77
Views
4
CrossRef citations to date
0
Altmetric
Review

Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

, , , , , , , , , , , , & show all
Pages 689-700 | Published online: 03 Jun 2014

References

  • Giannoglou GD Chatzizisis YS Zamlis C Parcharidis GE Mikhailidis DP Louridas GE Elevated heart rate and atherosclerosis. An overview of the pathogenetic mechanisms Int J Cardiol 2008 126 3 302 312 18068835
  • Scicchitano P Carbonara S Ricci G HCN channels and heart rate Molecules 2012 17 4 4225 4235 22481543
  • Colin P Ghaleh B Monnet X Contributions of heart rate and contractility to myocardial oxygen balance during exercise Am J Physiol Heart Circ Physiol 2003 284 2 H676 H682 12399255
  • Parakh N Bhargara B Rate control with Ivabradine Am J Cardiovasc Drugs 2011 11 1 1 12 21090826
  • Thollon C Villaine JP If inhibition in cardiovascular diseases Adv Pharmacol 2010 59 53 92 20933199
  • Tardif JC Clinical results of If current inhibitor by ivabradine Drugs 2007 67 Suppl 2 S35 S41
  • Riccioni G Vitulano N D’Orazio N Ivabradine: beyond heart rate control Adv Ther 2009 26 1 12 24 19165437
  • Menown IB Ivabradine: a new strategy for management of stable angina Br J Hosp Med 2007 68 6 21 25
  • Thollon C Bidouard JP Cambarrat C Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+) -S 16257 Eur J Pharmacol 1997 339 1 43 51 9450615
  • Ragueneau I Laveille C Jochemsen R Resplandy G Funck-Brentano C Jaillon P Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers Clin Pharmacol Ther 1998 64 2 192 203 9728900
  • Thollon C Cambarrat C Vian J Prost JF Peglion JL Vilaine JP Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49 Br J Pharmacol 1994 112 1 37 42 8032660
  • Bois P Bescond J Renaudon B Lenfant J Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells Br J Pharmacol 1996 118 4 1051 1057 8799581
  • Bucchi A Baruscotti M DiFrancesco D Current-dependent block of rabbit sino-atrial node If channels by ivabradine J Gen Physiol 2002 120 1 1 13 12084770
  • Savelieva I Camm AJ If inhibition with ivabradine: electrophysiological effects and safety Drug Saf 2008 31 2 95 107 18217787
  • Rosa GM Ferrero S Ghione P Valbusa A Brunelli C An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure Expert Opin Drug Metab Toxicol 2014 10 2 279 291 24377458
  • DiFrancesco D Camm JA Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease Drugs 2004 64 16 1757 1765 15301560
  • Borer JS Fox K Jaillon P Lerebours G Ivabradine Investigators Group Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial Circulation 2003 107 6 817 823 12591750
  • Tardif JC Ford I Tendera M Bourassa MG Fox K INITIATIVE Investigators Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina Eur Heart J 2005 26 23 2529 2536 16214830
  • Camm AJ How does pure heart rate lowering impact on cardiac tolerability? Eur Heart J Suppl 2006 8 Suppl D D9 D15
  • Murat SN Orcan S Akdemir R Dogan M Kara E Balci M Arrhythmic effects of ivabradine in patients with coronary artery disease Clin Invest Med 2009 32 5 E322 E326 19796572
  • Scott AE Kruszewski K Leslie SJ Sinus node If channel inhibition – a new therapeutic approach to heart rate lowering Curr Drug Therapy 2009 4 1 12 18
  • Swedberg K Komajda M Bohm M SHIFT Investigators Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study Lancet 2010 376 9744 875 885 20801500
  • Custodis F Baumhäkel M Schlimmer N Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice Circulation 2008 117 18 2377 2387 18443241
  • Dominguez-Rodriguez A Blanco-Palacios G Abreu-Gonzales P Increased heart rate and atherosclerosis: potential implications of ivabradine therapy World J Cardiol 2011 3 4 101 104 21526046
  • Fox K Ford I Steg PG Tendera M Ferrari R BEAUTIFUL Investigators Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial Lancet 2008 372 9641 807 816 18757088
