Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

References

• Xanthoudakis S Curran T Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity EMBO J 1992 11 2 653 665 1537340
   PubMed Web of Science ®Google Scholar
• Robson CN Hickson ID Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants Nucleic Acids Res 1991 19 20 5519 5523 1719477
   PubMed Web of Science ®Google Scholar
• Demple B Herman T Chen DS Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes Proc Natl Acad Sci U S A 1991 88 24 11450 11454 1722334
   PubMed Web of Science ®Google Scholar
• Helleday T Petermann E Lundin C Hodgson B Sharma RA DNA repair pathways as targets for cancer therapy Nat Rev Cancer 2008 8 3 193 204 18256616
   PubMed Web of Science ®Google Scholar
• Xanthoudakis S Curran T Redox regulation of AP-1: a link between transcription factor signaling and DNA repair Adv Exp Med Biol 1996 387 69 75 8794196
   PubMedGoogle Scholar
• Tell G Damante G Caldwell D Kelley MR The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 2005 7 3–4 367 384 15706084
   PubMed Web of Science ®Google Scholar
• Li Y Li S Wu Z Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population Med Oncol 2013 30 2 505 23430444
   PubMed Web of Science ®Google Scholar
• Cun Y Dai N Xiong C Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model PLoS One 2013 8 2 e55313 23418439
   PubMed Web of Science ®Google Scholar
• Wu HH Chu YC Wang L Cytoplasmic Ape1 expression elevated by p53 aberration may predict survival and relapse in resected non-small cell lung cancer Ann Surg Oncol 2013 20 Suppl 3 S336 S347 22688662
   PubMed Web of Science ®Google Scholar
• Sheng Q Zhang Y Wang R Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer Med Oncol 2012 29 2 1265 1271 21479902
   PubMed Web of Science ®Google Scholar
• Kim JS Kim JM Liang ZL Prognostic significance of human apurinic/apyrimidinic endonuclease (APE/Ref-1) expression in rectal cancer treated with preoperative radiochemotherapy Int J Radiat Oncol Biol Phys 2012 82 1 130 137 21075552
   PubMed Web of Science ®Google Scholar
• Qing Y Yang XQ Zhong ZY Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays BMC Cancer 2010 10 71 20184742
   PubMed Web of Science ®Google Scholar
• Wang D Luo M Kelley MR Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition Mol Cancer Ther 2004 3 6 679 686 15210853
   PubMed Web of Science ®Google Scholar
• Al-Attar A Gossage L Fareed KR Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers Br J Cancer 2010 102 4 704 709 20087352
   PubMed Web of Science ®Google Scholar
• Xie JY Li MX Xiang DB Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma Clin Lymphoma Myeloma Leuk 2010 10 5 385 393 21030352
   PubMed Web of Science ®Google Scholar
• Kelley MR Cheng L Foster R Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer Clin Cancer Res 2001 7 4 824 830 11309329
   PubMed Web of Science ®Google Scholar
• Robertson KA Bullock HA Xu Y Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation Cancer Res 2001 61 5 2220 2225 11280790
   PubMed Web of Science ®Google Scholar
• Luo M He H Kelley MR Georgiadis MM Redox regulation of DNA repair: implications for human health and cancer therapeutic development Antioxid Redox Signal 2010 12 11 1247 1269 19764832
   PubMed Web of Science ®Google Scholar
• Luo M Delaplane S Jiang A Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1 Antioxid Redox Signal 2008 10 11 1853 1867 18627350
   PubMed Web of Science ®Google Scholar
• Xie K Wei D Huang S Transcriptional anti-angiogenesis therapy of human pancreatic cancer Cytokine Growth Factor Rev 2006 17 3 147 156 16516532
   PubMed Web of Science ®Google Scholar
• Li M Wilson DM Human apurinic/apyrimidinic endonuclease 1 Antioxid Redox Signal 2014 20 4 678 707 23834463
   PubMed Web of Science ®Google Scholar
• Kelley MR Georgiadis MM Fishel ML APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1 Curr Mol Pharmacol 2012 5 1 36 53 22122463
   PubMedGoogle Scholar
• Al-Safi RI Odde S Shabaik Y Neamati N Small-molecule inhibitors of APE1 DNA repair function: an overview Curr Mol Pharmacol 2012 5 1 14 35 22122462
   PubMedGoogle Scholar
• Yang S Irani K Heffron SE Jurnak F Meyskens FL Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor Mol Cancer Ther 2005 4 12 1923 1935 16373707
   PubMed Web of Science ®Google Scholar
• Shimizu N Sugimoto K Tang J High-performance affinity beads for identifying drug receptors Nat Biotechnol 2000 18 8 877 881 10932159
   PubMed Web of Science ®Google Scholar
• Kelley MR Luo M Reed A Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1 Antioxid Redox Signal 2011 14 8 1387 1401 20874257
   PubMed Web of Science ®Google Scholar
• Nyland RL Luo M Kelley MR Borch RF Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1) J Med Chem 2010 53 3 1200 1210 20067291
