Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

References

• Ferlay J Soerjomataram I Ervik M GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No 11 [homepage on the Internet] Lyon, France International Agency for Research on Cancer 2013 Available from: http://globocan.iarc.fr Accessed September 11, 2014
   Google Scholar
• Hartgrink HH Jansen EP van Grieken NC van de Velde CJ Gastric cancer Lancet 2009 374 9688 477 490 19625077
   PubMed Web of Science ®Google Scholar
• Siegel R Ma J Zou Z Jemal A Cancer statistics, 2014 CA Cancer J Clin 2014 64 1 9 29 24399786
   PubMed Web of Science ®Google Scholar
• Takahashi T Saikawa Y Kitagawa Y Gastric cancer: current status of diagnosis and treatment Cancers (Basel) 2013 5 1 48 63 24216698
   PubMedGoogle Scholar
• DeSantis CE Lin CC Mariotto AB Cancer treatment and survivorship statistics, 2014 CA Cancer J Clin 2014 64 4 252 271 24890451
   PubMed Web of Science ®Google Scholar
• Ortiz R Melguizo C Prados J New gene therapy strategies for cancer treatment: a review of recent patents Recent Pat Anticancer Drug Discov 2012 7 3 297 312 22339358
   PubMed Web of Science ®Google Scholar
• Wang D Gao G State-of-the-art human gene therapy: Part I Gene delivery technologies Discov Med 2014 18 97 67 77 25091489
   PubMed Web of Science ®Google Scholar
• Wadhwa R Song S Lee JS Yao Y Wei Q Ajani JA Gastric cancer – molecular and clinical dimensions Nat Rev Clin Oncol 2013 10 11 643 655 24061039
   PubMed Web of Science ®Google Scholar
• Prockop DJ Marrow stromal cells as stem cells for nonhematopoietic tissues Science 1997 276 5309 71 74 9082988
   PubMed Web of Science ®Google Scholar
• Bianco P Riminucci M Gronthos S Robey PG Bone marrow stromal stem cells: nature, biology, and potential applications Stem Cells 2001 19 3 180 192 11359943
   PubMed Web of Science ®Google Scholar
• Spaeth E Klopp A Dembinski J Andreeff M Marini F Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells Gene Ther 2008 15 10 730 738 18401438
   PubMed Web of Science ®Google Scholar
• Bao B Ahmad A Li Y Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells Expert Opin Ther Targets 2012 16 10 1041 1054 22877147
   PubMed Web of Science ®Google Scholar
• Dvorak HF Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing N Engl J Med 1986 315 26 1650 1659 3537791
   PubMed Web of Science ®Google Scholar
• Alagesan S Griffin MD Autologous and allogeneic mesenchymal stem cells in organ transplantation: what do we know about their safety and efficacy? Curr Opin Organ Transplant 2014 19 1 65 72 24370985
   PubMed Web of Science ®Google Scholar
• Bronckaers A Hilkens P Martens W Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis Pharmacol Ther 2014 143 2 181 196 24594234
   PubMed Web of Science ®Google Scholar
• Farini A Sitzia C Erratico S Meregalli M Torrente Y Clinical applications of mesenchymal stem cells in chronic diseases Stem Cells Int 2014 2014 306573 24876848
   PubMed Web of Science ®Google Scholar
• Sharma RR Pollock K Hubel A McKenna D Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices Transfusion 2014 54 5 1418 1437 24898458
   PubMed Web of Science ®Google Scholar
• Stagg J Galipeau J Mechanisms of immune modulation by mesenchymal stromal cells and clinical translation Curr Mol Med 2013 13 5 856 867 23642066
   PubMed Web of Science ®Google Scholar
• Atoui R Chiu RC Immune responses after mesenchymal stem cell implantation Methods Mol Biol 2013 1036 107 120 23807791
   PubMedGoogle Scholar
• Lotfinegad P Shamsasenjan K Movassaghpour A Majidi J Baradaran B Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy Adv Pharm Bull 2014 4 1 5 13 24409403
   PubMedGoogle Scholar
• Serakinci N Fahrioglu U Christensen R Mesenchymal stem cells, cancer challenges and new directions Eur J Cancer 2014 50 8 1522 1530 24613620
   PubMed Web of Science ®Google Scholar
• Uchibori R Tsukahara T Ohmine K Ozawa K Cancer gene therapy using mesenchymal stem cells Int J Hematol 2014 99 4 377 382 24578184
   PubMed Web of Science ®Google Scholar
• Nakamura T Nishizawa T Hagiya M Molecular cloning and expression of human hepatocyte growth factor Nature 1989 342 6248 440 443 2531289
   PubMed Web of Science ®Google Scholar
• Montesano R Matsumoto K Nakamura T Orci L Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor Cell 1991 67 5 901 908 1835669
   PubMed Web of Science ®Google Scholar
• Bottaro DP Rubin JS Faletto DL Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product Science 1991 251 4995 802 804 1846706
   PubMed Web of Science ®Google Scholar
• Takami T Kaposi-Novak P Uchida K Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis Cancer Res 2007 67 20 9844 9851 17942915
   PubMed Web of Science ®Google Scholar
