Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors

References

• Alexandrov LB Nik-Zainal S Wedge DC Australian Pancreatic Cancer Genome Initiative ICGC Breast Cancer Consortium ICGC MMML-Seq Consortium ICGC PedBrain Signatures of mutational processes in human cancer Nature 2013 500 7463 415 421 23945592
   PubMed Web of Science ®Google Scholar
• Deng N Goh LK Wang H A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets Gut 2012 61 5 673 684 22315472
   PubMed Web of Science ®Google Scholar
• Waite KA Eng C Protean PTEN: form and function Am J Hum Genet 2002 70 4 829 844 11875759
   PubMed Web of Science ®Google Scholar
• Zhang LL Liu J Lei S Zhang J Zhou W Yu HG PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression Cell Signal 2014 26 5 1011 1020 24486402
   PubMed Web of Science ®Google Scholar
• Schneider E Keppler R Prawitt D Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN Int J Oncol 2011 38 3 823 831 21206972
   PubMed Web of Science ®Google Scholar
• Ye B Jiang LL Xu HT Zhou DW Li ZS Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis Int J Immunopathol Pharmacol 2012 25 3 627 636 23058013
   PubMed Web of Science ®Google Scholar
• Baig RM Mahjabeen I Sabir M Genetic changes in the PTEN gene and their association with breast cancer in Pakistan Asian Pac J Cancer Prev 2011 12 10 2773 2778 22320991
   PubMedGoogle Scholar
• Kandoth C Schultz N Cherniack AD Cancer Genome Atlas Research Network Integrated genomic characterization of endometrial carcinoma Nature 2013 497 7447 67 73 23636398
   PubMed Web of Science ®Google Scholar
• Moon SH Kim DK Cha Y Jeon I Song J Park KS PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line Int J Oncol 2013 42 3 921 928 23314408
   PubMed Web of Science ®Google Scholar
• Patel R Gao M Ahmad I Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression J Clin Invest 2013 123 3 1157 1175 23434594
   PubMed Web of Science ®Google Scholar
• Romano C Schepis C PTEN gene: a model for genetic diseases in dermatology Scientific World Journal 2012 2012 252457 22623890
   PubMed Web of Science ®Google Scholar
• Correia NC Gírio A Antunes I Martins LR Barata JT The multiple layers of non-genetic regulation of PTEN tumour suppressor activity Eur J Cancer 2014 50 1 216 225 24054978
   PubMed Web of Science ®Google Scholar
• Lee JO Yang H Georgescu MM Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell 1999 99 3 323 334 10555148
   PubMed Web of Science ®Google Scholar
• Papa A Wan L Bonora M Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function Cell 2014 157 3 595 610 24766807
   PubMed Web of Science ®Google Scholar
• Liaw D Marsh DJ Li J Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nat Genet 1997 16 1 64 67 9140396
   PubMed Web of Science ®Google Scholar
• Shenoy SS Nanda H Lösche M Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail J Struct Biol 2012 180 3 394 408 23073177
   PubMed Web of Science ®Google Scholar
• Sun Z Huang C He J PTEN C-terminal deletion causes genomic instability and tumor development Cell Rep 2014 6 5 844 854 24561254
   PubMed Web of Science ®Google Scholar
• Yang Z Yuan XG Chen J Luo SW Luo ZJ Lu NH Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation Clin Res Hepatol Gastroenterol 2013 37 1 72 79 22521126
   PubMed Web of Science ®Google Scholar
• Xu WT Yang Z Lu NH Roles of PTEN (Phosphatase and Tensin Homolog) in gastric cancer development and progression Asian Pac J Cancer Prev 2014 15 1 17 24 24528021
   PubMedGoogle Scholar
• Cordier F Chaffotte A Terrien E Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR J Am Chem Soc 2012 134 50 20533 20543 23171049
   PubMed Web of Science ®Google Scholar
• Bolduc D Rahdar M Tu-Sekine B Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis Elife 2013 2 e00691 23853711