  • Fox K Ford I Steg PG Tendera M Robertson M Ferrari R BEAUTIFUL investigators Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial Lancet 2008 372 9641 817 821 18757091
  • Bruguera Cortada J Varela A Role of heart rate in cardiovascular diseases: how the results of the BEAUTIFUL study change clinical practice Am J Cardiovasc Drugs 2009 9 Suppl 9 12 20000882
  • Fox K Ford I Steg PG Tendera M Robertson M Ferrari R BEAUTIFUL Investigators Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial Eur Heart J 2009 30 19 2337 2345 19720635
  • Tendera M Talajic M Robertson M BEAUTIFUL Investigators Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy) Am J Cardiol 2011 107 6 805 811 21247517
  • Ferrari R A step further with ivabradine: SIGNIfY (Study assessInG the morbidity–mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease) Eur Heart J 2009 11 Suppl D 19 27
  • Lucats L Ghaleh B Colin P Monnet X Bizé A Berdeaux A Heart rate reduction by inhibition of If or by beta-blockade has different effects on postsystolic wall thickening Br J Pharmacol 2007 150 3 335 341 17179940
  • Tardif JC Ponikowski P Kahan T ASSOCIATE Investigators Effects of ivabradine in patients with stable angina receiving beta-blockers according to baseline heart rate: an analysis of the ASSOCIATE study Int J Cardiol 2013 168 2 789 794 23138014
  • Köster R Kaehler J Meinertz T REDUCTION Study Group Treatment of stable angina pectoris by ivabradine in every day practice: the REDUCTION study Am Heart J 2009 158 4 51 57
  • Heusch G Skyschally A Gres P van Caster P Schilawa D Schulz R Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction Eur Heart J 2008 29 18 2265 2275 18621770
  • Beere PA Glagov S Zarins CK Retarding effect of lowered heart rate on coronary atherosclerosis Science 1984 226 4671 180 182 6484569
  • Prosi M Perktold K Ding Z Friedman MH Influence of curvature dynamics on pulsatile coronary artery flow in a realistic bifurcation model J Biomech 2004 37 11 1767 1775 15388320
  • Drouin A Gendron ME Thorin E Gillis MA Mahlberg-Gaudin F Tardif JC Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice Br J Pharmacol 2008 154 4 749 757 18414390
  • Rogowski O Shapira I Shirom A Melamed S Toker S Berliner S Heart rate and microinflammation in men: a relevant atherothrombotic link Heart 2007 93 8 940 944 17237129
  • Monnet X Ghaleh B Colin P de Curzon OP Giudicelli JF Berdeaux A Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning J Pharmacol Exp Ther 2001 299 3 1133 1139 11714904
  • Monnet X Colin P Ghaleh B Hittinger L Giudicelli JF Berdeaux A Heart rate reduction during exercise-induced myocardial ischaemia and stunning Eur Heart J 2004 25 7 579 586 15120055
  • Lucats L Ghaleh B Monnet X Colin P Bizé A Berdeaux A Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunning Eur Heart J 2007 28 7 872 879 17376788
  • Pagidipati NJ Gaziano TA Estimating deaths from cardiovascular disease: a review of global methodologies of mortality measurement Circulation 2013 127 6 749 756 23401116
  • Heusch G Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents Br J Pharmacol 2008 153 8 1589 1601 18223669
  • Custodis F Schirmer SH Baumhäkel M Heusch G Böhm M Laufs U Vascular pathophysiology in response to increased heart rate J Am Coll Cardiol 2010 56 24 1973 1983 21126638
  • Skalidis EI Hamilos MI Chlouverakis G Zacharis EA Vardas PE Ivabradine improves coronary flow reserve in patients with stable coronary artery disease Atherosclerosis 2011 215 1 160 165 21183181
  • Zuanetti G Mantini L Hernández-Bernal F Relevance of heart rate as a prognostic factor in patients with acute myocardial infarction: insights from the GISSI-2 study Eur Heart J 1998 19 Suppl F F19 F26 9651731
