Leptin signaling molecular actions and drug target in hepatocellular carcinoma

References

• WHO World Health Organization Fact Sheet for World Wide Prevalence of Obesity 2006 Available from: http://www.who.int/mediacentre/factsheets/fs311/en/ Accessed November 3, 2014
   Google Scholar
• James WP International association for the study of obesity and China Obes Rev 2008 9 suppl 1 2 3 18307691
   PubMed Web of Science ®Google Scholar
• Bibiloni MD Pons A Tur JA Prevalence of overweight and obesity in adolescents: a systematic review ISRN Obes 2013 2013 392747 24555142
   PubMedGoogle Scholar
• De Pergola G Silvestris F Obesity as a major risk factor for cancer J Obes 2013 2013 291546 24073332
   PubMedGoogle Scholar
• Baskin ML Ard J Franklin F Allison DB Prevalence of obesity in the United States Obes Rev 2005 6 5 7 15655032
   PubMed Web of Science ®Google Scholar
• Ogden CL Carroll MD Curtin LR McDowell MA Tabak CJ Flegal KM Prevalence of overweight and obesity in the United States, 1999–2004 JAMA 2006 295 1549 1555 16595758
   PubMed Web of Science ®Google Scholar
• Huxley R Mendis S Zheleznyakov E Reddy S Chan J Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk – a review of the literature Eur J Clin Nutr 2010 64 16 22 19654593
   PubMed Web of Science ®Google Scholar
• Cote AT Harris KC Panagiotopoulos C Sandor GG Devlin AM Childhood obesity and cardiovascular dysfunction J Am Coll Cardiol 2013 62 1309 1319 23954339
   PubMed Web of Science ®Google Scholar
• Kramer H Dugas L Shoham D Obesity as an effect modifier of the risk of death in chronic kidney disease Nephrol Dial Transplant 2013 28 suppl 4 iv65 iv72 24068779
   PubMed Web of Science ®Google Scholar
• de Vries AP Ruggenenti P Ruan XZ ERA-EDTA Working Group Diabesity Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease Lancet Diabetes Endocrinol 2014 2 417 426 24795255
   PubMed Web of Science ®Google Scholar
• Hall ME do Carmo JM da Silva AA Juncos LA Wang Z Hall JE Obesity, hypertension, and chronic kidney disease Int J Nephrol Renovasc Dis 2014 7 75 88 24600241
   PubMedGoogle Scholar
• Franssen R Monajemi H Stroes ES Kastelein JJ Obesity and dyslipidemia Endocrinol Metab Clin North Am 2008 37 623 633 viii 18775355
   PubMed Web of Science ®Google Scholar
• Kotsis V Stabouli S Papakatsika S Rizos Z Parati G Mechanisms of obesity-induced hypertension Hypertens Res 2010 33 386 393 20442753
   PubMed Web of Science ®Google Scholar
• DeMarco VG Aroor AR Sowers JR The pathophysiology of hypertension in patients with obesity Nat Rev Endocrinol 2014 10 364 376 24732974
   PubMed Web of Science ®Google Scholar
• Cohen JC Horton JD Hobbs HH Human fatty liver disease: old questions and new insights Science 2011 332 1519 1523 21700865
   PubMed Web of Science ®Google Scholar
• Hui E Xu A Bo Yang H Lam KS Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: role of adipokines J Diabetes Investig 2013 4 413 425
   PubMed Web of Science ®Google Scholar
• Jung UJ Choi MS Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease Int J Mol Sci 2014 15 6184 6223 24733068
   PubMed Web of Science ®Google Scholar
• Travers ME McCarthy MI Type 2 diabetes and obesity: genomics and the clinic Hum Genet 2011 130 41 58 21647602
   PubMed Web of Science ®Google Scholar
• Basen-Engquist K Chang M Obesity and cancer risk: recent review and evidence Curr Oncol Rep 2011 13 71 76 21080117
   PubMed Web of Science ®Google Scholar
• Paz-Filho G Lim EL Wong ML Licinio J Associations between adipokines and obesity-related cancer Front Biosci 2011 16 1634 1650
   PubMed Web of Science ®Google Scholar