   PubMed Web of Science ®Google Scholar
• Rahdar M Inoue T Meyer T Zhang J Vazquez F Devreotes PN A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN Proc Natl Acad Sci U S A 2009 106 2 480 485 19114656
   PubMed Web of Science ®Google Scholar
• Liang K Esteva FJ Albarracin C Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation Cancer Cell 2010 18 5 423 435 21075308
   PubMed Web of Science ®Google Scholar
• Jang HD Noh JY Shin JH Lin JJ Lee SY PTEN regulation by the Akt/GSK-3β axis during RANKL signaling Bone 2013 55 1 126 131 23419777
   PubMed Web of Science ®Google Scholar
• Mehenni H Lin-Marq N Buchet-Poyau K LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes Hum Mol Genet 2005 14 15 2209 2219 15987703
   PubMed Web of Science ®Google Scholar
• Odriozola L Singh G Hoang T Chan AM Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain J Biol Chem 282 32 23306 23315 17565999
   PubMed Web of Science ®Google Scholar
• Vemula S Shi J Hanneman P Wei L Kapur R ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability Blood 2010 115 9 1785 1796 20008297
   PubMed Web of Science ®Google Scholar
• Vo K Amarasinghe B Washington K Gonzalez A Berlin J Dang TP Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation Mol Cancer 2011 10 138 22074495
   PubMed Web of Science ®Google Scholar
• Papakonstanti EA Ridley AJ Vanhaesebroeck B The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN EMBO J 2007 26 13 3050 3061 17581634
   PubMed Web of Science ®Google Scholar
• Yim EK Peng G Dai H Rak functions as a tumor suppressor by regulating PTEN protein stability and function Cancer Cell 2009 15 4 304 314 19345329
   PubMed Web of Science ®Google Scholar
• Okahara F Itoh K Nakagawara A Murakami M Kanaho Y Maehama T Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation Mol Biol Cell 2006 17 11 4888 4895 16971513
   PubMed Web of Science ®Google Scholar
• Choi BH Pagano M Dai W Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog (PTEN) and Regulates Its Mitotic Activity during the Cell Cycle J Biol Chem 2014 289 20 14066 14074 24706748
   PubMed Web of Science ®Google Scholar
• Gomes AM Soares MV Ribeiro P Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels Haematologica 2014 99 6 1062 1068 24561792
   PubMed Web of Science ®Google Scholar
• Pallares J Llobet D Santacana M CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation Am J Pathol 2009 174 1 287 296 19056846
   PubMed Web of Science ®Google Scholar
• Lin C Liang Y Zhu H Zhang J Zhong X R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway Neurosci Lett 2012 529 1 60 65 22999923
   PubMed Web of Science ®Google Scholar
• Xu C Fillmore CM Koyama S Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression Cancer Cell 2014 25 5 590 604 24794706
   PubMed Web of Science ®Google Scholar
• Tanwar PS Mohapatra G Chiang S Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer Carcinogenesis 2014 35 3 546 553 24170201
   PubMed Web of Science ®Google Scholar
• Liu XS Song B Elzey BD Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation J Biol Chem 2011 286 41 35795 35800 21890624
   PubMed Web of Science ®Google Scholar
• Torres J Pulido R The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation J Biol Chem 2001 276 2 993 998 11035045
   PubMed Web of Science ®Google Scholar
• Trotman LC Wang X Alimonti A Ubiquitination regulates PTEN nuclear import and tumor suppression Cell 2007 128 1 141 156 17218261
   PubMed Web of Science ®Google Scholar
• Song MS Carracedo A Salmena L Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner Cell 2011 144 2 187 199 21241890
   PubMed Web of Science ®Google Scholar