• Marx-Stoelting P Borowiak M Knorpp T Birchmeier C Buchmann A Schwarz M Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met Int J Cancer 2009 124 8 1767 1772 19123478
   PubMed Web of Science ®Google Scholar
• Vigna E Comoglio PM Targeting the oncogenic Met receptor by antibodies and gene therapy Oncogene Epub 2014 6 2
   Web of Science ®Google Scholar
• Lee YH Morrison BL Bottaro DP Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia J Biol Chem 2014 289 30 20448 20461 24914205
   PubMed Web of Science ®Google Scholar
• Matsumoto K Nakamura T Sakai K Nakamura T Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4 Proteomics 2008 8 16 3360 3370 18646008
   PubMed Web of Science ®Google Scholar
• Matsumoto K Nakamura T NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics Cancer Sci 2003 94 4 321 327 12824898
   PubMed Web of Science ®Google Scholar
• Mizuno S Nakamura T HGF-MET cascade, a key target for inhibiting cancer metastasis: the impact of NK4 discovery on cancer biology and therapeutics Int J Mol Sci 2013 14 1 888 919 23296269
   PubMed Web of Science ®Google Scholar
• Matsumoto K Nakamura T Mechanisms and significance of bifunctional NK4 in cancer treatment Biochem Biophys Res Commun 2005 333 2 316 327 15950947
   PubMed Web of Science ®Google Scholar
• Suzuki Y Sakai K Ueki J Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma Int J Cancer 2010 127 8 1948 1957 20104519
   PubMed Web of Science ®Google Scholar
• Parikh RA Wang P Beumer JH Chu E Appleman LJ The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment Onco Targets Ther 2014 7 969 983 24959084
   PubMed Web of Science ®Google Scholar
• Kishi Y Kuba K Nakamura T Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models Cancer Sci 2009 100 7 1351 1358 19438869
   PubMed Web of Science ®Google Scholar
• Ogura Y Mizumoto K Nagai E Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival Cancer Gene Ther 2006 13 5 520 529 16341142
   PubMed Web of Science ®Google Scholar
• Kubota T Taiyoh H Matsumura A NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells Clin Exp Metastasis 2009 26 5 447 456 19234748
   PubMed Web of Science ®Google Scholar
• Kanehira M Xin H Hoshino K Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells Cancer Gene Ther 2007 14 11 894 903 17693990
   PubMed Web of Science ®Google Scholar
• Mohr A Lyons M Deedigan L Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model J Cell Mol Med 2008 12 6B 2628 2643 18373740
   PubMed Web of Science ®Google Scholar
• Zhu Y Cheng M Lu N Luo S Xie Y Liu D Construction of NK4 gene lentiviral vector and its expression in bone mesenchymal stem cells Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2011 28 5 976 981 Chinese 22097267
   PubMedGoogle Scholar
• Fu J Malm IJ Kadayakkara DK Levitsky H Pardoll D Kim YJ Preclinical evidence that PD1 blockade cooperates with cancer vaccine TEGVAX to elicit regression of established tumors Cancer Res 2014 74 15 4042 4052 24812273
   PubMed Web of Science ®Google Scholar
• Tsuji S Kawano S Sawaoka H Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines Prostaglandins Leukot Essent Fatty Acids 1996 55 3 179 183 8931116
   PubMed Web of Science ®Google Scholar
• Azizi SA Stokes D Augelli BJ DiGirolamo C Prockop DJ Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats – similarities to astrocyte grafts Proc Natl Acad Sci U S A 1998 95 7 3908 3913 9520466
   PubMed Web of Science ®Google Scholar
• Conget PA Minguell JJ Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells J Cell Physiol 1999 181 1 67 73 10457354
   PubMed Web of Science ®Google Scholar
• Nakamizo A Marini F Amano T Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas Cancer Res 2005 65 8 3307 3318 15833864
   PubMed Web of Science ®Google Scholar
• Beckermann BM Kallifatidis G Groth A VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma Br J Cancer 2008 99 4 622 631 18665180
   PubMed Web of Science ®Google Scholar
• Shinojima N Hossain A Takezaki T TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells Cancer Res 2013 73 7 2333 2344 23365134
   PubMed Web of Science ®Google Scholar
• Alt E Yan Y Gehmert S Fibroblasts share mesenchymal phenotypes with stem cells, but lack their differentiation and colony-forming potential Biol Cell 2011 103 4 197 208 21332447
   PubMed Web of Science ®Google Scholar
• Lordick F Targeting the HGF/MET pathway in gastric cancer Lancet Oncol 2014 15 9 914 916 24965570
   PubMed Web of Science ®Google Scholar
• Comoglio PM Giordano S Trusolino L Drug development of MET inhibitors: targeting oncogene addiction and expedience Nat Rev Drug Discov 2008 7 6 504 516 18511928
   PubMed Web of Science ®Google Scholar
• Rice J Ottensmeier CH Stevenson FK DNA vaccines: precision tools for activating effective immunity against cancer Nat Rev Cancer 2008 8 2 108 120 18219306
