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Original Research

Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma

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Pages 2129-2136 | Published online: 31 Oct 2014

References

  • Esteller M Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg Clin Immunol 2003 109 80 88 14585279
  • Feinberg AP Tycko B The history of cancer epigenetics Nat Rev Cancer 2004 4 143 153 14732866
  • Ghavifekr Fakhr M Farshdousti Hagh M Shanehbandi D Baradaran B DNA methylation pattern as important epigenetic criterion in cancer Genet Res Int 2013 2013 317569 24455281
  • Delpu Y Cordelier P Cho WC Torrisani J DNA methylation and cancer diagnosis Int J Mol Sci 2013 14 15029 15058 23873296
  • Ma X Wang YW Zhang MQ Gazdar AF DNA methylation data analysis and its application to cancer research Epigenomics 2013 5 301 316 23750645
  • Dimopoulos K Gimsing P Gronbaek K The role of epigenetics in the biology of multiple myeloma Blood Cancer J 2014 4 e207 24786391
  • Sharma A Heuck CJ Fazzari MJ DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer Wiley Interdiscip Rev Syst Biol Med 2010 2 654 669 20890963
  • Rollig C Illmer T The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review Cancer Treat Rev 2009 35 425 30 19464807
  • Siegel R Ward E Brawley O Jemal A Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 2011 61 212 236 21685461
  • Kyle RA Therneau TM Rajkumar SV A long-term study of prognosis in monoclonal gammopathy of undetermined significance N Engl J Med 2002 346 564 569 11856795
  • Fonseca R Bailey RJ Ahmann GJ Genomic abnormalities in monoclonal gammopathy of undetermined significance Blood 2002 100 1417 1424 12149226
  • Chim CS Kwong YL Liang R Gene hypermethylation in multiple myeloma: lessons from a cancer pathway approach Clin Lymphoma Myeloma 2008 8 331 339 19064397
  • Walker BA Wardell CP Chiecchio L Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma Blood 2011 117 553 562 20944071
  • Wong KY Huang X Chim CS DNA methylation of microRNA genes in multiple myeloma Carcinogenesis 2012 33 1629 1638 22715154
  • International Myeloma Working Group Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group Br J Haematol 2003 121 749 757 12780789
  • Durie BG Salmon SE A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival Cancer 1975 36 842 854 1182674
  • Braggio E Maiolino A Gouveia ME Methylation status of nine tumor suppressor genes in multiple myeloma Int J Hematol 2010 91 87 96 20037750
  • Chen W Wu Y Zhu J Liu J Tan S Xia C Methylation of p16 and p15 genes in multiple myeloma Chin Med Sci J 2002 17 101 105 12906163
  • Chim CS Kwong YL Fung TK Liang R Methylation profiling in multiple myeloma Leuk Res 2004 28 379 385 15109538
  • Fan H Guo X Wu Q Detection of high methylation of p15(INK4B) and p16(INK4A) genes in multiple myeloma Zhongguo Shi Yan Xue Ye Xue Za Zhi 2000 8 271 274 Chinese 12578664
  • Galm O Wilop S Reichelt J DNA methylation changes in multiple myeloma Leukemia 2004 18 1687 1692 15318245
  • Guillerm G Depil S Wolowiec D Quesnel B Different prognostic values of p15(INK4b) and p16(INK4a) gene methylations in multiple myeloma Haematologica 2003 88 476 478 12681979
  • Guillerm G Gyan E Wolowiec D p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance Blood 2001 98 244 246 11418489
  • Martin P Garcia-Cosio M Santon A Bellas C Aberrant gene promoter methylation in plasma cell dyscrasias Exp Mol Pathol 2008 84 256 261 18410922
  • Ng MH Chung YF Lo KW Wickham NW Lee JC Huang DP Frequent hypermethylation of p16 and p15 genes in multiple myeloma Blood 1997 89 2500 2506 9116295
  • Seidl S Ackermann J Kaufmann H DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies Cancer 2004 100 2598 2606 15197802
  • Stanganelli C Arbelbide J Fantl DB Corrado C Slavutsky I DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance Ann Hematol 2010 89 191 199 19727727
  • Wu Q Guo X Fan H P15(INK4B) gene methylation in malignant hematopoietic diseases Zhonghua Xue Ye Xue Za Zhi 2000 21 644 646 Chinese 11877040
  • Gonzalez M Mateos MV Garcia-Sanz R De novo methylation of tumor suppressor gene p16/ INK4a is a frequent finding in multiple myeloma patients at diagnosis Leukemia 2000 14 183 187 10637494
  • Ng MH To KW Lo KW Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma Clin Cancer Res 2001 7 1724 1729 11410512
  • Li Y Nagai H Ohno T Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype Blood 2002 100 2572 2577 12239171
  • Chen CY Tsay W Tang JL SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia Genes Chromosomes Cancer 2003 37 300 305 12759928
  • Tasaka T Asou H Munker R Methylation of the p16INK4A gene in multiple myeloma Br J Haematol 1998 101 558 564 9633902
  • Voso MT Scardocci A Guidi F Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes Blood 2004 103 698 700 14504087
  • Heuck CJ Mehta J Bhagat T Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis J Immunol 2013 190 2966 2975 23408834
  • Wang X Zhu YB Cui HP Yu TT Aberrant promoter methylation of p15 and p16 genes may contribute to the pathogenesis of multiple myeloma: a meta-analysis Tumour Biol Epub 2014 6 8