  • Riccioni G Ivabradine: an intelligent drug for the treatment of ischemic heart disease Molecules 2012 17 11 13592 13604 23159921
  • Riccioni G Ivabradine: the hope for a good treatment of ischemic heart disease Curr Med Chem 2013 20 4 1817 1823 23394554
  • Mulder P Barbier S Chagraoui A Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure Circulation 2004 109 13 1674 1679 14981003
  • Fasullo S Cannizzaro S Maringhini G Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings J Card Fail 2009 15 10 856 863 19944362
  • Riccioni G Ivabradine: from molecular basis to clinical effectiveness Adv Ther 2010 27 3 160 167 20419486
  • Rozanski A Qureshi E Bauman M Reed G Pillar G Diamond GA Peripheral Arterial Responses to treadmill exercise among healthy subjects and atherosclerotic patients Circulation 2001 103 2084 2089 11319199
  • Böhm M Reil JC Perspectives of I(f) inhibition by ivabradine in cardiology Drugs 2007 67 Suppl 2 43 49 17999563
  • Simon L Ghaleh B Puybasset L Giudicelli JF Berdeaux A Coronary and hemodynamic effects of S16257, a new bradycardic agent, in resting and exercising conscious dogs J Pharmacol Exp Ther 1995 275 2 659 666 7473152
  • Linka AZ Sklenar J Wei K Jayaweera AR Skyba DM Kaul S Assessment of transmural distribution of myocardial perfusion with contrast echocardiography Circulation 1998 98 18 1912 1920 9799213
  • Van Camp G Ay T Pasquet A Quantification of myocardial blood flow and assessment of its transmural distribution with real-time power modulation myocardial contrast echocardiography J Am Soc Echocardiogr 2003 16 3 263 270 12618735
  • Schulz R Heusch G The relationship between regional blood flow and contractile function in normal, ischemic, and reperfused myocardium Basic Res Cardiol 1998 93 6 455 462 9879451
  • Decking UK Schrader J Spatial heterogeneity of myocardial perfusion and metabolism Basic Res Cardiol 1998 93 6 439 445 9879449
  • Hsu LY Groves DW Aletras AH Kellman P Arai AE A fully quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans JACC Cardiovasc Imaging 2012 5 2 154 166 22340821
  • Fox K Garcia MA Ardissino D Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology ESC Committee for Practice Guidelines (CPG) Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology Eur Heart J 2006 27 11 1341 1381 16735367
  • Canet E Lerebours G Vilaine JP Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine Ann N Y Acad Sci 2011 1222 90 99 21434947
  • Fox K Ford I Steg PG Tardif JC Tendera M Ferrari R Rationale, design, and baseline characteristics of the Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial): a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease without clinical heart failure Am Heart J 2013 166 4 654 661.e6 24093844
  • Tardif JC Ponikowski P Kahan T ASSOCIATE Study Investigators Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial Eur Heart J 2009 30 5 540 548 19136486
  • Amosova E Andrejev E Zaderey I Rudenko U Ceconi C Ferrari R Efficacy of ivabradine in combination with Beta-blocker versus uptitration of Beta-blocker in patients with stable angina Cardiovasc Drugs Ther 2011 25 6 531 537 21830063
  • Ruzyllo W Tendera M Ford I Fox KM Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial Drugs 2007 67 3 393 405 17335297
  • Marquis-Gravel G Tardif JC Ivabradine: the evidence of its therapeutic impact in angina Core Evid 2008 3 1 1 12 20694080
  • Vaillant F Timour Q Descotes J Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study J Cardiovasc Pharmacol 2008 52 6 548 554 19034029
  • Vaillant F Dehina L Mazzadi A Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: role of myocyte structure and myocardial perfusion Resuscitation 2011 82 8 1092 1019 21561702
  • Vaillant F Dehina L Dizerens N Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status Resuscitation 2013 84 3 384 390 22940600
