84
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

, , , , , , , , , , , & show all
Pages 1929-1939 | Published online: 16 Oct 2014

References

  • Gomes CM Protein misfolding in disease and small molecule therapies Curr Top Med Chem 2012 12 22 2460 2469 23339300
  • MacDonald M The Huntington’s Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes Cell 1993 72 6 971 983 8458085
  • Orr HT Chung MY Banfi S Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1 Nat Genet 1993 4 3 221 226 8358429
  • Pulst SM Nechiporuk A Nechiporuk T Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2 Nat Genet 1996 14 3 269 276 8896555
  • Kawaguchi Y Okamoto T Taniwaki M CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1 Nat Genet 1994 8 3 221 228 7874163
  • Zhuchenko O Bailey J Bonnen P Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α 1A-voltage-dependent calcium channel Nat Genet 1997 15 1 62 69 8988170
  • David G Abbas N Stevanin G Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion Nat Genet 1997 17 1 65 70 9288099
  • Moseley ML Zu T Ikeda Y Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8 Nat Genet 2006 38 7 758 769 16804541
  • Koide R Kobayashi S Shimohata T A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? Hum Mol Genet 1999 8 11 2047 2053 10484774
  • Denny RA Gavrin LK Saiah E Recent developments in targeting protein misfolding diseases Bioorg Med Chem Lett 2013 23 7 1935 1944 23454013
  • Gostout B Liu Q Sommer SS “Cryptic” repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic: analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (TBP) genes Am J Hum Genet 1993 52 6 1182 1190 8503450
  • Nakamura K Jeong SY Uchihara T SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein Hum Mol Genet 2001 10 14 1441 1448 11448935
  • Fujigasaki H Martin JJ De Deyn PP CAG repeat expansion in the TATA box-binding protein gene causes autosomal dominant cerebellar ataxia Brain 2001 124 Pt 10 1939 1947 11571212
  • Silveira I Miranda C Guimarães L Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus Arch Neurol 2002 59 4 623 629 11939898
  • Wu YR Lin HY Chen CM Genetic testing in spinocerebellar ataxia in Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated with typical Parkinson’s disease Clin Genet 2004 65 3 209 214 14756671
  • Wu YR Fung HC Lee-Chen GJ Analysis of polyglutamine-coding repeats in the TATA-binding protein in different neurodegenerative diseases J Neural Transm 2005 112 4 539 546 15365789
  • Chen CM Lane HY Wu YR Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia Schizophr Res 2005 78 2–3 131 136 16054804
  • Lin IS Wu RM Lee-Chen GJ Shan DE Gwinn-Hardy K The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairment Parkinsonism Relat Disord 2007 13 4 246 249 16793320
  • Hartl FU Hayer-Hartl M Molecular chaperones in the cytosol: from nascent chain to folded protein Science 2002 295 5561 1852 1858 11884745
  • Welch WJ Gething M-J Clarke AR Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells Philos Trans R Soc Lond B Biol Sci 1993 339 1289 327 333 8098537
  • Jäättelä M Heat shock proteins as cellular lifeguards Ann Med 1999 31 4 261 271 10480757
  • Daugaard M Rohde M Jäättelä M The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions FEBS Lett 2007 581 19 3702 3710 17544402
  • Warrick JM Chan HY Gray-Board GL Chai Y Paulson HL Bonini NM Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 Nat Genet 1999 23 4 425 428 10581028
  • Iijima-Ando K Wu P Drier EA Iijima K Yin JC cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila Proc Natl Acad Sci U S A 2005 102 29 10261 10266 16009936
  • Cummings CJ Sun Y Opal P Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice Hum Mol Genet 2001 10 14 1511 1518 11448943
  • Ahmad A Biersack B Li Y Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy Anticancer Agents Med Chem 2013 13 7 1002 1013 23272910