• Wang X Trotman LC Koppie T NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN Cell 2007 128 1 129 139 17218260
   PubMed Web of Science ®Google Scholar
• Amodio N Scrima M Palaia L Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas Am J Pathol 2010 177 5 2622 2634 20889565
   PubMed Web of Science ®Google Scholar
• Eide PW Cekaite L Danielsen SA NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway Cell Signal 2013 25 1 12 18 22974840
   PubMed Web of Science ®Google Scholar
• Van Themsche C Leblanc V Parent S Asselin E X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization J Biol Chem 2009 284 31 20462 20466 19473982
   PubMed Web of Science ®Google Scholar
• Maddika S Kavela S Rani N WWP2 is an E3 ubiquitin ligase for PTEN Nat Cell Biol 2011 13 6 728 733 21532586
   PubMed Web of Science ®Google Scholar
• Song MS Salmena L Carracedo A The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network Nature 2008 455 7214 813 817 18716620
   PubMed Web of Science ®Google Scholar
• González-Santamaría J Campagna M Ortega-Molina A Regulation of the tumor suppressor PTEN by SUMO Cell Death Dis 2012 3 e393 23013792
   PubMed Web of Science ®Google Scholar
• Huang J Yan J Zhang J SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane Nat Commun 2012 3 911 22713753
   PubMed Web of Science ®Google Scholar
• Okumura K Mendoza M Bachoo RM DePinho RA Cavenee WK Furnari FB PCAF modulates PTEN activity J Biol Chem 2006 281 36 26562 26568 16829519
   PubMed Web of Science ®Google Scholar
• Ding L Chen S Liu P CBP loss cooperates with PTEN haploin-sufficiency to drive prostate cancer: implications for epigenetic therapy Cancer Res 2014 74 7 2050 2061 24491799
   PubMed Web of Science ®Google Scholar
• Chae HD Broxmeyer HE SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells Stem Cells Dev 2011 20 7 1277 1285 21083429
   PubMed Web of Science ®Google Scholar
• Cho SH Lee CH Ahn Y Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signaling FEBS Lett 2004 560 1–3 7 13 15017976
   PubMed Web of Science ®Google Scholar
• Lee SR Yang KS Kwon J Lee C Jeong W Rhee SG Reversible inactivation of the tumor suppressor PTEN by H2O2 J Biol Chem 2002 277 23 20336 20342 11916965
   PubMed Web of Science ®Google Scholar
• Gebremedhin D Terashvili M Wickramasekera N Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries PLoS One 2013 8 7 e68498 23861911
   PubMed Web of Science ®Google Scholar
• Leslie NR Bennett D Lindsay YE Stewart H Gray A Downes CP Redox regulation of PI 3-kinase signalling via inactivation of PTEN EMBO J 2003 22 20 5501 5510 14532122
   PubMed Web of Science ®Google Scholar
• Wu KL Wu CA Wu CW Chan SH Chang AY Chan JY Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats Antioxid Redox Signal 2013 18 1 36 50 22746319
   PubMed Web of Science ®Google Scholar
• Wu Y Zhou H Wu K Lee S Li R Liu X PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress Antioxid Redox Signal 2014 20 9 1382 1395 24063548
   PubMed Web of Science ®Google Scholar
• Cao J Schulte J Knight A Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity EMBO J 2009 28 10 1505 1517 19369943
   PubMed Web of Science ®Google Scholar
• Hui ST Andres AM Miller AK Txnip balances metabolic and growth signaling via PTEN disulfide reduction Proc Natl Acad Sci U S A 2008 105 10 3921 3926 18322014
   PubMed Web of Science ®Google Scholar
• Kwon J Lee SR Yang KS Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors Proc Natl Acad Sci U S A 2004 101 47 16419 16424 15534200
   PubMed Web of Science ®Google Scholar
• Xu J Tian W Ma X The molecular mechanism underlying morphine-induced Akt activation: roles of protein phosphatases and reactive oxygen species Cell Biochem Biophys 2011 61 2 303 311 21626435
   PubMed Web of Science ®Google Scholar