References
- Bacher S Schmitz ML The NF-kappaB pathway as a potential target for autoimmune disease therapy Curr Pharm Des 2004 10 23 2827 2837 15379671
- Grilli M Memo M Nuclear factor-kappaB/Rel proteins: a point of convergence of signalling pathways relevant in neuronal function and dysfunction Biochem Pharmacol 1999 57 1 1 7 9920279
- Roman-Blas JA Jimenez SA NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis Osteoarthritis Cartilage 2006 14 9 839 848 16730463
- Yamamoto Y Gaynor RB Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer J Clin Invest 2001 107 2 135 142 11160126
- Yan J Greer JM NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis CNS Neurol Disord Drug Targets 2008 7 6 536 557 19128210
- Brown GC Neher JJ Inflammatory neurodegeneration and mechanisms of microglial killing of neurons Mol Neurobiol 2010 41 2–3 242 247 20195798
- Tak PP Firestein GS NF-kappaB: a key role in inflammatory diseases J Clin Invest 2001 107 1 7 11 11134171
- Pande V Ramos MJ NF-kappaB in human disease: current inhibitors and prospects for de novo structure based design of inhibitors Curr Med Chem 2005 12 3 357 374 15723624
- Lleo A Galea E Sastre M Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases Cell Mol Life Sci 2007 64 11 1403 1418 17447008
- Rao NA McCalman MT Moulos P Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes Genome Res 2011 21 9 1404 1416 21750107
- Potter C Cordell HJ Barton A Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways Ann Rheum Dis 2010 69 7 1315 1320 20448286
- Fraser JH Rincon M McCoy KD Le Gros G CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells Eur J Immunol 1999 29 3 838 844 10092086
- Fan H Morand EF Targeting the side effects of steroid therapy in autoimmune diseases: the role of GILZ Discov Med 2012 13 69 123 133 22369971
- Cannarile L Zollo O D’Adamio F Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene Cell Death Differ 2001 8 2 201 203 11313722
- D’Adamio F Zollo O Moraca R A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death Immunity 1997 7 6 803 812 9430225
- Ayroldi E Zollo O Bastianelli A GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling J Clin Invest 2007 117 6 1605 1615 17492054
- Berrebi D Bruscoli S Cohen N Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10 Blood 2003 101 2 729 738 12393603
- Cannarile L Cuzzocrea S Santucci L Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis Gastroenterology 2009 136 2 530 541 18996377
- Cannarile L Fallarino F Agostini M Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines Blood 2006 107 3 1039 1047 16204313
- Di Marco B Massetti M Bruscoli S Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain Nucleic Acids Res 2007 35 2 517 528 17169985
- Ayroldi E Riccardi C Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action FASEB J 2009 23 11 3649 3658 19567371
- Riccardi C GILZ (glucocorticoid-induced leucine zipper), a mediator of the anti-inflammatory and immunosuppressive activity of glucocorticoids Ann Ig 2010 22 1 Suppl 1 53 59 20701225
- Ayroldi E Migliorati G Bruscoli S Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB Blood 2001 98 3 743 753 11468175
- Ball LJ Kuhne R Schneider-Mergener J Oschkinat H Recognition of proline-rich motifs by protein-protein-interaction domains Angew Chem Int Ed Engl 2005 44 19 2852 2869 15880548
- Ravi Chandra B Gowthaman R Raj Akhouri R Gupta D Sharma A Distribution of proline-rich (PxxP) motifs in distinct proteomes: functional and therapeutic implications for malaria and tuberculosis Protein Eng Des Sel 2004 17 2 175 182 15047914
- Srinivasan M Dunker AK Proline rich motifs as drug targets in immune mediated disorders Int J Pept 2012 2012 634769 22666276
- Srinivasan M Janardhanam S Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis J Biol Chem 2011 286 52 44799 44810 21965677
- Srinivasan M Wardrop RM Gienapp IE Stuckman SS Whitacre CC Kaumaya PT A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro J Immunol 2001 167 1 578 585 11418697
- Wang MH Frishman LJ Otteson DC Intracellular delivery of proteins into mouse Muller glia cells in vitro and in vivo using Pep-1 transfection reagent J Neurosci Methods 2009 177 2 403 419 19056421
- Klegeris A Walker DG McGeer PL Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells J Neuroimmunol 1997 78 1–2 152 161 9307240
- Lee M Suk K Kang Y McGeer E McGeer PL Neurotoxic factors released by stimulated human monocytes and THP-1 cells Brain Res 2011 1400 99 111 21640980