• Lashinger LM Ford NA Hursting SD Interacting inflammatory and growth factor signals underlie the obesity-cancer link J Nutr 2014 144 109 113 24285690
   PubMed Web of Science ®Google Scholar
• Teucher B Rohrmann S Kaaks R Obesity: focus on all-cause mortality and cancer Maturitas 2010 65 112 116 20022719
   PubMed Web of Science ®Google Scholar
• Wolin KY Carson K Colditz GA Obesity and cancer Oncologist 2010 15 556 565 20507889
   PubMed Web of Science ®Google Scholar
• Han G Zhao W Wang L Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression Brain Res 2014 1543 1 8 24161825
   PubMed Web of Science ®Google Scholar
• Colditz GA Wolin KY Gehlert S Applying what we know to accelerate cancer prevention Sci Transl Med 2012 4 127rv4
   PubMed Web of Science ®Google Scholar
• Prieto-Hontoria PL Perez-Matute P Fernandez-Galilea M Bustos M Martinez JA Moreno-Aliaga MJ Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach Biochim Biophys Acta 2011 1807 664 678 21111705
   PubMed Web of Science ®Google Scholar
• Zhang Y Bellows CF Kolonin MG Adipose tissue-derived progenitor cells and cancer World J Stem Cells 2010 2 103 113 21607127
   PubMedGoogle Scholar
• Kwaan HC McMahon B The role of plasminogen-plasmin system in cancer Cancer Treat Res 2009 148 43 66 19377918
   PubMedGoogle Scholar
• Khan S Shukla S Sinha S Meeran SM Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets Cytokine Growth Factor Rev 2013 24 6 503 513 24210902
   PubMed Web of Science ®Google Scholar
• Riondino S Roselli M Palmirotta R Della-Morte D Ferroni P Guadagni F Obesity and colorectal cancer: role of adipokines in tumor initiation and progression World J Gastroenterol 2014 20 5177 5190 24833848
   PubMed Web of Science ®Google Scholar
• Rogers CJ Prabhu KS Vijay-Kumar M The microbiome and obesity-an established risk for certain types of cancer Cancer J 2014 20 176 180 24855004
   PubMed Web of Science ®Google Scholar
• von Scholten BJ Andresen EN Sorensen TI Jess T Aetiological factors behind adipose tissue inflammation: an unexplored research area Public Health Nutr 2013 16 27 35 22464010
   PubMed Web of Science ®Google Scholar
• Russell WR Duncan SH Flint HJ The gut microbial metabolome: modulation of cancer risk in obese individuals Proc Nutr Soc 2013 72 178 188 23174203
   PubMed Web of Science ®Google Scholar
• Zhang Y Proenca R Maffei M Barone M Leopold L Friedman JM Positional cloning of the mouse obese gene and its human homologue Nature 1994 372 425 432 7984236
   PubMed Web of Science ®Google Scholar
• Renehan AG Tyson M Egger M Heller RF Zwahlen M Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 2008 371 569 578 18280327
   PubMed Web of Science ®Google Scholar
• Polesel J Zucchetto A Montella M The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma Ann Oncol 2009 20 353 357 18723550
   PubMed Web of Science ®Google Scholar
• Calle EE Rodriguez C Walker-Thurmond K Thun MJ Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 2003 348 1625 1638 12711737
   PubMed Web of Science ®Google Scholar
• Bianchini F Kaaks R Vainio H Overweight, obesity, and cancer risk Lancet Oncol 2002 3 565 574 12217794
   PubMed Web of Science ®Google Scholar
• Larsson SC Wolk A Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies Br J Cancer 2007 97 1005 1008 17700568
   PubMed Web of Science ®Google Scholar
• Sadik NA Ahmed A Ahmed S The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients Hum Exp Toxicol 2012 31 311 321 22249387
   PubMed Web of Science ®Google Scholar
• Wang YY Lin SY Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis Horm Res 2003 60 185 190 14530607
   PubMedGoogle Scholar