   PubMed Web of Science ®Google Scholar
• Nabel GJ Genetic, cellular and immune approaches to disease therapy: past and future Nat Med 2004 10 2 135 141 14760423
   PubMed Web of Science ®Google Scholar
• Wu TL Zhou D Viral delivery for gene therapy against cell movement in cancer Adv Drug Deliv Rev 2011 63 8 671 677 21616108
   PubMed Web of Science ®Google Scholar
• Aboody KS Najbauer J Danks MK Stem and progenitor cell-mediated tumor selective gene therapy Gene Ther 2008 15 10 739 752 18369324
   PubMed Web of Science ®Google Scholar
• Colter DC Class R DiGirolamo CM Prockop DJ Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow Proc Natl Acad Sci U S A 2000 97 7 3213 3218 10725391
   PubMed Web of Science ®Google Scholar
• Conget PA Minguell JJ Adenoviral-mediated gene transfer into ex vivo expanded human bone marrow mesenchymal progenitor cells Exp Hematol 2000 28 4 382 390 10781896
   PubMed Web of Science ®Google Scholar
• Hong IS Lee HY Kang KS Mesenchymal stem cells and cancer: Friends or enemies? Mutat Res Fundam Mol Mech Mutagen Epub 2014 2 7
   Web of Science ®Google Scholar
• Amara I Touati W Beaune P de Waziers I Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors Biochimie Epub 2014 6 27
   Web of Science ®Google Scholar
• Lee K Majumdar MK Buyaner D Hendricks JK Pittenger MF Mosca JD Human mesenchymal stem cells maintain transgene expression during expansion and differentiation Mol Ther 2001 3 6 857 866 11407899
   PubMed Web of Science ®Google Scholar
• Eliopoulos N Al-Khaldi A Crosato M Lachapelle K Galipeau J A neovascularized organoid derived from retrovirally engineered bone marrow stroma leads to prolonged in vivo systemic delivery of erythropoietin in nonmyeloablated, immunocompetent mice Gene Ther 2003 10 6 478 489 12621452
   PubMed Web of Science ®Google Scholar
• Glennie S Soeiro I Dyson PJ Lam EW Dazzi F Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells Blood 2005 105 7 2821 2827 15591115
   PubMed Web of Science ®Google Scholar
• Mizuguchi H Sasaki T Kawabata K Sakurai F Hayakawa T Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cells Biochem Biophys Res Commun 2005 332 4 1101 1106 15922299
   PubMed Web of Science ®Google Scholar
• Cavazza A Moiani A Mavilio F Mechanisms of retroviral integration and mutagenesis Hum Gene Ther 2013 24 2 119 131 23330935
   PubMed Web of Science ®Google Scholar
• Van Damme A Thorrez L Ma L Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells Stem Cells 2006 24 4 896 907 16339997
   PubMed Web of Science ®Google Scholar
• Emeagi PU Goyvaerts C Maenhout S Pen J Thielemans K Breckpot K Lentiviral vectors: a versatile tool to fight cancer Curr Mol Med 2013 13 4 602 625 22973872
   PubMed Web of Science ®Google Scholar
• Inoue H Murakami T Ajiki T Hara M Hoshino Y Kobayashi E Bioimaging assessment and effect of skin wound healing using bone-marrow-derived mesenchymal stromal cells with the artificial dermis in diabetic rats J Biomed Opt 2008 13 6 064036 19123682
   PubMed Web of Science ®Google Scholar
• Barcellos-de-Souza P Gori V Bambi F Chiarugi P Tumor microenvironment: bone marrow-mesenchymal stem cells as key players Biochim Biophys Acta 2013 1836 2 321 335 24183942
   PubMed Web of Science ®Google Scholar
• Goubran HA Kotb RR Stakiw J Emara ME Burnouf T Regulation of tumor growth and metastasis: the role of tumor microenvironment Cancer Growth Metastasis 2014 7 9 18 24926201
   PubMedGoogle Scholar
• Zhu Y Cheng M Xie Y Chemotaxis of bone marrow derived-mesenchymal stem cells to gastric cancer cells in vivo and in vitro Chinese Journal of Cancer Biotherapy 2011 6 647 652
   Google Scholar
• Jie JZ Wang JW Qu JG Hung T Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model World J Gastroenterol 2007 13 13 1938 1946 17461494
   PubMed Web of Science ®Google Scholar
• Son G Hirano T Seki E Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice J Hepatol 2006 45 5 688 695 16839638
   PubMed Web of Science ®Google Scholar
• Murakami M Nagai E Mizumoto K Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice Int J Cancer 2005 117 1 160 165 15880501
   PubMed Web of Science ®Google Scholar
• Wen J Matsumoto K Taniura N Tomioka D Nakamura T Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice Biochem Biophys Res Commun 2007 358 1 117 123 17467663
   PubMed Web of Science ®Google Scholar
• Buhles A Collins SA van Pijkeren JP Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours Genet Vaccines Ther 2009 7 5 19272140
   PubMedGoogle Scholar
• Kubota T Taiyoh H Matsumura A Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T lymphocyte activation Int J Cancer 2009 125 12 2879 2886 19588506
   PubMed Web of Science ®Google Scholar