Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action

References

• Larsen MA Goll R Lekahl S Moen OS Florholmen J Delayed clearance of triglyceride-rich lipoproteins in young, healthy obese subjects Clin Obes 2015 5 6 349 357 26469529
   PubMedGoogle Scholar
• Kral JG Heymsfield S Morbid obesity: definitions, epidemiology, and methodological problems Gastroenterol Clin North Am 1987 16 2 197 205
   Web of Science ®Google Scholar
• Kumanyika SK Obarzanek E Stettler N Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: a scientific statement from American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for Prevention (formerly the expert panel on population and prevention science) Circulation 2008 118 4 428 464 18591433
   PubMed Web of Science ®Google Scholar
• Nguyen DM El-Serag HB The epidemiology of obesity Gastroenterol Clin North Am 2010 39 1 1 7 20202574
   PubMed Web of Science ®Google Scholar
• Macdonald KG Overview of the epidemiology of obesity and the early history of procedures to remedy morbid obesity Arch Surg 2003 138 4 357 360 12686520
   PubMedGoogle Scholar
• Galgani J Ravussin E Energy metabolism, fuel selection and body weight regulation Int J Obes 2008 32 Suppl 7 S109 S119
   Web of Science ®Google Scholar
• Gibson TM Ehrhardt MJ Ness KK Obesity and metabolic syndrome among adult survivors of childhood leukemia Curr Treat Options Oncol 2016 17 4 17 26951206
   PubMed Web of Science ®Google Scholar
• Alberti KG Zimmet PZ Pf Z Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 1998 15 7 539 553 9686693
   PubMed Web of Science ®Google Scholar
• Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 2001 285 19 2486 2497 11368702
   PubMed Web of Science ®Google Scholar
• Desroches S Lamarche B The evolving definitions and increasing prevalence of the metabolic syndrome Appl Physiol Nutr Metab 2007 32 1 23 32 17332782
   PubMed Web of Science ®Google Scholar
• Kolovou GD Anagnostopoulou KK Salpea KD Mikhailidis DP The prevalence of metabolic syndrome in various populations Am J Med Sci 2007 333 6 362 371 17570989
   PubMed Web of Science ®Google Scholar
• Anis KV Rajeshkumar NV Kuttan R Inhibition of chemical carcinogenesis by berberine in rats and mice J Pharm Pharmacol 2001 53 5 763 768 11370717
   PubMed Web of Science ®Google Scholar
• Gurib-Fakim A Medicinal plants: traditions of yesterday and drugs of tomorrow Mol Aspects Med 2006 27 1 1 93 16105678
   PubMedGoogle Scholar
• Rounsaville TJ Ranney TG Ploidy levels and genome sizes of Berberis L. and Mahonia Nutt. species, hybrids, and cultivars HortScience 2010 45 7 1029 1033
   Web of Science ®Google Scholar
• Mokhber-Dezfuli N Saeidnia S Gohari AR Kurepaz-Mahmoodabadi M Phytochemistry and pharmacology of Berberis species Pharmacogn Rev 2014 8 15 8 24600191
   PubMedGoogle Scholar
• Arayne MS Sultana N Bahadur SS The berberis story: Berberis vulgaris in therapeutics Pak J Pharm Sci 2007 20 1 83 92 17337435
   PubMed Web of Science ®Google Scholar
• Abd El-Wahab AE Ghareeb DA Sarhan EE Abu-Serie MM El Demellawy MA In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, antidiabetic and anticancer effects BMC Complement Altern Med 2013 13 218 24007270
   PubMedGoogle Scholar
• di Pierro F Villanova N Agostini F Marzocchi R Soverini V Marchesini G Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control Diabetes Metab Syndr Obes 2012 5 213 22924000
   PubMedGoogle Scholar
• Choi BH Ahn IS Kim YH Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte Exp Mol Med 2006 38 6 599 605 17202835
   PubMed Web of Science ®Google Scholar