• Garofalo C Surmacz E Leptin and cancer J Cell Physiol 2006 207 12 22 16110483
   PubMed Web of Science ®Google Scholar
• Jarde T Perrier S Vasson MP Caldefie-Chezet F Molecular mechanisms of leptin and adiponectin in breast cancer Eur J Cancer 2011 47 33 43 20889333
   PubMed Web of Science ®Google Scholar
• Ray A Cleary MP Leptin as a potential therapeutic target for breast cancer prevention and treatment Expert Opin Ther Targets 2010 14 443 451 20230196
   PubMed Web of Science ®Google Scholar
• Ribeiro R Lopes C Medeiros R Leptin and prostate: implications for cancer prevention – overview of genetics and molecular interactions Eur J Cancer Prev 2004 13 359 368 15452447
   PubMed Web of Science ®Google Scholar
• Wang SN Lee KT Ker CG Leptin in hepatocellular carcinoma World J Gastroenterol 2010 16 5801 5809 21155000
   PubMed Web of Science ®Google Scholar
• Guo S Liu M Wang G Torroella-Kouri M Gonzalez-Perez RR Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells Biochim Biophys Acta 2012 1825 207 222 22289780
   PubMed Web of Science ®Google Scholar
• Farooqi IS Jebb SA Langmack G Effects of recombinant leptin therapy in a child with congenital leptin deficiency N Engl J Med 1999 341 879 884 10486419
   PubMed Web of Science ®Google Scholar
• Halaas JL Gajiwala KS Maffei M Weight-reducing effects of the plasma protein encoded by the obese gene Science 1995 269 543 546 7624777
   PubMed Web of Science ®Google Scholar
• Leinninger GM Location, location, location: the CNS sites of leptin action dictate its regulation of homeostatic and hedonic pathways Int J Obes (Lond) 2009 33 suppl 2 S14 S17 19528973
   PubMed Web of Science ®Google Scholar
• Myers MGJr Munzberg H Leinninger GM Leshan RL The geometry of leptin action in the brain: more complicated than a simple ARC Cell Metab 2009 9 117 123 19187770
   PubMed Web of Science ®Google Scholar
• Robertson SA Leinninger GM Myers MGJr Molecular and neural mediators of leptin action Physiol Behav 2008 94 637 642 18501391
   PubMed Web of Science ®Google Scholar
• Ashwin PJ Dilipbhai PJ Leptin and the cardiovascular system: a review Recent Pat Cardiovasc Drug Discov 2007 2 100 109 18221108
   PubMedGoogle Scholar
• Imagawa K Numata Y Katsuura G Structure-function studies of human leptin J Biol Chem 1998 273 35245 35249 9857064
   PubMed Web of Science ®Google Scholar
• Fruhbeck G Intracellular signalling pathways activated by leptin Biochem J 2006 393 7 20 16336196
   PubMed Web of Science ®Google Scholar
• Friedman J Leptin, leptin receptors, and the control of body weight Blum WF Kiess W Rascher W Leptin – The Voice of Adipose Tissue Heidelberg JA Barth Verlag 1997 3 22
   Google Scholar
• Tartaglia LA Dembski M Weng X Identification and expression cloning of a leptin receptor, OB-R Cell 1995 83 1263 1271 8548812
   PubMed Web of Science ®Google Scholar
• Bazan JF Structural design and molecular evolution of a cytokine receptor superfamily Proc Natl Acad Sci U S A 1990 87 6934 6938 2169613
   PubMed Web of Science ®Google Scholar
• Tartaglia LA The leptin receptor J Biol Chem 1997 272 6093 6096 9102398
   PubMed Web of Science ®Google Scholar
• Banks AS Davis SM Bates SH Myers MGJr Activation of downstream signals by the long form of the leptin receptor J Biol Chem 2000 275 14563 14572 10799542
   PubMed Web of Science ®Google Scholar
• Bjorbaek C Uotani S da Silva B Flier JS Divergent signaling capacities of the long and short isoforms of the leptin receptor J Biol Chem 1997 272 32686 32695 9405487
   PubMed Web of Science ®Google Scholar
• Stahl N Farruggella TJ Boulton TG Zhong Z Darnell JEJr Yancopoulos GD Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors Science 1995 267 1349 1353 7871433