  • Biersack B Schobert R Indole compounds against breast cancer: recent developments Curr Drug Targets 2012 13 14 1705 1719 23140282
  • Janreddy D Kavala V Bosco JWJ Kuo CW Yao CF An easy access to carbazolones and 2,3-disubstituted indoles Eur J Org Chem 2011 12 12 2360 2365
  • Chang KH Chen WL Lee LC Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3 Evid Based Complement Alternat Med 2013 2013 471659 23533486
  • Lee LC Chen CM Wang HC Role of the CCAAT-binding protein NFY in SCA17 pathogenesis PLoS ONE 2012 7 4 e35302 22530004
  • Furuya S Makino A Hirabayashi Y An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting Brain Res Brain Res Protoc 1998 3 2 192 198 9813321
  • Gimenez-Cassina A Lim F Diaz-Nido J Gene transfer into Purkinje cells using herpesviral amplicon vectors in cerebellar cultures Neurochem Int 2007 50 1 181 188 16989924
  • Tanaka M Yanagawa Y Hirashima N Transfer of small interfering RNA by single-cell electroporation in cerebellar cell cultures J Neurosci Methods 2009 178 1 80 86 19114056
  • Chang YC Lin CY Hsu CM Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17 J Neurochem 2011 118 2 288 303 21554323
  • Birgbauer E Rao TS Webb M Lysolecithin induces demyelination in vitro in a cerebellar slice culture system J Neurosci Res 2004 78 2 157 166 15378614
  • Lee CH Yao CF Huang SM Novel 2-step synthetic indole compound 1,1,3-tri(3-indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models Cancer 2008 113 4 815 825 18618576
  • Ishihara K Yamagishi N Hatayama T Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs Eur J Biochem 2004 271 22 4552 4558 15560796
  • Yamanaka K Takahashi N Ooie T Kaneda K Yoshimatsu H Saikawa T Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart J Mol Cell Cardiol 2003 35 7 785 794 12818569
  • Sidell N Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro J Natl Cancer Inst 1982 68 4 589 596 7040765
  • Cheung YT Lau WK Yu MS Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research Neurotoxicology 2009 30 1 127 135 19056420
  • Aggarwal BB Ichikawa H Molecular targets and anticancer potential of indole-3-carbinol and its derivatives Cell Cycle 2005 4 9 1201 1215 16082211
  • Rogan EG The natural chemopreventive compound indole-3-carbinol: state of the science In Vivo 2006 20 2 221 228 16634522
  • Chai Y Koppenhafer SL Bonini NM Paulson HL Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease J Neurosci 1999 19 23 10338 10347 10575031
  • Lee LC Chen CM Chen FL Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis Clin Chim Acta 2009 400 1–2 56 62 19014922
  • Chen CM Lee LC Soong BW SCA17 repeat expansion: mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications Clin Chim Acta 2010 411 5–6 375 380 20004653
  • Fujimoto M Takaki E Hayashi T Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models J Biol Chem 2005 280 41 34908 34916 16051598
  • Fujikake N Nagai Y Popiel HA Okamoto Y Yamaguchi M Toda T Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones J Biol Chem 2008 283 38 26188 26197 18632670
  • Choi Y Kim Y Park S Lee KW Park T Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice J Nutr Biochem 2012 23 12 1732 1739 22569347
  • Wu TY Saw CL Khor TO Pung D Boyanapalli SS Kong AN In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways Mol Carcinog 2012 51 10 761 770 21837756
  • Crotti A Benner C Kerman BE Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors Nat Neurosci 2014 17 4 513 521 24584051
  • Johri A Beal MF Antioxidants in Huntington’s disease Biochim Biophys Acta 2012 1822 5 664 674 22138129
  • Humphrey GR Kuethe JT Practical methodologies for the synthesis of indoles Chem Rev 2006 106 7 2875 2911 16836303
  • Cacchi S Fabrizi G Update 1 of: Synthesis and functionalization of indoles through palladium-catalyzed reactions Chem Rev 2011 111 5 PR215 PR283 21557620