   PubMed Web of Science ®Google Scholar
• Lin YC Chitcharoenthum M Rikihisa Y Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats Contraception 1987 36 5 581 592 3447817
   PubMed Web of Science ®Google Scholar
• Le Blanc M Russo J Kudelka AP Smith JA An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines Pharmacol Res 2002 46 6 551 555 12457630
   PubMed Web of Science ®Google Scholar
• Band V Hoffer AP Band H Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines Gynecol Oncol 1989 32 3 273 277 2920946
   PubMed Web of Science ®Google Scholar
• Tuszynski GP Cossu G Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines Cancer Res 1984 44 2 768 771 6581864
   PubMed Web of Science ®Google Scholar
• Dodou K Anderson RJ Small DA Groundwater PW Investigations on gossypol: past and present developments Expert Opin Investig Drugs 2005 14 11 1419 1434
   PubMed Web of Science ®Google Scholar
• Kitada S Leone M Sareth S Zhai D Reed JC Pellecchia M Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins J Med Chem 2003 46 20 4259 4264 13678404
   PubMed Web of Science ®Google Scholar
• Zhao J Gao F Zhang Y Wei K Liu Y Deng X Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity J Biol Chem 2008 283 15 9925 9932 18263880
   PubMed Web of Science ®Google Scholar
• Li M Vascotto C Xu S Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1 Free Radic Biol Med 2012 53 2 237 248 22580151
   PubMed Web of Science ®Google Scholar
• Li MX Wang D Zhong ZY Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress Free Radic Biol Med 2008 45 5 592 601 18515104
   PubMed Web of Science ®Google Scholar
• Wilson DM Takeshita M Demple B A basic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sites Nucleic Acids Res 1997 25 5 933 939 9023101
   PubMed Web of Science ®Google Scholar
• Swann MJ Peel LL Carrington S Freeman NJ Dual-polarization interferometry: an analytical technique to measure changes in protein structure in real time, to determine the stoichiometry of binding events, and to differentiate between specific and nonspecific interactions Anal Biochem 2004 329 2 190 198 15158477
   PubMed Web of Science ®Google Scholar
• Karim K Taylor JD Cullen DC Swann MJ Freeman NJ Measurement of conformational changes in the structure of transglutaminase on binding calcium ions using optical evanescent dual polarisation interferometry Anal Chem 2007 79 8 3023 3031 17367112
   PubMed Web of Science ®Google Scholar
• Chen DS Herman T Demple B Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA Nucleic Acids Res 1991 19 21 5907 5914 1719484
   PubMed Web of Science ®Google Scholar
• Tell G Quadrifoglio F Tiribelli C Kelley MR The many functions of APE1/Ref-1: not only a DNA repair enzyme Antioxid Redox Signal 2009 11 3 601 620 18976116
   PubMed Web of Science ®Google Scholar
• Vascotto C Bisetto E Li M Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function Mol Biol Cell 2011 22 20 3887 3901 21865600
   PubMed Web of Science ®Google Scholar
• Hu F Mah K Teramura DJ Gossypol effects on cultured normal and malignant melanocytes In Vitro Cell Dev Biol 1986 22 10 583 588 3771439
   PubMed Web of Science ®Google Scholar
• Yeow WS Baras A Chua A Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand J Thorac Cardiovasc Surg 2006 132 6 1356 1362 17140955
   PubMed Web of Science ®Google Scholar
• Van Poznak C Seidman AD Reidenberg MM Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial Breast Cancer Res Treat 2001 66 3 239 248 11510695
   PubMed Web of Science ®Google Scholar
• Parsons JL Dianova II Dianov GL APE1 is the major 3′-phosphoglycolate activity in human cell extracts Nucleic Acids Res 2004 32 12 3531 3536 15247342
   PubMed Web of Science ®Google Scholar
• Vascotto C Cesaratto L Zeef LA Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells Proteomics 2009 9 4 1058 1074 19180539
   PubMed Web of Science ®Google Scholar
• Huang YW Wang LS Chang HL Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells Anticancer Res 2006 26 3A 1925 1933 16827126
   PubMed Web of Science ®Google Scholar
• Volate SR Kawasaki BT Hurt EM Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells Mol Cancer Ther 2010 9 2 461 470 20124455
   PubMed Web of Science ®Google Scholar
• Sung B Ravindran J Prasad S Pandey MK Aggarwal BB Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL J Biol Chem 2010 285 46 35418 35427 20837473
   PubMed Web of Science ®Google Scholar
• Wang Y Lonard DM Yu Y Chow DC Palzkill TG O’Malley BW Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1 Mol Endocrinol 2011 25 12 2041 2053 22053001
   PubMedGoogle Scholar
• Carrero P Okamoto K Coumailleau P O’Brien S Tanaka H Poellinger L Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1 alpha Mol Cell Biol 2000 20 1 402 415 10594042
   PubMed Web of Science ®Google Scholar