• Zhao W Xue R Zhou ZX Kong WJ Jiang JD Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis Biomed Pharmacother 2008 62 10 730 731 18337056
   PubMed Web of Science ®Google Scholar
• Mohammadi A Sahebkar A Kermani T Zhilaee M Tavallaie S Ghayour Mobarhan M Barberry administration and pro-oxidant-antioxidant balance in patients with metabolic syndrome Iran Red Crescent Med J 2014 16 12 e16786 25763235
   PubMed Web of Science ®Google Scholar
• Potdar D Hirwani RR Dhulap S Phyto-chemical and pharmacological applications of Berberis aristata Fitoterapia 2012 83 5 817 830 22808523
   PubMed Web of Science ®Google Scholar
• Giri S Rattan R Haq E AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model Nutr Metab 2006 3 31
   Google Scholar
• Hu Y Davies GE Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation Phytomedicine 2009 16 9 864 873 19403287
   PubMed Web of Science ®Google Scholar
• Tong Q Tsai J Hotamisligil GS GATA transcription factors and fat cell formation Drug News Perspect 2003 16 9 585 588 14702139
   PubMedGoogle Scholar
• Hu Y Davies GE Berberine inhibits adipogenesis in high-fat diet-induced obesity mice Fitoterapia 2010 81 5 358 366 19861153
   PubMed Web of Science ®Google Scholar
• Tong Q Tsai J Tan G Dalgin G Hotamisligil GS Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation Mol Cell Biol 2005 25 2 706 715 15632071
   PubMed Web of Science ®Google Scholar
• Wang H Zhu C Ying Y Luo L Huang D Luo Z Metformin and berberine, two versatile drugs in treatment of common metabolic diseases Oncotarget 2018 9 11 10135 10146 29515798
   PubMedGoogle Scholar
• Xie M Roy R AMP-activated kinase regulates lipid droplet localization and stability of adipose triglyceride lipase in C. elegans Dauer Larvae PLoS One 2015 10 6 e0130480 26098762
   PubMed Web of Science ®Google Scholar
• Jiang SJ Dong H Li JB Berberine inhibits hepatic gluconeogen-esis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats World J Gastroenterol 2015 21 25 7777 7785 26167077
   PubMed Web of Science ®Google Scholar
• Fan X Wang J Hou J Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway J Transl Med 2015 13 92 25884210
   PubMed Web of Science ®Google Scholar
• di Pierro F Putignano P Villanova N Montesi L Moscatiello S Marchesini G Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes Clin Pharmacol 2013 5 167 24277991
   PubMedGoogle Scholar
• Derosa G Maffioli P Cicero AF Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials Expert Opin Biol Ther 2012 12 8 1113 1124 22780092
   PubMed Web of Science ®Google Scholar
• Yin J Xing H Ye J Efficacy of berberine in patients with type 2 diabetes mellitus Metabolism 2008 57 5 712 717 18442638
   PubMed Web of Science ®Google Scholar
• Wang ZQ Lu FE Leng SH Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity World J Gastroenterol 2008 14 39 6004 18932278
   PubMed Web of Science ®Google Scholar
• Yi P Lu FE Xu LJ Chen G Dong H Wang KF Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta World J Gastroenterol 2008 14 6 876 18240344
   PubMed Web of Science ®Google Scholar
• Zhou JY Zhou SW Zhang KB Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats Biol Pharm Bull 2008 31 6 1169 1176 18520050
   PubMed Web of Science ®Google Scholar
• Huang C Zhang Y Gong Z Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway Biochem Biophys Res Commun 2006 348 2 571 578 16890192
   PubMed Web of Science ®Google Scholar
• Li H Chen W Zhou Y Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements J Lipid Res 2009 50 5 820 831 19141871
   PubMed Web of Science ®Google Scholar