   PubMed Web of Science ®Google Scholar
• Wang XJ Yuan SL Lu Q Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma World J Gastroenterol 2004 10 2478 2481 15300888
   PubMed Web of Science ®Google Scholar
• Wang SN Yeh YT Yang SF Chai CY Lee KT Potential role of leptin expression in hepatocellular carcinoma J Clin Pathol 2006 59 930 934 16565221
   PubMed Web of Science ®Google Scholar
• Chen L Shi Y Jiang CY Sun Q Wang LX Dai GH Expression of leptin and leptin receptor in hepatocellular carcinoma and the clinicopathological significance Nan Fang Yi Ke Da Xue Xue Bao 2011 31 830 833 21602135
   PubMedGoogle Scholar
• Zhou J Lei W Shen L Luo HS Shen ZX Primary study of leptin and human hepatocellular carcinoma in vitro World J Gastroenterol 2008 14 2900 2904 18473418
   PubMed Web of Science ®Google Scholar
• Myers MG Cowley MA Munzberg H Mechanisms of leptin action and leptin resistance Annu Rev Physiol 2008 70 537 556 17937601
   PubMed Web of Science ®Google Scholar
• Zhou W Tian Y Gong H Guo S Luo C Oncogenic role and therapeutic target of leptin signaling in colorectal cancer Expert Opin Ther Targets 2014 19 1 11
   Google Scholar
• Steelman LS Stadelman KM Chappell WH Akt as a therapeutic target in cancer Expert Opin Ther Targets 2008 12 1139 1165 18694380
   PubMed Web of Science ®Google Scholar
• Wickenden JA Watson CJ Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts Breast Cancer Res 2010 12 202 20398329
   PubMed Web of Science ®Google Scholar
• Agarwal E Brattain MG Chowdhury S Cell survival and metastasis regulation by Akt signaling in colorectal cancer Cell Signal 2013 25 1711 1719 23603750
   PubMed Web of Science ®Google Scholar
• Zhou Q Lui VW Yeo W Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma Future Oncol 2011 7 1149 1167 21992728
   PubMed Web of Science ®Google Scholar
• Sabbah M Emami S Redeuilh G Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers Drug Resist Updat 2008 11 123 151 18718806
   PubMed Web of Science ®Google Scholar
• Lamouille S Derynck R Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition Cells Tissues Organs 2011 193 8 22 21041997
   PubMed Web of Science ®Google Scholar
• Fu Z Ren L Wei H Effects of Tyroserleutide on phosphatidylinositol 3′-kinase/AKT pathway in human hepatocellular carcinoma cell J Drug Target 2014 22 146 155 24147456
   PubMed Web of Science ®Google Scholar
• Cheng SP Yin PH Hsu YC Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways Oncol Rep 2011 26 1265 1271 21750869
   PubMed Web of Science ®Google Scholar
• Uddin S Bu R Ahmed M Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma Leuk Lymphoma 2010 51 1305 1314 20443680
   PubMed Web of Science ®Google Scholar
• Uddin S Bavi P Siraj AK Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma Endocr Relat Cancer 2010 17 191 202 20008098
   PubMed Web of Science ®Google Scholar
• Riolfi M Ferla R Del Valle L Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy Brain Pathol 2010 20 481 489 19775291
   PubMed Web of Science ®Google Scholar
• Uddin S Bu R Ahmed M Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer Mol Cancer 2009 8 74 19765303
   PubMed Web of Science ®Google Scholar
• Uddin S Bavi PP Hussain AR Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication Carcinogenesis 2009 30 1832 1840 19520793
   PubMed Web of Science ®Google Scholar
• Shen Y Wang Q Zhao Q Zhou J Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis Mol Med Rep 2009 2 295 299 21475828
   PubMed Web of Science ®Google Scholar
• Gao J Tian J Lv Y Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells Cancer Sci 2009 100 389 395 19154413
