230
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study

, , , , , & show all
Pages 2039-2050 | Received 16 Mar 2023, Accepted 08 Jun 2023, Published online: 05 Jul 2023

References

  • Dabbah MA, Graham J, Petropoulos IN, Tavakoli M, Malik RA. Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Med Image Anal. 2011;15:738–747. doi:10.1016/j.media.2011.05.016
  • Copeland KC, Silverstein J, Moore KR, et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics. 2013;131:364–382. doi:10.1542/peds.2012-3494
  • Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 2016;92:63–69. doi:10.1136/postgradmedj-2015-133281
  • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Diabetes Care. 2012;35:1364–1379. doi:10.2337/dc12-0413
  • Kahn SE, Haffner SM, Heise MA, et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427–2443. doi:10.1056/NEJMoa066224
  • Ahrén B, Foley J, Bosi E. Clinical evidence and mechanistic basis for vildagliptin’s action when added to metformin. Diabetes Obes Metab. 2011;13:193–203. doi:10.1111/j.1463-1326.2010.01321.x
  • American Diabetes Association. 6. Glycemic targets: standards of medical care in diabetes-2020. Diabetes Care. 2020;43:S66–S76. doi:10.2337/dc20-S006
  • Mody R, Huang Q, Yu M, et al. Adherence, persistence, glycaemic control and costs among patients with type 2 diabetes initiating dulaglutide compared with liraglutide or exenatide once weekly at 12‐month follow‐up in a real‐world setting in the United States. Diabetes Obes Metab. 2019;21:920–929. doi:10.1111/dom.13603
  • Edelman SV, Polonsky WH. Type 2 diabetes in the real world: the elusive nature of glycemic control. Diabetes Care. 2017;40:1425–1432. doi:10.2337/dc16-1974
  • Davies MJ, D’Alessio DA, Fradkin J, et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018;61:2461–2498. doi:10.1007/s00125-018-4729-5
  • Ohta S. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther. 2014;144:1–11. doi:10.1016/j.pharmthera.2014.04.006
  • Huang CS, Kawamura T, Toyoda Y, Nakao A. Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res. 2010;44:971–982. doi:10.3109/10715762.2010.500328
  • Ming Y, Ma QH, Han XL, Li HY. Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress. Exp Ther Med. 2020;20:359–366. doi:10.3892/etm.2020.8708
  • Zheng M, Yu H, Xue Y, et al. The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus. Mol Cell Biochem. 2021;476:3089–3097. doi:10.1007/s11010-021-04145-x
  • Zhang XL, Liu J, Jin K, et al. Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig. 2018;9:83–90. doi:10.1111/jdi.12674
  • Wang QJ, Zha X-J, Kang Z-M, et al. Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J. 2012;125:1633–1637. doi:10.3760/cma.j.issn.0366-6999.2012.09.020
  • Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28:137–143. doi:10.1016/j.nutres.2008.01.008
  • LeBaron TW, Singh R, Fatima G, et al. The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: a randomized controlled trial. Diabetes Metab Syndr Obes. 2020;13:889–896. doi:10.2147/dmso.S240122
  • Zhao ZY, Ji H, Zhao Y, et al. Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: a retrospective, observational, double-arm, real-life clinical study. Front Endocrinol. 2023;13. doi:10.3389/fendo.2022.1114221
  • LeBaron TW, Laher I, Kura B, Slezak J. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Can J Physiol Pharmacol. 2019;97:797–807. doi:10.1139/cjpp-2019-0067
  • Amitani H, Asakawa A, Cheng K, et al. Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. PLoS One. 2013;8:e53913. doi:10.1371/journal.pone.0053913
  • Hegazi R, El-Gamal M, Abdel-Hady N, Hamdy OJ. Epidemiology of and risk factors for type 2 diabetes in Egypt. Ann Glob Health. 2015;81:814–820. doi:10.1016/j.aogh.2015.12.011
  • Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci. 2018;187:85–89. doi:10.1007/s11845-017-1638-4
  • Aslam M, Aggarwal S, Sharma KK, Galav V, Madhu SV. Postprandial hypertriglyceridemia predicts development of insulin resistance glucose intolerance and type 2 diabetes. PLoS One. 2016;11:e0145730. doi:10.1371/journal.pone.0145730
  • Qiu J, Liu Y, Yue Y, Qin Y, Li Z. Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. Nutr Res. 2016;36:1392–1401. doi:10.1016/j.nutres.2016.11.007
  • Kamimura N, Nishimaki K, Ohsawa I, Ohta SJO. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity. 2011;19:1396–1403. doi:10.1038/oby.2011.6
  • Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD. High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 2012;32:2813–2820. doi:10.1161/ATVBAHA.112.300133
  • Song GH, Li M, Sang H, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013;54:1884–1893. doi:10.1194/jlr.M036640
  • Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46:140–149. doi:10.3164/jcbn.09-100
  • Snel M, Jonker JT, Schoones J, et al. Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol. 2012;2012:983814. doi:10.1155/2012/983814
  • Yoritaka A, Kobayashi Y, Hayashi T, Saiki S, Hattori N. Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. Neurol Sci. 2021;42:4767–4770. doi:10.1007/s10072-021-05489-4
  • Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13:688–694. doi:10.1038/nm1577
  • Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res. 2010;38:1893–1903. doi:10.1177/147323001003800602