- Harrison LM Cherla RP van den Hoogen C Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells Microb Pathog 2005 38 2–3 63 76 15748808
- Sharif O Bolshakov VN Raines S Newham P Perkins ND Transcriptional profiling of the LPS induced NF-kappaB response in macrophages BMC Immunol 2007 8 1 17222336
- Mertlikova-Kaiserova H Votruba I Matousova M Holy A Hajek M Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells Anticancer Res 2010 30 7 2791 2798 20683014
- Cen O Gorska MM Stafford SJ Sur S Alam R Identification of UNC119 as a novel activator of SRC-type tyrosine kinases J Biol Chem 2003 278 10 8837 8845 12496276
- Srinivasan M Gienapp IE Stuckman SS Suppression of experimental autoimmune encephalomyelitis using peptide mimics of CD28 J Immunol 2002 169 4 2180 2188 12165548
- Klegeris A Walker DG McGeer PL Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs) Neuropharmacology 1999 38 7 1017 1025 10428420
- Srinivasan M Janardhanam S Novel p65 binding glucocorticoid-induced leucine zipper peptide suppresses experimental autoimmune encephalomyelitis J Biol Chem 2011 286 52 44799 44810 21965677
- Srinivasan R Rose GD A physical basis for protein secondary structure Proc Natl Acad Sci U S A 1999 96 25 14258 14263 10588693
- Cubellis MV Caillez F Blundell TL Lovell SC Properties of polyproline II, a secondary structure element implicated in protein-protein interactions Proteins 2005 58 4 880 892 15657931
- Freund C Schmalz HG Sticht J Kühne R Proline-rich sequence recognition domain (PRD): ligands, function and inhibition Klussmann E Scott J Protein-Protein Interactions as New Drug Targets Heidelberg, Berlin, Germany Springer-Verlag 2008
- Gu W Helms V Dynamical binding of proline-rich peptides to their recognition domains Biochim Biophys Acta 2005 1754 1–2 232 238 16203190
- Zarrinpar A Bhattacharyya RP Lim WA The structure and function of proline recognition domains Sci STKE 2003 2003 179 RE8 12709533
- Eguchi M Kahn M Design, synthesis, and application of peptide secondary structure mimetics Mini Rev Med Chem 2002 2 5 447 462 12370046
- Srinivasan M Roeske RW Immunomodulatory peptides from IgSF proteins: a review Curr Protein Pept Sci 2005 6 2 185 196 15853654
- Cochran AG Antagonists of protein-protein interactions Chem Biol 2000 7 4 R85 R94 10779412
- Unal EB Gursoy A Erman B Conformational energies and entropies of peptides, and the peptide-protein binding problem Phys Biol 2009 6 3 036014 19549999
- Groner B Peptides as Drugs: Discovery and Development Weinheim, Germany Wiley-VCH Verlag GmbH & Co KGaA 2009
- Guan QH Pei DS Zong YY Xu TL Zhang GY Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways Neuroscience 2006 139 2 609 627 16504411
- Mason JM Design and development of peptides and peptide mimetics as antagonists for therapeutic intervention Future Med Chem 2010 2 12 1813 1822 21428804
- Kurzawa L Pellerano M Morris MC PEP and CADY-mediated delivery of fluorescent peptides and proteins into living cells Biochim Biophys Acta 2010 1798 12 2274 2285 20188697
- Bailey JA Lahiri DK A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer’s disease J Neurochem 2010 112 4 843 853 19912467
- Bisht S Khan MA Bekhit M A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation Lab Invest 2011 91 9 1383 1395 21691262
- Ray B Bisht S Maitra A Maitra A Lahiri DK Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer’s disease J Alzheimers Dis 2011 23 1 61 77 20930270
- Zhang YH Mann D Raymick J Sarkar S Paule MG Lahiri DK Dumas M Bell-Cohen A Schmued LC K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice Curr Alzheimer Res 2014 11 3 299 308 24552157
- Hinkerohe D Smikalla D Schoebel A Dexamethasone prevents LPS-induced microglial activation and astroglial impairment in an experimental bacterial meningitis co-culture model Brain Res 2010 1329 45 54 20230803
- Figuera-Losada M Rojas C Slusher BS Inhibition of microglia activation as a phenotypic assay in early drug discovery J Biomol Screen 2014 19 1 17 31 23945875
- Srinivasan M Lu D Eri R CD80 binding polyproline helical peptide inhibits T cell activation J Biol Chem 2005 280 11 10149 10155 15598660
- Srinivasan M Srihari J Glucocorticoid induced leucine zipper mimic inhibits experimental autoimmune encephalomyelitis J Immunol 2012 188 Meeting Abstract Supplement Abstract 119.7
- Ray B Lahiri DK Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin Curr Opin Pharmacol 2009 9 4 434 444 19656726