   PubMed Web of Science ®Google Scholar
• Miyazaki T Bub JD Iwamoto Y c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt Biochim Biophys Acta 2008 1782 593 604 18718531
   PubMed Web of Science ®Google Scholar
• Saxena NK Sharma D Ding X Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 2007 67 2497 2507 17363567
   PubMed Web of Science ®Google Scholar
• Fletcher S Drewry JA Shahani VM Page BD Gunning PT Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein Biochem Cell Biol 2009 87 825 833 19935868
   PubMed Web of Science ®Google Scholar
• Masciocchi D Gelain A Villa S Meneghetti F Barlocco D Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy Future Med Chem 2011 3 567 597 21526897
   PubMed Web of Science ®Google Scholar
• Zhang HF Lai R STAT3 in cancer-friend or foe? Cancers (Basel) 2014 6 1408 1440 24995504
   PubMed Web of Science ®Google Scholar
• Mankan AK Greten FR Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors Expert Opin Investig Drugs 2011 20 1263 1275
   PubMed Web of Science ®Google Scholar
• Zhao M Jiang B Gao FH Small molecule inhibitors of STAT3 for cancer therapy Curr Med Chem 2011 18 26 4012 4018 21824090
   PubMed Web of Science ®Google Scholar
• Bates SH Kulkarni RN Seifert M Myers MGJr Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis Cell Metab 2005 1 169 178 16054060
   PubMed Web of Science ®Google Scholar
• Ratke J Entschladen F Niggemann B Zanker KS Lang K Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways Endocr Relat Cancer 2010 17 179 189 19952122
   PubMed Web of Science ®Google Scholar
• Catalano S Giordano C Rizza P Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation J Cell Physiol 2009 218 490 500 18988190
   PubMed Web of Science ®Google Scholar
• Li L Gao Y Zhang LL He DL Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells Cancer Biol Ther 2008 7 1787 1792 18787400
   PubMed Web of Science ®Google Scholar
• Saxena NK Vertino PM Anania FA Sharma D Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3 J Biol Chem 2007 282 13316 13325 17344214
   PubMed Web of Science ®Google Scholar
• Pai R Lin C Tran T Tarnawski A Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation Biochem Biophys Res Commun 2005 331 984 992 15882975
   PubMed Web of Science ®Google Scholar
• Yin N Wang D Zhang H Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin Cancer Res 2004 64 5870 5875 15313931
   PubMed Web of Science ®Google Scholar
• Dieudonne MN Machinal-Quelin F Serazin-Leroy V Leneveu MC Pecquery R Giudicelli Y Leptin mediates a proliferative response in human MCF7 breast cancer cells Biochem Biophys Res Commun 2002 293 622 628 12054648
   PubMed Web of Science ®Google Scholar
• Ogunwobi OO Beales IL The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt Int J Colorectal Dis 2007 22 401 409 16912864
   PubMed Web of Science ®Google Scholar
• Russo VC Metaxas S Kobayashi K Harris M Werther GA Antiapoptotic effects of leptin in human neuroblastoma cells Endocrinology 2004 145 4103 4112 15166121
   PubMed Web of Science ®Google Scholar
• Ren H Zhao T Wang X Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells Biochem Biophys Res Commun 2010 394 59 63 20171193
   PubMed Web of Science ®Google Scholar
• Cascio S Ferla R D’Andrea A Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells J Cell Physiol 2009 221 189 194 19492417
   PubMed Web of Science ®Google Scholar
• Gonzalez-Perez RR Xu Y Guo S Watters A Zhou W Leibovich SJ Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation Cell Signal 2010 22 1350 1362 20466060
   PubMed Web of Science ®Google Scholar