• Liu W Tang F Deng Y Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition Mol Cell Biochem 2009 325 1–2 99 105 19142714
   PubMed Web of Science ®Google Scholar
• Cameron J Ranheim T Kulseth MA Leren TP Berge KE Berberine decreases PCSK9 expression in HepG2 cells Atherosclerosis 2008 201 2 266 273 18355829
   PubMed Web of Science ®Google Scholar
• Choi BH Ahn IS Kim YH Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte Exp Mol Med 2006 38 6 599 605 17202835
   PubMed Web of Science ®Google Scholar
• Lazavi F Mirmiran P Sohrab G Nikpayam O Angoorani P Hedayati M The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: a randomized clinical trial Complement Ther Clin Pract 2018 31 170 174 29705451
   PubMed Web of Science ®Google Scholar
• Fatehi-Hassanabad Z Jafarzadeh M Tarhini A Fatehi M The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats Phytother Res 2005 19 3 222 225 15934023
   PubMed Web of Science ®Google Scholar
• Peychev L Pharmacological investigation on the cardiovascular effects of Berberis vulgaris on tested animals Pharmacia 2005 52 1–2 118 121
   Google Scholar
• Ko WH Yao XQ Lau CW Vasorelaxant and antiproliferative effects of berberine Eur J Pharmacol 2000 399 2–3 187 196 10884519
   PubMed Web of Science ®Google Scholar
• Wong KK Mechanism of the aortic relaxation induced by low concentrations of berberine Planta Med 1998 64 8 756 757 9933995
   PubMed Web of Science ®Google Scholar
• Zilaee M Safarian M Kermany T Emamian M Mobarhan M Ferns G Effect of barberry treatment on blood pressure in patients with metabolic syndrome J Nat Prod 2015 8 59 63
   Google Scholar
• Pan LR Tang Q Fu Q Hu BR Xiang JZ Qian JQ Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice Acta Pharmacol Sin 2005 26 11 1334 1338 16225755
   PubMed Web of Science ®Google Scholar
• Kang DG Sohn EJ Kwon EK Han JH Oh H Lee HS Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels Vascul Pharmacol 2002 39 6 281 286 14567065
   PubMed Web of Science ®Google Scholar
• Liang KW Yin SC Ting CT Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells Eur J Pharmacol 2008 590 1–3 343 354 18590725
   PubMed Web of Science ®Google Scholar
• Liang KW Ting CT Yin SC Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury Biochem Pharmacol 2006 71 6 806 817 16448624
   PubMed Web of Science ®Google Scholar
• Cho BJ Im EK Kwon JH Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells Mol Cells 2005 20 3 429 434 16404160
   PubMed Web of Science ®Google Scholar
• Iloon Kashkooli R Najafi SS Sharif F The effect of Berberis vulgaris extract on transaminase activities in non-alcoholic fatty liver disease Hepat Mon 2015 15 2 e25067 25788958
   PubMed Web of Science ®Google Scholar
• Li XX Li CB Xiao J Berberine attenuates vascular remodeling and inflammation in a rat model of metabolic syndrome Biol Pharm Bull 2015 38 6 862 868 26027825
   PubMed Web of Science ®Google Scholar
• Moazezi Z Qujeq D Berberis fruit extract and biochemical parameters in patients with type II diabetes Jundishapur J Nat Pharm Prod 2014 9 2 e13490 24872938
   PubMedGoogle Scholar
• Pérez-Rubio KG González-Ortiz M Martínez-Abundis E Robles-Cervantes JA Espinel-Bermúdez MC Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion Metab Syndr Relat Disord 2013 11 5 366 369 23808999
   PubMed Web of Science ®Google Scholar
• Ebrahimi-Mamaghani M Arefhosseini S Golzarand M Aliasgarzadeh A Vahed-Jabbary M Long-term effects of processed Berberis vulgaris on some metabolic syndrome components Iran J Endocrinol Metab 2009 11 1
   Google Scholar