberger MA Sinibaldi VJ Reyno LM Phase I and clinical evaluation of a pharmacologically guided regimen of suramin in patients with hormone-refractory prostate cancer J Clin Oncol 1995 13 9 2174 2186 7666076
  • Ito T Ando H Suzuki T Identification of a primary target of thalidomide teratogenicity Science 2010 327 5971 1345 1350 20223979
  • Yoshikawa D Ojima H Kokubu A Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma Br J Cancer 2009 100 8 1257 1266 19319137
  • Motzer RJ Nosov D Eisen T Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial J Clin Oncol 2013 31 30 3791 3799 24019545
  • Scagliotti GV Vynnychenko I Park K International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1 J Clin Oncol 2012 30 23 2829 2836 22753922
  • Ingber D Fujita T Kishimoto S Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth Nature 1990 348 6301 555 557 1701033
  • Fong TAT Shawver LK Sun L SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types Cancer Res 1999 59 1 99 106 9892193
  • Kuenen BC Tabernero J Baselga J Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma Clin Cancer Res 2003 9 5 1648 1655 12738717
  • Rustin GJ Shreeves G Nathan PD A phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer Br J Cancer 2010 102 9 1355 1360 20389300
  • Nicoli S Ribatti D Cotelli F Presta M Mammalian tumor xenografts induce neovascularization in zebrafish embryos Cancer Res 2007 67 7 2927 2931 17409396
  • Lee SL Rouhi P Dahl Jensen L Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model Proc Natl Acad Sci U S A 2009 106 46 19485 19490 19887629