  • Heusch G A BEAUTIFUL lesson – ivabradine protects from ischaemia, but not from heart failure: through heart rate reduction or more? Eur Heart J 2009 30 19 2300 2301 19720636
  • Dickstein K Cohen-Solal A Filippatos G ESC Committee for Practice Guidelines (CPG) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) Eur J Heart Fail 2008 10 10 933 989 18826876
  • Heusch G Heart rate and heart failure. Not a simple relationship Circ J 2011 75 2 229 236 21041970
  • McAlister FA Wiebe N Ezekowitz JA Leung AA Armstrong PW Meta-analysis: beta-blockers dose, heart rate reduction, and death in patients with heart failure Ann Intern Med 2009 150 784 794 19487713
  • Doughty RN Whalley GA Walsh HA Gamble GD López-Sendón J Sharpe N CAPRICORN Echo Substudy Investigators Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: the CAPRICORN Echo Substudy Circulation 2004 109 2 201 206 14707020
  • Ferrari R Perindopril and Remodeling in Elderly with Acute Myocardial Infarction Investigators Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study Arch Intern Med 2006 166 6 59 66
  • Remme WJ Riegger G Hildebrandt P The benefits of early combination treatment of carvedilol and an ACE-inhibitor in mild heart failure and left ventricular systolic dysfunction The carvedilol and ACE-inhibitor remodelling mild heart failure evaluation trial (CARMEN) 2004 18 1 57 66
  • Flannery G Gehrig-Mills R Billah B Krum H Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers Am J Cardiol 2008 101 6 865 869 18328855
  • Ekman I Chassany O Komajda M Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study Eur Heart J 2011 32 19 2395 2404 21875859
  • Teerlink JR Ivabradine in heart failure – no paradigm SHIFT … yet Lancet 2010 376 9744 847 849 20801501
  • Fang Y Debunne M Vercauteren M Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia J Cardiovasc Pharmacol 2012 59 3 260 267 22075752
  • Reil JC Reil GH Böhm M Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction Trends Cardiovasc Med 2009 19 5 152 157 20005474
  • Setakis E Kassianos G Cockle S Adverse events and subsequent changes in beta-blocker treatment in coronary heart disease patients in UK primary care Eur Heart J 2009 30 974 Suppl 1 Abstract P5476
  • Couvreur N Tissier R Pons S Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression Eur Heart J 2010 31 12 1529 1537 20028694
  • Ceconi C Freedman SB Tardif JC BEAUTIFUL Echo-BNP Investigators Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL Int J Cardiol 2011 14 408 414 21112101
  • Troughton RW Richards AM Yandle TG Frampton CM Nicholls MG The effects of medications on circulating levels of cardiac natriuretic peptides Ann Med 2007 39 4 242 260 17558597
  • Difrancesco D Funny channel gene mutations associated with arrhythmias J Physiol 2013 591 17 4117 4124 23507880
  • Benezet-Mazuecos J Rubio JM Farré J Quiñones MÁ Sanchez-Borque P Macía E Long-term outcomes of ivabradine in inappropriate sinus tachycardia patients: appropriate efficacy or inappropriate patients Pacing Clin Electrophysiol 2013 36 7 830 836 23510001
  • Kuwabara Y Kuwahara K Takano M Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts J Am Heart Assoc 2013 2 3 e000150 23709563
  • Suenari K Cheng CC Chen YC Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis J Cardiovasc Electrophysiol 2012 23 2 200 206 21914029
  • Plotnikov AN Bucchi A Shlapakova I HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade Heart Rhythm 2008 5 2 282 288 18242555
  • Tamura A Ogura T Uemura H Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current J Pharmacol Sci 2009 110 2 150 159 19498275
  • Fan X Chen Y Wu P Novel electropharmacological activity of amiodarone on human HCN channels heterologously expressed in the Xenopus oocytes Eur J Pharmacol 2011 669 1–3 15 23 21839071