66
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

, , , , , , , , & show all
Pages 1613-1619 | Published online: 26 Sep 2014

References

  • Riddler SA Haubrich R DiRienzo AG Class-sparing regimens for initial treatment of HIV-1 infection N Engl J Med 2008 358 20 2095 2106 18480202
  • Thompson MA Aberg JA Hoy JF Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society – USA panel JAMA 2012 308 4 387 402 22820792
  • Palella FJJr Delaney KM Moorman AC Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators N Engl J Med 1998 338 13 853 860 9516219
  • Pauwels R New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections Curr Opin Pharmacol 2004 4 5 437 446 15351347
  • Arastéh K Rieger A Yeni P Short-term randomized proof-of-principle trial of TMC278 in patients with HIV type-1 who have previously failed antiretroviral therapy Antivir Ther 2009 14 5 713 722 19704175
  • Shubber Z Calmy A Andrieux-Meyer I Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis AIDS 2013 27 9 1403 1412 23343913
  • Hammer SM Eron JJJr Reiss P Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society – USA panel JAMA 2008 300 5 555 570 18677028
  • Carr A Cooper DA Adverse effects of antiretroviral therapy Lancet 2000 356 9239 1423 1430 11052597
  • Garvey L Winston A Rilpivirine: a novel non-nucleoside reverse transcriptase inhibitor Expert Opin Investig Drugs 2009 18 7 1035 1041
  • Scholler-Gyure M Kakuda TN Raoof A De Smedt G Hoetelmans RM Clinical pharmacokinetics and pharmacodynamics of etravirine Clin Pharmacokinet 2009 48 9 561 574 19725591
  • Bacheler LT Anton ED Kudish P Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy Antimicrob Agents Chemother 2000 44 9 2475 2484 10952598
  • Kainos Medicine Inc Single Ascending Dose (SAD)/Multiple Ascending Dose (MAD) Safety/Pharmacokinetic (PK) Study of KM-023 [ClinicalTrials.gov identifier NCT01348516]
  • Smith PF DiCenzo R Morse GD Clinical pharmacokinetics of non-nucleoside reverse transcriptase inhibitors Clin Pharmacokinet 2001 40 12 893 905 11735608
  • Adkins JC Noble S Efavirenz Drugs 1998 56 6 1055 1064 9878993
  • Cheeseman SH Hattox SE McLaughlin MM Pharmacokinetics of nevirapine: initial single-rising-dose study in humans Antimicrob Agents Chemother 1993 37 2 178 182 8452345
  • Ludden TM Nonlinear pharmacokinetics: clinical Implications Clinical pharmacokinetics 1991 20 6 429 446 2044328