• Jiang H Yu J Guo H Song H Chen S Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells Biochem Biophys Res Commun 2008 368 1 5 18242580
   PubMed Web of Science ®Google Scholar
• Fan Y Mao R Yang J NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer Protein Cell 2013 4 176 185 23483479
   PubMed Web of Science ®Google Scholar
• He G Karin M NF-kappaB and STAT3 – key players in liver inflammation and cancer Cell Res 2011 21 159 168 21187858
   PubMed Web of Science ®Google Scholar
• Guo S Gonzalez-Perez RR Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer PLoS One 2011 6 6 e21467 21731759
   PubMed Web of Science ®Google Scholar
• Zhou W Guo S Gonzalez-Perez RR Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling Br J Cancer 2011 104 128 137 21139583
   PubMed Web of Science ®Google Scholar
• Ohba S Lanigan TM Roessler BJ Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes Osteoarthritis Cartilage 2010 18 1620 1629 20868760
   PubMed Web of Science ®Google Scholar
• Endo H Hosono K Uchiyama T Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis Gut 2011 60 1363 1371 21406387
   PubMed Web of Science ®Google Scholar
• Michelotti GA Machado MV Diehl AM NAFLD, NASH and liver cancer Nat Rev Gastroenterol Hepatol 2013 10 656 665 24080776
   PubMed Web of Science ®Google Scholar
• Duan XY Zhang L Fan JG Qiao L NAFLD leads to liver cancer: do we have sufficient evidence? Cancer Lett 2014 345 230 234 23941829
   PubMed Web of Science ®Google Scholar
• White DL Kanwal F El-Serag HB Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review Clin Gastroenterol Hepatol 2012 10 1342.e2 e1359.e2 23041539
   PubMed Web of Science ®Google Scholar
• Polyzos SA Kountouras J Zavos C Deretzi G The potential adverse role of leptin resistance in nonalcoholic fatty liver disease: a hypothesis based on critical review of the literature J Clin Gastroenterol 2011 45 50 54 20717042
   PubMed Web of Science ®Google Scholar
• Ikejima K Honda H Yoshikawa M Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals Hepatology 2001 34 288 297 11481614
   PubMed Web of Science ®Google Scholar
• Aleffi S Petrai I Bertolani C Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells Hepatology 2005 42 1339 1348 16317688
   PubMed Web of Science ®Google Scholar
• Gonzalez RR Leavis PC A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells Endocrine 2003 21 185 195 12897384
   PubMed Web of Science ®Google Scholar
• Gonzalez RR Cherfils S Escobar M Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2) J Biol Chem 2006 281 26320 26328 16825198
   PubMed Web of Science ®Google Scholar
• Rene Gonzalez R Watters A Xu Y Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer Breast Cancer Res 2009 11 R36 19531256
   PubMed Web of Science ®Google Scholar
• Otvos LJr Kovalszky I Riolfi M Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer Eur J Cancer 2011 47 1578 1584 21353530
   PubMed Web of Science ®Google Scholar
• Beccari S Kovalszky I Wade JD Otvos LJr Surmacz E Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity Peptides 2013 44 127 134 23567149
   PubMed Web of Science ®Google Scholar
• Zabeau L Verhee A Catteeuw D Selection of non-competitive leptin antagonists using a random nanobody-based approach Biochem J 2012 441 425 434 21851341
   PubMed Web of Science ®Google Scholar
• Fazeli M Zarkesh-Esfahani H Wu Z Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation J Immunol Methods 2006 312 190 200 16690078
   PubMed Web of Science ®Google Scholar
• Carpenter B Hemsworth GR Wu Z Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody Structure 2012 20 487 497 22405007
   PubMed Web of Science ®Google Scholar